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54 papers 100 to 500 followers Just some articles I come across which interest me
https://www.readbyqxmd.com/read/26813214/association-of-immunotherapies-with-outcomes-in-relapsing-remitting-multiple-sclerosis
#1
Irene Tramacere, Cinzia Del Giovane, Graziella Filippini
CLINICAL QUESTION: What immunotherapies for multiple sclerosis are associated with the greatest benefit and highest risk of discontinuation due to adverse events in patients with relapsing-remitting multiple sclerosis? BOTTOM LINE: Alemtuzumab, natalizumab, and fingolimod were associated with the greatest benefit with regard to relapse prevention. Their association with prevention of disability worsening was unclear. Fingolimod was associated with a high risk of treatment discontinuation due to adverse events...
January 26, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26700907/understanding-idiopathic-intracranial-hypertension-mechanisms-management-and-future-directions
#2
REVIEW
Keira A Markey, Susan P Mollan, Rigmor H Jensen, Alexandra J Sinclair
Idiopathic intracranial hypertension is a disorder characterised by raised intracranial pressure that predominantly affects young, obese women. Pathogenesis has not been fully elucidated, but several causal factors have been proposed. Symptoms can include headaches, visual loss, pulsatile tinnitus, and back and neck pain, but the clinical presentation is highly variable. Although few studies have been done to support evidence-based management, several recent advances have the potential to enhance understanding of the causes of the disease and to guide treatment decisions...
January 2016: Lancet Neurology
https://www.readbyqxmd.com/read/26567270/the-wernicke-area-modern-evidence-and-a-reinterpretation
#3
REVIEW
Jeffrey R Binder
The term "Wernicke's area" is most often used as an anatomical label for the gyri forming the lower posterior left sylvian fissure. Although traditionally this region was held to support language comprehension, modern imaging and neuropsychological studies converge on the conclusion that this region plays a much larger role in speech production. This evidence is briefly reviewed, and a simple schematic model of posterior cortical language processing is described.
December 15, 2015: Neurology
https://www.readbyqxmd.com/read/26603369/headache-in-acute-ischaemic-stroke-a-lesion-mapping-study
#4
Christian L Seifert, Etienne M Schönbach, Stefano Magon, Elena Gross, Claus Zimmer, Anette Förschler, Thomas R Tölle, Mark Mühlau, Till Sprenger, Holger Poppert
Headache is a common symptom in acute ischaemic stroke, but the underlying mechanisms are incompletely understood. The aim of this lesion mapping study was to identify brain regions, which are related to the development of headache in acute ischaemic stroke. Patients with acute ischaemic stroke (n = 100) were assessed by brain MRI at 3 T including diffusion weighted imaging. We included 50 patients with stroke and headache as well as 50 patients with stroke but no headache symptoms. Infarcts were manually outlined and images were transformed into standard stereotaxic space using non-linear warping...
January 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/26554081/entraining-the-free-running-circadian-clocks-of-blind-people
#5
COMMENT
Charmane Eastman
No abstract text is available yet for this article.
October 31, 2015: Lancet
https://www.readbyqxmd.com/read/26551304/effect-of-clopidogrel-and-aspirin-vs-aspirin-alone-on-migraine-headaches-after-transcatheter-atrial-septal-defect-closure-the-canoa-randomized-clinical-trial
#6
RANDOMIZED CONTROLLED TRIAL
Josep Rodés-Cabau, Eric Horlick, Reda Ibrahim, Asim N Cheema, Marino Labinaz, Najaf Nadeem, Mark Osten, Mélanie Côté, Josep Ramon Marsal, Donald Rivest, Alier Marrero, Christine Houde
IMPORTANCE: The occurrence of new-onset migraine attacks is a complication of transcatheter atrial septal defect (ASD) closure. It has been suggested that clopidogrel may reduce migraine attacks after ASD closure. OBJECTIVE: To assess the efficacy of clopidogrel, used in addition to taking aspirin, for the prevention of migraine attacks following ASD closure. DESIGN, SETTING, AND PARTICIPANTS: Randomized, double-blind clinical trial performed in 6 university hospitals in Canada...
