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Severe sepsis

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2 papers 1000+ followers Questioning Medicine Podcast #FOAMed #medquestioning
By Joe Weatherly FM/Hospitalist-CoFounder of QuestioningMedicine and PCRAP contributor.
https://www.readbyqxmd.com/read/23984731/severe-sepsis-and-septic-shock
#1
REVIEW
Derek C Angus, Tom van der Poll
New England Journal of Medicine, Volume 369, Issue 9, Page 840-851, August 2013.
August 29, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/23348980/a-multicenter-randomized-trial-of-atorvastatin-therapy-in-intensive-care-patients-with-severe-sepsis
#2
RANDOMIZED CONTROLLED TRIAL
Peter Kruger, Michael Bailey, Rinaldo Bellomo, David James Cooper, Meg Harward, Alisa Higgins, Belinda Howe, Darryl Jones, Chris Joyce, Karam Kostner, John McNeil, Alistair Nichol, Michael S Roberts, Gillian Syres, Bala Venkatesh
RATIONALE: Observational studies link statin therapy with improved outcomes in patients with severe sepsis. OBJECTIVES: To test whether atorvastatin therapy affects biologic and clinical outcomes in critically ill patients with severe sepsis. METHODS: Phase II, multicenter, prospective, randomized, double-blind, placebo-controlled trial stratified by site and prior statin use. A cohort of 250 critically ill patients (123 statins, 127 placebo) with severe sepsis were administrated either atorvastatin (20 mg daily) or matched placebo...
April 1, 2013: American Journal of Respiratory and Critical Care Medicine
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