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167 papers 25 to 100 followers Vascularized composite allotransplantation of the face
By Mafer Amber QxMD ambassador, Mexican med student currently in 4° year, doing clinical research in vascularized composite allotransplantation
https://www.readbyqxmd.com/read/29489486/achievements-and-challenges-in-facial-transplantation
#1
William J Rifkin, Joshua A David, Natalie M Plana, Rami S Kantar, J Rodrigo Diaz-Siso, Bruce E Gelb, Daniel J Ceradini, Eduardo D Rodriguez
: The first facial transplantation in 2005 ushered in a new era in reconstructive surgery, offering new possibilities for the repair of severe disfigurements previously limited by conventional techniques. Advances in allograft design, computerized preoperative planning, surgical technique, and postoperative revisions have helped push the boundaries in this new frontier of vascularized composite allotransplantation. Over the past 12 years, 40 of these procedures have been performed across the world, offering the field the opportunity to reflect on current outcomes...
August 2018: Annals of Surgery
https://www.readbyqxmd.com/read/30102615/chronic-rejection-in-vascularized-composite-allotransplantation
#2
Emmanuel Morelon, Palmina Petruzzo, Jean Kanitakis
PURPOSE OF REVIEW: Vascularized composite allografts (VCA), which restore severely damaged body parts that cannot be repaired with conventional surgical techniques, often undergo acute skin rejection episodes in the early postgraft period. Although the risk of human VCA to be affected by chronic rejection was initially unknown, such cases were recently observed. RECENT FINDINGS: Chronic rejection targets preferentially the skin (dermal sclerosis, adnexal atrophy, necrosis) and vessels (graft vasculopathy) and may cause graft dysfunction, often resulting in ischemic graft loss...
October 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/30046652/kidney-dysfunction-after-vascularized-composite-allotransplantation
#3
Nicco Krezdorn, Sotirios Tasigiorgos, Luccie Wo, Rachel Lopdrup, Marvee Turk, Harriet Kiwanuka, Salman Ahmed, Palmina Petruzzo, Ericka Bueno, Bohdan Pomahac, Leonardo V Riella
Background: Kidney dysfunction is a major complication after nonrenal solid organ transplants. Transplantation of vascularized composite allografts (VCA) has yielded successful midterm outcomes despite high rates of acute rejection and greater requirements of immunosuppression. Whether this translates in higher risks of kidney complications is unknown. Methods: Ninety-nine recipients of facial or extremity transplants from the Brigham and Women's Hospital (BWH) and the International Registry on Hand and Composite Tissue Transplantation (IR) were reviewed...
July 2018: Transplantation Direct
https://www.readbyqxmd.com/read/30048375/the-public-face-of-transplantation-the-potential-of-education-to-expand-the-face-donor-pool
#4
Filippo Boriani, Paolo G Morselli
No abstract text is available yet for this article.
October 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/30057945/theatres-of-surgery-the-cultural-pre-history-of-the-face-transplant
#5
Suzannah Biernoff
The first facial transplant, using a donor's nose, chin and mouth, was performed on Isabelle Dinoire in France in 2005, but the idea of removing or replacing the face - either with a mask, or with a living face - has been around for much longer. This article explores the cultural pre-history of face transplantation: its speculative existence in legend, literature and film before it became a medical possibility at the beginning of the twenty-first century. One of the questions posed here is: how (and for what purpose) do medical 'firsts' like Dinoire's surgery acquire a history? The article begins by considering the uses of the past by transplant surgeons themselves, and by those who are concerned about the ethical or psychological implications of organ and face transplantation...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/30080696/pediatric-face-transplantation-a-viable-option
#6
Miguel I Dorante, Sotirios Tasigiorgos, Bohdan Pomahac
PURPOSE OF REVIEW: Face transplantation is no longer a young field. Reported outcomes suggest that this life-enhancing transplantation is viable and ethically justified for appropriate patients. Given that pediatric hand transplantation has been performed with promising reported outcomes, it is time to consider how to properly expand the field of face transplantation into pediatric patients. RECENT FINDINGS: Appropriate collaboration between adult and pediatric colleagues can mitigate risks associated with expanding surgical innovation between respective patient demographics...
October 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/30098294/innovations-in-reconstructive-microsurgery-reconstructive-transplantation
#7
REVIEW
Branislav Kollar, Sotirios Tasigiorgos, Miguel I Dorante, Matthew J Carty, Simon G Talbot, Bohdan Pomahac
In the past 20 years, reconstructive transplantation (RT) has emerged as a viable reconstructive option for carefully selected patients. More than 100 upper extremity and 40 face transplants have been performed worldwide to date. Concomitantly, the portfolio of reconstructive transplantation has been extended by additional procedures such as lower extremities, abdominal wall, neck, uterus, genitourinary, and pediatric transplants. In the present review article, we aim to summarize the current state of knowledge about this exciting field...
