Chengbiao Zhang, Lijun Wang, Junhui Zhang, Xiao-Tong Su, Dao-Hong Lin, Ute I Scholl, Gerhard Giebisch, Richard P Lifton, Wen-Hui Wang
The renal phenotype induced by loss-of-function mutations of inwardly rectifying potassium channel (Kir), Kcnj10 (Kir4.1), includes salt wasting, hypomagnesemia, metabolic alkalosis and hypokalemia. However, the mechanism by which Kir.4.1 mutations cause the tubulopathy is not completely understood. Here we demonstrate that Kcnj10 is a main contributor to the basolateral K conductance in the early distal convoluted tubule (DCT1) and determines the expression of the apical Na-Cl cotransporter (NCC) in the DCT...
August 12, 2014: Proceedings of the National Academy of Sciences of the United States of America