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Rush Resident Stars

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49 papers 100 to 500 followers Collection of articles published by the Rush General Surgery Residents
Laura Grimmer, Erik Liederbach, Jose Velasco, Catherine Pesce, Chi-Hsiung Wang, Katharine Yao
BACKGROUND: The rate of contralateral prophylactic mastectomy (CPM) for unilateral breast cancer has increased over the past decade, particularly for young women. This study investigates the impact of race and socioeconomic status (SES) on use of CPM. STUDY DESIGN: Using the National Cancer Data Base (NCDB), we selected 1,781,409 stage 0 to II unilateral breast cancer patients between 1998 and 2011. Trends in use of CPM by race and SES were analyzed using chi-square tests and logistic regression models...
July 2015: Journal of the American College of Surgeons
Nahid Rianon, Gillian Alex, Glenda Callender, Camilo Jimenez, Mimi Hu, Elizabeth Grubbs, Mauricio Moreno, Chetna Wathoo, Steven Petak, Nancy Perrier
BACKGROUND: Persistent postoperative elevation of parathyroid hormone (POePTH) following successful parathyroidectomy for primary hyperparathyroidism (PHPT) is presumed to result from bone remineralization. Predicting which patients may need treatment is difficult. This study investigated whether preoperative serum osteocalcin (OC), a bone turnover marker involved in mineralization, can predict POePTH. METHODS: A total of 198 patients (155 women and 43 men) with parathyroidectomy from November 2007 to October 2009 in MD Anderson Cancer Center, Houston, TX, USA, were included in our analysis...
June 2012: World Journal of Surgery
Paxton V Dickson, Gillian C Alex, Elizabeth G Grubbs, Montserrat Ayala-Ramirez, Camilo Jimenez, Douglas B Evans, Jeffrey E Lee, Nancy D Perrier
INTRODUCTION: Laparoscopic adrenalectomy (LA) is a safe minimally invasive approach for treatment of pheochromocytoma (PHEO). Posterior retroperitoneoscopic adrenalectomy (PRA) is an alternative minimally invasive technique; however, there is a lack of data regarding the appropriateness of this approach in patients with PHEO. METHODS: Our endocrine surgery database was queried to identify patients who underwent LA or PRA for PHEO. Patient and tumor characteristics, as well as operative details and postoperative course were compared between the 2 groups...
September 2011: Surgery
Vidya A Fleetwood, Shannon Zielsdorf, Sheila Eswaran, Shriram Jakate, Edie Y Chan
We are reporting the first documented case of an abdominal desmoid tumor presenting primarily after liver transplantation. This tumor, well described in the literature as occurring both in conjunction with familial adenomatous polyposis as well as in the post-surgical patient, has never been noted after solid organ transplantation and was therefore not included in our differential upon presentation. Definitive diagnosis required the patient to undergo surgical excision and immunochemical staining of the mass for confirmation...
June 24, 2014: World Journal of Transplantation
Rana Ballo, Mina Saeed, Shaun Daly, Maria Pinzon, Amanda Francescatti, Keith W Millikan, Jonathan A Myers, Steven F Bines, Minh B Luu
No abstract text is available yet for this article.
February 2015: American Surgeon
Dae Won Kim, Andrew Zloza, Joseph Broucek, Jason M Schenkel, Carl Ruby, Georges Samaha, Howard L Kaufman
BACKGROUND: High-dose IL-2 (HDIL2) is approved for the treatment of metastatic melanoma and renal cell carcinoma, but its use is limited in part by toxicity related to the development of vascular leak syndrome (VLS). Therefore, an understanding of the mechanisms that underlie the initiation and progression of HDIL2-induced increases in endothelial cell (EC) permeability leading to VLS are of clinical importance. METHODS: We established a novel ex vivo approach utilizing primary human pulmonary microvascular ECs to evaluate EC barrier dysfunction in response to IL-2...
2014: Journal of Translational Medicine
Tasha Hughes, Matthew Klairmont, Joseph Broucek, Gail Iodice, Sanjib Basu, Howard L Kaufman
High-dose interleukin-2 (HD IL-2) is an approved immunotherapy agent for metastatic melanoma and renal cell carcinoma resulting in objective responses in 15-20 % of patients. An additional subset of patients achieves stable disease, and the natural history of these patients has not been well documented. We hypothesized that stable disease following HD IL-2 is associated with a survival advantage. To explore this hypothesis, a retrospective chart review of 305 patients diagnosed with metastatic melanoma or renal cell carcinoma treated with HD IL-2 was conducted...
