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179 papers 100 to 500 followers
By Jeff Bank Internal Medicine R2 at the University of Utah
https://www.readbyqxmd.com/read/27888668/inflammatory-bowel-disease-a-global-disease-that-needs-a%C3%A2-broader-ensemble-of-populations
#1
EDITORIAL
Andre Franke
No abstract text is available yet for this article.
November 23, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27660341/3-european-evidence-based-consensus-on-the-diagnosis-and-management-of-crohn-s-disease-2016-part-1-diagnosis-and-medical-management
#2
Fernando Gomollón, Axel Dignass, Vito Annese, Herbert Tilg, Gert Van Assche, James O Lindsay, Laurent Peyrin-Biroulet, Garret J Cullen, Marco Daperno, Torsten Kucharzik, Florian Rieder, Sven Almer, Alessandro Armuzzi, Marcus Harbord, Jost Langhorst, Miquel Sans, Yehuda Chowers, Gionata Fiorino, Pascal Juillerat, Gerassimos J Mantzaris, Fernando Rizzello, Stephan Vavricka, Paolo Gionchetti
This paper is the first in a series of two publications relating to the European Crohn's and Colitis Organisation (ECCO) evidence based consensus on the diagnosis and management of Crohn's disease and concerns the methodology of the consensus process, classification, diagnosis and medical management of active and quiescent Crohn's disease. Surgical management as well as special situations including management of perianal Crohn's disease of this ECCO Consensus are covered in a subsequent second paper [Gionchetti et al JCC 2016]...
September 22, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27845055/is-stem-cell-therapy-ready-for-prime-time-in-treatment-of-inflammatory-bowel-diseases
#3
Christopher J Hawkey, Daniel W Hommes
Autologous hematopoietic stem cell transplantation (HSCT) and mesenchymal stromal cell therapy (MSCT) have been proposed for patients with refractory Crohn's disease (CD) and fistulizing CD respectively. Will these highly advanced techniques be available only for select patients, at specialized centers, or is further clinical development justified, with the aim of offering widespread, more definitive therapeutic options for often very difficult to treat disease? Patients with CD who are eligible for HSCT have typically been failed by most approved therapies, have undergone multiple surgeries, and have coped with years of disease activity and poor quality of life...
November 11, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27720839/mechanisms-management-and-treatment-of-fibrosis-in-patients-with-inflammatory-bowel-diseases
#4
Florian Rieder, Claudio Fiocchi, Gerhard Rogler
In the last 10 years, we have learned much about the pathogenesis, diagnosis, and management of intestinal fibrosis in patients with inflammatory bowel diseases (IBD). Just a decade ago, intestinal strictures were considered to be an inevitable consequence of long-term inflammation in patients who did not respond to anti-inflammatory therapies. IBD-associated fibrosis was seen as an irreversible process that frequently led to intestinal obstructions requiring surgical intervention. This paradigm has changed rapidly, due to the anti-fibrotic approaches that may become available...
October 5, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27548724/any-future-for-fecal-microbiota-transplantation-as-treatment-strategy-for-inflammatory-bowel-diseases
#5
Patrizia Kump, Christoph Högenauer
Fecal microbiota transplantation (FMT) is a novel therapeutic procedure aiming at restoring a normal intestinal microbiota by application of fecal microorganisms from a healthy subject into the gastrointestinal tract of a patient. FMT is the most effective treatment for recurrent Clostridium difficile infections (CDI). These infections also occur in patients with inflammatory bowel diseases (IBDs), where case series demonstrated a successful treatment of CDI by FMT in 83-92% of patients. The effect of FMT on the activity of IBD has mainly been investigated in ulcerative colitis (UC) patients, including 3 randomized controlled trials...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27780712/lessons-learned-from-trials-targeting-cytokine-pathways-in-patients-with-inflammatory-bowel-diseases
#6
Clara Abraham, Parambir S Dulai, Séverine Vermeire, William J Sandborn
Insights into the pathogenesis of inflammatory bowel diseases (IBD) have provided important information for the development of therapeutics. Levels of interleukin 23 (IL23) and T-helper (Th) 17 cell pathway molecules are elevated in inflamed intestinal tissues of patients with IBD. Loss of function variants of the interleukin 23 receptor gene (IL23R) protect against IBD, and in animals, blocking IL23 reduces severity of colitis. These findings indicated that the IL23 and Th17 cell pathways might be promising targets for treatment of IBD...
October 22, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27793606/diet-as-a-trigger-or-therapy-for-inflammatory-bowel-diseases
#7
James D Lewis, Maria T Abreu
The most common question asked by patients with inflammatory bowel disease is "doctor what should I eat?" Findings from epidemiology studies indicate that diets high in animal fat and low in fruits and vegetables are the most common pattern associated with an increased risk of IBD. Low levels of vitamin D also appear to be a risk factor for IBD. In murine models, diets high in fat, especially saturated animal fats, also increase inflammation, whereas supplementation with omega 3 long-chain fatty acids protect against intestinal inflammation...
