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Toxic

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3 papers 25 to 100 followers
By Lucy Astudillo A young Md trying to get the major... Work Work Work
https://www.readbyqxmd.com/read/22556181/successful-treatment-of-patients-with-paraquat-intoxication-three-case-reports-and-review-of-the-literature
#1
REVIEW
Qin Zhang, Wei-zhen Wu, Yuan-qiang Lu, Jie-zan Wang, An-dong Shang, Feng Yao, Yan Chen
OBJECTIVE: To report on three patients with paraquat (PQ) intoxication surviving after combined therapy with hemoperfusion (HP), cyclophosphamide (CTX), and glucocorticoid. METHODS: Three patients suffered acute renal failure in a few days after ingesting a lethal amount of PQ. Chest computed tomography (CT) scans revealed obvious pulmonary inflammation, pleural effusion, and fibrous lesions several days after ingestion. HP was performed immediately, followed by large doses of glucocorticoid (methylprednisolone, 500 g/d) and CTX (approximately 4 g)...
May 2012: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/24349340/predictors-of-acute-respiratory-distress-syndrome-in-patients-with-paraquat-intoxication
#2
Cheng-Hao Weng, Ching-Chih Hu, Ja-Liang Lin, Dan-Tzu Lin-Tan, Ching-Wei Hsu, Tzung-Hai Yen
INTRODUCTION: Paraquat poisoning is characterized by acute lung injury, pulmonary fibrosis, respiratory failure, and multi-organ failure, resulting in a high rate of mortality and morbidity. The objectives of this study were to identify predictors of acute respiratory distress syndrome (ARDS) in cases of paraquat poisoning and determine the association between these parameters. MATERIALS AND METHODS: In total, 187 patients were referred for management of intentional paraquat ingestion between 2000 and 2010...
2013: PloS One
https://www.readbyqxmd.com/read/21615775/medical-management-of-paraquat-ingestion
#3
REVIEW
Indika B Gawarammana, Nicholas A Buckley
Poisoning by paraquat herbicide is a major medical problem in parts of Asia while sporadic cases occur elsewhere. The very high case fatality of paraquat is due to inherent toxicity and lack of effective treatments. We conducted a systematic search for human studies that report toxicokinetics, mechanisms, clinical features, prognosis and treatment. Paraquat is rapidly but incompletely absorbed and then largely eliminated unchanged in urine within 12-24 h. Clinical features are largely due to intracellular effects...
November 2011: British Journal of Clinical Pharmacology
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