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Glomerulopathies

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56 papers 100 to 500 followers
By Erica Yama Nephrologist
https://www.readbyqxmd.com/read/27733943/updates-in-anca-associated-vasculitis
#1
REVIEW
Christian Pagnoux
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are small-vessel vasculitides that include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Renal-limited ANCA-associated vasculitides can be considered the fourth entity. Despite their rarity and still unknown cause(s), research pertaining to ANCA-associated vasculitides has been very active over the past decades. The pathogenic role of antimyeloperoxidase ANCA (MPO-ANCA) has been supported using several animal models, but that of antiproteinase 3 ANCA (PR3-ANCA) has not been as strongly demonstrated...
September 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27303658/history-of-nephrotic-syndrome-and-evolution-of-its-treatment
#2
REVIEW
Abhijeet Pal, Frederick Kaskel
The recognition, evaluation, and early treatment of nephrotic syndrome in infants and children originate from physicians dating back to Hippocrates. It took nearly another 1000 years before the condition was described for its massive edema requiring treatment with herbs and other remedies. A rich history of observations and interpretations followed over the course of centuries until the recognition of the combination of clinical findings of foamy urine and swelling of the body, and measurements of urinary protein and blood analyses showed the phenotypic characteristics of the syndrome that were eventually linked to the early anatomic descriptions from first kidney autopsies and then renal biopsy analyses...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27338776/eular-era-edta-recommendations-for-the-management-of-anca-associated-vasculitis
#3
M Yates, R A Watts, I M Bajema, M C Cid, B Crestani, T Hauser, B Hellmich, J U Holle, M Laudien, M A Little, R A Luqmani, A Mahr, P A Merkel, J Mills, J Mooney, M Segelmark, V Tesar, K Westman, A Vaglio, N Yalçındağ, D R Jayne, C Mukhtyar
In this article, the 2009 European League Against Rheumatism (EULAR) recommendations for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) have been updated. The 2009 recommendations were on the management of primary small and medium vessel vasculitis. The 2015 update has been developed by an international task force representing EULAR, the European Renal Association and the European Vasculitis Society (EUVAS). The recommendations are based upon evidence from systematic literature reviews, as well as expert opinion where appropriate...
September 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27263398/obesity-related-glomerulopathy-clinical-and-pathologic-characteristics-and-pathogenesis
#4
REVIEW
Vivette D D'Agati, Avry Chagnac, Aiko P J de Vries, Moshe Levi, Esteban Porrini, Michal Herman-Edelstein, Manuel Praga
The prevalence of obesity-related glomerulopathy is increasing in parallel with the worldwide obesity epidemic. Glomerular hypertrophy and adaptive focal segmental glomerulosclerosis define the condition pathologically. The glomerulus enlarges in response to obesity-induced increases in glomerular filtration rate, renal plasma flow, filtration fraction and tubular sodium reabsorption. Normal insulin/phosphatidylinositol 3-kinase/Akt and mTOR signalling are critical for podocyte hypertrophy and adaptation. Adipokines and ectopic lipid accumulation in the kidney promote insulin resistance of podocytes and maladaptive responses to cope with the mechanical forces of renal hyperfiltration...
August 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27095365/evidence-based-clinical-practice-guidelines-for-iga-nephropathy-2014
#5
REVIEW
Yukio Yuzawa, Ryohei Yamamoto, Kazuo Takahashi, Ritsuko Katafuchi, Makoto Tomita, Yoshihide Fujigaki, Hiroshi Kitamura, Masashi Goto, Takashi Yasuda, Mitsuhiro Sato, Maki Urushihara, Shuji Kondo, Shoji Kagami, Yoshinari Yasuda, Hiroyuki Komatsu, Miki Takahara, Yasuaki Harabuchi, Kenjiro Kimura, Seiichi Matsuo
No abstract text is available yet for this article.
August 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/26921911/primary-glomerulonephritides
#6
REVIEW
Jürgen Floege, Kerstin Amann
Most glomerulonephritides, even the more common types, are rare diseases. They are nevertheless important since they frequently affect young people, often cannot be cured, and can lead to chronic kidney disease, including end-stage renal failure, with associated morbidity and cost. For example, in young adults, IgA nephropathy is the most common cause of end-stage renal disease. In this Seminar, we summarise existing knowledge of clinical signs, pathogenesis, prognosis, and treatment of glomerulonephritides, with a particular focus on data published between 2008 and 2015, and the most common European glomerulonephritis types, namely IgA nephropathy, membranous glomerulonephritis, minimal change disease, focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis, and the rare complement-associated glomerulonephritides such as dense deposit disease and C3 glomerulonephritis...