October 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27793607/understanding-and-preventing-the-global-increase-of-inflammatory-bowel-disease
#8
Gilaad G Kaplan, Siew C Ng
The inflammatory bowel diseases (IBD) are contemporary conditions of industrialized societies. The prevalence of IBD continues to increase steadily in Western countries, and newly industrialized countries have a rapidly increasing incidence. The global spread of IBD appears to associate with Westernization of diets and environments, which affects the intestinal microbiome and increases risk of IBD in genetically susceptible individuals. It is important to increase our understanding of these events to slow progression of IBD...
October 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27742763/molecular-classification-of-crohn-s-disease-reveals-two-clinically-relevant-subtypes
#9
Matthew Weiser, Jeremy M Simon, Bharati Kochar, Adelaide Tovar, Jennifer W Israel, Adam Robinson, Gregory R Gipson, Matthew S Schaner, Hans H Herfarth, R Balfour Sartor, Dermot P B McGovern, Reza Rahbar, Timothy S Sadiq, Mark J Koruda, Terrence S Furey, Shehzad Z Sheikh
OBJECTIVE: The clinical presentation and course of Crohn's disease (CD) is highly variable. We sought to better understand the cellular and molecular mechanisms that guide this heterogeneity, and characterise the cellular processes associated with disease phenotypes. DESIGN: We examined both gene expression and gene regulation (chromatin accessibility) in non-inflamed colon tissue from a cohort of adult patients with CD and control patients. To support the generality of our findings, we analysed previously published expression data from a large cohort of treatment-naïve paediatric CD and control ileum...
October 14, 2016: Gut
https://www.readbyqxmd.com/read/27769809/drug-safety-and-risk-of-adverse-outcomes-for-pregnant-patients-with-inflammatory-bowel-diseases
#10
Uma Mahadevan, Ryan A McConnell, Christina Chambers
The management of the pregnant patient with inflammatory bowel disease (IBD) is complicated by multiple providers, misinformation and a disease entity that, particularly when active, can adversely affect pregnancy outcomes. This paper seeks to frame the debate on medication safety in pregnancy and lactation using the Food and Drug Administration's new Pregnancy and Lactation Labeling Rule (PLLR) and the most up to date safety information to discuss the risks and benefits of using each class of IBD medication...
October 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27743873/complementary-and-alternative-medicines-used-by-patients-with-inflammatory-bowel-diseases
#11
Adam S Cheifetz, Robert Gianotti, Raphael Luber, Peter R Gibson
Patients and physicians often have many questions regarding the role of complementary and alternative medicines (CAMs), or non-allopathic therapies, for inflammatory bowel diseases (IBD). CAMs of various forms are used by more than half of patients with IBD during some point in their disease course. We summarize the available evidence for the most commonly used and discussed CAMs. We discuss evidence for the effects of herbs (such as cannabis and curcumin), probiotics, acupuncture, exercise, and mind-body therapy...
October 12, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27751880/advances-in-use-of-endoscopy-radiology-and-biomarkers-to-monitor-inflammatory-bowel-diseases
#12
Julian Panes, Vipul Jairath, Barrett G Levesque
Crohn's disease and ulcerative colitis are heterogeneous inflammatory bowel disease (IBD), and therapeutic requirements vary among patients. We have a limited capacity to predict disease progression for individual patients, so it is important that they are evaluated for presence of active disease when symptoms are mild or even absent, when patients are more likely to respond to new treatment interventions. It is then important to monitor responses to treatment, to quickly identify those therapies that are ineffective, modify or change therapy, and avoid disease complications...
October 14, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27729212/paneth-cell-alterations-in-the-development-and-phenotype-of-crohn-s-disease
#13
Thaddeus S Stappenbeck, Dermot P B McGovern
Pathogenesis of Crohn's disease (CD) involves immune and microbial dysregulation, induced by environmental factors in genetically susceptible individuals. There are believed to be multiple subtypes of CD, which contributes to its observed clinical heterogeneity. This concept has been reinforced by recognition of the complexity of the genetic, microbial, immune, and environmental factors that affect risk for CD. Paneth cells mediate immunity in and maintain the small intestinal epithelium; defects in activities of these cells have been observed in high proportions of patients with CD, and associated with more aggressive CD phenotype...
October 8, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27720840/management-strategies-to-improve-outcomes-of-patients-with-inflammatory-bowel-diseases
#14
Jean-Frederic Colombel, Neeraj Narula, Laurent Peyrin-Biroulet
Strategies for management of inflammatory bowel diseases (IBD) are shifting from simple control of symptoms toward full control of these diseases (clinical and endoscopic remission), with the final aim of blocking their progression and preventing bowel damage and disability. New goals have been proposed for treatment, such as treat to target and tight control based on therapeutic monitoring and early intervention. For patients who achieve clinical remission, there is often interest in discontinuation of therapy due to safety and/or economic concerns...
