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Vitamin D and obesity

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152 papers 100 to 500 followers Papers about vitamin D testing, deficiency, effects on adipose tissue, links to obesity and bariatric surgery, and the VDR.
By Clare Dix Dietitian, PhD candidate, researching vitamin D and obesity
I Bazuin, S Pouwels, S Houterman, S W Nienhuijs, J F Smulders, A K Boer
BACKGROUND/OBJECTIVES: Most bariatric guidelines recommend frequent lab monitoring of patients to detect nutrient and vitamin deficiencies as early as possible. The aim of this study was to optimize the cost effectiveness of the nutrient panel, by developing an algorithm, which detects nutrient deficiencies at lower costs. SUBJECTS/METHODS: In this retrospective study, 2055 patients who had undergone Laparoscopic Roux-Y Gastric Bypass (LRYGB) and Laparoscopic Sleeve Gastrectomy (LSG) surgery at Catharina Hospital Eindhoven between January 2009 and December 2013 were included...
December 14, 2016: European Journal of Clinical Nutrition
Ana Obispo Entrenas, David Legupin Tubio, Fabiola Lucena Navarro, Francisco Martín Carvajal, Norberto Gandara Adan, Maximino Redondo Bautista, Jimena Abiles Osinaga
No abstract text is available yet for this article.
December 29, 2016: Obesity Surgery
Maria Luger, Renate Kruschitz, Christian Kienbacher, Stefan Traussnigg, Felix B Langer, Gerhard Prager, Karin Schindler, Enikö Kallay, Friedrich Hoppichler, Michael Trauner, Michael Krebs, Rodrig Marculescu, Bernhard Ludvik
BACKGROUND: Bariatric patients often suffer from vitamin D deficiency (VDD), and both, morbid obesity and VDD, are related to non-alcoholic fatty liver disease. However, limited data are available regarding best strategies for treating VDD, particularly, in bariatric patients undergoing omega-loop gastric bypass (OLGB). Therefore, we examined the efficacy and safety of a forced vitamin D dosing regimen and intervention effects in liver fibrotic patients. METHODS: In this double-blind, randomized, placebo-controlled trial, 50 vitamin D-deficient patients undergoing OLGB were randomly assigned to receive, in the first month postoperatively, oral vitamin D3 (≤3 doses of 100,000 IU; intervention group) or placebo as loading dose (control group) with subsequent maintenance dose (3420 IU/day) in both groups until 6-month visit...
November 12, 2016: Obesity Surgery
Clare F Dix, Judith D Bauer, Olivia R L Wright
BACKGROUND: Bariatric patients regularly present with insufficient vitamin D status before and after surgery, which requires substantial supplementation to treat. This review aims to assess the effect of sleeve gastrectomy on vitamin D status and the effectiveness of vitamin D supplementation. METHODS: This review was conducted in accordance with the Guidelines for Meta-Analyses and Systematic Reviews of Observational Studies. RESULTS: The current guidelines recommend initial vitamin D supplementation of at least 3000 IU/day post-operatively, with no need for follow-up testing after sleeve gastrectomy...
January 2017: Obesity Surgery
Borja Bandera Merchan, Francisco José Tinahones, Manuel Macías-González
The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Specifically, PPARG has been implicated in the regulation of processes concerning metabolism, inflammation, atherosclerosis, cell differentiation, and proliferation. Thus, a considerable amount of literature has emerged in the last ten years linking PPARG signalling with metabolic conditions such as obesity and diabetes, cardiovascular disease, and, more recently, cancer...
2016: PPAR Research
Sandra Gillon, Yvonne M Jeanes, John Roger Andersen, Villy Våge
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has become more popular in recent years. The aim of this study was to determine the vitamin and mineral status in patients up to 5 years after LSG and to explore changes that occurred from pre-operatively to 1, 2 and 5 years after surgery. METHODS: Data reviewed included age, sex, weight and body mass index (BMI), micronutrient supplements consumed and blood levels of 25 hydroxyvitamin D (25 (OH) D), PTH (parathyroid hormone), ferritin, haemoglobin, folate and vitamin B12, prior to and post-LSG...