November 24, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26537743/neuromyelitis-optica-evaluation-of-871-attacks-and-1-153-treatment-courses
#7
Ingo Kleiter, Anna Gahlen, Nadja Borisow, Katrin Fischer, Klaus-Dieter Wernecke, Brigitte Wegner, Kerstin Hellwig, Florence Pache, Klemens Ruprecht, Joachim Havla, Markus Krumbholz, Tania Kümpfel, Orhan Aktas, Hans-Peter Hartung, Marius Ringelstein, Christian Geis, Christoph Kleinschnitz, Achim Berthele, Bernhard Hemmer, Klemens Angstwurm, Jan-Patrick Stellmann, Simon Schuster, Martin Stangel, Florian Lauda, Hayrettin Tumani, Christoph Mayer, Lena Zeltner, Ulf Ziemann, Ralf Linker, Matthias Schwab, Martin Marziniak, Florian Then Bergh, Ulrich Hofstadt-van Oy, Oliver Neuhaus, Alexander Winkelmann, Wael Marouf, Jürgen Faiss, Brigitte Wildemann, Friedemann Paul, Sven Jarius, Corinna Trebst
OBJECTIVE: Neuromyelitis optica (NMO) attacks often are severe, are difficult to treat, and leave residual deficits. Here, we analyzed the frequency, sequence, and efficacy of therapies used for NMO attacks. METHODS: A retrospective review was made of patient records to assess demographic/diagnostic data, attack characteristics, therapies, and the short-term remission status (complete remission [CR], partial remission [PR], no remission [NR]). Inclusion criteria were NMO according to Wingerchuk's 2006 criteria or aquaporin-4 antibody-positive NMO spectrum disorder (NMOSD)...
February 2016: Annals of Neurology
https://www.readbyqxmd.com/read/26529161/endovascular-thrombectomy-for-acute-ischemic-stroke-a-meta-analysis
#8
Jetan H Badhiwala, Farshad Nassiri, Waleed Alhazzani, Magdy H Selim, Forough Farrokhyar, Julian Spears, Abhaya V Kulkarni, Sheila Singh, Abdulrahman Alqahtani, Bram Rochwerg, Mohammad Alshahrani, Naresh K Murty, Adel Alhazzani, Blake Yarascavitch, Kesava Reddy, Osama O Zaidat, Saleh A Almenawer
IMPORTANCE: Endovascular intervention for acute ischemic stroke improves revascularization. But trials examining endovascular therapy yielded variable functional outcomes, and the effect of endovascular intervention among subgroups needs better definition. OBJECTIVE: To examine the association between endovascular mechanical thrombectomy and clinical outcomes among patients with acute ischemic stroke. DATA SOURCES: We systematically searched MEDLINE, EMBASE, CINAHL, Google Scholar, and the Cochrane Library without language restriction through August 2015...
November 3, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26501533/naproxen-with-cyclobenzaprine-oxycodone-acetaminophen-or-placebo-for-treating-acute-low-back-pain-a-randomized-clinical-trial
#9
RANDOMIZED CONTROLLED TRIAL
Benjamin W Friedman, Andrew A Dym, Michelle Davitt, Lynne Holden, Clemencia Solorzano, David Esses, Polly E Bijur, E John Gallagher
IMPORTANCE: Low back pain (LBP) is responsible for more than 2.5 million visits to US emergency departments (EDs) annually. These patients are usually treated with nonsteroidal anti-inflammatory drugs, acetaminophen, opioids, or skeletal muscle relaxants, often in combination. OBJECTIVE: To compare functional outcomes and pain at 1 week and 3 months after an ED visit for acute LBP among patients randomized to a 10-day course of (1) naproxen + placebo; (2) naproxen + cyclobenzaprine; or (3) naproxen + oxycodone/acetaminophen...
