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Face transplant

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105 papers 25 to 100 followers Vascularized composite allotransplantation of the face
By Mafer Amber QxMD ambassador, Mexican med student currently in 4° year, doing clinical research in vascularized composite allotransplantation
Mutaz B Habal
No abstract text is available yet for this article.
October 2016: Journal of Craniofacial Surgery
Harriet Kiwanuka, Mario A Aycart, David F Gitlin, Elaine Devine, Bridget J Perry, Thet-Su Win, Ericka M Bueno, Muayyad Alhefzi, Nicco Krezdorn, Bohdan Pomahac
BACKGROUND: Facial self-inflicted gunshot wounds (SIGSWs) cause a devastating midfacial defect and pose a challenging problem to the reconstructive surgeon. Face transplantation (FT) has the potential for near-normal restoration in otherwise non-reconstructible defects. Two out of 7 FT recipients at Brigham and Women's Hospital (BWH) sustained SIGSWs. In this study, we illustrate the role of FT in the management of SIGSWs through an aesthetic, functional, and psychosocial examination of outcomes...
September 8, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Jeff Chang, Scott S Graves, Tiffany Butts-Miwongtum, George E Sale, Rainer Storb, David W Mathes
BACKGROUND: The development of safe and reliable protocols for the transplantation of the face and hands may be accomplished with animal modeling of transplantation of vascularized composite allografts (VCA). Previously, we demonstrated that tolerance to a VCA could be achieved after canine recipients were simultaneously given marrow from a dog leukocyte antigen (DLA) identical donor. In the present study, we extend those findings across a DLA mismatched barrier. METHODS: Eight Recipient dogs received total body irradiation (4...
September 27, 2016: Transplantation
Mario A Aycart, Muayyad Alhefzi, Maximilian Kueckelhaus, Nicco Krezdorn, Ericka M Bueno, Edward J Caterson, Julian J Pribaz, Bohdan Pomahac
BACKGROUND: Face transplantation has emerged as a viable option for certain patients in the treatment of devastating facial injuries. However, as with autologous free tissue transfer, the need for secondary revisions in face transplantation also exists. The authors' group has quantified the number of revision operations in their cohort and has assessed the rationale, safety, and outcomes of posttransplantation revisions. METHODS: A retrospective analysis of prospectively collected data of the authors' seven face transplants was performed from April of 2009 to July of 2015...
October 2016: Plastic and Reconstructive Surgery
Tracy Espiritu McKay, Matina Balou, Daniel J Kao, Derek J Ho, Jeffrey Cohen, Eduardo D Rodriguez
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Stefan G Tullius, Bohdan Pomahac, Heung Bae Kim, Matthew J Carty, Simon G Talbot, Helen M Nelson, Francis L Delmonico
We report on the to date largest recovery of 11 organs from a single deceased donor with the transplantation of face, bilateral upper extremities, heart, 1 lung, liver (split for 2 recipients), kidneys, pancreas, and intestine. Although logistically challenging, this case demonstrates the feasibility and safety of the recovery of multiple thoracic and abdominal organs with multiple vascular composite allotransplants and tissues. Our experience of 8 additional successful multiple vascular composite allotransplants, thoracic, and abdominal organ recoveries suggests that such procedures are readily accomplishable from the same deceased donor...
October 2016: Transplantation
Laurent Lantieri, Philippe Grimbert, Nicolas Ortonne, Caroline Suberbielle, Dominique Bories, Salvador Gil-Vernet, Cédric Lemogne, Frank Bellivier, Jean Pascal Lefaucheur, Nathaniel Schaffer, Fréderic Martin, Jean Paul Meningaud, Pierre Wolkenstein, Mikael Hivelin
BACKGROUND: More than 30 face transplantations have been done worldwide since 2005 but no documented long-term follow-up has been reported in the literature. We aimed to answer remaining question about the long-term risks and benefits of face transplant. METHODS: In this single-centre, prospective, open study, we assessed 20 patients presenting with facial defects. Ten patients were selected, and, after three were secondarily excluded, seven were transplanted: two with neurofibromatosis 1, one with a burn, and four with self-inflicted facial gunshot injuries...
October 1, 2016: Lancet
Annemarie Weissenbacher, Alexandre Loupy, Anil Chandraker, Stefan Schneeberger
PURPOSE OF REVIEW: The presence of donor-specific antibodies (DSA) increases the risk of graft failure. Although DSA characteristics, human leukocyte antigen class specificity, mean fluorescence intensity and immunoglobulin G subclasses, and their impact on the graft are quite well studied in solid organ transplants, very little information is known about their impact on vascularized composite allotransplantation (VCA). The aim of this review is to highlight recent publications regarding occurrence and effects of DSA, their follow-up and treatment in the field of VCA...
October 2016: Current Opinion in Organ Transplantation
Antoine Sicard, Jean Kanitakis, Valérie Dubois, Palmina Petruzzo, Lionel Badet, Olivier Thaunat, Emmanuel Morelon
PURPOSE OF REVIEW: Vascularized composite allotransplantation (VCA) has several immunological peculiarities that imply a specific immune monitoring. Here, we provide an integrated view of current procedures of immune monitoring in VCA and potential complementary approaches learned from organ transplantation. RECENT FINDINGS: Because the skin is highly immunogenic and is the main target of the alloimmune response, immune monitoring in VCA essentially relies on visual inspection and pathological examination of for-causes and protocol skin biopsies...