October 5, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27670602/biomarkers-in-search-of-precision-medicine-in-ibd
#15
Ray K Boyapati, Rahul Kalla, Jack Satsangi, Gwo-Tzer Ho
The completion of the human genome project in 2003 represented a major scientific landmark, ushering in a new era with hopes and expectations of fresh insights into disease mechanisms and treatments. In inflammatory bowel disease (IBD), many important discoveries soon followed, notably the identification of >200 genetic susceptibility loci and characterization of the gut microbiome. As "big data", driven by advances in technology, becomes increasingly available and affordable, individuals with IBD and clinicians alike yearn for tangible outcomes from the promise of "precision medicine"-precise diagnosis, monitoring, and treatment...
September 27, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27612488/real-life-chromoendoscopy-for-neoplasia-detection-and-characterisation-in-long-standing-ibd
#16
Sabela Carballal, Sandra Maisterra, Antonio López-Serrano, Antonio Z Gimeno-García, María Isabel Vera, José Carlos Marín-Garbriel, José Díaz-Tasende, Lucía Márquez, Marco Antonio Álvarez, Luis Hernández, Luisa De Castro, Jordi Gordillo, Ignasi Puig, Pablo Vega, Marco Bustamante-Balén, Juan Acevedo, Beatriz Peñas, María López-Cerón, Elena Ricart, Miriam Cuatrecasas, Mireya Jimeno, María Pellisé
OBJECTIVE: Outside clinical trials, the effectiveness of chromoendoscopy (CE) for long-standing IBD surveillance is controversial. We aimed to assess the effectiveness of CE for neoplasia detection and characterisation, in real-life. DESIGN: From June 2012 to 2014, patients with IBD were prospectively included in a multicentre cohort study. Each colonic segment was evaluated with white light followed by 0.4% indigo carmine CE. Specific lesions' features were recorded...
September 9, 2016: Gut
https://www.readbyqxmd.com/read/27641359/building-better-bones-with-biologics-a-new-approach-to-osteoporosis
#17
EDITORIAL
Clifford J Rosen, Julie R Ingelfinger
No abstract text is available yet for this article.
October 20, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27596694/serum-calprotectin-a-novel-diagnostic-and-prognostic-marker-in-inflammatory-bowel-diseases
#18
Rahul Kalla, Nicholas A Kennedy, Nicholas T Ventham, Ray K Boyapati, Alex T Adams, Elaine R Nimmo, Micaela R Visconti, Hazel Drummond, Gwo-Tzer Ho, Rebecca J Pattenden, David C Wilson, Jack Satsangi
OBJECTIVES: There is an unmet need for novel blood-based biomarkers that offer timely and accurate diagnostic and prognostic testing in inflammatory bowel diseases (IBD). We aimed to investigate the diagnostic and prognostic utility of serum calprotectin (SC) in IBD. METHODS: A total of 171 patients (n=96 IBD, n=75 non-IBD) were prospectively recruited. A multi-biomarker model was derived using multivariable logistic regression analysis. Cox proportional hazards model was derived to assess the contribution of each variable to disease outcomes...
September 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27619836/birth-outcomes-in-children-fathered-by-men-treated-with-anti-tnf-%C3%AE-agents-before-conception
#19
Michael Due Larsen, Sonia Friedman, Bjarne Magnussen, Bente Mertz Nørgård
OBJECTIVES: The safety of paternal use of anti-tumor necrosis factor-α (TNF-α) agents immediately prior to conception is practically unknown. On the basis of nationwide data from Danish health registries, we examined the association between paternal use of anti-TNF-α agents within 3 months before conception and adverse birth outcomes. METHODS: This nationwide cohort study is based on data from all women who had a live born singleton child in Denmark from 1 January 2007 through 2013...
September 13, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27565523/level-of-fecal-calprotectin-correlates-with-severity-of%C3%A2-small%C3%A2-bowel-crohn-s-disease-measured-by-balloon-assisted%C3%A2-enteroscopy-and-computed-tomography%C3%A2-enterography
#20
Tsunetaka Arai, Ken Takeuchi, Miyuki Miyamura, Rumiko Ishikawa, Akihiro Yamada, Masao Katsumata, Yoshinori Igarashi, Yasuo Suzuki
BACKGROUND & AIMS: Previous studies have not found a correlation between fecal level of calprotectin and small bowel Crohn's disease (CD). However, these studies evaluated patients mainly by ileocolonoscopy, which views up to only the terminal ileum rather than entire small intestine. We investigated whether level of fecal calprotectin (FC) is a marker of active CD of the small bowel, identified by balloon-assisted enteroscopy and computed tomography enterography (CTE). METHODS: We performed a prospective study of 123 patients with CD (35 with ileitis, 72 with ileocolitis, and 16 with colitis) evaluated by balloon-assisted enteroscopy from May 2012 through July 2015 at Toho University Sakura Medical Centre in Japan...
August 23, 2016: Clinical Gastroenterology and Hepatology
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