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Vascularized composite allotransplantation

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134 papers 25 to 100 followers Includes face, upper limb and hand, uterine and penile transplantation
By Mafer Amber QxMD ambassador, Mexican med student currently in 4° year, doing clinical research in vascularized composite allotransplantation
https://www.readbyqxmd.com/read/27826601/plasma-micrornas-are-potential-biomarkers-of-acute-rejection-after-hindlimb-transplantation-in-rats
#1
Hiroki Oda, Ryosuke Ikeguchi, Hirofumi Yurie, Yukitoshi Kaizawa, Souichi Ohta, Koji Yamamoto, Tomoki Aoyama, Shuichi Matsuda
BACKGROUND: The development of effective immunosuppressive regimens has resulted in many cases of successful hand transplantation. Visual skin inspection and histological evaluation are used to assess the rejection of hand transplants, but these methods are largely subjective. In this study, we aimed to determine the potential of microRNAs (miRNAs) as biomarkers for acute rejection in vascularized composite allotransplants. METHODS: In allograft group, 7 male Brown-Norway rats (RT1(n)) were used as donors and 13 male Lewis rats (RT1(l)) were used as recipients...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27822384/immunomodulatory-role-of-mesenchymal-stem-cell-therapy-in-vascularized-composite-allotransplantation
#2
REVIEW
Richard Heyes, Andrew Iarocci, Yourka Tchoukalova, David G Lott
This review aims to summarize contemporary evidence of the in vitro and in vivo immunomodulatory effects of mesenchymal stem cells (MSCs) in promoting vascularized composite allotransplant (VCA) tolerance. An extensive literature review was performed to identify pertinent articles of merit. Prospective preclinical trials in mammal subjects receiving VCA (or skin allograft) with administration of MSCs were reviewed. Prospective clinical trials with intravascular delivery of MSCs in human populations undergoing solid organ transplant were also identified and reviewed...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27801681/immunological-effect-of-skin-allograft-in-burn-treatment-impact-on-future-vascularized-composite-allotransplantation
#3
Rebecca M Garza, Barry H Press, Dolly B Tyan, Yvonne L Karanas, Gordon K Lee
Skin allografts are the benchmark in temporary burn wound coverage, but allografts are hypothesized to place a high antigenic load on recipients. This project aims to determine the degree of human leukocyte antigen sensitization in burn patients treated with allografts. Serum was obtained from nine adult, nontransfused, and nontransplanted burn patients treated with allografts. Group 1 included patients tested in the acute burn period, while group 2 included different patients tested months to years after injury...
October 27, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27755395/an-anatomical-murine-model-of-heterotopic-periorbital-subunit-transplantation
#4
Bowen Gao, Qingxiong Yu, Feng Xie, Lingling Sheng, Xiyuan Mao, Qingfeng Li, Hainan Zhu
BACKGROUND: Conventional reconstructive methods fail to achieve satisfactory results in total eyelid defect cases. Vascularized composite tissue allotransplantation might provide both good appearance and function for these patients. The structure of the eyelid is exceptional because it simultaneously consists of skin, connective tissue, the striated muscle, fiber structure, aponeuroses, and mucosa. Thus, before clinical application of eyelid allotransplantation, more experiments are needed to clarify the impact of ischemia, immunal suppressive agents, and deinnervation effects on these sophisticated structures...
October 13, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27757352/fu-chan-wei-surgeon-innovator-and-leader-of-the-legendary-chang-gung-microsurgery-center
#5
Nidal Farhan Al Deek, Donald H Lalonde
Fu-Chan Wei is a world-renowned plastic and reconstructive surgeon. He is clearly one of the most influential and innovative surgeons in the history of plastic surgery. The Taiwanese legend is the innovator of the osteoseptocutaneous fibula flap, which revolutionized the reconstruction of composite bone and soft tissue defects in the jaw and extremities. He has pioneered several perforator flaps, including the free style variety. He has taken toe-to-hand microsurgical transplantation to a whole new level. He is not only recognized for his surgical skills and clinical innovations, but also for his vision, leadership, and teaching...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27753587/face-transplantation-in-a-highly-sensitized-recipient
#6
Anil Chandraker, Ramon Arscott, George Murphy, Christine Lian, Ericka Bueno, Francisco Marty, Helmut Rennke, Edgar Milford, Stefan Tullius, Bodhan Pomahac
No abstract text is available yet for this article.
