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RANDOMIZED CONTROLLED TRIAL
Phillip Scheinberg, Olga Nunez, Barbara Weinstein, Priscila Scheinberg, Angélique Biancotto, Colin O Wu, Neal S Young
BACKGROUND: In severe acquired aplastic anemia, hematopoietic failure is the result of immune-mediated destruction of bone marrow stem and progenitor cells. Immunosuppressive therapy with antithymocyte globulin (ATG) plus cyclosporine is an effective alternative to stem-cell transplantation and improves blood counts and survival. Although horse ATG is the standard therapy, rabbit ATG is more potent in depleting peripheral-blood lymphocytes and is preferred in other clinical circumstances...
August 4, 2011: New England Journal of Medicine
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