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12 papers 25 to 100 followers
By Lucy Astudillo A young Md trying to get the major... Work Work Work
Irene Worthington, Tamara Pringsheim, Marek J Gawel, Jonathan Gladstone, Paul Cooper, Esma Dilli, Michel Aube, Elizabeth Leroux, Werner J Becker
OBJECTIVES: The primary objective of this guideline is to assist the practitioner in choosing an appropriate acute medication for an individual with migraine, based on current evidence in the medical literature and expert consensus. It is focused on patients with episodic migraine ( headache on ≤ 14 days a month). METHODS: A detailed search strategy was used to find a relevant meta-analyses, systematic reviews and randomized double-blind controlled trials. Recommendations were graded with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group, using a consensus group...
September 2013: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
S D Silberstein, D W Dodick, A S Lindblad, K Holroyd, M Harrington, N T Mathew, D Hirtz
OBJECTIVE: To assess the efficacy and safety of adding propranolol to topiramate in chronic migraine subjects inadequately controlled with topiramate alone. METHODS: This was a double-blind, placebo-controlled, randomized clinical trial conducted through the National Institute of Neurological Disorders and Stroke Clinical Research Collaboration, expected to randomize 250 chronic migraine subjects inadequately controlled (≥10 headaches/month) with topiramate (50-100 mg/day) to either propranolol LA (long acting) (240 mg/day) or placebo...
March 27, 2012: Neurology
Lawrence P Richer, Keri Laycock, Kelly Millar, Eleanor Fitzpatrick, Simi Khangura, Maala Bhatt, Chantal Guimont, Gina Neto, Steve Noseworthy, Ron Siemens, Serge Gouin, Brian H Rowe
OBJECTIVE: Children with migraine may present to an emergency department (ED) when outpatient management has failed; however, only limited research has examined migraine-abortive medications among children. METHODS: A retrospective chart review of ED presentations for migraine or headache between July 1, 2004, and June 30, 2005, in 10 Canadian pediatric EDs was conducted. A priori, evidence-based treatments were defined as any treatment that was based on high-quality evidence and an absence of opioids as first-line agents...
July 2010: Pediatrics
Shervin Farahmand, Said Shiralizadeh, Mohammad-Taghi Talebian, Shahram Bagheri-Hariri, Mona Arbab, Hamed Basirghafouri, Morteza Saeedi, Mojtaba Sedaghat, Habibolla Mirzababai
OBJECTIVE: Intravenous morphine has been used as a common method of pain control in emergency care. Nebulized fentanyl is also an effective temporary substitute. This study was designed to compare the effectiveness of nebulized fentanyl with intravenous (IV) morphine on management of acute limb pain. METHODS: This was a placebo-controlled, double-blind randomized clinical trial. Ninety emergency department patients with moderate to severe pain aged 15 to 50 years were blocked randomized and enrolled in this study...
September 2014: American Journal of Emergency Medicine
Alena Lira, Michael R Pinsky
No abstract text is available yet for this article.
May 19, 2014: Critical Care: the Official Journal of the Critical Care Forum
Perry M Elliott, Aris Anastasakis, Michael A Borger, Martin Borggrefe, Franco Cecchi, Philippe Charron, Albert Alain Hagege, Antoine Lafont, Giuseppe Limongelli, Heiko Mahrholdt, William J McKenna, Jens Mogensen, Petros Nihoyannopoulos, Stefano Nistri, Petronella G Pieper, Burkert Pieske, Claudio Rapezzi, Frans H Rutten, Christoph Tillmanns, Hugh Watkins
No abstract text is available yet for this article.
October 14, 2014: European Heart Journal
Yahya A Al-Abed, Nasser Alobaid, Fiona Myint
BACKGROUND: An adequate medical history combined with clinical examination is usually enough to make the diagnosis of acute appendicitis. The aim of this study was to determine the value of elevated white cell count (WCC), C-reactive protein (CRP), and bilirubin as diagnostic markers of acute appendicitis. METHODS: A retrospective analysis was carried out on consecutive patients who underwent appendicectomy over a 3-year period. All data including patients' age, sex, blood test results, and appendix histology were summarized...
June 2015: American Journal of Surgery
William J Anderson, Philip M Short, Peter A Williamson, Arvind Manoharan, Brian J Lipworth
The murine asthma model shows that switching off airway β2 receptors with an inverse agonist may confer anti-inflammatory effects as well as corticosteroid-sparing activity. We have assessed for any corticosteroid-sparing effects of propranolol, an inverse agonist, added to low-dose inhaled corticosteroid (ICS) compared with higher dose ICS. A randomized double-blind placebo-controlled cross-over trial in mild-to-moderate persistent asthmatic patients was performed. After a run-in (2 weeks) on hydrofluoroalkane-beclometasone dipropionate (HFA-BDP) at 100 μg/day (HFA-BDP100), patients received randomized treatments (4 weeks) with propranolol at 80 mg/day plus HFA-BDP at 100 μg/day compared with placebo plus HFA-BDP at 400 μg/day (HFA-BDP400)...
December 2014: Clinical Science (1979-)
Julie L Welch, Dylan D Cooper
No abstract text is available yet for this article.
June 2014: Annals of Emergency Medicine
Eldar Søreide, David Lockey
No abstract text is available yet for this article.
June 2014: Critical Care Medicine
Maria Richter, Christoph Schroeter, Theresa Puensch, Thomas Straube, Holger Hecht, Alexander Ritter, Wolfgang H R Miltner, Thomas Weiss
BACKGROUND: Negative affective and pain-related cues, such as pictures or words, have been shown to act as primes and enhance the perceived intensity of subsequent painful events. For pain-related semantic primes, it remains unclear whether this effect depends on negative valence itself or, specifically, on the pain-relatedness of the words. OBJECTIVES: To investigate the effect of pain-related, negative affective (pain-unrelated) and neutral semantic primes on the perception of subsequent noxious target stimuli...
March 2014: Pain Research & Management: the Journal of the Canadian Pain Society
J Adam Law, Natasha Broemling, Richard M Cooper, Pierre Drolet, Laura V Duggan, Donald E Griesdale, Orlando R Hung, Philip M Jones, George Kovacs, Simon Massey, Ian R Morris, Timothy Mullen, Michael F Murphy, Roanne Preston, Viren N Naik, Jeanette Scott, Shean Stacey, Timothy P Turkstra, David T Wong
BACKGROUND: Appropriate planning is crucial to avoid morbidity and mortality when difficulty is anticipated with airway management. Many guidelines developed by national societies have focused on management of difficulty encountered in the unconscious patient; however, little guidance appears in the literature on how best to approach the patient with an anticipated difficult airway. METHODS: To review this and other subjects, the Canadian Airway Focus Group (CAFG) was re-formed...
November 2013: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
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