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3 papers 100 to 500 followers Breast Cancer
By Sebastian Sole Medical Director of Oncology Clinic
https://www.readbyqxmd.com/read/24357525/progress-and-controversies-radiation-therapy-for-invasive-breast-cancer
#1
REVIEW
Reshma Jagsi
Radiation therapy is a critical component of the multidisciplinary management of invasive breast cancer. In appropriately selected patients, radiation not only improves local control, sparing patients the morbidity and distress of local recurrence, but it also improves survival by preventing seeding and reseeding of distant metastases from persistent reservoirs of locoregional disease. In recent years, considerable progress has been made toward improving our ability to select patients most likely to benefit from radiotherapy and to administer treatment in ways that maximize clinical benefit while minimizing toxicity and burden...
March 2014: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/25035292/adjuvant-zoledronic-acid-in-patients-with-early-breast-cancer-final-efficacy-analysis-of-the-azure-big-01-04-randomised-open-label-phase-3-trial
#2
RANDOMIZED CONTROLLED TRIAL
Robert Coleman, David Cameron, David Dodwell, Richard Bell, Caroline Wilson, Emma Rathbone, Maccon Keane, Miguel Gil, Roger Burkinshaw, Robert Grieve, Peter Barrett-Lee, Diana Ritchie, Victoria Liversedge, Samantha Hinsley, Helen Marshall
BACKGROUND: The role of adjuvant bisphosphonates in early breast cancer is uncertain. We therefore did a large randomised trial to investigate the effect of the adjuvant use of zoledronic acid on disease-free survival (DFS) in high-risk patients with early breast cancer. METHODS: In the AZURE trial, an open-label, international, multicentre, randomised, controlled, parallel-group phase 3 trial, women (age ≥18 years) with stage II or III breast cancer were randomly assigned (1:1) by a central automated 24-h computer-generated telephone minimisation system (balanced for number of involved axillary lymph nodes, tumour stage, oestrogen receptor status, type and timing of systemic therapy, menopausal status, statin use, and treatment centre) to receive standard adjuvant systemic treatment alone (control group) or with 4 mg intravenous zoledronic acid every 3-4 weeks for six doses, then every 3 months for eight doses, followed by every 6 months for five doses, for a total of 5 years of treatment...
August 2014: Lancet Oncology
https://www.readbyqxmd.com/read/24939061/influence-of-boost-radiotherapy-in-patients-with-ductal-carcinoma-in-situ-breast-cancer-a-multicenter-retrospective-study-in-korea-krog-11-04
#3
MULTICENTER STUDY
Jin Hee Kim, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Sung Whan Ha, Kyubo Kim, Yong Bae Kim, Ji Woon Yea, Min Kyu Kang, Kyung Hwan Shin, Dong Won Kim, Ji Hae Lee, Chang-Ok Suh
To estimate the effect of boost radiotherapy on local recurrence-free survival (LRFS) in patients with ductal carcinoma in situ (DCIS) breast cancer. We included patients from nine institutions who met the following criteria: having Tis, age 18 years or older, having breast conserving surgery (BCS) and radiotherapy within 12 weeks after surgery. From 1995 through 2006, 728 patients were analyzed retrospectively by the Korean Radiation Oncology Group. All patients received whole-breast radiation therapy (WBRT) after BCS...
July 2014: Breast Cancer Research and Treatment
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