Carolien Roos, Marc E A Spaanderman, Ewoud Schuit, Kitty W M Bloemenkamp, Antoinette C Bolte, Jérôme Cornette, Johannes J J Duvekot, Jim van Eyck, Maureen T M Franssen, Christianne J de Groot, Joke H Kok, Anneke Kwee, Ashley Merién, Bas Nij Bijvank, Brent C Opmeer, Martijn A Oudijk, Mariëlle G van Pampus, Dimitri N M Papatsonis, Martina M Porath, Hubertina C J Scheepers, Sicco A Scherjon, Krystyna M Sollie, Sylvia M C Vijgen, Christine Willekes, Ben Willem J Mol, Joris A M van der Post, Fred K Lotgering
IMPORTANCE: In threatened preterm labor, maintenance tocolysis with nifedipine, after an initial course of tocolysis and corticosteroids for 48 hours, may improve perinatal outcome. OBJECTIVE: To determine whether maintenance tocolysis with nifedipine will reduce adverse perinatal outcomes due to premature birth. DESIGN, SETTING, AND PARTICIPANTS: APOSTEL-II (Assessment of Perinatal Outcome with Sustained Tocolysis in Early Labor) is a double-blind, placebo-controlled trial performed in 11 perinatal units including all tertiary centers in The Netherlands...
January 2, 2013: JAMA