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Blood transfusion stuff for an ICU doc

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12 papers 500 to 1000 followers
By Jason Mann No BS pulmonary critical care fellow
https://www.readbyqxmd.com/read/26836806/benefits-and-harms-of-red-blood-cell-transfusions-in-patients-with-septic-shock-in-the-intensive-care-unit
#1
REVIEW
Lars Broksø Holst
BACKGROUND: Transfusion of red blood cells (RBCs) is widely used for non-bleeding patients with septic shock in the intensive care unit (ICU). The evidence for effect and safety are limited showing conflicting results and transfused RBCs have the potential to harm subgroups of critically ill patients. Our aim was to assess the benefits and harms of RBC transfusion in patients with septic shock in a randomised clinical trial and to conduct an up-to-date systematic review with meta-analysis of all randomised clinical trials comparing different transfusion strategies...
February 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/25647203/transfusion-of-plasma-platelets-and-red-blood-cells-in-a-1-1-1-vs-a-1-1-2-ratio-and-mortality-in-patients-with-severe-trauma-the-proppr-randomized-clinical-trial
#2
RANDOMIZED CONTROLLED TRIAL
John B Holcomb, Barbara C Tilley, Sarah Baraniuk, Erin E Fox, Charles E Wade, Jeanette M Podbielski, Deborah J del Junco, Karen J Brasel, Eileen M Bulger, Rachael A Callcut, Mitchell Jay Cohen, Bryan A Cotton, Timothy C Fabian, Kenji Inaba, Jeffrey D Kerby, Peter Muskat, Terence O'Keeffe, Sandro Rizoli, Bryce R H Robinson, Thomas M Scalea, Martin A Schreiber, Deborah M Stein, Jordan A Weinberg, Jeannie L Callum, John R Hess, Nena Matijevic, Christopher N Miller, Jean-Francois Pittet, David B Hoyt, Gail D Pearson, Brian Leroux, Gerald van Belle
IMPORTANCE: Severely injured patients experiencing hemorrhagic shock often require massive transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red blood cells), defined as damage control resuscitation, has been associated with improved outcomes; however, there have been no large multicenter clinical trials. OBJECTIVE: To determine the effectiveness and safety of transfusing patients with severe trauma and major bleeding using plasma, platelets, and red blood cells in a 1:1:1 ratio compared with a 1:1:2 ratio...
February 3, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/9357904/extreme-hemodilution-due-to-massive-blood-loss-in-tumor-surgery
#3
A Zollinger, P Hager, T Singer, H P Friedl, T Pasch, D R Spahn
No abstract text is available yet for this article.
October 1997: Anesthesiology
https://www.readbyqxmd.com/read/25314239/transfusion-strategy-in-multiple-trauma-patients
#4
REVIEW
Oliver M Theusinger, Philipp Stein, Donat R Spahn
PURPOSE OF REVIEW: To point out the tolerance of anemia, the possible use of alternatives to allogeneic blood products as well as the pathophysiological effects of transfusions in the context of multiple trauma patients. RECENT FINDINGS: Restrictive transfusion triggers are beneficial for patient outcome in trauma.The actual European Trauma Treatment Guidelines suggest the use of point-of-care devices, the use of transfusion algorithms and factor concentrates to control coagulopathy...
December 2014: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/25270276/transfusion-threshold-of-7-g-per-deciliter-the-new-normal
#5
EDITORIAL
Paul C Hébert, Jeffrey L Carson
New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print.
October 9, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/24691607/health-care-associated-infection-after-red-blood-cell-transfusion-a-systematic-review-and-meta-analysis
#6
REVIEW
Jeffrey M Rohde, Derek E Dimcheff, Neil Blumberg, Sanjay Saint, Kenneth M Langa, Latoya Kuhn, Andrew Hickner, Mary A M Rogers
IMPORTANCE: The association between red blood cell (RBC) transfusion strategies and health care-associated infection is not fully understood. OBJECTIVE: To evaluate whether RBC transfusion thresholds are associated with the risk of infection and whether risk is independent of leukocyte reduction. DATA SOURCES: MEDLINE, EMBASE, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, Cochrane Database of Sytematic Reviews, ClinicalTrials...