April 2015: Cancer Immunology, Immunotherapy: CII
Howard L Kaufman, Dae Won Kim, Seunghee Kim-Schulze, Gail DeRaffele, Michael C Jagoda, Joseph R Broucek, Andrew Zloza
Oncolytic viruses have shown promise as gene delivery vehicles in the treatment of cancer; however, their efficacy may be inhibited by the induction of anti-viral antibody titers. Fowlpox virus is a nonreplicating and nononcolytic vector that has been associated with lesser humoral but greater cell-mediated immunity in animal tumor models. To test whether fowlpox virus gene therapy is safe and can elicit immune responses in patients with cancer, we conducted a randomized phase I clinical trial of two recombinant fowlpox viruses encoding human B7...
May 2014: Human Gene Therapy
John Kubasiak, Keith C Hood, Shaun Daly, Daniel J Deziel, Jonathan A Myers, Keith W Millikan, Imke Janssen, Minh B Luu
A consensus on the optimal surgical approach for repair of a paraesophageal hernia has not been reached. The aim of this study was to examine the outcomes of open and laparoscopic paraesophageal hernia repairs (PHR), both with and without mesh. A review of the National Surgical Quality Improvement Program (NSQIP) database from 2007 to 2011 was conducted. Patients who underwent an open or laparoscopic PHR were included. The primary outcome was 30-day mortality. Secondary outcomes included infections, respiratory and cardiac complications, intraoperative or perioperative transfusions, sepsis, and septic shock...
September 2014: American Surgeon
Brett A Fair, John C Kubasiak, Imke Janssen, Jonathan A Myers, Keith W Millikan, Daniel J Deziel, Minh B Luu
BACKGROUND: Surgery is indicated for acute uncomplicated appendicitis but the optimal timing is controversial. Recent literature is conflicting on the effect of time to intervention. METHODS: We queried the American College of Surgeons National Surgical Quality Improvement Project dataset for patients undergoing laparoscopic and open appendectomy between 2007 and 2012. Logistic regression was used to evaluate 30-day morbidity and mortality of intervention at different time periods, adjusting for preoperative risk factors...
March 2015: American Journal of Surgery
Shaun Daly, John C Kubasiak, Daniel Rinewalt, Ravi Pithadia, Sanjib Basu, Cristina Fhied, Gabriela C Lobato, Christopher W Seder, Edward Hong, William H Warren, Gary Chmielewski, Michael J Liptay, Philip Bonomi, Jeffrey A Borgia
BACKGROUND: Dysregulation of angiogenesis is known to be associated with tumorigenesis and metastatic progression in multiple carcinomas. The aim of this study was to evaluate the prognostic value of circulating angiogenesis biomarkers in lung adenocarcinoma progression. For that, we hypothesize that circulating levels of biomarkers characteristic for discrete processes within angiogenesis are associated with specific phases of disease progression. Appreciation of these profiles may have important implications for disease detection and prognostication...
December 2014: Annals of Thoracic Surgery
John C Kubasiak, Christopher W Seder, Ravi Pithadia, Sanjib Basu, Cristina Fhied, William W Phillips, Shaun Daly, David D Shersher, Mark A Yoder, Gary Chmielewski, Eric S Edell, Fabien Maldonado, Michael J Liptay, Jeffrey A Borgia
OBJECTIVE: Circulating biomarkers related to insulin-like growth factor (IGF) signaling are associated with disease progression in multiple carcinomas, but their potential diagnostic value for lung cancer screening has been inadequately examined. We evaluated 9 circulating IGF-related factors for their ability to assign clinical significance to indeterminate pulmonary nodules identified via computed tomography-based radiologic studies. METHODS: Patients (n = 224 stage I non-small cell lung cancer; n = 123 benign) were enrolled by Rush University and the Mayo Clinic and had pretreatment serum evaluated for levels of IGF-1, IGF-2, and insulin-like growth factor binding proteins (IGFBPs) 1-7...
March 2015: Journal of Thoracic and Cardiovascular Surgery
Chetan V Aher, John C Kubasiak, Shaun C Daly, Imke Janssen, Daniel J Deziel, Keith W Millikan, Jonathan A Myers, Minh B Luu
BACKGROUND: Numerous prospective studies and randomized controlled trials have demonstrated shorter length of stay, lower morbidity rates, and similar recurrence rates with laparoscopic ventral hernia repair (VHR) when compared to open VHR. Despite these promising results, previous data showed low utilization of laparoscopic VHR. The aim of our study was to evaluate the utilization of laparoscopic VHR using the most updated information from the American College of Surgeons-National Surgical Quality Improvement Project (NSQIP) dataset...