October 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29510722/recovery-of-facial-expressions-using-functional-electrical-stimulation-after-full-face-transplantation
#8
Çağdaş Topçu, Hilmi Uysal, Ömer Özkan, Özlenen Özkan, Övünç Polat, Merve Bedeloğlu, Arzu Akgül, Ela Naz Döğer, Refik Sever, Ömer Halil Çolak
BACKGROUND: We assessed the recovery of 2 face transplantation patients with measures of complexity during neuromuscular rehabilitation. Cognitive rehabilitation methods and functional electrical stimulation were used to improve facial emotional expressions of full-face transplantation patients for 5 months. Rehabilitation and analyses were conducted at approximately 3 years after full facial transplantation in the patient group. We report complexity analysis of surface electromyography signals of these two patients in comparison to the results of 10 healthy individuals...
March 6, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29561493/lacrimal-apparatus-procurement-in-face-transplantation
#9
Asif Hasan, Colin Maciver, Gaoussou Toure, Jean-Paul Meningaud
The aesthetic outcome of a well-planned and executed vascularized composite tissue face allotransplant is unquestionable; however, complete functional restoration is necessary. The authors studied the possibility of restoring tear duct function in face transplant recipients. They also examined the technical specifics and feasibility of incorporating a lacrimal drainage apparatus into facial allografting. The authors performed a standardized face vascularized composite allograft on 4 hemi-faces (2 fresh cadavers)...
June 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29671724/facial-disfigurement-and-identity-a-review-of-the-literature-and-implications-for-facial-transplantation
#10
William J Rifkin, Rami S Kantar, Safi Ali-Khan, Natalie M Plana, J Rodrigo Diaz-Siso, Manos Tsakiris, Eduardo D Rodriguez
Facial disfigurement can significantly affect personal identity and access to social roles. Although conventional reconstruction can have positive effects with respect to identity, these procedures are often inadequate for more severe facial defects. In these cases, facial transplantation (FT) offers patients a viable reconstructive option. However, FT's effect on personal identity has been less well examined, and ethical questions remain regarding the psychosocial ramifications of the procedure. This article reviews the literature on the different roles of the face as well as psychological and social effects of facial disfigurement...
April 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29750725/face-transplant-status-of-current-supporting-technology-to-plan-and-perform-the-operation-and-monitor-the-graft-in-the-postoperative-period
#11
Edward J Caterson, Justin C McCarty
Face transplant has rapidly advanced since the first operation in 2005, and to date, 40 partial or full-face transplants have been performed. The safety and efficacy of this operation are aided at all phases by supporting technologies. These include advanced imaging techniques to plan the operation, devices to monitor the flap in the immediate perioperative period, and noninvasive imaging and serum markers to monitor for acute and chronic rejection. Some of the technologies, such as those used in the immediate perioperative period, have extensive evidence supporting their use, whereas those to detect acute or chronic rejection remain investigational...
June 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29771838/face-transplantation-an-update-for-the-united-states-trauma-system
#12
REVIEW
Scott J Farber, Rami S Kantar, J Rodrigo Diaz-Siso, Eduardo D Rodriguez
Face transplantation has evolved over the last 12 years into a safe and feasible reconstructive solution, with good aesthetic and functional outcomes for patients with severe facial defects who are not amenable to reconstruction through conventional and autologous approaches. Among patients who underwent face transplantation to date, a significant proportion did so following trauma, mostly ballistic and thermal injuries. It is therefore important for trauma surgeons who deal with these injuries regularly to be familiar with the literature on face transplantation following traumatic injuries...
June 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29771842/perceived-esthetic-outcomes-of-face-transplantation-a-survey-of-the-general-public
#13
Alessandra E Cabrera, Laura L Kimberly, Rami S Kantar, Elisa K Atamian, Amit K Manjunath, Lauren K Rangel, Michelle W McQuinn, J Rodrigo Diaz-Siso, Eduardo D Rodriguez
Facial transplantation (FT) has attracted the interest of individuals with facial disfigurement as a path to social reintegration. The perception among face transplant recipients and the reconstructive surgery community appears to be that superior functional and esthetic outcomes can be obtained with FT compared to autologous reconstruction (AR). Although lifelong immunosuppression adds well-known risks to FT, its benefits have proven difficult to quantify, especially because of its non-life-saving nature. Evidence that the general public perceives facial allograft recipients as less disfigured than AR patients may dramatically alter the currently accepted risk/benefit ratio of this novel procedure...
June 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29861176/quality-of-life-and-psychosocial-functioning-2-years-following-facial-transplantation
#14
Megan L Oser, Marie-Christine Nizzi, Jennifer L Zinser, Marvee Turk, Russell Epstein, Ericka Bueno, David Gitlin, Bohdan Pomahac
BACKGROUND: Face transplantation is a novel option for patients with severe facial disfigurement. Quality of life (QoL) outcomes of face transplantation remain poorly understood. OBJECTIVES: We sought to evaluate psychosocial functioning among 6 patients undergoing facial transplantation. METHODS: We prospectively assessed depressive symptoms, health status, mental and physical QoL, and self-esteem at 3-month intervals for 2 years. Social desirability was assessed pretransplant...
