Dirk von Lewinski, Ewald Kolesnik, Norbert J Tripolt, Peter N Pferschy, Martin Benedikt, Markus Wallner, Hannes Alber, Rudolf Berger, Michael Lichtenauer, Christoph H Saely, Deddo Moertl, Pia Auersperg, Christian Reiter, Thomas Rieder, Jolanta M Siller-Matula, Gloria M Gager, Matthias Hasun, Franz Weidinger, Thomas R Pieber, Peter M Zechner, Markus Herrmann, Andreas Zirlik, Rury R Holman, Abderrahim Oulhaj, Harald Sourij
AIMS: Sodium-glucose co-transporter 2 inhibition reduces the risk of hospitalization for heart failure and for death in patients with symptomatic heart failure. However, trials investigating the effects of this drug class in patients following acute myocardial infarction are lacking. METHODS AND RESULTS: In this academic, multicentre, double-blind trial, patients (n = 476) with acute myocardial infarction accompanied by a large creatine kinase elevation (>800 IU/L) were randomly assigned to empagliflozin 10 mg or matching placebo once daily within 72 h of percutaneous coronary intervention...
November 1, 2022: European Heart Journal