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Gastroenterolgy

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2 papers 0 to 25 followers
By Jose M. Barria Castro MD from Panama
https://www.readbyqxmd.com/read/28082121/changes-in-the-luminal-environment-of-the-colonic-epithelial-cells-and-physiopathological-consequences
#1
REVIEW
François Blachier, Martin Beaumont, Mireille Andriamihaja, Anne-Marie Davila, Annaig Lan, Marta Grauso, Lucie Armand, Robert Benamouzig, Daniel Tomé
Evidence, mostly from experimental models, has accumulated, indicating that modifications of bacterial metabolite concentrations in the large intestine luminal content, notably after changes in the dietary composition, may have important beneficial or deleterious consequences for the colonic epithelial cell metabolism and physiology in terms of mitochondrial energy metabolism, reactive oxygen species production, gene expression, DNA integrity, proliferation, and viability. Recent data suggest that for some bacterial metabolites, like hydrogen sulfide and butyrate, the extent of their oxidation in colonocytes affects their capacity to modulate gene expression in these cells...
January 9, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/24818542/antiemetic-use-for-nausea-and-vomiting-in-adult-emergency-department-patients-randomized-controlled-trial-comparing-ondansetron-metoclopramide-and-placebo
#2
RANDOMIZED CONTROLLED TRIAL
Diana Egerton-Warburton, Robert Meek, Michaela J Mee, George Braitberg
STUDY OBJECTIVE: We compare efficacy of ondansetron and metoclopramide with placebo for adults with undifferentiated emergency department (ED) nausea and vomiting. METHODS: A prospective, randomized, double-blind, placebo-controlled trial was conducted in 2 metropolitan EDs in Melbourne, Australia. Eligible patients with ED nausea and vomiting were randomized to receive 4 mg intravenous ondansetron, 20 mg intravenous metoclopramide, or saline solution placebo. Primary outcome was mean change in visual analog scale (VAS) rating of nausea severity from enrollment to 30 minutes after study drug administration...
November 2014: Annals of Emergency Medicine
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