August 5, 2016: Obesity Surgery
Paola Andreozzi, Walter Verrusio, Giovanni Viscogliosi, Maria Luna Summa, Nicolò Gueli, Mauro Cacciafesta, Carlina V Albanese
OBJECTIVE: The aim of this study was to explore the relationship between 25-hydroxyvitamin D (25[OH]D) serum concentrations and body fat distribution in a sample of postmenopausal women. METHODS: We enrolled sixty-two postmenopausal women; 25(OH)D serum concentrations, serum intact parathyroid hormone, blood analyses, and anthropometric measurements were carried out. Body fat composition was evaluated by dual-energy X-ray absorptiometry. Insulin resistance was estimated by homeostatic model assessment of insulin resistance (HOMA-IR) calculation...
June 2016: Nutrition
Nazy Zarshenas, Maria Nacher, Ken W Loi, John O Jorgensen
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) as a single-stage procedure has shown to be effective in achieving significant weight loss and resolving obesity-related co-morbidities. However, its nutrition consequences have not been extensively explored. This study aims to investigate weight loss and evolution of nutritional deficiencies in a group of patients 3 years post LSG. METHODS: Retrospective data of a group of patients, 3 years following LSG as a stand-alone procedure was collected...
May 5, 2016: Obesity Surgery
Jose I Botella-Carretero, Christian Lafuente, Rafael Montes-Nieto, Jose Balsa, Belen Vega-Piñero, Francisca Garcia-Moreno, Roberto Peromingo, Julio Galindo, Jose L San-Millan, Hector Escobar-Morreale
INTRODUCTION: Low bone mass after obesity surgery may arise as a consequence of chronic malabsorption of calcium and vitamin D. However, we have not found any role of serum 25-hydroxyvitamin D or of polymorphisms in the vitamin D receptor gene in previous studies. PURPOSE: To investigate the circulating bioavailable 25-hydroxyvitamin D in women after bariatric procedures and its association with bone mass. PATIENTS AND METHODS: The study consisted of 91 women on follow-up for 7 ± 2 years after bariatric surgery...
April 26, 2016: Obesity Surgery
Leigh A Peterson, Xiange Zeng, Christine P Caufield-Noll, Michael A Schweitzer, Thomas H Magnuson, Kimberley E Steele
BACKGROUND: Bariatric surgery is the most effective long-term weight loss method. The most common procedures are Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG). Bariatric patients are at high risk of vitamin D deficiency (VDD) and insufficiency (VDI), which are associated with skeletal and nonskeletal ailments. There is no consensus regarding the optimal treatment for VDD/VDI in bariatric patients. OBJECTIVES: To critically examine the literature on vitamin D status (serum 25[OH]D concentrations) pre- and postbariatric surgery as well as supplementation regimens currently used...
March 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Lara Pizzorno
Obesity is now a global epidemic affecting a significant and rapidly increasing number of adults, adolescents, and children. As the incidence of obesity has increased, so has the use of bariatric surgery as a medical solution. A growing number of studies now report that, despite calcium and vitamin D supplementation, the most frequently performed types of bariatric surgery, the Roux-en-Y gastric bypass and the sleeve gastrectomy, cause significant ongoing bone loss. In resources available to the general public and to physicians, this adverse outcome is rarely mentioned or is attributed solely to reduced calcium absorption...
March 2016: Integrative Medicine
V Camozzi, A C Frigo, M Zaninotto, F Sanguin, M Plebani, M Boscaro, L Schiavon, G Luisetto
UNLABELLED: After a single cholecalciferol load, peak serum 25-hydroxycholecalciferol (25OHD) is lower in individuals with a higher body mass index (BMI), probably due to it being distributed in a greater volume. Its subsequent disappearance from the serum is slower the higher the individual's BMI, probably due to the combination of a larger body volume and a slower release into the circulation of vitamin D stored in adipose tissue. INTRODUCTION: The aim of the study is to examine 25-hydroxycholecalciferol (25OHD) response to a single oral load of cholecalciferol in the normal weight, overweight, and obese...
August 2016: Osteoporosis International
Shokoufeh Bonakdaran, Farzaneh Fakhraee, Maryam Saberi Karimian, Seyed Reza Mirhafez, Haleh Rokni, Mohsen Mohebati, Mohsen Mazidi, Mina Mousavi, Gordon A Ferns, Majid Ghayour-Mobarhan
PURPOSE: There is now good evidence that 25-hydroxyvitamin D (25OHD) status may have an important impact on the development and progression of cardiovascular disease. Because of the potential involvement of vitamin D deficiency in blood pressure control and immune responses, we aimed to investigate whether there was a relationship between 25OHD status and the prevalence of metabolic syndrome in an Iranian population. MATERIAL/METHODS: The study was carried out on a sample of 846 subjects [357(42...
