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63 papers 25 to 100 followers
Petra M A Lemmers, Manon J N L Benders, Rita D'Ascenzo, Jorine Zethof, Thomas Alderliesten, Karina J Kersbergen, Ivana Isgum, Linda S de Vries, Floris Groenendaal, Frank van Bel
BACKGROUND AND OBJECTIVES: A hemodynamically significant patent ductus arteriosus (PDA) can compromise perfusion and oxygenation of the preterm brain. Reports suggest that PDA is associated with increased mortality and morbidity. We hypothesize that long-standing low cerebral oxygenation due to PDA might affect brain volume at term equivalent age. METHODS: Observational study in 140 infants investigating the relationship between near-infrared spectroscopy-monitored cerebral oxygen saturation (rSco2) and MRI-assessed regional brain volume and maturation of the posterior limb of the internal capsule at term-equivalent age in 3 groups: those whose PDA closed with indomethacin, those who needed additional surgical closure, and matched controls...
April 2016: Pediatrics
Marcus P Haw
The ductus arteriosus is a fetal vascular connection between the pulmonary and systemic circulations. It fails to close after birth in a small number of term infants, and in a larger number of infants with cyanotic congenital heart disease. In contemporary practice the majority of patients present with a patent ductus arteriosus (PDA) are premature infants before the gestational age of 28 weeks. The surgical management of PDA in preterm infants is critical for optimal outcomes and is discussed in this article...
2016: Current Pediatric Reviews
Haşim Olgun, Naci Ceviz, İbrahim Kartal, İbrahim Caner, Mehmet Karacan, Ayhan Taştekin, Necip Becit
BACKGROUND: There are limited data about the results of repeated oral ibuprofen (OIBU) treatment. This study aimed to describe patent ductus arteriosus (PDA) closure rates and adverse events after repeated courses of OIBU in premature infants with PDA. METHODS: Preterm infants with hemodynamically significant (hs)PDA were enrolled in the study. If the first course of OIBU treatment failed, a second and, if required, third course was administered. RESULTS: A total of 100 patients received OIBU...
April 29, 2016: Pediatrics and Neonatology
Afif El-Khuffash, Dany E Weisz, Patrick J McNamara
Despite a large body of scientific evidence on the management of premature infants with a patent ductus arteriosus controversy remains and neonatologists remain challenged for knowing which patient to treat, what is the most optimal timing of treatment and which treatments have a positive impact on both short-term and long-term outcomes. In this review article we discuss the increased body of evidence over the past 10 years, much of which questions the role of treatment and suggests the need to reconsider how haemodynamic significance is adjudicated...
September 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
Kei Inomata, Shinji Taniguchi, Hiroki Yonemoto, Takeshi Inoue, Akihiko Kawase, Yuichi Kondo
BACKGROUND: Early postnatal hyperoxia is a major risk factor for retinopathy of prematurity (ROP) in extremely premature infants. To reduce the occurrence of ROP, we adopted an early postnatal lower oxygen saturation (SpO2 ) target range (85-92%) since April 2011. However a lower SpO2 target range may lead to hypoxemia and an increase in the risk of ductus arteriosus (DA) closure failure. OBJECTIVE: To determine whether a lower SpO2 target range, during the early postnatal stage, increases the risk of ductus arteriosus closure failure...
March 22, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Kalyan Chakravarthy Balla, Vinu John, Suman Rao Pn, Kiron Varghese
BACKGROUND: Patent ductus arteriosus (PDA) is a significant problem in preterm babies <34 weeks old. Echocardiogram (echo) is the gold standard for diagnosing PDA. Perfusion index (PI) using a pulse oximeter could aid in diagnosing a hemodynamically significant PDA (HsPDA). OBJECTIVE: To evaluate the accuracy of delta-PI (ΔPI; pre-ductal - post-ductal PI) in diagnosing HsPDA in preterm babies <34 weeks old. DESIGN: Prospective analytical cross-sectional (observational) study...
