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Uma S Valeti, Rick A Nishimura, David R Holmes, Philip A Araoz, James F Glockner, Jerome F Breen, Steve R Ommen, Bernard J Gersh, A Jamil Tajik, Charanjit S Rihal, Hartzell V Schaff, Barry J Maron
OBJECTIVES: This study sought to describe the acute morphologic differences that result from septal myectomy and alcohol septal ablation using cardiac magnetic resonance (CMR) imaging. BACKGROUND: Surgical septal myectomy and alcohol septal ablation relieve left ventricular outflow tract obstruction in severely symptomatic patients with hypertrophic cardiomyopathy (HCM). METHODS: Cine and contrast-enhanced CMR images were obtained in HCM patients before and after septal myectomy (n = 24) and alcohol septal ablation (n = 24)...
January 23, 2007: Journal of the American College of Cardiology
Uma S Valeti, Todd D Miller, David O Hodge, Raymond J Gibbons
BACKGROUND: In a recent study, we reported that the Duke treadmill score was unable to effectively stratify elderly patients according to risk. The purpose of this study was to evaluate the prognostic value of exercise single-photon emission computed tomography (SPECT) in this same population and to examine results by gender. METHODS AND RESULTS: A cohort of 247 elderly (age > or =75 years) patients (108 women, 139 men, age 77+/-3 years) who underwent exercise thallium-201 SPECT were followed up for a median duration of 6...
April 12, 2005: Circulation
Paul Sorajja, Uma Valeti, Rick A Nishimura, Steve R Ommen, Charanjit S Rihal, Bernard J Gersh, David O Hodge, Hartzell V Schaff, David R Holmes
BACKGROUND: The clinical efficacy of alcohol septal ablation for drug-refractory hypertrophic cardiomyopathy remains unclear. This study examines the outcome of alcohol septal ablation performed at a tertiary hypertrophic cardiomyopathy referral center. METHODS AND RESULTS: Among 601 patients with severely symptomatic obstructive hypertrophic cardiomyopathy referred for alcohol septal ablation or myectomy from 1998 to 2006, 138 patients (median age, 64 years; 39% men) chose to undergo ablation...
July 8, 2008: Circulation
Kevin A Bybee, Brian D Powell, Uma Valeti, A Gabriela Rosales, Stephen L Kopecky, Charles Mullany, R Scott Wright
BACKGROUND: Aspirin is beneficial in the setting of atherosclerotic cardiovascular disease. There are limited data evaluating preoperative aspirin administration preceding coronary artery bypass grafting and associated postoperative outcomes. METHODS AND RESULTS: Using prospectively collected data from 1636 consecutive patients undergoing first-time isolated coronary artery bypass surgery at our institution from January 2000 through December 2002, we evaluated the association between aspirin usage within the 5 days preceding coronary bypass surgery and risk of adverse in-hospital postoperative events...
August 30, 2005: Circulation
James A Goldstein, Kavitha M Chinnaiyan, Aiden Abidov, Stephan Achenbach, Daniel S Berman, Sean W Hayes, Udo Hoffmann, John R Lesser, Issam A Mikati, Brian J O'Neil, Leslee J Shaw, Michael Y H Shen, Uma S Valeti, Gilbert L Raff
OBJECTIVES: The purpose of this study was to compare the efficiency, cost, and safety of a diagnostic strategy employing early coronary computed tomographic angiography (CCTA) to a strategy employing rest-stress myocardial perfusion imaging (MPI) in the evaluation of acute low-risk chest pain. BACKGROUND: In the United States, >8 million patients require emergency department evaluation for acute chest pain annually at an estimated diagnostic cost of >$10 billion...
September 27, 2011: Journal of the American College of Cardiology
Manesh R Patel, Stephen G Worthley, Amanda Stebbins, Thorsten Dill, Frank E Rademakers, Uma S Valeti, Uma S Velleti, Gregory W Barsness, Frans Van de Werf, Christian W Hamm, Paul W Armstrong, Christopher B Granger, Raymond J Kim
OBJECTIVES: The purpose of the study was to understand determinants of infarct size in a primary percutaneous intervention (PCI) population treated with pexelizumab compared with placebo. BACKGROUND: In the multicenter APEX-AMI (Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction) trial, pexelizumab did not reduce 90-day mortality. Cardiac magnetic resonance (CMR) with delayed enhancement was used in a substudy evaluating infarct size and left ventricular ejection fraction (LVEF)...
