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Transfusion and MI

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5 papers 100 to 500 followers
By Jason Mann No BS pulmonary critical care fellow
https://www.readbyqxmd.com/read/23708168/liberal-versus-restrictive-transfusion-thresholds-for-patients-with-symptomatic-coronary-artery-disease
#1
RANDOMIZED CONTROLLED TRIAL
Jeffrey L Carson, Maria Mori Brooks, J Dawn Abbott, Bernard Chaitman, Sheryl F Kelsey, Darrell J Triulzi, Vankeepuram Srinivas, Mark A Menegus, Oscar C Marroquin, Sunil V Rao, Helaine Noveck, Elizabeth Passano, Regina M Hardison, Thomas Smitherman, Tudor Vagaonescu, Neil J Wimmer, David O Williams
BACKGROUND: Prior trials suggest it is safe to defer transfusion at hemoglobin levels above 7 to 8 g/dL in most patients. Patients with acute coronary syndrome may benefit from higher hemoglobin levels. METHODS: We performed a pilot trial in 110 patients with acute coronary syndrome or stable angina undergoing cardiac catheterization and a hemoglobin <10 g/dL. Patients in the liberal transfusion strategy received one or more units of blood to raise the hemoglobin level ≥10 g/dL...
June 2013: American Heart Journal
https://www.readbyqxmd.com/read/24331453/impact-of-more-restrictive-blood-transfusion-strategies-on-clinical-outcomes-a-meta-analysis-and-systematic-review
#2
REVIEW
Shelley R Salpeter, Jacob S Buckley, Saurav Chatterjee
BACKGROUND: There is accumulating evidence that restricting blood transfusions improves outcomes, with newer trials showing greater benefit from more restrictive strategies. We systematically evaluated the impact of various transfusion triggers on clinical outcomes. METHODS: The MEDLINE database was searched from 1966 to April 2013 to find randomized trials evaluating a restrictive hemoglobin transfusion trigger of <7 g/dL, compared with a more liberal trigger...
February 2014: American Journal of Medicine
https://www.readbyqxmd.com/read/23266861/here-we-go-again-blood-transfusion-kills-patients-comment-on-association-of-blood-transfusion-with-increased-mortality-in-myocardial-infarction-a-meta-analysis-and-diversity-adjusted-study-sequential-analysis
#3
COMMENT
https://www.readbyqxmd.com/read/24570247/patterns-and-outcomes-of-red-blood-cell-transfusion-in-patients-undergoing-percutaneous-coronary-intervention
#4
Matthew W Sherwood, Yongfei Wang, Jeptha P Curtis, Eric D Peterson, Sunil V Rao
IMPORTANCE: Studies have shown variation in the use of red blood cell transfusion among patients with acute coronary syndromes. There are no definitive data for the efficacy of transfusion in improving outcomes, and concerning data exist about possible association with harm. Current transfusion practices in patients undergoing percutaneous coronary intervention (PCI) are not well understood. OBJECTIVE: To determine the current patterns of blood transfusion among patients undergoing PCI and the association of transfusion with adverse cardiac outcomes across hospitals in the United States...
February 26, 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/23266500/association-of-blood-transfusion-with-increased-mortality-in-myocardial-infarction-a-meta-analysis-and-diversity-adjusted-study-sequential-analysis
#5
Saurav Chatterjee, Jørn Wetterslev, Abhishek Sharma, Edgar Lichstein, Debabrata Mukherjee
BACKGROUND: The benefit of blood transfusion in patients with myocardial infarction is controversial, and a possibility of harm exists. METHODS: A systematic search of studies published between January 1, 1966, and March 31, 2012, was conducted using MEDLINE, EMBASE, CINAHL, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials databases. English-language studies comparing blood transfusion with no blood transfusion or a liberal vs restricted blood transfusion strategy were identified...
January 28, 2013: JAMA Internal Medicine
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