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John Goffin, Christina Lacchetti, Peter M Ellis, Yee C Ung, William K Evans
INTRODUCTION: Non-small cell lung cancer (NSCLC) frequently presents at an incurable stage, and a majority of patients will be considered for palliative chemotherapy at some point in their disease. This article reviews the growing evidence for first-line treatment in NSCLC. METHODS: Studies of first-line chemotherapy regimens including new agents (docetaxel, gemcitabine, irinotecan, paclitaxel, pemetrexed, and vinorelbine) and targeted agents (bevacizumab, erlotinib, and gefitinib) were identified through Medline, Embase, the Cochrane databases, and web sites of guideline organizations...
February 2010: Journal of Thoracic Oncology
Kyung-Ho Jung, Jin Hee Lee, Cung Hoa Thien Quach, Jin-Young Paik, Hyunhee Oh, Jin Won Park, Eun Jeong Lee, Seung-Hwan Moon, Kyung-Han Lee
UNLABELLED: Resveratrol is gaining attention for its anticancer effects and is also recognized for its antioxidant properties and influence on glucose metabolism. Augmented reactive oxygen species (ROS) and high glycolytic flux are common characteristics of malignant cells. We thus evaluated the effect of resveratrol on cancer cell glucose metabolism and investigated the role of ROS in the response. METHODS: Cancer cells were measured for cell content and (18)F-FDG uptake...
December 2013: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Heesun Cheong, Chao Lu, Tullia Lindsten, Craig B Thompson
The metabolism of cancer cells is reprogrammed both by oncogene signaling and by dysregulation of metabolic enzymes. The resulting altered metabolism supports cellular proliferation and survival but leaves cancer cells dependent on a continuous supply of nutrients. Thus, many metabolic enzymes have become targets for new cancer therapies. Recently, two processes—expression of specific isoforms of metabolic enzymes and autophagy—have been shown to be crucial for the adaptation of tumor cells to changes in nutrient availability...
July 2012: Nature Biotechnology
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