January 2010: JACC. Cardiovascular Imaging
Ronen Rubinshtein, James F Glockner, Steve R Ommen, Philip A Araoz, Michael J Ackerman, Paul Sorajja, J Martijn Bos, A Jamil Tajik, Uma S Valeti, Rick A Nishimura, Bernard J Gersh
BACKGROUND: Myocardial late gadolinium enhancement (LGE) on contrast-enhanced magnetic resonance imaging (CE-MRI) of patients with hypertrophic cardiomyopathy (HCM) has been suggested to represent intramyocardial fibrosis and, as such, an adverse prognostic risk factor. We evaluated the characteristics of LGE on CE-MRI and explored whether LGE among patients with HCM was associated with genetic testing, severe symptoms, ventricular arrhythmias, or sudden cardiac death (SCD). METHODS AND RESULTS: Four hundred twenty-four patients with HCM (age=55+/-16 years [range 2 to 90], 41% females), without a history of septal ablation/myectomy, underwent CE-MRI (GE 1...
January 2010: Circulation. Heart Failure
Deepak R Talreja, Rick A Nishimura, William D Edwards, Uma S Valeti, Steve R Ommen, A Jamil Tajik, Joseph A Dearani, Hartzell V Schaff, David R Holmes
OBJECTIVES: This study was designed to evaluate the effect of septal reduction therapies on the conduction system for patients with hypertrophic cardiomyopathy (HCM). BACKGROUND: Heart block is a potential complication of both catheter-based and surgical procedures to relieve left ventricular outflow tract obstruction in HCM, but it is important to understand the different effects of these treatments on the conduction system. METHODS: The electrocardiograms and postoperative course of patients who underwent percutaneous alcohol septal ablation or surgical myectomy at Mayo Clinic between 1999 and 2003 were reviewed...
December 21, 2004: Journal of the American College of Cardiology
Kenneth W Baran, Kathryn A Kamrowski, Jay J Westwater, Victor H Tschida, Charles F Alexander, Margaret M Beahrs, Thomas A Biggs, Patrick T Koller, Brian D Mahoney, Sara T Murray, Thomas E Raya, Peter K Rusterholz, Uma S Valeti, Thomas A Wiberg
No abstract text is available yet for this article.
July 2010: Circulation. Cardiovascular Quality and Outcomes
Raymond J Gibbons, Uma S Valeti, Philip A Araoz, Allan S Jaffe
We sought to summarize the published evidence regarding the measurement of infarct size by serum markers, technetium-99m sestamibi single-photon emission computed tomography (SPECT) myocardial perfusion imaging, and magnetic resonance imaging. The measurement of infarct size is an attractive surrogate end point for the early assessment of new therapies for acute myocardial infarction. For each of these three approaches, we reviewed reports published in English providing the clinical validation for the measurement of infarct size and the relevant clinical trial experience...
October 19, 2004: Journal of the American College of Cardiology
D Arab, V Valeti, H J Schünemann, A López-Candales
Prolongation of the QTc interval during stress testing predicts myocardial ischemia with a sensitivity of 88% and a specificity of 93%. Measurement of the QTc segment should be considered as an adjunctive electrocardiographic variable in the interpretation of stress tests and is even useful in patients who are not able to achieve the age-predicted target heart rate level.
March 15, 2000: American Journal of Cardiology
Philip A Araoz, James F Glockner, Kiaran P McGee, D Dean Potter, V Uma Valeti, David W Stanley, Timothy F Christian
PURPOSE: To compare myocardial enhancement during first-pass myocardial perfusion imaging at 3.0 Tesla (T) and 1.5T. MATERIALS AND METHODS: First-pass myocardial perfusion imaging was performed on twelve normal subjects at 3T and 1.5T using an interleaved notched saturation recovery gradient echo pulse sequence. Subjects received either 0.10 mmol/kg for both scans (group 1), 0.075 mmol/kg for both scans (group 2), or 0.075 mmol/kg for the 3T scan and 0.10 mmol/kg for the 1...