October 2016: Military Medicine
https://www.readbyqxmd.com/read/27789209/three-dimensional-printing-for-restoration-of-the-donor-face-a-new-digital-technique-tested-and-used-in-the-first-facial-allotransplantation-patient-in-finland
#7
A A Mäkitie, M Salmi, A Lindford, J Tuomi, P Lassus
BACKGROUND AND AIMS: Prosthetic mask restoration of the donor face is essential in current facial transplant protocols. The aim was to develop a new three-dimensional (3D) printing (additive manufacturing; AM) process for the production of a donor face mask that fulfilled the requirements for facial restoration after facial harvest. MATERIALS AND METHODS: A digital image of a single test person's face was obtained in a standardized setting and subjected to three different image processing techniques...
October 5, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27741042/immunomodulation-by-mesenchymal-stem-cells-lessons-from-vascularized-composite-allotransplantation
#8
Martin J Hoogduijn
No abstract text is available yet for this article.
October 12, 2016: Transplantation
https://www.readbyqxmd.com/read/27740465/perioperative-management-of-a-bilateral-forearm-allograft
#9
M Clerc, J Prothet, T Rimmelé
Composite tissue allotransplantation (CTA) is a complex procedure requiring a multidisciplinary collaboration between surgeons, anesthetists, and transplantation specialists. We will describe the perioperative management of a bilateral forearm allograft performed at our facility. A 40-year-old man who lost both forearms was registered on the transplant waiting list; a suitable graft was available 11months later. Anesthesia required planning for vascular access, hemodynamic monitoring, fluid therapy management and prevention of deep vein thrombosis...
June 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27741206/are-face-transplants-today-more-of-the-same-or-going-into-a-more-selective-process-guidelines-for-future-implementation
#10
Mutaz B Habal
No abstract text is available yet for this article.
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27720683/the-role-of-face-transplantation-in-the-self-inflicted-gunshot-wound
#11
Harriet Kiwanuka, Mario A Aycart, David F Gitlin, Elaine Devine, Bridget J Perry, Thet-Su Win, Ericka M Bueno, Muayyad Alhefzi, Nicco Krezdorn, Bohdan Pomahac
BACKGROUND: Facial self-inflicted gunshot wounds (SIGSWs) cause a devastating midfacial defect and pose a challenging problem to the reconstructive surgeon. Face transplantation (FT) has the potential for near-normal restoration in otherwise non-reconstructible defects. Two out of 7 FT recipients at Brigham and Women's Hospital (BWH) sustained SIGSWs. In this study, we illustrate the role of FT in the management of SIGSWs through an aesthetic, functional, and psychosocial examination of outcomes...
September 8, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27681267/long-term-tolerance-towards-haploidentical-vascularized-composite-allograft-transplantation-in-a-canine-model-using-bone-marrow-or-mobilized-stem-cells
#12
Jeff Chang, Scott S Graves, Tiffany Butts-Miwongtum, George E Sale, Rainer Storb, David W Mathes
BACKGROUND: The development of safe and reliable protocols for the transplantation of the face and hands may be accomplished with animal modeling of transplantation of vascularized composite allografts (VCA). Previously, we demonstrated that tolerance to a VCA could be achieved after canine recipients were simultaneously given marrow from a dog leukocyte antigen (DLA) identical donor. In the present study, we extend those findings across a DLA mismatched barrier. METHODS: Eight Recipient dogs received total body irradiation (4...
September 27, 2016: Transplantation
https://www.readbyqxmd.com/read/27673540/a-retrospective-analysis-of-secondary-revisions-after-face-transplantation-assessment-of-outcomes-safety-and-feasibility
#13
Mario A Aycart, Muayyad Alhefzi, Maximilian Kueckelhaus, Nicco Krezdorn, Ericka M Bueno, Edward J Caterson, Julian J Pribaz, Bohdan Pomahac
BACKGROUND: Face transplantation has emerged as a viable option for certain patients in the treatment of devastating facial injuries. However, as with autologous free tissue transfer, the need for secondary revisions in face transplantation also exists. The authors' group has quantified the number of revision operations in their cohort and has assessed the rationale, safety, and outcomes of posttransplantation revisions. METHODS: A retrospective analysis of prospectively collected data of the authors' seven face transplants was performed from April of 2009 to July of 2015...
October 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27672839/poster-71-new-frontiers-inpatient-comprehensive-rehabilitation-after-full-face-transplantation-a%C3%A2-case-report
#14
Tracy Espiritu McKay, Matina Balou, Daniel J Kao, Derek J Ho, Jeffrey Cohen, Eduardo D Rodriguez
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27638100/technology-and-vascularized-composite-allotransplantation-vca-lessons-learned-from-the-first-bilateral-pediatric-hand-transplant
#15
REVIEW
Arash Momeni, Benjamin Chang, L Scott Levin
The reconstructive principle of replacing "like with like" is best met with vascularized composite allotransplantation in which the components of an existing defect are "matched" to the greatest extent possible in a single stage restoration. Hand transplantation is a labor-intensive and time-intensive process and can be conceptualized into distinct phases that include (1) patient selection and preoperative preparation, (2) technical execution of the procedure, and (3) postoperative rehabilitation and follow-up...
