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RANDOMIZED CONTROLLED TRIAL
Horng H Chen, Kevin J Anstrom, Michael M Givertz, Lynne W Stevenson, Marc J Semigran, Steven R Goldsmith, Bradley A Bart, David A Bull, Josef Stehlik, Martin M LeWinter, Marvin A Konstam, Gordon S Huggins, Jean L Rouleau, Eileen O'Meara, W H Wilson Tang, Randall C Starling, Javed Butler, Anita Deswal, G Michael Felker, Christopher M O'Connor, Raphael E Bonita, Kenneth B Margulies, Thomas P Cappola, Elizabeth O Ofili, Douglas L Mann, Víctor G Dávila-Román, Steven E McNulty, Barry A Borlaug, Eric J Velazquez, Kerry L Lee, Monica R Shah, Adrian F Hernandez, Eugene Braunwald, Margaret M Redfield
IMPORTANCE: Small studies suggest that low-dose dopamine or low-dose nesiritide may enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction; however, neither strategy has been rigorously tested. OBJECTIVE: To test the 2 independent hypotheses that, compared with placebo, addition of low-dose dopamine (2 μg/kg/min) or low-dose nesiritide (0.005 μg/kg/min without bolus) to diuretic therapy will enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction...
December 18, 2013: JAMA
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