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IBD

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By Jeff Bank Internal Medicine R2 at the University of Utah
https://www.readbyqxmd.com/read/29775795/response-to-biologics-delay-progression-of-crohn-s-disease-in-children-but-not-early-surgery
#1
EDITORIAL
Cortney R Ballengee, Subra Kugathasan
No abstract text is available yet for this article.
May 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29754190/allergic-and-immunologic-perspectives-of-inflammatory-bowel-disease
#2
REVIEW
Kofi Clarke, Jayakrishna Chintanaboina
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial, and host factors including genetic factors, although the exact mechanism is not known. Dietary factors have been shown to play a role in the pathogenesis of IBD and can potentially alter the intestinal microbiota as well as disrupt the immune function in the gut...
May 12, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29759161/outcome-analysis-in-crohn-s-disease-using-endomicroscopy-how-important-and-reliable-is-in-vivo-analysis-of-microscopic-changes
#3
EDITORIAL
Ralf Kiesslich
No abstract text is available yet for this article.
June 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29713028/post-operative-morbidity-and-mortality-of-a-cohort-of-steroid-refractory-acute-severe-ulcerative-colitis-nationwide-multicenter-study-of-the-geteccu-eneida-registry
#4
I Ordás, E Domènech, M Mañosa, V García-Sánchez, E Iglesias-Flores, F Rodríguez-Moranta, L Márquez, O Merino, F Fernández-Bañares, F Gomollón, M Vera, A Gutiérrez, J LLaó, J P Gisbert, M Aguas, L Arias, I Rodríguez-Lago, C Muñoz, N Alcaide, X Calvet, C Rodríguez, M A Montoro, S García, M L De Castro, M Piqueras, L Pareja, J Ribes, J Panés, M Esteve
BACKGROUND: Despite the increased use of rescue medical therapies for steroid refractory acute severe ulcerative colitis, mortality related to this entity still remains high. We aimed to assess the mortality and morbidity related to colectomy and their predictive factors in steroid refractory acute severe ulcerative colitis, and to evaluate the changes in mortality rates, complications, indications of colectomy, and the use of rescue therapy over time. METHODS: We performed a multicenter observational study of patients with steroid refractory acute severe ulcerative colitis requiring colectomy, admitted to 23 Spanish hospitals included in the ENEIDA registry (GETECCU) from 1989 to 2014...
May 1, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29702298/increased-risk-of-acute-myocardial-infarction-and-heart-failure-in-patients-with-inflammatory-bowel-diseases
#5
Satimai Aniwan, Darrell S Pardi, William J Tremaine, Edward V Loftus
BACKGROUND & AIMS: There are conflicting data as to whether inflammatory bowel diseases (IBD) increase risk for cardiovascular disease. We sought to examine the risk of acute myocardial infarction (AMI) and heart failure in patients with IBD. METHODS: We identified patients diagnosed with IBD in Olmsted County, Minnesota from 1980 through 2010 (n=736). For each patient, 2 individuals without IBD (controls, n=1472) were randomly selected, matched for age, sex, and index date of disease diagnosis...
April 24, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29702300/budesonide-suppositories-are-effective-and-safe-for-treating-acute-ulcerative-proctitis
#6
Wolfgang Kruis, Viacheslav Neshta, Marina Pesegova, Olga Alekseeva, Pavel Andreev, Oleksii Datsenko, Olena Levchenko, Sayar Abdulkhakov, Yuriy Lozynskyy, Yuriy Mostovoy, Konstatin Soloviev, Andrey E Dorofeyev, Michael Vieth, Michael Stiess, Roland Greinwald, Ralf Mohrbacher, Britta Siegmund
BACKGROUND & AIMS: Though proctitis is the most limited form of ulcerative colitis, it causes unpleasant symptoms. Topical mesalamine, the standard treatment, is not always effective. We conducted a randomized phase 2 trial to determine the efficacy and safety of 2 doses of a budesonide suppository vs mesalamine suppositories vs combined budesonide and mesalamine suppositories for proctitis. METHODS: We performed a prospective, double-blind, double-dummy, multicenter trial in 337 patients with active proctitis to compare the efficacies of 4 different suppository treatments...
April 24, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29610508/acg-clinical-guideline-management-of-crohn-s-disease-in-adults
#7
Gary R Lichtenstein, Edward V Loftus, Kim L Isaacs, Miguel D Regueiro, Lauren B Gerson, Bruce E Sands
Crohn's disease is an idiopathic inflammatory disorder of unknown etiology with genetic, immunologic, and environmental influences. The incidence of Crohn's disease has steadily increased over the past several decades. The diagnosis and treatment of patients with Crohn's disease has evolved since the last practice guideline was published. These guidelines represent the official practice recommendations of the American College of Gastroenterology and were developed under the auspices of the Practice Parameters Committee for the management of adult patients with Crohn's disease...
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29610516/ustekinumab-iv-6-mg-kg-loading-dose-re-induction-improves-clinical-and-endoscopic-response-in-crohn-s-disease-a-case-series
#8
Sunhee Park, Elisabeth Evans, William J Sandborn, Brigid Boland
No abstract text is available yet for this article.
