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Ovarian stimulation protocols

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30 papers 0 to 25 followers
Ningxin Qin, Qiuju Chen, Qingqing Hong, Renfei Cai, Hongyuan Gao, Yun Wang, Lihua Sun, Shaozhen Zhang, Haiyan Guo, Yonglun Fu, Ai Ai, Hui Tian, Qifeng Lyu, Salim Daya, Yanping Kuang
OBJECTIVE: To investigate flexibility in starting controlled ovarian stimulation at any phase of the menstrual cycle in infertile women undergoing treatment with assisted reproduction. DESIGN: Retrospective cohort study. SETTING: Academic tertiary-care medical center. PATIENT(S): At total of 150 infertile patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment. Ninety of the women also underwent frozen embryo transfer (FET) procedures...
August 2016: Fertility and Sterility
Li-Hong Wei, Wen-Hong Ma, Ni Tang, Ji-Hong Wei
OBJECTIVE: Poor ovarian response to ovarian hyperstimulation is one of the biggest challenges in assisted reproduction technology. Although many stimulation protocols have been established to improve clinical outcomes in poor ovarian responders (PORs), which protocol is the most effective remains controversial. Luteal-phase ovarian stimulation (LPOS) has been used in normal ovarian responders with satisfactory outcomes. However, the efficacy of LPOS in PORs is unclear. This study aimed to compare the efficacy of LPOS and GnRH antagonist (GnRH-ant) in PORs...
February 2016: Taiwanese Journal of Obstetrics & Gynecology
Antonio La Marca, Anna Pia Ferraretti, Roberto Palermo, Filippo M Ubaldi
Ovarian reserve markers have been documented to perform very well in the clinical practice. While this is widely recognized, still now there is no consensus on how to use new biomarkers in the clinical practice. This study was conducted among Italian IVF centres using the Delphi technique, a validated consensus-building process. Briefly three consecutive questionnaires were developed for clinicians in charge of IVF centres. In the first rounds, participants were asked to rate the importance of a list of statements regarding the categorization of ovarian response and the diagnostic role of biomarkers...
2016: Gynecological Endocrinology
Thi Ngoc Lan Vuong, Manh Tuong Ho, Tan Duc Ha, Huy Tuan Phung, Gia Bao Huynh, Peter Humaidan
OBJECTIVE: To determine the optimal GnRH agonist dose for triggering of oocyte maturation in oocyte donors. DESIGN: Single-center, randomized, parallel, investigator-blinded trial. SETTING: IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam. PATIENT(S): One hundred sixty-five oocyte donors (aged 18-35 years, body mass index [BMI] <28 kg/m(2), antimüllerian hormone level >1.25 ng/mL, and antral follicle count ≥6)...
February 2016: Fertility and Sterility
Julia K Bosdou, Efstratios M Kolibianakis, Christos A Venetis, Leonidas Zepiridis, Katerina Chatzimeletiou, Anastasios Makedos, Stylianos Triantafyllidis, Sevasti Masouridou, Anna Mitsoli, Basil Tarlatzis
The aim of this study was to evaluate whether prolongation of the time interval between HCG administration and oocyte retrieval, from 36 h to 38 h, affects oocyte retrieval rate in women undergoing ovarian stimulation with gonadotrophins and GnRH antagonists for IVF. One hundred and fifty-six normo-ovulatory women were randomized to have oocyte retrieval performed 36 h (n = 78) or 38 h (n = 78) following HCG administration. Oocyte retrieval rate was defined as number of cumulus-oocyte-complex (COC) retrieved/follicle ≥ 11 mm present on day of HCG administration...
November 2015: Reproductive Biomedicine Online
John J Zhang, Zaher Merhi, Mingxue Yang, Daniel Bodri, Alejandro Chavez-Badiola, Sjoerd Repping, Madelon van Wely
BACKGROUND: Minimal stimulation in vitro fertilization (mini-in vitro fertilization) is an alternative in vitro fertilization treatment protocol that may reduce ovarian hyperstimulation syndrome, multiple pregnancy rates, and cost while retaining high live birth rates. OBJECTIVE: We performed a randomized noninferiority controlled trial with a prespecified border of 10% that compared 1 cycle of mini-in vitro fertilization with single embryo transfer with 1 cycle of conventional in vitro fertilization with double embryo transfer...
January 2016: American Journal of Obstetrics and Gynecology
Anna Pia Ferraretti, Luca Gianaroli, Maria Cristina Magli, Paul Devroey
OBJECTIVE: To validate the use of clomiphene citrate in IVF when mild stimulation approaches are chosen to reduce patient discomfort, risk, and cost. DESIGN: Prospective cohort study. SETTING: Private IVF clinic. PATIENT(S): A total of 163 patients undergoing IVF and with a good prognosis (defined as ≤38 years old with normal ovarian reserve and normovulatory cycles, body mass index <29 kg/m(2), no previous assisted reproductive technology cycles, no severe endometriosis, no history of recurrent miscarriage, no endocrine/autoimmune diseases, and no surgical semen extraction)...