April 2, 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/23939351/restrictive-versus-liberal-transfusion-strategies-for-older-mechanically-ventilated-critically-ill-patients-a-randomized-pilot-trial
#7
RANDOMIZED CONTROLLED TRIAL
Timothy S Walsh, Julia A Boyd, Douglas Watson, David Hope, Steff Lewis, Ashma Krishan, John F Forbes, Pamela Ramsay, Rupert Pearse, Charles Wallis, Christopher Cairns, Stephen Cole, Duncan Wyncoll
OBJECTIVES: To compare hemoglobin concentration (Hb), RBC use, and patient outcomes when restrictive or liberal blood transfusion strategies are used to treat anemic (Hb≤90 g/L) critically ill patients of age≥55 years requiring≥4 days of mechanical ventilation in ICU. DESIGN: Parallel-group randomized multicenter pilot trial. SETTING: Six ICUs in the United Kingdom participated between August 2009 and December 2010. PATIENTS: One hundred patients (51 restrictive and 49 liberal groups)...
October 2013: Critical Care Medicine
https://www.readbyqxmd.com/read/24066259/anemia-and-blood-transfusions-in-critically-ill-patients
#8
REVIEW
M Kamran Athar, Nitin Puri, David R Gerber
Anemia is common in critically ill patients. As a consequence packed red blood cell (PRBC) transfusions are frequent in the critically ill. Over the past two decades a growing body of literature has emerged, linking PRBC transfusion to infections, immunosuppression, organ dysfunction, and a higher mortality rate. However, despite growing evidence that risk of PRBC transfusion outweighs its benefit, significant numbers of critically ill patients still receive PRBC transfusion during their intensive care unit (ICU) stay...
2012: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/7916402/blood-transfusion-as-a-cause-of-leucocytosis-in-critically-ill-patients
#9
J C Fenwick, M Cameron, S C Naiman, L P Haley, J J Ronco, B R Wiggs, M G Tweeddale
The diagnosis of infection in the intensive care unit is confounded by the presence of non-infectious causes of leucocytosis. Unless such causes are recognised, time and effort will be spent on unnecessary investigations and treatments. In a prospective study we have shown that the transfusion of blood frequently (45/50 patients) causes an acute leucocytosis in such patients. This effect was not seen in 8 patients who received plasma. Blood transfusion should be added to the list of non-infectious causes of leucocytosis in the critically ill...
September 24, 1994: Lancet
https://www.readbyqxmd.com/read/24331453/impact-of-more-restrictive-blood-transfusion-strategies-on-clinical-outcomes-a-meta-analysis-and-systematic-review
#10
REVIEW
Shelley R Salpeter, Jacob S Buckley, Saurav Chatterjee
BACKGROUND: There is accumulating evidence that restricting blood transfusions improves outcomes, with newer trials showing greater benefit from more restrictive strategies. We systematically evaluated the impact of various transfusion triggers on clinical outcomes. METHODS: The MEDLINE database was searched from 1966 to April 2013 to find randomized trials evaluating a restrictive hemoglobin transfusion trigger of <7 g/dL, compared with a more liberal trigger...
February 2014: American Journal of Medicine
https://www.readbyqxmd.com/read/20804562/anemia-and-blood-transfusion-and-outcome-on-the-intensive-care-unit
#11
LETTER
Marcella C A Müller, Nicole P Juffermans
No abstract text is available yet for this article.
2010: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/21792054/reducing-noninfectious-risks-of-blood-transfusion
#12
REVIEW
Brian M Gilliss, Mark R Looney, Michael A Gropper
As screening for transfusion-associated infections has improved, noninfectious complications of transfusion now cause the majority of morbidity and mortality associated with transfusion in the United States. For example, transfusion-related acute lung injury, transfusion-associated circulatory overload, and hemolytic transfusion-reactions are the first, second, and third leading causes of death from transfusion, respectively. These complications and others are reviewed, and several controversial methods for prevention of noninfectious complications of transfusion are discussed, including universal leukoreduction of erythrocyte units, use of male-only plasma, and restriction of erythrocyte storage age...
September 2011: Anesthesiology
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