August 2016: Journal of Tropical Pediatrics
Souvik Mitra, Anthony K Chan, Bosco A Paes
OBJECTIVE: To conduct a meta-analysis of the association of platelet counts and pharmacotherapeutic failure in preterms with a patent ductus arteriosus (PDA). METHODS: MEDLINE, Embase, Science Citation Index, abstracts and conference proceedings were searched, and principal authors contacted. Included studies reported indomethacin or ibuprofen use for PDA closure, compared a group which failed treatment versus a group which did not and reported the association between platelet counts and indomethacin or ibuprofen failure...
April 14, 2016: Journal of Maternal-fetal & Neonatal Medicine
A Montaner Ramón, Z Galve Pradel, C Fernández Espuelas, L Jiménez Montañés, M P Samper Villagrasa, S Rite Gracia
INTRODUCTION: Patent ductus arteriosus (PDA) is a prevalent condition in preterm infants, and may be related to increased morbidity and mortality in the most immature newborns. Recent studies have examined the usefulness of brain natriuretic propeptide (proBNP) in the diagnosis of this pathology. The aim of the study was to evaluate the diagnostic efficacy of proBNP as a marker of hemodynamic overload in PDA. PAIENTS AND METHODS: A retrospective study was conducted on preterm infants less than 32 weeks of gestation and/or weight less than 1500 grams...
February 27, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Laura Vargas Dornelles, Andréa Lúcia Corso, Rita de Cássia Silveira, Renato Soibelmann Procianoy
OBJECTIVE: To compare the efficacy of intravenous ibuprofen at high (20-10-10mg/kg/dose) and low doses (10-5-5mg/kg/dose) the closure of patent ductus arteriosus in preterm newborns. METHODS: A cohort study with historical control of newborns that received high- and low-dose intravenous ibuprofen, from 2010 to 2013 in a neonatal intensive care unit, for closure of the patent ductus arteriosus, documented by echocardiography. Secondary outcomes included the number of ibuprofen cycles, incidence of bronchopulmonary dysplasia, necrotizing enterocolitis, changes in renal function, and death...
May 2016: Jornal de Pediatria
Sindhu Sivanandan, Ramesh Agarwal
Opinions are divided regarding the management of a persistently patent ductus arteriosus (PDA). Some of the adverse effects associated with a large hemodynamically significant duct, including prolonged ventilation, pulmonary hemorrhage, bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), and mortality, indicate that active management of infants with large ductal shunts may sometimes be necessary. Indomethacin and ibuprofen are the two US FDA-approved cyclooxygenase (COX) inhibitors used for the closure of a ductus in preterm babies...
April 2016: Paediatric Drugs
Pankaj Kumar Mohanty, N Karthik Nagesh, Abdul Razak
We prospectively studied the effect of oral paracetamol in closing hemodynamically significant Patent ductus arteriosus in preterm infants (gestational age <32 weeks) where Ibuprofen was contraindicated. 29 of 40 neonates (72.5%) showed successful response while 11 (29.5%) failed to show any response. No major complications were seen.
February 2016: Indian Pediatrics
Carl H Backes, Sharon L Cheatham, Grace M Deyo, Scott Leopold, Molly K Ball, Charles V Smith, Vidu Garg, Ralf J Holzer, John P Cheatham, Darren P Berman
BACKGROUND: Percutaneous closure of patent ductus arteriosus (PDA) in term neonates is established, but data regarding outcomes in infants born very preterm (<32 weeks of gestation) are minimal, and no published criteria exist establishing a minimal weight of 4 kg as a suitable cutoff. We sought to analyze outcomes of percutaneous PDA occlusion in infants born very preterm and referred for PDA closure at weights <4 kg. METHODS AND RESULTS: Retrospective analysis (January 2005-January 2014) was done at a single pediatric center...
February 2016: Journal of the American Heart Association
D Louis, R Torgalkar, J Shah, P S Shah, A Jain
OBJECTIVE: Enteral feeds are often discontinued or reduced during indomethacin treatment for patent ductus arteriosus (PDA) in preterm neonates, but the clinical impact of this practice is unknown. The objective of this study was to study the associations between enteral feed volume at the time of indomethacin therapy in preterm neonates with PDA and subsequent gastrointestinal outcomes. STUDY DESIGN: Retrospective cohort study. Single-center level III Neonatal Intensive Care Unit...
