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Copd and macrolides

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2 papers 500 to 1000 followers
By Jason Mann No BS pulmonary critical care fellow
https://www.readbyqxmd.com/read/24779680/predictors-of-chronic-obstructive-pulmonary-disease-exacerbation-reduction-in-response-to-daily-azithromycin-therapy
#1
RANDOMIZED CONTROLLED TRIAL
MeiLan K Han, Nabihah Tayob, Susan Murray, Mark T Dransfield, George Washko, Paul D Scanlon, Gerard J Criner, Richard Casaburi, John Connett, Stephen C Lazarus, Richard Albert, Prescott Woodruff, Fernando J Martinez
RATIONALE: Daily azithromycin decreases acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but long-term side effects are unknown. OBJECTIVES: To identify the types of exacerbations most likely to be reduced and clinical subgroups most likely to benefit from azithromycin, 250 mg daily, added to usual care. METHODS: Enrollment criteria included irreversible airflow limitation and AECOPD requiring corticosteroids, emergency department visit, or hospitalization in the prior year or use of supplemental oxygen...
June 15, 2014: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/24746000/azithromycin-maintenance-treatment-in-patients-with-frequent-exacerbations-of-chronic-obstructive-pulmonary-disease-columbus-a-randomised-double-blind-placebo-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
Sevim Uzun, Remco S Djamin, Jan A J W Kluytmans, Paul G H Mulder, Nils E van't Veer, Anton A M Ermens, Aline J Pelle, Henk C Hoogsteden, Joachim G J V Aerts, Menno M van der Eerden
BACKGROUND: Macrolide resistance is an increasing problem; there is therefore debate about when to implement maintenance treatment with macrolides in patients with chronic obstructive pulmonary disease (COPD). We aimed to investigate whether patients with COPD who had received treatment for three or more exacerbations in the previous year would have a decrease in exacerbation rate when maintenance treatment with azithromycin was added to standard care. METHODS: We did a randomised, double-blind, placebo-controlled, single-centre trial in The Netherlands between May 19, 2010, and June 18, 2013...
May 2014: Lancet Respiratory Medicine
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