August 2015: Fertility and Sterility
Yanping Kuang, Qiuju Chen, Yonglun Fu, Yun Wang, Qingqing Hong, Qifeng Lyu, Ai Ai, Zeev Shoham
OBJECTIVE: To investigate the use of medroxyprogesterone acetate (MPA) to prevent LH surge during controlled ovarian hyperstimulation (COH) and to compare cycle characteristics and pregnancy outcomes in subsequently frozen-thawed ET (FET) cycles. DESIGN: A prospective controlled study. SETTING: Tertiary-care academic medical center. PATIENT(S): Three hundred patients undergoing IVF/intracytoplasmic sperm injection treatment...
July 2015: Fertility and Sterility
Human Mousavi Fatemi, Juan Garcia-Velasco
Ovarian hyperstimulation syndrome (OHSS) is one of the most serious, and potentially lethal, complications of controlled ovarian stimulation (COS). Induction of final oocyte maturation with a bolus of gonadotropin-releasing hormone (GnRH) agonist (GnRHa), instead of the criterion standard hCG, in patients undergoing ovarian stimulation significantly reduces the risk of OHSS and could be considered to be more physiologic. A bolus of GnRHa used in this context also acts as a luteolytic agent. From a clinical point of view, the most significant benefit of GnRHa trigger is its ability to induce quick and reversible luteolysis and thus reducing the risk of OHSS development...
April 2015: Fertility and Sterility
Stefano Palomba
Normogonadotropic anovulation, including polycystic ovary syndrome (PCOS), is one of the main causes of infertility. Recent meta-analysis and randomized controlled trial suggest the use of aromatase inhibitors (ie, letrozole) as effective drug and first-line treatment to restore fertility in these patients. The current manuscript will give a critical, provocative, and personal point of view on the topic.
May 2015: Journal of Clinical Endocrinology and Metabolism
Brooke Hodes-Wertz, David H McCulloh, Alan S Berkeley, Jamie A Grifo
OBJECTIVE: To compare the euploidy outcome in patients that underwent 2 ovarian stimulation cycles with trophectoderm biopsy. DESIGN: Retrospective repeated-measures cohort study. SETTING: University-based fertility center. PATIENT(S): A total of 116 patients, from 2011 through 2013, that underwent 2 ovarian stimulation cycles followed by trophectoderm biopsy with array comparative genomic hybridization. INTERVENTION(S): Days of stimulation, average diameter of the 2 lead follicles on day of trigger, dose of gonadotropins, type of cycle (gonadotropin-releasing hormone [GnRH] antagonist, GnRH-antagonist plus clomiphene citrate [CC], microdose GnRH agonist)...
April 2015: Fertility and Sterility
Robert F Casper
A single bolus of human chorionic gonadotropin (hCG) at midcycle has been the gold standard for triggering final oocyte maturation and ovulation in assisted reproductive technology cycles. More recently, gonadotropin-releasing hormone (GnRH)-agonist (GnRH-a) triggering has been introduced. The GnRH-a trigger may allow a more physiologic surge of both luteinizing hormone (LH) and follicle-stimulating hormone, although whether the combined surge will result in improved oocyte and embryo quality remains to be seen...
April 2015: Fertility and Sterility
Bo Hyon Yun, Seung Joo Chon, Joo Hyun Park, Seok Kyo Seo, SiHyun Cho, Young Sik Choi, Seok Hyun Kim, Byung Seok Lee
PURPOSE: To evaluate the efficacy of minimal stimulation using discretely administered gonadotropin combined with clomiphene citrate (CC) or letrozole (LTZ) for intrauterine insemination (IUI) cycles. MATERIALS AND METHODS: Total 257 IUI cycles from 158 infertile couples were assessed. A CC dose of 100 mg/day (n=126 cycles) or a LTZ dose of 5 mg/day (n=131 cycles) was administered on days 3-5 of the menstrual cycle for 5 days. Each group received human menopausal gonadotropin at a dose of 150 IU by two or three alternative day: CC combined with alternate-day regimen for 2 or 3 days (CC+300, n=37; CC+450, n=89) and LTZ combined with alternate-day regimen for 2 or 3 days (LTZ+300, n=36; LTZ+450, n=95)...