July 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Hannes Sallmon, Petra Koehne, Georg Hansmann
A patent ductus arteriosus (PDA) is associated with several adverse clinical conditions. Several strategies for PDA treatment exist, although data regarding the benefits of PDA treatment on outcomes are sparse. Moreover, the optimal treatment strategy for preterm neonates with PDA remains subject to debate. It is still unknown whether and when PDA treatment should be initiated and which approach (conservative, pharmacologic, or surgical) is best for individual patients (tailored therapies). This article reviews the current strategies for PDA treatment with a special focus on recent developments such as oral ibuprofen, high-dose regimens, and the use of paracetamol (oral, intravenous)...
March 2016: Clinics in Perinatology
A Avila-Alvarez, M Serantes Lourido, R Barriga Bujan, C Blanco Rodriguez, F Portela-Torron, V Bautista-Hernandez
INTRODUCTION: Surgical closure of patent ductus arteriosus in premature neonates is an aggressive technique and is not free of complications. A study was designed with the aim of describing our experience with a less invasive technique, the extra-pleural approach via a posterior minithoracotomy, and to compare the results with the classic transpleural approach. PATIENTS AND METHODS: A retrospective cohort study was conducted on premature neonates on whom surgical closure of the ductus was performed during a ten-year period (March 2005 to March 2015)...
January 27, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Laura Bourgoin, Cecile Cipierre, Quentin Hauet, Helene Basset, Veronique Gournay, Jean-Christophe Rozé, Cyril Flamant, Geraldine Gascoin
BACKGROUND: Patent ductus arteriosus (PDA) is a condition frequently found in very preterm infants, and its treatment remains a subject of debate. Furthermore, there are only a few studies available that have examined the impact of these treatments on the neurological outcome of the patient. OBJECTIVE: To evaluate the neurodevelopmental outcome of PDA treatment on preterm infants born between 24+0 and 28+6 weeks of gestation. METHODS: We conducted an observational multicentric cohort study (LIFT Cohort)...
2016: Neonatology
Shabnam Lainwala, Naveed Hussain
Background Cyclo-oxygenase inhibitors (COX-I) treatment of patent ductus arteriosus (PDA) in very low birth weight (VLBW) infants during the early postnatal period is well established, but their use beyond early postnatal period is not well studied. Objective The objective of this study was to determine the effectiveness of postnatal COX-I for PDA treatment beyond 2 weeks of age in VLBW infants. Study Design A retrospective cohort of VLBW infants admitted to two tertiary NICUs between 1990 and 2008 were studied...
May 2016: American Journal of Perinatology
William E Benitz
Despite a large body of basic science and clinical research and clinical experience with thousands of infants over nearly 6 decades,(1) there is still uncertainty and controversy about the significance, evaluation, and management of patent ductus arteriosus in preterm infants, resulting in substantial heterogeneity in clinical practice. The purpose of this clinical report is to summarize the evidence available to guide evaluation and treatment of preterm infants with prolonged ductal patency in the first few weeks after birth...
January 2016: Pediatrics
Hsiu-Lin Chen, Rei-Cheng Yang, Wei-Te Lee, Pei-Lun Lee, Jong-Hau Hsu, Jiunn-Ren Wu, Zen-Kong Dai
BACKGROUND: Persistent patent ductus arteriosus (PDA) during hospitalization is thought to be associated with adverse pulmonary outcomes in very preterm infants. This observational study aimed to compare the lung function in very preterm infants with and without PDA at discharge. METHODS: Very preterm infants, admitted to our neonatal intensive unit, who required respiratory support soon after birth and had undergone a lung function test at discharge, were enrolled...
2015: BMC Pediatrics
Jeff Reese, Matthew M Laughon
No abstract text is available yet for this article.
November 2015: Journal of Pediatrics
2015-09-05 06:54:06
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