April 20, 2018: Psychosomatics
https://www.readbyqxmd.com/read/29888023/absence-of-rejection-in-a-facial-allograft-recipient-with-a-positive-flow-crossmatch-24-months-after-induction-with-rabbit-anti-thymocyte-globulin-and-anti-cd20-monoclonal-antibody
#15
Bruce E Gelb, J Rodrigo Diaz-Siso, Natalie M Plana, Adam Jacoby, William J Rifkin, Kimberly S Khouri, Daniel J Ceradini, Eduardo D Rodriguez
Background: Donor-specific antibodies (DSA) to human leukocyte antigen increase the risk of accelerated rejection and allograft damage and reduce the likelihood of successful transplantation. Patients with full-thickness facial burns may benefit from facial allotransplantation. However, they are at a high risk of developing DSA due to standard features of their acute care. Case Presentation: A 41-year-old male with severe disfigurement from facial burns consented to facial allotransplantation in 2014; panel reactive antibody score was 0%...
2018: Case Reports in Transplantation
https://www.readbyqxmd.com/read/29978024/a-lifesaving-view-of-vascularized-composite-allotransplantation-patient-experience-of-social-death-before-and-after-face-hand-and-larynx-transplant
#16
Katrina A Bramstedt
Introduction: Most solid organ transplantation is viewed as lifesaving, whereas vascularized composite allotransplantation (VCA) has been viewed as life enhancing. This article challenges the latter and argues that "social death" evident in severe face, hand, and larynx disfigurement can be potentially treated via VCA. Social death (from a social science perspective) consists of a combination of 7 components: social isolation, loneliness, ostracism, loss of personhood, change of role and identity, harm, and disfigurement...
June 2018: Journal of patient experience
https://www.readbyqxmd.com/read/29178479/face-allotransplantation-for-various-types-of-facial-disfigurements-a-series-of-five-cases
#17
Ömer Özkan, Özlenen Özkan, Mehmetcan Ubur, Necmiye Hadimioğlu, Melike Cengiz, İsmail Afşar
BACKGROUND: The aim of this report is to present our long-term experiences with a series of 5 face-transplanted patients in terms of surgical aspects and postoperative outcomes, and to describe possible salvage strategies in case of difficulties. METHODS: Five patients, 4 receiving full-face transplantation and 1 undergoing partial transplantation at our institution were included. The patients were aged between 19 and 54 years. Two had extensive burn scars to the face, and 3 had suffered gunshot injuries...
November 27, 2017: Microsurgery
https://www.readbyqxmd.com/read/29203260/the-helsinki-face-transplantation-surgical-aspects-and-1-year-outcome
#18
Patrik Lassus, Andrew Lindford, Jyrki Vuola, Leif Bäck, Sinikka Suominen, Karri Mesimäki, Tommy Wilkman, Tuija Ylä-Kotola, Erkki Tukiainen, Hannu Kuokkanen, Jyrki Törnwall
BACKGROUND: Since 2005, at least 38 facial transplantations have been performed worldwide. We herein describe the surgical technique and 1-year clinical outcome in Finland's first face transplant case. METHODS: A 34-year-old male who had a severe facial deformity following ballistic trauma in 1999 underwent facial transplantation at the Helsinki University Hospital on 8th February 2016. Three-dimensional (3D) technology was used to manufacture donor and recipient patient-specific osteotomy guides and a donor face mask...
February 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29280879/the-public-face-of-transplantation-the-potential-of-education-to-expand-the-face-donor-pool
#19
Natalie M Plana, Laura L Kimberly, Brendan Parent, Kimberly S Khouri, J Rodrigo Diaz-Siso, Elise M Fryml, Catherine C Motosko, Daniel J Ceradini, Arthur Caplan, Eduardo D Rodriguez
BACKGROUND: Despite the growing success of facial transplantation, organ donor shortages remain challenging. Educational health campaigns can effectively inform the general public and institute behavioral modifications. A brief educational introduction to facial transplantation may positively influence the public's position on facial donation. METHODS: The authors anonymously surveyed 300 participants, gathering basic demographic information, donor registration status, awareness of facial transplantation, and willingness to donate solid organs and facial allografts...
January 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29303865/facing-a-new-face-an-interpretative-phenomenological-analysis-of-the-experiences-of-a-blind-face-transplant-patient-and-his-partner
#20
Hannelore Hendrickx, Phillip N Blondeel, Hanna Van Parys, Nathalie A Roche, Patrick C Peeters, Hubert F Vermeersch, Xavier Rogiers, Kristiane Van Lierde, Gilbert M D Lemmens
Increasing evidence points to good functional, aesthetic, and psychosocial outcomes after face transplantation. However, research investigating how patients and their families subjectively experience the transplantation process is lacking thus far. This study aims to investigate the personal experiences of a blind face transplant patient and his partner. In-depth interviews exploring different experiences were conducted with both partners separately 20 months after face transplantation. The interviews were analyzed using interpretative phenomenological analysis...
June 2018: Journal of Craniofacial Surgery
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