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Thyroid hormones

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13 papers 0 to 25 followers
By Ehud Ur Professor and Head, Endocrinology, UBC, Vancouver
https://www.readbyqxmd.com/read/27811932/thyroid-hormones-and-cardiovascular-disease
#1
REVIEW
Avais Jabbar, Alessandro Pingitore, Simon H S Pearce, Azfar Zaman, Giorgio Iervasi, Salman Razvi
Myocardial and vascular endothelial tissues have receptors for thyroid hormones and are sensitive to changes in the concentrations of circulating thyroid hormones. The importance of thyroid hormones in maintaining cardiovascular homeostasis can be deduced from clinical and experimental data showing that even subtle changes in thyroid hormone concentrations - such as those observed in subclinical hypothyroidism or hyperthyroidism, and low triiodothyronine syndrome - adversely influence the cardiovascular system...
November 4, 2016: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27737898/diagnosis-of-endocrine-disease-how-reliable-are-free-thyroid-and-total-t3-hormone-assays
#2
REVIEW
Kerry J Welsh, Steven J Soldin
Hypothyroidism is a very common disorder worldwide, for which the usual treatment is monotherapy with levothyroxine (L-T4). However, a number of patients treated with L-T4 continue to report symptoms of hypothyroidism despite seemingly normal levels of thyroid-stimulating hormone (TSH), free-T3 (FT3) and free-T4 (FT4) measured by immunoassay. This review summarizes the limitations of the immunoassays commonly used to measure thyroid hormone levels and emphasizes the advantages of the role of liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
December 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27700539/is-a-normal-tsh-synonymous-with-euthyroidism-in-levothyroxine-monotherapy
#3
Sarah J Peterson, Elizabeth A McAninch, Antonio C Bianco
CONTEXT: Levothyroxine (LT4) monotherapy is the standard of care for hypothyroidism. OBJECTIVE: To determine whether LT4 at doses that normalize the serum TSH is associated with normal markers of thyroid status. DESIGN: Cross-sectional data from the US National Health and Nutrition Examination Survey (2001-2012) was used to evaluate 52 clinical parameters. LT4-users were compared to healthy controls and controls matched for age, sex, race, and serum TSH...
October 4, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27038492/hyperthyroidism
#4
REVIEW
Simone De Leo, Sun Y Lee, Lewis E Braverman
Hyperthyroidism is characterised by increased thyroid hormone synthesis and secretion from the thyroid gland, whereas thyrotoxicosis refers to the clinical syndrome of excess circulating thyroid hormones, irrespective of the source. The most common cause of hyperthyroidism is Graves' disease, followed by toxic nodular goitre. Other important causes of thyrotoxicosis include thyroiditis, iodine-induced and drug-induced thyroid dysfunction, and factitious ingestion of excess thyroid hormones. Treatment options for Graves' disease include antithyroid drugs, radioactive iodine therapy, and surgery, whereas antithyroid drugs are not generally used long term in toxic nodular goitre, because of the high relapse rate of thyrotoxicosis after discontinuation...
August 27, 2016: Lancet
https://www.readbyqxmd.com/read/26886951/thyroid-hormone-replacement-in-patients-following-thyroidectomy-for-thyroid-cancer
#5
REVIEW
Zeina C Hannoush, Roy E Weiss
Thyroid hormone replacement therapy in patients following thyroidectomy for thyroid cancer, although a potentially straightforward clinical problem, can present the clinician and patient with a variety of challenges. Most often the problems are related to the dose and preparation of thyroid hormone (TH) to use. Some patients feel less well following thyroidectomy and/or radioiodine ablation than they did before their diagnosis. We present evidence that levothyroxine (L-T4) is the preparation of choice, and keeping the thyroid-stimulating hormone (TSH) between detectable and 0...
2016: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/26891118/iodine-supplementation-of-mildly-iodine-deficient-adults-lowers-thyroglobulin-a-randomized-controlled-trial
#6
Zheng Feei Ma, Bernard J Venn, Patrick J Manning, Claire M Cameron, Sheila A Skeaff
This study demonstrates that thyroglobulin decreases when iodine status improves, demonstrating that thyroglobulin is a useful index of iodine status in a group of adults.
April 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26851767/serum-thyroglobulin-as-a-biomarker-of-iodine-deficiency-in-adult-populations
#7
Anne Krejbjerg, Lena Bjergved, Inge Bülow Pedersen, Allan Carlé, Nils Knudsen, Hans Perrild, Lars Ovesen, Lone Banke Rasmussen, Peter Laurberg
OBJECTIVE: To clarify which factors may influence the serum Tg level in an adult population and how this may affect Tg as a biomarker of iodine deficiency (ID). DESIGN AND METHODS: Two identical cross-sectional studies were performed before (C1a: 1997-98, n = 4649) and after (C2: 2004-05, n = 3570) the Danish mandatory iodine fortification (IF) of salt (2000). Additionally, a follow-up study of C1a was performed after IF (C1b: 2008-10, n = 2465). The studies took place in two regions with mild (Copenhagen) and moderate (Aalborg) ID before IF...
