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https://www.readbyqxmd.com/read/23303956/medial-prefrontal-cortex-inversely-regulates-toluene-induced-changes-in-markers-of-synaptic-plasticity-of-mesolimbic-dopamine-neurons
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Jacob T Beckley, Caitlin E Evins, Hleb Fedarovich, Meghin J Gilstrap, John J Woodward
Toluene is a volatile solvent that is intentionally inhaled by children, adolescents, and adults for its intoxicating effects. Although voluntary use of toluene suggests that it possesses rewarding properties and abuse potential, it is unknown whether toluene alters excitatory synaptic transmission in reward-sensitive dopamine neurons like other drugs of abuse. Here, using a combination of retrograde labeling and slice electrophysiology, we show that a brief in vivo exposure of rats to a behaviorally relevant concentration of toluene vapor enhances glutamatergic synaptic strength of dopamine (DA) neurons projecting to nucleus accumbens core and medial shell neurons...
January 9, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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