March 2015: Yonsei Medical Journal
Shannon M Bates
Assisted reproductive technology is widely used to treat couples affected by infertility. Complications associated with assisted reproduction include venous thromboembolism, ovarian hyperstimulation syndrome, and recurrent implantation failure. It has also been proposed that thrombophilia may be associated with an increased likelihood of these events. Although data are limited, antithrombotic therapy is frequently used to enhance the likelihood of successful assisted reproduction. This chapter reviews the risks of venous and arterial thromboembolism associated with assisted reproduction, as well as available data regarding the impact of thrombophilia on the risks of thromboembolism and failure of implantation...
December 5, 2014: Hematology—the Education Program of the American Society of Hematology
Veronique Viardot-Foucault, Sadhana Nadarajah, Weng Kit Lye, Heng Hao Tan
Scheduling gonadotrophin-releasing hormone antagonist (GnRH-ant) cycles for IVF intracytoplasmic sperm injection in patients is a challenge because of unpredictable ovum retrieval procedures on weekends, when less manpower is available. Recently, the use of GnRH-ant pre-treatment to delay an IVF and intracytoplasmic sperm injection (ICSI) cycle showed no negative effect on clinical pregnancy rates. An age-matched, case-control study was conducted to evaluate the effectiveness of such pre-treatment for scheduling purposes...
April 2015: Reproductive Biomedicine Online
Chisa Tabata, Toshihiro Fujiwara, Miki Sugawa, Momo Noma, Hiroki Onoue, Maki Kusumi, Noriko Watanabe, Takako Kurosawa, Osamu Tsutsumi
PURPOSE: To compare the embryo outcomes of in vitro fertilization/intra-cytoplasmic sperm injection with a gonadotropin-releasing hormone (GnRH) antagonist protocol with follicle stimulating hormone (FSH) and with human menopausal gonadotropin (hMG). METHODS: We performed a retrospective cohort study in 465 patients. Stimulation was started by daily FSH injection, and either FSH was continued (FSH alone group) or hMG was administrated (FSH-hMG group) after administration of a GnRH antagonist...
2015: Reproductive Medicine and Biology
Jianmei Yu, Yanping Ma, Ze Wu, Yonggang Li, Li Tang, Yunxiu Li, Bo Deng
PURPOSE: To assess which is the optimal protocol in terms of endometrial preparation prior to frozen-thawed embryo transfer (FET) in women with polycystic ovarian syndrome (PCOS) and to explore the effect in stimulated cycle with the addition of vaginal 17-β oestradiol. METHODS: Five hundred and seventy-six patients with PCOS were prepared for FET using artificial cycle induced with oestradiol and progesterone supplementation (n = 291) and stimulated cycle induced by human menopausal gonadotrophin (HMG) within or without the addition of vaginal 17-β oestradiol (n = 285)...
January 2015: Archives of Gynecology and Obstetrics
Paul Devroey, Mohamed Aboulghar, Juan Garcia-Velasco, Georg Griesinger, Peter Humaidan, Efstratios Kolibianakis, William Ledger, Candido Tomás, Bart C J M Fauser
Patients undergoing IVF/ICSI frequently experience substantial treatment burden, risk and psychological distress. These three related elements contribute to a negative patient experience that can lead to treatment discontinuation if pregnancy is not achieved. One approach to minimize these factors is the use of protocols designed to achieve high term, singleton birth rates per IVF treatment started, while improving the patient's welfare. Gonadotrophin-releasing hormone (GnRH) antagonists may be suitable for inclusion in such a protocol...
April 2009: Human Reproduction
Anat Hershko Klement, Arie Berkovitz, Amir Wiser, Ofer Gonen, Keren Amichay, Ilan Cohen, Yehudith Ghetler, Adrian Shulman
OBJECTIVE: Testing the ability to program IVF GnRH-antagonist cycles to avoid weekend oocyte retrieval. STUDY DESIGN: Preliminary randomized clinical trial. Patients presenting an indication for IVF or IVF-ICSI were assigned into either the Treatment Group - GnRH antagonist protocol, programmed to start stimulatory agents on a Friday, with oral 2mg estradiol valerate twice a day from the 2nd day of cycle until the first Friday to follow, or to the Control Group - long luteal GnRH agonist protocol...
February 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Chan Woo Park, Yu Im Hwang, Hwa Seon Koo, Inn Soo Kang, Kwang Moon Yang, In Ok Song
OBJECTIVE: To assess whether an early GnRH antagonist start leads to better follicular synchronization and an improved clinical pregnancy rate (CPR). METHODS: A retrospective cohort study. A total of 218 infertile women who underwent IVF between January 2011 and February 2013. The initial cohort (Cohort I) that underwent IVF between January 2011 and March 2012 included a total of 68 attempted IVF cycles. Thirty-four cycles were treated with the conventional GnRH antagonist protocol, and 34 cycles with an early GnRH antagonist start protocol...
December 2014: Clinical and Experimental Reproductive Medicine
2015-01-22 04:33:44
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