October 20, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26506088/vascular-defects-and-spinal-cord-hypoxia-in-spinal-muscular-atrophy
#10
Eilidh Somers, Robert D Lees, Katie Hoban, James N Sleigh, Haiyan Zhou, Francesco Muntoni, Kevin Talbot, Thomas H Gillingwater, Simon H Parson
OBJECTIVE: Spinal muscular atrophy (SMA) is a major inherited cause of infant death worldwide. It results from mutations in a single, ubiquitously expressed gene (SMN1), with loss of lower motor neurons being the primary pathological signature. Systemic defects have also been reported in SMA patients and animal models. We investigated whether defects associated with the vasculature contribute to motor neuron pathology in SMA. METHODS: Development and integrity of the capillary bed was examined in skeletal muscle and spinal cord of SMA mice, and muscle biopsies from SMA patients and controls, using quantitative morphometric approaches on immunohistochemically labeled tissue...
February 2016: Annals of Neurology
https://www.readbyqxmd.com/read/26506407/leigh-syndrome-one-disorder-more-than-75-monogenic-causes
#11
REVIEW
Nicole J Lake, Alison G Compton, Shamima Rahman, David R Thorburn
Leigh syndrome is the most common pediatric presentation of mitochondrial disease. This neurodegenerative disorder is genetically heterogeneous, and to date pathogenic mutations in >75 genes have been identified, encoded by 2 genomes (mitochondrial and nuclear). More than one-third of these disease genes have been characterized in the past 5 years alone, reflecting the significant advances made in understanding its etiological basis. We review the diverse biochemical and genetic etiology of Leigh syndrome and associated clinical, neuroradiological, and metabolic features that can provide clues for diagnosis...
February 2016: Annals of Neurology
https://www.readbyqxmd.com/read/26456231/near-infrared-light-is-neuroprotective-in-a-monkey-model-of-parkinson-disease
#12
Fannie Darlot, Cécile Moro, Nabil El Massri, Claude Chabrol, Daniel M Johnstone, Florian Reinhart, Diane Agay, Napoleon Torres, Dhaïf Bekha, Vincent Auboiroux, Thomas Costecalde, Cassandra L Peoples, Helena D T Anastascio, Victoria E Shaw, Jonathan Stone, John Mitrofanis, Alim-Louis Benabid
OBJECTIVE: To examine whether near-infrared light (NIr) treatment reduces clinical signs and/or offers neuroprotection in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkey model of Parkinson disease. METHODS: We implanted an optical fiber device that delivered NIr (670 nm) to the midbrain of macaque monkeys, close to the substantia nigra of both sides. MPTP injections (1.5-2.1mg/kg) were made over a 5- to 7-day period, during which time the NIr device was turned on...
January 2016: Annals of Neurology
https://www.readbyqxmd.com/read/26376969/myasthenia-gravis-subgroup-classification-and-therapeutic-strategies
#13
REVIEW
Nils Erik Gilhus, Jan J Verschuuren
Myasthenia gravis is an autoimmune disease that is characterised by muscle weakness and fatigue, is B-cell mediated, and is associated with antibodies directed against the acetylcholine receptor, muscle-specific kinase (MUSK), lipoprotein-related protein 4 (LRP4), or agrin in the postsynaptic membrane at the neuromuscular junction. Patients with myasthenia gravis should be classified into subgroups to help with therapeutic decisions and prognosis. Subgroups based on serum antibodies and clinical features include early-onset, late-onset, thymoma, MUSK, LRP4, antibody-negative, and ocular forms of myasthenia gravis...
October 2015: Lancet Neurology
https://www.readbyqxmd.com/read/26418341/simvastatin-and-vitamin-d-for-migraine-prevention-a-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Catherine Buettner, Rony-Reuven Nir, Suzanne M Bertisch, Carolyn Bernstein, Aaron Schain, Murray A Mittleman, Rami Burstein
OBJECTIVE: The aim of this work was to assess efficacy and tolerability of simvastatin plus vitamin D for migraine prevention in adults with episodic migraine. METHODS: We performed a randomized, double-blind, placebo-controlled trial with a 12-week baseline period and 24-week intervention period in 57 adults with episodic migraine. Participants were randomly assigned to simvastatin 20 mg tablets twice-daily plus vitamin D3 1,000 international units capsules twice-daily or matching placebo tablets and capsules...
