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HD/ESRD

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53 papers 100 to 500 followers
By Venkatesh Ariyamuthu Transplant Nephrologist at UT Southwestern Medical Center
https://www.readbyqxmd.com/read/27516235/bp-control-and-long-term-risk-of-esrd-and-mortality
#1
Elaine Ku, Jennifer Gassman, Lawrence J Appel, Miroslaw Smogorzewski, Mark J Sarnak, David V Glidden, George Bakris, Orlando M Gutiérrez, Lee A Hebert, Joachim H Ix, Janice Lea, Michael S Lipkowitz, Keith Norris, David Ploth, Velvie A Pogue, Stephen G Rostand, Edward D Siew, Mohammed Sika, C Craig Tisher, Robert Toto, Jackson T Wright, Christina Wyatt, Chi-Yuan Hsu
We recently showed an association between strict BP control and lower mortality risk during two decades of follow-up of prior participants in the Modification of Diet in Renal Disease (MDRD) trial. Here, we determined the risk of ESRD and mortality during extended follow-up of the African American Study of Kidney Disease and Hypertension (AASK) trial. We linked 1067 former AASK participants with CKD previously randomized to strict or usual BP control (mean arterial pressure ≤92 mmHg or 102-107 mmHg, respectively) to the US Renal Data System and Social Security Death Index; 397 patients had ESRD and 475 deaths occurred during a median follow-up of 14...
August 11, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27492146/central-venous-occlusion-in-the-hemodialysis-patient
#2
Vinay Narasimha Krishna, Joseph B Eason, Michael Allon
Central venous stenosis (CVS) is encountered frequently among hemodialysis patients. Prior ipsilateral central venous catheterization and cardiac rhythm device insertions are common risk factors, but CVS can also occur in the absence of this history. Chronic CVS can cause thrombosis with partial or complete occlusion of the central vein at the site of stenosis. CVS is frequently asymptomatic and identified as an incidental finding during imaging studies. Symptomatic CVS presents most commonly as an upper- or lower-extremity edema ipsilateral to the CVS...
November 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27493258/coronary-revascularization-in-patients-with-ckd-stage-5d-pragmatic-considerations
#3
Gautam R Shroff, Charles A Herzog
Coronary revascularization decisions for patients with CKD stage 5D present a dilemma for clinicians because of high baseline risks of mortality and future cardiovascular events. This population differs from the general population regarding characteristics of coronary plaque composition and behavior, accuracy of noninvasive testing, and response to surgical and percutaneous revascularization, such that findings from the general population cannot be automatically extrapolated. However, this high-risk population has been excluded from all randomized trials evaluating outcomes of revascularization...
December 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27085737/novel-extracorporeal-therapies-for-combined-renal-pulmonary-dysfunction
#4
REVIEW
Stefano Romagnoli, Zaccaria Ricci, Claudio Ronco
In modern intensive care medicine, lungs and kidneys frequently are involved in the context of multiorgan failure. When organ dysfunction occurs, the primary clinical management of critically ill patients is based on support/replacement of organ function until recovery. Mechanical ventilation is the first-line intervention in case of respiratory failure, but in most severe cases may, itself, cause ventilator-induced lung injury. The same inflammatory mechanism also may harm the kidney through mediator spillover from the injured lungs into the bloodstream...
January 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27133436/management-of-the-hemodialysis-unit-core-curriculum-2016
#5
Susan M Blankschaen, Sharmeela Saha, Jay B Wish
No abstract text is available yet for this article.
August 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26976799/efficacy-of-direct-acting-antiviral-combination-for-patients-with-hepatitis-c-virus-genotype-1-infection-and-severe-renal-impairment-or-end-stage-renal-disease
#6
Paul J Pockros, K Rajender Reddy, Parvez S Mantry, Eric Cohen, Michael Bennett, Mark S Sulkowski, David E Bernstein, Daniel E Cohen, Nancy S Shulman, Deli Wang, Amit Khatri, Manal Abunimeh, Thomas Podsadecki, Eric Lawitz
BACKGROUND & AIMS: Although hepatitis C virus (HCV) infection is common in patients with end-stage renal disease, highly efficacious, well-tolerated, direct-acting antiviral regimens have not been extensively studied in this population. We investigated the safety and efficacy of ombitasvir co-formulated with paritaprevir and ritonavir, administered with dasabuvir (with or without ribavirin) in a prospective study of patients with stage 4 or 5 chronic kidney disease (CKD). METHODS: We performed a single-arm, multicenter study of treatment-naïve adults with HCV genotype 1 infection, without cirrhosis and with CKD stage 4 (estimated glomerular filtration rate, 15-30 mL/min/1...