May 2015: Surgical Endoscopy
Tina J Hieken, Roberto Hernández-Irizarry, Julia M Boll, Jamie E Jones Coleman
BACKGROUND AND OBJECTIVES: While excisional biopsy is recommended to diagnose cutaneous melanoma, various biopsy techniques are used in practice. We undertook this study to identify how frequently final tumor stage and treatment recommendations changed from diagnostic biopsy to final histopathology after wide local excision (WLE). METHODS: We compared the histopathology of the dermatopathologist-reviewed diagnostic biopsy and final WLE in 332 cutaneous melanoma patients...
2013: International Journal of Surgical Oncology
Jeffrey A Mosenson, Andrew Zloza, John D Nieland, Elizabeth Garrett-Mayer, Jonathan M Eby, Erica J Huelsmann, Previn Kumar, Cecele J Denman, Andrew T Lacek, Frederick J Kohlhapp, Ahmad Alamiri, Tasha Hughes, Steven D Bines, Howard L Kaufman, Andreas Overbeck, Shikhar Mehrotra, Claudia Hernandez, Michael I Nishimura, Jose A Guevara-Patino, I Caroline Le Poole
Vitiligo is an autoimmune disease characterized by destruction of melanocytes, leaving 0.5% of the population with progressive depigmentation. Current treatments offer limited efficacy. We report that modified inducible heat shock protein 70 (HSP70i) prevents T cell-mediated depigmentation. HSP70i is the molecular link between stress and the resultant immune response. We previously showed that HSP70i induces an inflammatory dendritic cell (DC) phenotype and is necessary for depigmentation in vitiligo mouse models...
February 27, 2013: Science Translational Medicine
Daniel Rinewalt, Hongyan Du, Jose M Velasco
BACKGROUND: Simulation training may be an invaluable tool in training and assessing surgeons. Questions remain regarding its true impact on acquisition of laparoscopic skills and their transferability to the operating room. METHODS: Twenty general surgery residents completed 5 exercises: bean drop/rope drill, foam cutting/endoloop, checkerboard, endostitch, and suturing/intracorporeal knot. After baseline scoring, residents had 3 weeks to practice before re-testing...
October 2012: Surgery
Joseph R Broucek, Amanda B Francescatti, Garth R Swanson, Ali Keshavarzian, Marc I Brand, Theodore J Saclarides
No abstract text is available yet for this article.
June 2012: American Surgeon
Dana M Hayden, Maria C Mora Pinzon, Amanda B Francescatti, Sarah C Edquist, Matthew R Malczewski, Jennifer M Jolley, Marc I Brand, Theodore J Saclarides
BACKGROUND: Ileostomy creation has complications, including rehospitalization for fluid and electrolyte abnormalities. Although studies have identified predictors of this morbidity, readmission rates remain high. METHODS: The researchers conducted a retrospective chart review of all patients with ileostomy creation at a tertiary institution from January 2008 to June 2011. RESULTS: One hundred fifty-four patients (154) were included in this study; 71 (46...
February 2013: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Steven R Bonomo, Benjamin R Veenstra, Thomas M Komar, Harry M Richter
True left-sided gallbladder (sinistroposition) is a rare anatomic anomaly in which the gallbladder is found to the left of the falciform ligament, under the left lobe of the liver. Though uncommon, it is important for the surgeon to recognize this finding because the ductal anatomy is unique and the mechanics of the operation provide a technical challenge. Multiple case reports have documented safe management of sinistroposition encountered during conventional laparoscopic cholecystectomy. We present a case of sinistroposition encountered during a single-incision laparoscopic cholecystectomy...
April 2014: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Marta Batus, Salman Waheed, Carl Ruby, Lindsay Petersen, Steven D Bines, Howard L Kaufman
Melanoma is increasing in incidence and remains a major public health threat. Although the disease may be curable when identified early, advanced melanoma is characterized by widespread metastatic disease and a median survival of less than 10 months. In recent years, however, major advances in our understanding of the molecular nature of melanoma and the interaction of melanoma cells with the immune system have resulted in several new therapeutic strategies that are showing significant clinical benefit. Current therapeutic approaches include surgical resection of metastatic disease, chemotherapy, immunotherapy, and targeted therapy...
June 2013: American Journal of Clinical Dermatology
2014-07-10 21:01:17
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