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29609069/therapeutic-objectives-in-crohn-s-disease-mucosal-or-transmural-healing
#9
EDITORIAL
Julián Panés, Jordi Rimola
No abstract text is available yet for this article.
March 30, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29596987/heterogeneity-in-definitions-of-efficacy-and-safety-endpoints-for-clinical-trials-of-crohn-s-disease-a-systematic-review-for-development-of-a-core-outcome-set
#10
REVIEW
Christopher Ma, Isra M Hussein, Yousef J Al-Abbar, Remo Panaccione, Richard N Fedorak, Claire E Parker, Tran M Nguyen, Reena Khanna, Corey A Siegel, Laurent Peyrin-Biroulet, Rish K Pai, Niels Vande Casteele, Geert R D'Haens, William J Sandborn, Brian G Feagan, Vipul Jairath
BACKGROUND & AIMS: Endpoints in randomized controlled trials (RCTs) of Crohn's disease (CD) are evolving. We performed a systematic review of efficacy and safety outcomes reported in placebo-controlled RCTs of patients with CD. METHODS: MEDLINE, EMBASE, and the Cochrane Library were searched to March 1, 2017 for placebo-controlled RCTs of adult patients with CD treated with aminosalicylates, immunomodulators, corticosteroids, biologics, and oral small molecules...
March 26, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29551740/high-prevalence-of-anal-canal-high-risk-human-papillomavirus-infection-in-patients-with-crohn-s-disease
#11
Lucine Vuitton, Elise Jacquin, Anne-Laure Parmentier, Elise Crochet, Francine Fein, Anne-Claire Dupont-Gossart, Laurianne Plastaras, Charles-Henri Bretagne, Frédéric Mauny, Stéphane Koch, Jean-Luc Prétet, Christiane Mougin, Séverine Valmary-Degano
BACKGROUND & AIMS: The increasing incidence of anal canal carcinomas requires better knowledge on anal human papillomavirus (HPV) infection. We aimed to assess anal canal HPV infection prevalence and risk factors among patients seen at a gastroenterology department in France. METHODS: We analyzed anal tissue samples collected from 469 consecutive patients (median age 54 years, 52% women), including 112 who received immunosuppressant therapies and 101 with inflammatory bowel disease (70 with Crohn's disease), who underwent colonoscopy examinations from April 1, 2012 to April 30, 2015...
March 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29481970/combining-biologics-in-inflammatory-bowel-disease-and-other-immune-mediated-inflammatory-disorders
#12
REVIEW
Robert P Hirten, Marietta Iacucci, Shailja Shah, Subrata Ghosh, Jean-Frederic Colombel
Current therapies used in the treatment of inflammatory bowel disease (IBD) are not effective in all patients. Biologic agents result in approximately 40% remission rates at 1 year in selected populations, prompting a growing interest in combining biologic therapy to improve outcomes. There are limited published data regarding the efficacy and safety of combination targeted therapy in IBD specifically, which include only 1 exploratory randomized control trial and 3 case reports or series. This review evaluates the published literature regarding this therapeutic paradigm in IBD and its extensive utilization in the treatment of other immune-mediated inflammatory disorders...
March 2, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29486253/biologics-delay-progression-of-crohn-s-disease-but-not-early-surgery-in-children
#13
Basavaraj Kerur, Jason T Machan, Jason M Shapiro, Carolina S Cerezo, James Markowitz, David R Mack, Anne M Griffiths, Anthony R Otley, Marian D Pfefferkorn, Joel R Rosh, David J Keljo, Brendan Boyle, Maria Oliva-Hemker, Marsha H Kay, Shehzad A Saeed, Andrew B Grossman, Boris Sudel, Michael D Kappelman, Marc Schaefer, Gitit Tomer, Athos Bousvaros, Trudy Lerer, Jeffrey S Hyams, Neal S LeLeiko
BACKGROUND & AIMS: Up to 30% of patients with Crohn's disease (CD) require surgery within the first 5 years from diagnosis. We investigated the recent risk of bowel surgery in an inception cohort of pediatric patients with CD and whether early use of biologics (tumor necrosis factor antagonists) alters later disease course. METHODS: We collected data from the Pediatric Inflammatory Bowel Disease Collaborative Research Group registry on 1442 children (age, ≤16 y) diagnosed with CD from January 2002 through December 2014...
March 2, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29467539/editorial-increasing-incidence-of-pediatric-inflammatory-bowel-disease-in-france-implications-for-etiology-diagnosis-prognosis-and-treatment
#14
Edward L Barnes, Michael D Kappelman
The significant increase in pediatric-onset inflammatory bowel disease in recent decades appears to be a global phenomenon, with studies from multiple geographic areas noting an increase in Crohn's disease (CD) and ulcerative colitis (UC). In this large, population-based cohort from northern France, the rapid increase in pediatric CD and UC from 1988-2011 may be due to multiple potential etiologies including environmental factors and advancements in diagnostic capabilities. We should consider the clinical implications of this rise in incidence, including potential risk stratification approaches that may offer the ability to modify the disease course of patients with earlier diagnosis...