September 2016: Advances in Medical Sciences
Poonam K Pannu, Yun Zhao, Mario J Soares
The purpose of this review was to confirm a volumetric dilution of vitamin D in obesity. It was based on the hypothesis that weight loss, particularly fat loss, would increase serum 25-hydroxyvitamin D (25OHD) in the obese. We conducted a systematic review of the literature over the last 21 years and included human trials that reported changes in 25OHD, weight, or body composition after weight loss. Study arms were excluded if vitamin D was supplemented, dietary intake exceeded 800 IU/d, or extreme sun exposure was reported...
March 2016: Nutrition Research
I S Shafinaz, F M Moy
BACKGROUND: Vitamin D deficiency is highly prevalent in both temperate as well as tropical countries. Obesity is one of the factors contributing to vitamin D deficiency. As our country has a high prevalence of overweight and obesity, we aimed to study serum 25-hydroxyvitamin D (25(OH)D) level and its association with adiposity using various adiposity indicators; and to study other risk factors that affect serum 25(OH)D level among multi-ethnic adults in Kuala Lumpur, Malaysia. METHODS: This was a cross sectional study conducted with a multistage sampling...
March 7, 2016: BMC Public Health
Marlene Toufic Chakhtoura, Nancy N Nakhoul, Khaled Shawwa, Christos Mantzoros, Ghada A El Hajj Fuleihan
BACKGROUND: Obesity is a public health problem that carries global and substantial social and economic burden. Relative to non-surgical interventions, bariatric surgery has the most substantial and lasting impact on weight loss. However, it leads to a number of nutritional deficiencies requiring long term supplementation. OBJECTIVES: The aims of this paper are to review 25-hydroxyvitamin D [25(OH)D] status pre and post bariatric surgery, describe the dose response of vitamin D supplementation, and assess the effect of the surgical procedure on 25(OH)D level following supplementation...
April 2016: Metabolism: Clinical and Experimental
Marlene Toufic Chakhtoura, Nancy Nakhoul, Elie A Akl, Christos S Mantzoros, Ghada A El Hajj Fuleihan
INTRODUCTION: Bariatric surgery is the most effective therapeutic option to reduce weight in morbidly obese individuals, but it results in a number of mineral and vitamin deficiencies. Clinical Practice Guidelines (CPGs) attempt to balance those benefits and harms to provide guidance to physicians and patients. OBJECTIVES: We compare and evaluate the quality of the evidence and of the development process of current CPGs that provide recommendations on vitamin D replacement in patients undergoing bariatric surgery, using a validated tool...
April 2016: Metabolism: Clinical and Experimental
Jaime Ruiz-Tovar, Carolina Llavero, Lorea Zubiaga, Evangelina Boix
INTRODUCTION: After all bariatric procedures, multivitamin supplements are uniformly prescribed to minimize eventual deficiencies. These supplements are usually maintained long time, even during the whole life after malabsorptive techniques, while these are maintained at least during 1 year after restrictive procedures. Given that sleeve gastrectomy does not alter intestinal absorption, the supplements are possibly unnecessary, once the patient can take an adequate diet. PATIENTS AND METHODS: A prospective randomized study of patients undergoing a laparoscopic sleeve gastrectomy was performed...
October 2016: Obesity Surgery
Leigh A Peterson, Lawrence J Cheskin, Michael A Schweitzer, Thomas H Magnuson, Kimberley E Steele
BACKGROUND: Since obesity increases vitamin D deficiency (VDD) risk, bariatric surgery candidates are high-risk. Previously, we documented 71.4% VDD at our center. OBJECTIVES: To investigate diagnosis and treatment for VDD in our bariatric candidates. METHODS: 25(OH)D, if pending, and supplementation (form, dosing, frequency) were prospectively documented in 265 candidates. RESULTS: Candidates were 83.0% female, 48.9% white, age 43 ± 13 years and BMI 46...
May 2016: Obesity Surgery
David A Jolliffe, Robert T Walton, Christopher J Griffiths, Adrian R Martineau
Polymorphisms in genes encoding proteins involved in vitamin D metabolism and transport are recognised to influence vitamin D status. Syntheses of genetic association studies linking these variants to non-skeletal health outcomes are lacking. We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D)...
November 2016: Journal of Steroid Biochemistry and Molecular Biology
2016-01-04 11:17:00
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