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Allergy

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13 papers 25 to 100 followers
https://www.readbyqxmd.com/read/26179009/european-society-of-contact-dermatitis-guideline-for-diagnostic-patch-testing-recommendations-on-best-practice
#1
Jeanne D Johansen, Kristiina Aalto-Korte, Tove Agner, Klaus E Andersen, Andreas Bircher, Magnus Bruze, Alicia Cannavó, Ana Giménez-Arnau, Margarida Gonçalo, An Goossens, Swen M John, Carola Lidén, Magnus Lindberg, Vera Mahler, Mihály Matura, Thomas Rustemeyer, Jørgen Serup, Radoslaw Spiewak, Jacob P Thyssen, Martine Vigan, Ian R White, Mark Wilkinson, Wolfgang Uter
The present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions and discussions of different pertinent topics are followed by a highlighted short practical recommendation. Topics comprise, after an introduction with important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special considerations, children, patients with occupational contact dermatitis and drug eruptions as special groups, patch testing of materials brought in by the patient, adverse effects of patch testing, and the final evaluation and patient counselling based on this judgement...
October 2015: Contact Dermatitis
https://www.readbyqxmd.com/read/26233429/applications-of-molecular-diagnostic-testing-in-food-allergy
#2
REVIEW
Karin Hoffmann-Sommergruber, Sabine Pfeifer, Merima Bublin
IgE-mediated food allergy is a relevant health problem inducing symptoms ranging from mild local reactions up to severe life-threatening situations. Currently, no immunotherapy is available and avoidance of the incriminating food is the method of choice. Therefore, reliable diagnostic tools to formulate dietary recommendations and to avoid unnecessary exclusion diets for the individual patient are urgently needed. This review provides an update on the current knowledge on food allergens and their application in various diagnostic approaches such as skin prick test, basophil activation test, and serum IgE testing...
September 2015: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/25720596/the-use-of-the-medall-chip-to-assess-ige-sensitization-a-new-diagnostic-tool-for-allergic-disease
#3
COMPARATIVE STUDY
Ingebjørg Skrindo, Christian Lupinek, Rudolf Valenta, Vegard Hovland, Sandra Pahr, Alexandra Baar, Kai-Håkon Carlsen, Petter Mowinckel, Magnus Wickman, Erik Melen, Jean Bousquet, Josep M Anto, Karin C Lødrup Carlsen
BACKGROUND: Allergic sensitization is frequently present in asthma and rhinitis, but the role of specific immunoglobulin E (s-IgE) is not always clear. Multiple s-IgE analyses may provide insight into this relationship, thus a microarray chip was developed within the EU-funded MeDALL project. The main objective was to evaluate the performance of the MeDALL-chip compared to ImmunoCAP and skin prick test (SPT) in detecting allergic sensitization in children and secondarily to investigate the association to asthma and allergic rhinitis...
May 2015: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/25720528/allergenicity-of-pasteurized-whole-raw-hen-s-egg-compared-with-fresh-whole-raw-hen-s-egg
#4
COMPARATIVE STUDY
Merryn Netting, Adaweyah Donato, Maria Makrides, Michael Gold, Patrick Quinn, Irmeli Penttila
BACKGROUND: Oral food challenges for diagnosis and management of egg allergy using fresh egg are common; however, to limit the risk of foodborne infection, many allergy units use pasteurized raw egg. Pasteurization and drying processes have the potential to affect the structure of egg proteins in egg powder and thus the allergenicity when compared to fresh egg. Our aim was to compare the binding of serum IgE from egg-allergic children to in vitro digested and undigested pasteurized whole raw egg powder with unpasteurized fresh whole raw egg...
May 2015: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/23453797/vitamin-d-insufficiency-is-associated-with-challenge-proven-food-allergy-in-infants
#5
Katrina J Allen, Jennifer J Koplin, Anne-Louise Ponsonby, Lyle C Gurrin, Melissa Wake, Peter Vuillermin, Pamela Martin, Melanie Matheson, Adrian Lowe, Marnie Robinson, Dean Tey, Nicholas J Osborne, Thanh Dang, Hern-Tze Tina Tan, Leone Thiele, Deborah Anderson, Helen Czech, Jeeva Sanjeevan, Giovanni Zurzolo, Terence Dwyer, Mimi L K Tang, David Hill, Shyamali C Dharmage
BACKGROUND: Epidemiological evidence has shown that pediatric food allergy is more prevalent in regions further from the equator, suggesting that vitamin D insufficiency may play a role in this disease. OBJECTIVE: To investigate the role of vitamin D status in infantile food allergy. METHODS: A population sample of 5276 one-year-old infants underwent skin prick testing to peanut, egg, sesame, and cow's milk or shrimp. All those with a detectable wheal and a random sample of participants with negative skin prick test results attended a hospital-based food challenge clinic...
April 2013: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/25692325/immunomodulating-properties-of-protein-hydrolysates-for-application-in-cow-s-milk-allergy
#6
REVIEW
M B G Kiewiet, M Gros, R J J van Neerven, M M Faas, P de Vos
Cow's milk proteins cause allergic symptoms in 2-3% of all infants. In these individuals, the tolerogenic state of the intestinal immune system is broken, which can lead to sensitization against antigens and eventually to allergic responses. Although a true treatment for food allergy is not available, symptoms can be avoided by providing the infants with hydrolyzed proteins. Hydrolyzed proteins are proteins that are enzymatically degraded. They lack typical allergenic IgE-binding epitopes but are also thought to play a pertinent role in other mechanisms inducing hypoallergenic effects...