November 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27607529/intragraft-and-systemic-immune-parameters-discriminating-between-rejection-and-longterm-graft-function-in-a-preclinical-model-of-intestinal-transplantation
#16
Undine Ariane Gerlach, Maren Klöpfel, Georgi Atanasov, Dietrich Polenz, Katrin Vogt, Stefanie Ahrlich, Marion Marksteiner, Anke Jurisch, Christoph Loddenkemper, Anja Reutzel-Selke, Birgit Sawitzki, Andreas Pascher
BACKGROUND: The pathology and diagnosis of acute and chronic rejection in intestinal transplantation are far from being completely understood. We established models of acute and chronic intestinal graft rejection and analysed peripheral and intragraft immune responses. METHODS: We performed intestinal transplantation (ITX) from Dark Agouti into Lewis rats applying single-dose tacrolimus (TAC) at varying concentrations. Graft histology and immunohistology were assessed on POD7,14,45...
September 8, 2016: Transplantation
https://www.readbyqxmd.com/read/27607535/which-donor-for-uterus-transplants-brain-dead-donor-or-living-donor-a-systematic-review
#17
Vincent Lavoué, Cécile Vigneau, Solène Duros, Karim Boudjema, Jean Levêque, Pascal Piver, Yves Aubard, Tristan Gauthier
BACKGROUND: The aim of this systematic review was to evaluate and compare the pros and cons of using living donors or brain-dead donors in uterus transplantation programs, 2 years after the first worldwide live birth after uterus transplantation. METHODS: The Medline database and the Central Cochrane Library were used to locate uterine transplantation studies carried out in human or non-human primates. All types of articles (case reports, original studies, meta-analyses, reviews) in English or French were considered for inclusion...
September 8, 2016: Transplantation
https://www.readbyqxmd.com/read/27556621/a-porcine-orthotopic-forelimb-vascularized-composite-allotransplantation-model-technical-considerations-and-translational-implications
#18
C Anton Fries, Carole Y Villamaria, Jerry R Spencer, Rory F Rickard, Vijay S Gorantla, Michael R Davis
BACKGROUND: The restoration of complex tissue deficits with vascularized composite allotransplantation is a paradigm shift in reconstructive surgery. Clinical adoption of vascularized composite allotransplantation is limited by the need for systemic immunosuppression, with associated morbidity and mortality. Small-animal models lack the biological fidelity and preclinical relevance to enable translation of immunologic insights to humans. Large-animal models have been described; however, limitations persist, including the inability of heterotopic models to evaluate functional nerve regeneration, and the sensitivity of primates to toxicity of immunosuppressive drugs...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27624820/successful-recovery-and-transplantation-of-11-organs-including-face-bilateral-upper-extremities-and-thoracic-and-abdominal-organs-from-a-single-deceased-organ-donor
#19
Stefan G Tullius, Bohdan Pomahac, Heung Bae Kim, Matthew J Carty, Simon G Talbot, Helen M Nelson, Francis L Delmonico
We report on the to date largest recovery of 11 organs from a single deceased donor with the transplantation of face, bilateral upper extremities, heart, 1 lung, liver (split for 2 recipients), kidneys, pancreas, and intestine. Although logistically challenging, this case demonstrates the feasibility and safety of the recovery of multiple thoracic and abdominal organs with multiple vascular composite allotransplants and tissues. Our experience of 8 additional successful multiple vascular composite allotransplants, thoracic, and abdominal organ recoveries suggests that such procedures are readily accomplishable from the same deceased donor...
October 2016: Transplantation
https://www.readbyqxmd.com/read/27607877/deceased-donor-uterine-transplantation-innovation-and-adaptation
#20
Rebecca L Flyckt, Ruth M Farrell, Uma C Perni, Andreas G Tzakis, Tommaso Falcone
This commentary endeavors to share our practical experience in developing and implementing the first uterine transplant clinical trial in the United States. Uterine transplant is a promising novel treatment for uterine factor infertility. After reported successful live births after uterine transplant in Sweden, research teams around the world are either embarking on or are considering the development of uterine transplant protocols. Our observations on the applied rather than theoretical aspects of uterine transplantation research in human subjects are detailed in this article...
October 2016: Obstetrics and Gynecology
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