2005: Journal of Cardiovascular Magnetic Resonance
James A Fallavollita, Brian J Riegel, Gen Suzuki, Uma Valeti, John M Canty
Pigs with viable chronically dysfunctional myocardium and ischemic cardiomyopathy are at high risk of sudden cardiac death (SCD). We sought to identify the arrhythmic mechanism of SCD, the relation to changes in left ventricular (LV) function, and inducibility of malignant arrhythmias before SCD. Juvenile pigs (n = 72) were instrumented with chronic stenoses on proximal left anterior descending and circumflex arteries. Survival was only 29% 3 mo after instrumentation, and all deaths were sudden and without prodromal symptoms of heart failure...
December 2005: American Journal of Physiology. Heart and Circulatory Physiology
James A Fallavollita, Uma Valeti, Sameer Oza, John M Canty
BACKGROUND: Although electromechanical mapping has been used to assess cardiac physiology, interpretation is dependent upon the spatial variability of endocardial voltage and local shortening in normal and viable dysfunctional myocardium, which is currently unknown. METHODS: NOGA mapping was performed in 13 pigs with an established model of viable dysfunctional myocardium produced by a chronic LAD stenosis, and five uninstrumented controls. Voltage maps (122 +/- 7 points each) were obtained in the closed-chest anesthetized state, and (18)F-2-deoxyglucose uptake and TTC staining confirmed viability...
May 2004: Basic Research in Cardiology
Brian D Powell, Kevin A Bybee, Uma Valeti, Randal J Thomas, Stephen L Kopecky, Charles J Mullany, R Scott Wright
Statin therapy has recently been shown to decrease adverse perioperative events in patients undergoing vascular surgery. The potential beneficial effect of lipid-lowering therapy in patients undergoing coronary artery bypass grafting (CABG) is not well known. This was an observational analysis of 4,739 patients who underwent first-time isolated CABG at a single institution from 1995 to 2001. Patients were categorized into 2 groups based on treatment with a lipid-lowering agent within 30 days before surgery...
March 15, 2007: American Journal of Cardiology
Kavitha M Chinnaiyan, Abhay N Bilolikar, Edward Walsh, Daniel Wood, Ann DePetris, Ralph Gentry, Judith Boura, Suhny Abbara, Mouaz Al-Mallah, Kostaki Bis, Gilbert Boswell, Michael Gallagher, Ing-Orn Arunakul, Sandra Halliburton, Jill Jacobs, John Lesser, U Joseph Schoepf, Uma S Valeti, Gilbert L Raff
OBJECTIVES: To establish current radiation dose levels with contemporary scanners capable of prospectively triggered or high-pitch spiral scan modes to previous generation scanners among patients evaluated for coronary artery disease, pulmonary embolism, aortic disease, and "triple rule out" in a large population of patients at multiple centers. BACKGROUND: Previous small-scale studies with carefully controlled scan protocols report that CT scanners that facilitate prospectively triggered scanning and provide high-pitch spiral CT scan modes drastically lower radiation doses...
May 2014: Journal of Cardiovascular Computed Tomography
Timothy C Wong, Kayla M Piehler, Karolina M Zareba, Kathie Lin, Ashley Phrampus, Agam Patel, James C Moon, Martin Ugander, Uma Valeti, Jonathan E Holtz, Bo Fu, Chung-Chou H Chang, Michael Mathier, Peter Kellman, Javed Butler, Mihai Gheorghiade, Erik B Schelbert
BACKGROUND: Hospitalization for heart failure (HHF) is among the most important problems confronting medicine. Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) robustly identifies intrinsic myocardial damage. LGE may indicate inherent vulnerability to HHF, regardless of etiology, across the spectrum of heart failure stage or left ventricular ejection fraction (LVEF). METHODS AND RESULTS: We enrolled 1068 consecutive patients referred for CMR where 448 (42%) exhibited LGE...
2013: Journal of the American Heart Association
V Uma Valeti, Wookjin Chun, Donald D Potter, Philip A Araoz, Kiaran P McGee, James F Glockner, Timothy F Christian
PURPOSE: To determine whether imaging at 3 T could improve and prolong the tag contrast compared to images acquired at 1.5 T in normal volunteers, and whether such improvement would translate into the ability to perform strain measurements in diastole. MATERIALS AND METHODS: Normal volunteers (N = 13) were scanned at 1.5 T (GE Signa CV/i) and 3.0 T (GE VH/i). An ECG-triggered, segmented k-space, spoiled-gradient-echo grid-tagged sequence was used during cine acquisition...
April 2006: Journal of Magnetic Resonance Imaging: JMRI
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