May 2015: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/25217201/food-allergen-panel-testing-often-results-in-misdiagnosis-of-food-allergy
#7
J Andrew Bird, Maria Crain, Pooja Varshney
OBJECTIVE: To determine the utility of food allergy panel testing among patients referred to a pediatric food allergy center. STUDY DESIGN: Retrospective chart review of all new patients seen between September 2011 and December 2012 by 1 provider in a tertiary referral pediatric food allergy center. A cost analysis was performed to calculate the estimated cost of evaluation for patients who have received a food allergy panel. RESULTS: Of 797 new patient encounters, 284 (35%) patients had received a food allergy panel...
January 2015: Journal of Pediatrics
https://www.readbyqxmd.com/read/23532243/sublingual-immunotherapy-for-the-treatment-of-allergic-rhinoconjunctivitis-and-asthma-a-systematic-review
#8
REVIEW
Sandra Y Lin, Nkiruka Erekosima, Julia M Kim, Murugappan Ramanathan, Catalina Suarez-Cuervo, Yohalakshmi Chelladurai, Darcy Ward, Jodi B Segal
IMPORTANCE: Allergic rhinitis affects up to 40% of the US population. To desensitize allergic individuals, subcutaneous injection immunotherapy or sublingual immunotherapy may be administered. In the United States, sublingual immunotherapy is not approved by the Food and Drug Administration. However, some US physicians use aqueous allergens, off-label, for sublingual desensitization. OBJECTIVE: To systematically review the effectiveness and safety of aqueous sublingual immunotherapy for allergic rhinoconjunctivitis and asthma...
March 27, 2013: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/23845860/ige-mediated-food-allergy-in-children
#9
REVIEW
Giorgio Longo, Irene Berti, A Wesley Burks, Baruch Krauss, Egidio Barbi
Food allergy is a serious health issue affecting roughly 4% of children, with a substantial effect on quality of life. Prognosis is good for the most frequent allergens with almost all children outgrowing their allergy. However, the long-term implications for disease burden are substantial for children with persistent allergies (eg, peanuts, tree nuts, fish, and shellfish) and for those with high concentrations of milk, egg, and wheat IgE. Antigen avoidance has been the time-honoured approach both for prevention and treatment...
November 16, 2013: Lancet
https://www.readbyqxmd.com/read/25443975/native-and-denatured-egg-white-protein-ige-tests-discriminate-hen-s-egg-allergic-from-egg-tolerant-children
#10
Avigael H Benhamou Senouf, Magnus P Borres, Philippe A Eigenmann
BACKGROUND: Accurate diagnosis of egg allergy by IgE testing is challenged by a large number of atopic subjects sensitized, but clinically tolerant to eggs. In addition, discrimination between allergy to raw only, or raw and cooked egg allergy is important. In this study, we investigate the diagnostic performance of IgE tests to native and denatured egg proteins. METHODS: According to food challenges and clinical tolerance, study subjects were randomized to the following groups: (Group A) sensitized but clinically tolerant to egg, (Group B) allergic to raw egg only, or (Group C) allergic to raw and cooked egg...
February 2015: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/24942594/safety-and-efficacy-of-topical-e6005-a-phosphodiesterase-4-inhibitor-in-japanese-adult-patients-with-atopic-dermatitis-results-of-a-randomized-vehicle-controlled-multicenter-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Masutaka Furue, Yasumi Kitahara, Hideto Akama, Seiichiro Hojo, Nobukazu Hayashi, Hidemi Nakagawa
The safety and efficacy of topical E6005, a novel phosphodiesterase 4 inhibitor, in Japanese adults with atopic dermatitis were evaluated. A total of 78 patients were randomized to receive either the 0.2% E6005 ointment or vehicle control (without E6005) at an allocation ratio of 2:1. The randomization phase of 4 weeks was followed by an extension phase of 8 weeks. In the extension phase, all 67 subjects who completed the randomization phase were treated with 0.2% E6005 ointment. The 4-week application of topical E6005 twice daily was safe and well tolerated...
July 2014: Journal of Dermatology
https://www.readbyqxmd.com/read/24899389/the-first-thousand-days-intestinal-microbiology-of-early-life-establishing-a-symbiosis
#12
REVIEW
Harm Wopereis, Raish Oozeer, Karen Knipping, Clara Belzer, Jan Knol
The development of the intestinal microbiota in the first years of life is a dynamic process significantly influenced by early-life nutrition. Pioneer bacteria colonizing the infant intestinal tract and the gradual diversification to a stable climax ecosystem plays a crucial role in establishing host-microbe interactions essential for optimal symbiosis. This colonization process and establishment of symbiosis may profoundly influence health throughout life. Recent developments in microbiologic cultivation-independent methods allow a detailed view of the key players and factors involved in this process and may further elucidate their roles in a healthy gut and immune maturation...
August 2014: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/24893766/antipruritic-effects-of-the-probiotic-strain-lkm512-in-adults-with-atopic-dermatitis
#13
RANDOMIZED CONTROLLED TRIAL
Mitsuharu Matsumoto, Toshiya Ebata, Junko Hirooka, Ritsuko Hosoya, Natsuhiko Inoue, Satomi Itami, Kazuo Tsuji, Taketoshi Yaginuma, Koji Muramatsu, Atsuo Nakamura, Ayako Fujita, Toshikazu Nagakura
BACKGROUND: Evidence suggests that intestinal microbiota play an important role in the pathogenesis of atopic dermatitis (AD) through induction of immunosuppression and immune tolerance; however, the exact underlying mechanism is unclear. Few studies to date have examined the effects of probiotics on adult-type AD. OBJECTIVE: To examine the effects of the probiotic Bifidobacterium animalis subsp lactis LKM512 on adult-type AD and the expression of metabolites that are known to be influenced by gut microbiota in fecal samples...
August 2014: Annals of Allergy, Asthma & Immunology
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