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Preterm labor

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3 papers 500 to 1000 followers
Anna Galyean, Thomas J Garite, Kimberly Maurel, Diana Abril, Charles D Adair, Paul Browne, C Andrew Combs, Helen How, Brian K Iriye, Michelle Kominiarek, George Lu, David Luthy, Hugh Miller, Michael Nageotte, Tulin Ozcan, Manuel Porto, Mildred Ramirez, Shirley Sawai, Yoram Sorokin
OBJECTIVE: The decision of whether to retain or remove a previously placed cervical cerclage in women who subsequently rupture fetal membranes in a premature gestation is controversial and all studies to date are retrospective. We performed a multicenter randomized controlled trial of removal vs retention of cerclage in these patients to determine whether leaving the cerclage in place prolonged gestation and/or increased the risk of maternal or fetal infection. STUDY DESIGN: A prospective randomized multicenter trial of 27 hospitals was performed...
October 2014: American Journal of Obstetrics and Gynecology
Tonse N K Raju, Brian M Mercer, David J Burchfield, Gerald F Joseph
This is an executive summary of a workshop on the management and counseling issues of women anticipated to deliver at a periviable gestation (broadly defined as 20 0/7 through 25 6/7 weeks of gestation) and the treatment options for the newborn infant. Upon review of the available literature, the workshop panel noted that the rates of neonatal survival and neurodevelopmental disabilities among the survivors vary greatly across the periviable gestations and are significantly influenced by the obstetric and neonatal management practices (eg, antenatal steroid, tocolytic agents, and antibiotic administration; cesarean birth; and local protocols for perinatal care, neonatal resuscitation, and intensive care support)...
May 2014: American Journal of Obstetrics and Gynecology
Carolien Roos, Marc E A Spaanderman, Ewoud Schuit, Kitty W M Bloemenkamp, Antoinette C Bolte, Jérôme Cornette, Johannes J J Duvekot, Jim van Eyck, Maureen T M Franssen, Christianne J de Groot, Joke H Kok, Anneke Kwee, Ashley Merién, Bas Nij Bijvank, Brent C Opmeer, Martijn A Oudijk, Mariëlle G van Pampus, Dimitri N M Papatsonis, Martina M Porath, Hubertina C J Scheepers, Sicco A Scherjon, Krystyna M Sollie, Sylvia M C Vijgen, Christine Willekes, Ben Willem J Mol, Joris A M van der Post, Fred K Lotgering
IMPORTANCE: In threatened preterm labor, maintenance tocolysis with nifedipine, after an initial course of tocolysis and corticosteroids for 48 hours, may improve perinatal outcome. OBJECTIVE: To determine whether maintenance tocolysis with nifedipine will reduce adverse perinatal outcomes due to premature birth. DESIGN, SETTING, AND PARTICIPANTS: APOSTEL-II (Assessment of Perinatal Outcome with Sustained Tocolysis in Early Labor) is a double-blind, placebo-controlled trial performed in 11 perinatal units including all tertiary centers in The Netherlands...
January 2, 2013: JAMA: the Journal of the American Medical Association
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