September 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/26815881/antithyroid-drug-side-effects-in-the-population-and-in-pregnancy
#8
Stine Linding Andersen, Jørn Olsen, Peter Laurberg
In a Danish population study using health registers, agranulocytosis caused by antithyroid drugs was 4 times more frequent than liver failure. Both were very rare in pregnancy, where birth defects were the dominant side effect.
April 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26628920/a-single-bolus-of-high-dose-levothyroxine-l-t4-as-a-test-in-cases-of-suspected-poor-compliance-to-l-t4-therapy
#9
Krzysztof C Lewandowski, Katarzyna Dąbrowska, Iwona Komorowska-Dudek, Andrzej Lewiński
BACKGROUND: Though compliance (or adherence) problems, as well as inappropriate levothyroxine (L-T4) intake (e.g. with meal, other drugs or certain foods that can significantly affect absorption) are very common, the issue is often either not mentioned or even frankly denied by patients. CASE PRESENTATION: We describe three cases of patients who presented with high TSH (ranging from about 30 to 200 mIU/l), with concomitantly either high, normal or low free thyroxine (FT4), despite treatment with high doses of L-T4...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26342200/natural-history-of-subclinical-hypothyroidism-with-tsh-%C3%A2-10-miu-l-a-prospective-study
#10
Pedro W S Rosário, Marina Carvalho, Maria Regina Calsolari
OBJECTIVE: The risk of progression of subclinical hypothyroidism (SCH) to clinical dysfunction is one of the factors considered in the decision to treat this condition. This study evaluated the natural history of SCH in women with TSH ≤10 mIU/l. DESIGN: This is a prospective study. PATIENTS: Two hundred and fifty-two women with SCH and TSH levels ranging from 4·5 to 10 mIU/l were followed up for a period of 5 years. RESULTS: Among the 241 patients followed up until the completion of the study, 46 (19%) required levothyroxine (L-T4) therapy, 55 (22·8%) had spontaneous normalization of serum TSH, and 140 (58·1%) continued to meet the criteria for mild SCH...
June 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/25867812/thiamazole-pretreatment-lowers-the-131-i-activity-needed-to-cure-hyperthyroidism-in-patients-with-nodular-goiter
#11
RANDOMIZED CONTROLLED TRIAL
Aglaia Kyrilli, Bich-Ngoc-Thanh Tang, Valérie Huyge, Didier Blocklet, Serge Goldman, Bernard Corvilain, Rodrigo Moreno-Reyes
CONTEXT: Relatively low radioiodine uptake (RAIU) represents a common obstacle for radioiodine ((131)I) therapy in patients with multinodular goiter complicated by hyperthyroidism. OBJECTIVE: To evaluate whether thiamazole (MTZ) pretreatment can increase (131)I therapeutic efficacy. DESIGN AND SETTING: Twenty-two patients with multinodular goiter, subclinical hyperthyroidism, and RAIU < 50% were randomized to receive either a low-iodine diet (LID; n = 10) or MTZ 30 mg/d (n = 12) for 42 days...
June 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25259910/switching-levothyroxine-from-the-tablet-to-the-oral-solution-formulation-corrects-the-impaired-absorption-of-levothyroxine-induced-by-proton-pump-inhibitors
#12
COMPARATIVE STUDY
Roberto Vita, Giovanna Saraceno, Francesco Trimarchi, Salvatore Benvenga
CONTEXT: Proton-pump inhibitors (PPIs) impair tablet levothyroxine (LT4) intestinal absorption by increasing the gastric pH and decreasing LT4 dissolution in the stomach. OBJECTIVE: The purpose of this study was to verify whether a liquid formulation of LT4 would correct LT4 malabsorption induced by PPIs. DESIGN: This was a prospective observational cohort study. The study was conducted from 2012 to 2013, and the mean duration of the follow-up was 23...
December 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24433025/treatment-with-thyroid-hormone
#13
REVIEW
Bernadette Biondi, Leonard Wartofsky
Thyroid hormone deficiency can have important repercussions. Treatment with thyroid hormone in replacement doses is essential in patients with hypothyroidism. In this review, we critically discuss the thyroid hormone formulations that are available and approaches to correct replacement therapy with thyroid hormone in primary and central hypothyroidism in different periods of life such as pregnancy, birth, infancy, childhood, and adolescence as well as in adult patients, the elderly, and in patients with comorbidities...
June 2014: Endocrine Reviews
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