February 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29476085/defining-the-relationship-between-depression-and-disease-activity-in-ibd-using-clinical-disease-activity-indices-merit-or-misnomer
#15
David J Gracie, Alexander C Ford
No abstract text is available yet for this article.
February 23, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28625817/natural-history-of-adult-ulcerative-colitis-in-population-based-cohorts-a-systematic-review
#16
Mathurin Fumery, Siddharth Singh, Parambir S Dulai, Corinne Gower-Rousseau, Laurent Peyrin-Biroulet, William J Sandborn
BACKGROUND & AIMS: A comprehensive knowledge of the natural history of ulcerative colitis (UC) helps understand disease evolution, identify poor prognostic markers and impact of treatment strategies, and facilitates shared decision-making. We systematically reviewed the natural history of UC in adult population-based cohort studies with long-term follow-up. METHODS: Through a systematic literature review of MEDLINE through March 31, 2016, we identified 60 studies performed in 17 population-based inception cohorts reporting the long-term course and outcomes of adult-onset UC (n = 15,316 UC patients)...
March 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29460920/long-term-safety-of-in-utero-exposure-to-anti-tnf%C3%AE-drugs-for-the-treatment-of-inflammatory-bowel-disease-results-from-the-multicenter-european-teddy-study
#17
M Chaparro, A Verreth, T Lobaton, E Gravito-Soares, M Julsgaard, E Savarino, F Magro, I Avni Biron, P Lopez-Serrano, M J Casanova, M Gompertz, S Vitor, M Arroyo, D Pugliese, Y Zabana, R Vicente, M Aguas, A Bar-Gil Shitrit, A Gutierrez, G A Doherty, L Fernandez-Salazar, J Martínez Cadilla, J M Huguet, A O'Toole, E Stasi, N Manceñido Marcos, A Villoria, K Karmiris, J F Rahier, C Rodriguez, M Diz-Lois Palomares, G Fiorino, J M Benitez, M Principi, T Naftali, C Taxonera, G Mantzaris, L Sebkova, B Iade, D Lissner, I Ferrer Bradley, A Lopez-San Roman, I Marin-Jimenez, O Merino, M Sierra, M Van Domselaar, F Caprioli, I Guerra, P Peixe, M Piqueras, I Rodriguez-Lago, Y Ber, K van Hoeve, P Torres, M Gravito-Soares, D Rudbeck-Resdal, O Bartolo, A Peixoto, G Martin, A Armuzzi, A Garre, M G Donday, F J Martín de Carpi, J P Gisbert
OBJECTIVES: The long-term safety of exposure to anti-tumor necrosis factor (anti-TNFα) drugs during pregnancy has received little attention. We aimed to compare the relative risk of severe infections in children of mothers with inflammatory bowel disease (IBD) who were exposed to anti-TNFα drugs in utero with that of children who were not exposed to the drugs. METHODS: Retrospective multicenter cohort study. Exposed cohort: children from mothers with IBD receiving anti-TNFα medication (with or without thiopurines) at any time during pregnancy or during the 3 months before conception...
March 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29454042/when-do-you-start-and-when-do-you-stop-screening-for-colon-cancer-in-inflammatory-bowel-disease
#18
Millie D Long, Bruce E Sands
No abstract text is available yet for this article.
May 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29454043/what-is-the-role-of-the-inflammatory-bowel-disease-panel-in-diagnosis-and-treatment
#19
Millie D Long, Bruce E Sands
No abstract text is available yet for this article.
May 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29453383/hyperbaric-oxygen-therapy-is-well-tolerated-and-effective-for-ulcerative-colitis-patients-hospitalized-for-moderate-severe-flares-a-phase-2a-pilot-multi-center-randomized-double-blind-sham-controlled-trial
#20
Parambir S Dulai, Jay C Buckey, Laura E Raffals, Jason M Swoger, Paul L Claus, Kevin O'Toole, Judy A Ptak, Michael W Gleeson, Christella E Widjaja, John T Chang, Jeffery M Adler, Nihal Patel, Laurie A Skinner, Shawn P Haren, Kimberly Goldby-Reffner, Kimberly D Thompson, Corey A Siegel
BACKGROUND: Hyperbaric oxygen therapy (HBOT) markedly increases tissue oxygen delivery. Case series suggest it may have a potential therapeutic benefit in ulcerative colitis (UC). We investigated the therapeutic potential of HBOT as an adjunct to steroids for UC flares requiring hospitalization. METHODS: The study was terminated early due to poor recruitment with 18 of the planned 70 patients enrolled. UC patients hospitalized for moderate-severe flares (Mayo score ≥6, endoscopic sub-score ≥2) were block randomized to steroids + daily HBOT (n = 10) or steroids + daily sham hyperbaric air (n = 8)...
February 16, 2018: American Journal of Gastroenterology
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