October 2016: Current Opinion in Organ Transplantation
Sepehr Hashemi, Mehran Armand, Chad R Gordon
PURPOSE OF REVIEW: To describe the development and refinement of the computer-assisted planning and execution (CAPE) system for use in face-jaw-teeth transplants (FJTTs). RECENT FINDINGS: Although successful, some maxillofacial transplants result in suboptimal hybrid occlusion and may require subsequent surgical orthognathic revisions. Unfortunately, the use of traditional dental casts and splints pose several compromising shortcomings in the context of FJTT and hybrid occlusion...
October 2016: Current Opinion in Organ Transplantation
Sheila Jowsey-Gregoire, Martin Kumnig
PURPOSE OF REVIEW: Vascularized composite allotransplantation (VCA) encompasses hand, face, uterus, penile and lower extremity transplantation. Psychosocial factors are recognized as important, but no standard approach to the evaluation, selection or posttransplant care has been described and thus, the development of a standardized approach is needed. RECENT FINDINGS: Various psychosocial assessment tools have been reported. Body image and the functional impact of hand versus face transplantation are notable issues...
October 2016: Current Opinion in Organ Transplantation
Franka Messner, Johanna Grahammer, Theresa Hautz, Gerald Brandacher, Stefan Schneeberger
PURPOSE OF REVIEW: Ischemia and reperfusion injury (IRI) in vascularized tissue allotransplantation (VCA) remain largely undefined. Because VCA is comprised of different tissues, the sensitivity towards IRI may not be uniform. We, herein, attempt to address mechanistic aspects of IRI in VCA and provide a summary on potential technologies and targets for amelioration or treatment of IRI in this novel field. RECENT FINDINGS: IRI results in a loosened architecture of musculature, hypertrophic, centrally located cell nuclei as well as a high degree of neovascularization...
October 2016: Current Opinion in Organ Transplantation
Dimitra Kotsougiani, Caroline A Hundepool, Liselotte F Bulstra, Patricia Friedrich, Alexander Y Shin, Allen T Bishop
Current vascularized composite allotransplantation (VCA) transplantation protocols rely upon life-long immune modulation to maintain tissue perfusion. Alternatively, bone-only VCA viability may be maintained in small animal models using surgical angiogenesis from implanted autogenous vessels to develop a neoangiogenic bone circulation that will not be rejected. This study tests the method's efficacy in a large animal model as a bridge to clinical practice, quantifying the remodeling and mechanical properties of porcine tibial VCAs...
July 29, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Scott P Bartlett, Benjamin Chang, L Scott Levin
No abstract text is available yet for this article.
August 2016: Plastic and Reconstructive Surgery
Alexandre Marchac, Tomasine Kuschner, John Paris, Arnaud Picard, Marie Paule Vazquez, Laurent Lantieri
BACKGROUND: In 2005, face transplantation ceased to be fiction and became a scientific reality. Today, 10 teams from six different countries have performed 32 face transplantations. Immunosuppressive treatments are similar to other solid organ transplants, and patients have experienced a significant functional improvement. The authors are logically considering expanding face transplantation to children; however, children are not simply small adults. METHODS: The authors searched for pediatric patients in need of restoration of fundamental functions of the face, such as orbicularis oris or oculi muscle closure by, first, selecting cases from a pediatric plastic surgery reference center and, second, analyzing the feasibility of face transplantation in those patients...
August 2016: Plastic and Reconstructive Surgery
Jean-Paul Meningaud
No abstract text is available yet for this article.
July 2016: Plastic and Reconstructive Surgery
Laurent A Lantieri
No abstract text is available yet for this article.
July 2016: Plastic and Reconstructive Surgery
Andres Rodriguez-Lorenzo, Thorir Audolfsson, Corrine Wong, Daniel Saiepour, Daniel Nowinski, Shai Rozen
BACKGROUND: As the field of face transplantation develops, it may be possible to transplant segments of facial skin to replace facial aesthetic subunits in selected cases. The aim of this study is to identify the more reliable vascular pedicles of each facial aesthetic subunit for its use in transplantation METHODS:: Six full-facial soft tissue flaps were harvested and the external carotid arteries were identified and cannulated proximally to the facial arteries (FA). Next, radiopaque contrast was injected through the facial arteries in three of the facial flaps and though the superficial temporal arteries (STA) in the other three facial flaps...
July 5, 2016: Plastic and Reconstructive Surgery
Jack E Russo, Eric M Genden
Reconstruction of severe facial deformities poses a unique surgical challenge: restoring the aesthetic form and function of the face. Facial transplantation has emerged over the last decade as an option for reconstruction of these defects in carefully selected patients. As the world experience with facial transplantation grows, debate remains regarding whether such a highly technical, resource-intensive procedure is warranted, all to improve quality of life but not necessarily prolong it. This article reviews the current state of facial transplantation with focus on the current controversies and challenges, with particular attention to issues of technique, immunology, and ethics...
August 2016: Facial Plastic Surgery Clinics of North America
Undine Samuel
Vascularized composite allografts (VCAs) are a growing field within the area of transplantation. In 2014, the birth of a healthy baby after a successful uterus transplant from a living donor was reported in Sweden. VCAs are not specifically mentioned in any of the transplant acts of the Eurotransplant (ET) member states, which all belong to the European Union (EU). The Competent Authorities (CA) of the EU decided in 2012 that VCAs are to be regarded as organs. At the moment, there are no general guidelines in the ET area concerning wait list registration, allocation, procurement and transplantation, and also no regulations concerning reimbursement...
June 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
2016-07-07 20:10:04
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