June 2016: Gastroenterology
https://www.readbyqxmd.com/read/26918174/renal-replacement-therapy
#7
REVIEW
Zaccaria Ricci, Stefano Romagnoli, Claudio Ronco
During the last few years, due to medical and surgical evolution, patients with increasingly severe diseases causing multiorgan dysfunction are frequently admitted to intensive care units. Therapeutic options, when organ failure occurs, are frequently nonspecific and mostly directed towards supporting vital function. In these scenarios, the kidneys are almost always involved and, therefore, renal replacement therapies have become a common routine practice in critically ill patients with acute kidney injury...
2016: F1000Research
https://www.readbyqxmd.com/read/26926841/how-can-the-complications-of-central-vein-catheters-be-reduced-central-venous-stenosis-in-hemodialysis-patients
#8
Seth Toomay, John Rectenwald, Miguel A Vazquez
No abstract text is available yet for this article.
May 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/26709108/communication-skills-and-decision-making-for-elderly-patients-with-advanced-kidney-disease-a-guide-for-nephrologists
#9
REVIEW
Holly M Koncicki, Jane O Schell
Elderly patients comprise the most rapidly growing population initiating dialysis therapy and may derive particular benefit from comprehensive assessment of geriatric syndromes, coexisting comorbid conditions, and overall prognosis. Palliative care is a philosophy that aims to improve quality of life and assist with treatment decision making for patients with serious illness such as kidney disease. Palliative skills for the nephrology provider can aid in the care of these patients. This review provides nephrology providers with 4 primary palliative care skills to guide treatment decision making: (1) use prognostic tools to identify patients who may benefit from conservative management, (2) disclose prognostic information to patients who may not do well with dialysis therapy, (3) incorporate patient goals and values to outline a treatment plan, and (4) prepare patients and families for transitions and end of life...
April 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26709061/end-stage-kidney-disease-in-the-elderly-approach-to-dialysis-initiation-choosing-modality-and-predicting-outcomes
#10
REVIEW
Joseph R Berger, Vishal Jaikaransingh, S Susan Hedayati
The number of patients with end-stage kidney disease 65 years and older is growing, and this growth is expected to continue. The presence of medical comorbidities, limited life expectancy, frailty, and poor functional status in these patients poses substantial challenges in clinical decision-making and provision of optimal care. Frailty is more common in elderly patients with CKD than without and is associated with poor outcomes. Several prognostic tools were developed to estimate the rate of CKD progression among elderly, and risk of mortality after dialysis initiation...
January 2016: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/26712807/effect-of-lowering-the-dialysate-temperature-in-chronic-hemodialysis-a-systematic-review-and-meta-analysis
#11
Reem A Mustafa, Fadi Bdair, Elie A Akl, Amit X Garg, Heather Thiessen-Philbrook, Hassan Salameh, Sood Kisra, Gihad Nesrallah, Ahmad Al-Jaishi, Parth Patel, Payal Patel, Ahmad A Mustafa, Holger J Schünemann
BACKGROUND AND OBJECTIVES: Lowering the dialysate temperature may improve outcomes for patients undergoing chronic hemodialysis. We reviewed the reported benefits and harms of lower temperature dialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We searched the Cochrane Central Register, OVID MEDLINE, EMBASE, and Pubmed until April 15, 2015. We reviewed the reference lists of relevant reviews, registered trials, and relevant conference proceedings. We included all randomized, controlled trials that evaluated the effect of reduced temperature dialysis versus standard temperature dialysis in adult patients receiving chronic hemodialysis...
March 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26561355/intensive-hemodialysis-and-mortality-risk-in-australian-and-new-zealand-populations
#12
Mark R Marshall, Kevan R Polkinghorne, Peter G Kerr, Carmel M Hawley, John W M Agar, Stephen P McDonald
BACKGROUND: Intensive hemodialysis (HD) is characterized by increased frequency and/or session length compared to conventional HD. Previous analyses from Australia and New Zealand did not suggest benefit with intensive HD, although recent research suggests that relationships have changed. We present updated analyses. STUDY DESIGN: Observational cohort study using marginal structural modeling to adjust for changes in renal replacement modality and time-varying medical comorbid conditions...