December 2015: Annals of Neurology
https://www.readbyqxmd.com/read/26070341/early-eeg-contributes-to-multimodal-outcome-prediction-of-postanoxic-coma
#15
Jeannette Hofmeijer, Tim M J Beernink, Frank H Bosch, Albertus Beishuizen, Marleen C Tjepkema-Cloostermans, Michel J A M van Putten
OBJECTIVES: Early identification of potential recovery of postanoxic coma is a major challenge. We studied the additional predictive value of EEG. METHODS: Two hundred seventy-seven consecutive comatose patients after cardiac arrest were included in a prospective cohort study on 2 intensive care units. Continuous EEG was measured during the first 3 days. EEGs were classified as unfavorable (isoelectric, low-voltage, burst-suppression with identical bursts), intermediate, or favorable (continuous patterns), at 12, 24, 48, and 72 hours...
July 14, 2015: Neurology
https://www.readbyqxmd.com/read/23713579/blood-pressure-in-intracerebral-hemorrhage-how-low-should-we-go
#16
EDITORIAL
Jennifer A Frontera
No abstract text is available yet for this article.
June 20, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/25267983/opioids-for-chronic-noncancer-pain-a-position-paper-of-the-american-academy-of-neurology
#17
REVIEW
Gary M Franklin
The Patient Safety Subcommittee requested a review of the science and policy issues regarding the rapidly emerging public health epidemic of prescription opioid-related morbidity and mortality in the United States. Over 100,000 persons have died, directly or indirectly, from prescribed opioids in the United States since policies changed in the late 1990s. In the highest-risk group (age 35-54 years), these deaths have exceeded mortality from both firearms and motor vehicle accidents. Whereas there is evidence for significant short-term pain relief, there is no substantial evidence for maintenance of pain relief or improved function over long periods of time without incurring serious risk of overdose, dependence, or addiction...
September 30, 2014: Neurology
https://www.readbyqxmd.com/read/25847000/clinical-reasoning-a-57-year-old-woman-who-developed-acute-amnesia-following-fever-and-upper-respiratory-symptoms
#18
Brett A McCray, Deborah Forst, Jenelle Jindal, Galen V Henderson
No abstract text is available yet for this article.
April 7, 2015: Neurology
https://www.readbyqxmd.com/read/25531931/evaluation-of-no-evidence-of-disease-activity-in-a-7-year-longitudinal-multiple-sclerosis-cohort
#19
Dalia L Rotstein, Brian C Healy, Muhammad T Malik, Tanuja Chitnis, Howard L Weiner
IMPORTANCE: With multiple and increasingly effective therapies for relapsing forms of multiple sclerosis (MS), disease-free status or no evidence of disease activity (NEDA) has become a treatment goal and a new outcome measure. However, the persistence of NEDA over time and its predictive power for long-term prognosis are unknown. OBJECTIVE: To investigate NEDA during 7 years as measured by relapses, disability progression, and yearly magnetic resonance imaging (MRI)...
February 2015: JAMA Neurology
https://www.readbyqxmd.com/read/25401325/low-dose-aspirin-for-primary-prevention-of-cardiovascular-events-in-japanese-patients-60-years-or-older-with-atherosclerotic-risk-factors-a-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Yasuo Ikeda, Kazuyuki Shimada, Tamio Teramoto, Shinichiro Uchiyama, Tsutomu Yamazaki, Shinichi Oikawa, Masahiro Sugawara, Katsuyuki Ando, Mitsuru Murata, Kenji Yokoyama, Naoki Ishizuka
IMPORTANCE: Prevention of atherosclerotic cardiovascular diseases is an important public health priority in Japan due to an aging population. OBJECTIVE: To determine whether daily, low-dose aspirin reduces the incidence of cardiovascular events in older Japanese patients with multiple atherosclerotic risk factors. DESIGN, SETTING, AND PARTICIPANTS: The Japanese Primary Prevention Project (JPPP) was a multicenter, open-label, randomized, parallel-group trial...
December 17, 2014: JAMA: the Journal of the American Medical Association
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