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By Venkatesh Ariyamuthu Transplant Nephrologist at UT Southwestern Medical Center
Philip Kam-Tao Li, Cheuk Chun Szeto, Beth Piraino, Javier de Arteaga, Stanley Fan, Ana E Figueiredo, Douglas N Fish, Eric Goffin, Yong-Lim Kim, William Salzer, Dirk G Struijk, Isaac Teitelbaum, David W Johnson
No abstract text is available yet for this article.
September 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Rajnish Mehrotra, Olivier Devuyst, Simon J Davies, David W Johnson
Technical innovations in peritoneal dialysis (PD), now used widely for the long-term treatment of ESRD, have significantly reduced therapy-related complications, allowing patients to be maintained on PD for longer periods. Indeed, the survival rate for patients treated with PD is now equivalent to that with in-center hemodialysis. In parallel, changes in public policy have spurred an unprecedented expansion in the use of PD in many parts of the world. Meanwhile, our improved understanding of the molecular mechanisms involved in solute and water transport across the peritoneum and of the pathobiology of structural and functional changes in the peritoneum with long-term PD has provided new targets for improving efficiency and for intervention...
November 2016: Journal of the American Society of Nephrology: JASN
Qin Zhou, M-Auxiliadora Bajo, Gloria Del Peso, Xueqing Yu, Rafael Selgas
Long-term peritoneal dialysis causes morphologic and functional changes in the peritoneal membrane. Although mesothelial-mesenchymal transition of peritoneal mesothelial cells is a key process leading to peritoneal fibrosis, and bioincompatible peritoneal dialysis solutions (glucose, glucose degradation products, and advanced glycation end products or a combination) are responsible for altering mesothelial cell function and proliferation, mechanisms underlying these processes remain largely unclear. Peritoneal fibrosis has 2 cooperative parts, the fibrosis process itself and the inflammation...
September 2016: Kidney International
Ali M A Alkatheeri, Peter G Blake, Daryl Gray, Arsh K Jain
UNLABELLED:BACKGROUND: Many patients start renal replacement therapy urgently on in-center hemodialysis via a central venous catheter, which is considered suboptimal. An alternative approach to manage these patients is to start them on peritoneal dialysis (PD). In this report, we describe the first reported Canadian experience with an urgent-start PD program. Additionally we reviewed the literature in this area. ♦ METHODS: In this prospective observational study, we report on our experience in a single academic center...
March 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Bolesław Rutkowski, Paul Tam, Frank M van der Sande, Andreas Vychytil, Vedat Schwenger, Rainer Himmele, Adelheid Gauly
BACKGROUND: Peritoneal dialysis (PD) solutions with reduced sodium content may have advantages for hypertensive patients; however, they have lower osmolarity and solvent drag, so the achieved Kt/Vurea may be lower. Furthermore, the increased transperitoneal membrane sodium gradient can influence sodium balance with consequences for blood pressure (BP) control. STUDY DESIGN: Prospective, randomized, double-blind clinical trial to prove the noninferiority of total weekly Kt/Vurea with low-sodium versus standard-sodium PD solution, with the lower confidence limit above the clinically accepted difference of -0...
May 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Joni H Hansson, Suzanne Watnick
No abstract text is available yet for this article.
January 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Rajnish Mehrotra, Mark A Perazella, Michael J Choi
The Nephrology Quiz and Questionnaire (NQ&Q) remains an extremely popular session for attendees of the Annual Kidney Week Meeting of the American Society of Nephrology (ASN). Once again, the conference hall was overflowing with audience members and eager quiz participants. Topics covered by the expert discussants included electrolyte and acid-base disorders, glomerular disease, end-stage renal disease/dialysis, and transplantation. Complex cases representing each of these categories along with single best answer questions were prepared and submitted by the panel of experts...
June 5, 2015: Clinical Journal of the American Society of Nephrology: CJASN
Anand Yuvaraj, Priyanka Joseph Koshy, Anusha Rohit, P Nagarajan, Sanjeev Nair, Lakshmi Revathi, Georgi Abraham
No abstract text is available yet for this article.
March 2015: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Kunal Chaudhary, Ramesh Khanna
Clinical experience and literature evidence suggest that peritoneal dialysis (PD) is a safe and effective treatment in short term (3 to 5 years) for stage 5 chronic kidney disease patients. A major limitation to long-term PD has been peritoneal membrane structural and functional alterations over time, resulting in significant technique failure. Much evidence implicates glucose contained in conventional PD solutions as the major cause of membrane changes. Other harmful characteristics of glucose or its degradation products are thought to cause systemic undesirable metabolic and cardiovascular effects...
April 2010: Clinical Journal of the American Society of Nephrology: CJASN
Rodrigo A de Oliveira, Fellype C Barreto, Monique Mendes, Luciene M dos Reis, João Henrique Castro, Zita Maria L Britto, Igor D B Marques, Aluizio B Carvalho, Rosa M Moysés, Vanda Jorgetti
Chronic kidney disease--mineral bone disorder (CKD-MBD) is a complex syndrome influenced by various factors, such as age, CKD etiology, uremic toxins, and dialysis modality. Although extensively studied in hemodialysis (HD) patients, only a few studies exist for peritoneal dialysis (PD) patients. Since most of these older studies contain no bone biopsy data, we studied the pattern of renal osteodystrophy in 41 prevalent PD patients. The most common presentation was adynamic bone disease (49%). There was a significant inverse association between serum sclerostin (a Wnt/β-catenin pathway inhibitor that decreases osteoblast action and bone formation) and the bone formation rate...
May 2015: Kidney International
Jeffrey Perl, Andreas Pierratos, Gokulan Kandasamy, Brendan B McCormick, Robert R Quinn, Arsh K Jain, Anjie Huang, J Michael Paterson, Matthew J Oliver
BACKGROUND: The likelihood of peritoneal dialysis (PD) utilization following a PD catheter insertion attempt is poorly described. We explored the risk factors for PD nonuse, focusing on the method of PD catheter implantation. METHODS: This population-based retrospective cohort study employed Ontario administrative health data to identify 3886 predialysis adults who had an incident PD catheter implantation between 2002 and 2010. The impact of the method of catheter implantation including open-surgical (open, n = 1884), surgical-laparoscopic (laparoscopic, n = 1154), nephrology-percutaneous (nephrology, n = 498) and radiology-percutaneous (radiology, n = 350) on rates of PD utilization (defined as four consecutive weeks of PD) was examined...
February 2015: Nephrology, Dialysis, Transplantation
Madhukar Misra, Ramesh Khanna
No abstract text is available yet for this article.
November 2014: Seminars in Dialysis
Joseph Pulliam, Nien-Chen Li, Franklin Maddux, Raymond Hakim, Frederic O Finkelstein, Eduardo Lacson
BACKGROUND: Patterns of early outcomes in peritoneal dialysis (PD) are not well studied and dialysis providers need to establish a baseline of key outcomes for continuous quality improvement initiatives. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Incident PD patients from Fresenius Medical Care, North America from January 1 through December 31, 2009. FACTORS: Case-mix, comorbid illness, and baseline laboratory values...
November 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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