May 14, 2016: Lancet
https://www.readbyqxmd.com/read/26759049/the-mest-score-provides-earlier-risk-prediction-in-lga-nephropathy
#7
Sean J Barbour, Gabriela Espino-Hernandez, Heather N Reich, Rosanna Coppo, Ian S D Roberts, John Feehally, Andrew M Herzenberg, Daniel C Cattran
The Oxford Classification of IgA nephropathy (IgAN) includes the following four histologic components: mesangial (M) and endocapillary (E) hypercellularity, segmental sclerosis (S) and interstitial fibrosis/tubular atrophy (T). These combine to form the MEST score and are independently associated with renal outcome. Current prediction and risk stratification in IgAN requires clinical data over 2 years of follow-up. Using modern prediction tools, we examined whether combining MEST with cross-sectional clinical data at biopsy provides earlier risk prediction in IgAN than current best methods that use 2 years of follow-up data...
January 2016: Kidney International
https://www.readbyqxmd.com/read/26759052/nephrology-crossword-innovative-renal-pathology-for-precision-diagnosis
#8
Jeffrey B Tompkins, Banu Sis
No abstract text is available yet for this article.
January 2016: Kidney International
https://www.readbyqxmd.com/read/26457719/albumin-and-furosemide-combination-for-management-of-edema-in-nephrotic-syndrome-a-review-of-clinical-studies
#9
REVIEW
Margaret Duffy, Shashank Jain, Nicholas Harrell, Neil Kothari, Alluru S Reddi
The treatment of edema in patients with nephrotic syndrome is generally managed by dietary sodium restriction and loop diuretics. However, edema does not improve in some patients despite adequate sodium restriction and maximal dose of diuretics. In such patients, combination of albumin and a loop diuretic may improve edema by diuresis and natriuresis. The response to this combination of albumin and a diuretic has not been observed in all studies. The purpose of this review is to discuss the physiology of diuresis and natriuresis of this combination therapy, and provide a brief summary of various studies that have used albumin and a loop diuretic to improve diuretic-resistant edema...
October 7, 2015: Cells
https://www.readbyqxmd.com/read/26408242/ajkd-atlas-of-renal-pathology-fibrillary-glomerulonephritis
#10
Mark A Lusco, Agnes B Fogo, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
October 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26408241/ajkd-atlas-of-renal-pathology-glomerulonephritis-with-dominant-c3
#11
Mark A Lusco, Agnes B Fogo, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
October 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26300204/ajkd-atlas-of-renal-pathology-membranoproliferative-glomerulonephritis
#12
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
September 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26408243/ajkd-atlas-of-renal-pathology-immunotactoid-glomerulopathy
#13
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
October 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26408244/ajkd-atlas-of-renal-pathology-postinfectious-glomerulonephritis
#14
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
October 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26300203/ajkd-atlas-of-renal-pathology-membranous-nephropathy
#15
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
September 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26300205/ajkd-atlas-of-renal-pathology-dense-deposit-disease
#16
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
September 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26376134/new-developments-in-the-genetics-pathogenesis-and-therapy-of-iga-nephropathy
#17
REVIEW
Riccardo Magistroni, Vivette D D'Agati, Gerald B Appel, Krzysztof Kiryluk
Recent years have brought notable progress in the field of IgA nephropathy. Here, we highlight important new directions and latest developments, including successful discovery of several genetic susceptibility loci, formulation of the multihit pathogenesis model, introduction of the Oxford pathology scoring system, and formalization of the Kidney Disease Improving Global Outcomes (KDIGO) consensus treatment guidelines. We focus on the latest genetic findings that confirm a strong contribution of inherited factors and explain some of the geoethnic disparities in disease susceptibility...
November 2015: Kidney International
https://www.readbyqxmd.com/read/26210731/ajkd-atlas-of-renal-pathology-tip-lesion-variant-of-focal-segmental-glomerulosclerosis
#18
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
August 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26210730/ajkd-atlas-of-renal-pathology-collapsing-glomerulopathy
#19
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
August 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26210732/ajkd-atlas-of-renal-pathology-cellular-variant-of-focal-segmental-glomerulosclerosis
#20
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
August 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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