April 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26524584/in-the-clinic-restless-legs-syndrome
#13
REVIEW
Suzanne Bertisch
This issue provides a clinical overview of restless legs syndrome, focusing on diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
November 3, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/26498416/kdoqi-clinical-practice-guideline-for-hemodialysis-adequacy-2015-update
#14
REVIEW
(no author information available yet)
The National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQI) has provided evidence-based guidelines for all stages of chronic kidney disease (CKD) and related complications since 1997. The 2015 update of the KDOQI Clinical Practice Guideline for Hemodialysis Adequacy is intended to assist practitioners caring for patients in preparation for and during hemodialysis. The literature reviewed for this update includes clinical trials and observational studies published between 2000 and March 2014...
November 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26416943/receipt-of-intravenous-iron-and-clinical-outcomes-among-hemodialysis-patients-hospitalized-for-infection
#15
Julie H Ishida, Ben J Marafino, Charles E McCulloch, Lorien S Dalrymple, R Adams Dudley, Barbara A Grimes, Kirsten L Johansen
BACKGROUND AND OBJECTIVES: Anemia guidelines for CKD recommend withholding intravenous iron in the setting of active infection, although no data specifically support this recommendation. This study aimed to examine the association between intravenous iron and clinical outcomes among hemodialysis patients hospitalized for infection. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a retrospective observational cohort study using data from the US Renal Data System of 22,820 adult Medicare beneficiaries on in-center hemodialysis who had received intravenous iron in the 14 days preceding their first hospitalization for bacterial infection in 2010...
October 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26416944/is-intravenous-iron-supplementation-safe-to-administer-to-patients-on-hemodialysis-with-active-infection-what-do-we-know-and-what-more-do-we-need-to-know
#16
EDITORIAL
Charles Lee Bennett, Terhi Hermanson
No abstract text is available yet for this article.
October 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26413285/optimizing-haemodialysate-composition
#17
REVIEW
Francesco Locatelli, Vincenzo La Milia, Leano Violo, Lucia Del Vecchio, Salvatore Di Filippo
Survival and quality of life of dialysis patients are strictly dependent on the quality of the haemodialysis (HD) treatment. In this respect, dialysate composition, including water purity, plays a crucial role. A major aim of HD is to normalize predialysis plasma electrolyte and mineral concentrations, while minimizing wide swings in the patient's intradialytic plasma concentrations. Adequate sodium (Na) and water removal is critical for preventing intra- and interdialytic hypotension and pulmonary edema. Avoiding both hyper- and hypokalaemia prevents life-threatening cardiac arrhythmias...
October 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26408234/hemodialysis-access-in-patients-with-failed-kidney-transplants-nephrologist-heal-thyself
#18
EDITORIAL
Ali K Khalil, Jay B Wish
No abstract text is available yet for this article.
October 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26371529/multidisciplinary-approach-to-calcific-uremic-arteriolopathy
#19
REVIEW
Sagar U Nigwekar
PURPOSE OF REVIEW: Calcific uremic arteriolopathy (CUA), as known as calciphylaxis, is a rare and poorly understood disease seen predominantly in end stage renal disease patients. A collaborative multidisciplinary approach to develop and implement treatment and prevention methods is described. RECENT FINDINGS: Overall, the scientific literature on CUA is largely restricted to case reports and case series. Recent reports indicate that the incidence of CUA may be on the rise and emphasize an association with vitamin K antagonist therapy, obesity, and diabetes mellitus...
November 2015: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/25960299/calciphylaxis-risk-factors-diagnosis-and-treatment
#20
REVIEW
Sagar U Nigwekar, Daniela Kroshinsky, Rosalynn M Nazarian, Jeremy Goverman, Rajeev Malhotra, Vicki Ann Jackson, Mihir M Kamdar, David J R Steele, Ravi I Thadhani
Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in patients with chronic kidney failure treated with dialysis (uremic calciphylaxis) but is also described in patients with earlier stages of chronic kidney disease and with normal kidney function. In this review, we discuss the available medical literature regarding risk factors, diagnosis, and treatment of both uremic and nonuremic calciphylaxis...
July 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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