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Addiction treatment

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By Christopher Cook, BA,CADC, SAP Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's
https://www.readbyqxmd.com/read/29933901/clinical-management-of-gamma-hydroxybutyrate-ghb-withdrawal-delirium-with-ciwa-ar-protocol
#1
Po-Chiao Liao, Hu-Ming Chang, Lian-Yu Chen
Gamma-hydroxybutyrate (GHB) is a synthetic drug used mainly for recreational purpose. Although the prevalence of GHB abuse is low in Taiwan, GHB has become increasingly popular in certain subpopulations such as clubbers and men who have sex with men (MSM). GHB dependence could be associated with severe withdrawal syndrome including hallucinations and delirium. Despite systematic studies on detoxification and management of GHB withdrawal have been performed, no validated measurement for severity of GHB withdrawal syndrome is available...
June 19, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/30308378/effect-of-ghb-use-and-ghb-induced-comas-on-dorsolateral-prefrontal-cortex-functioning-in-humans
#2
Filipa Raposo Pereira, Minni T B McMaster, Nikki Polderman, Yvon D A T de Vries, Wim van den Brink, Guido A van Wingen
BACKGROUND: Gamma-hydroxybutyric acid (GHB) is a recreational drug associated with increasing numbers of GHB-dependent patients and emergency attendances often related to GHB-induced comas. Working memory (WM) deficits have been reported in association with GHB use, and animal studies have shown that GHB induces oxidative stress in vulnerable WM-related brain areas such as the dorsolateral prefrontal cortex (DLPFC). However, the effects of chronic GHB use and multiple GHB-induced comas on WM-related brain function in humans remains unknown...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/30426556/prohedonic-properties-of-gamma-hydroxybutyrate-are-associated-with-changes-in-limbic-resting-state-functional-connectivity
#3
Oliver G Bosch, Fabrizio Esposito, Dario Dornbierer, Robin von Rotz, Rainer Kraehenmann, Philipp Staempfli, Boris B Quednow, Erich Seifritz
OBJECTIVE: Gamma-hydroxybutyrate (GHB) is an endogenous GHB-/GABA-B receptor agonist and a narcolepsy treatment. However, GHB is also abused for its prohedonic effects. On a neuronal level, it was shown that GHB increases regional cerebral blood flow in limbic areas such as the right anterior insula (rAI) and the anterior cingulate cortex (ACC). We aimed to further explore the association between the subjective and neuronal signatures of GHB. METHOD: We assessed subjective effects and resting-state functional connectivity (rsFC) of an rAI- and an ACC-seed in 19 healthy male subjects after GHB (35 mg/kg p...
November 2018: Human Psychopharmacology
https://www.readbyqxmd.com/read/30513473/chemsex-behaviours-among-men-who-have-sex-with-men-a-systematic-review-of-the-literature
#4
Steven Maxwell, Maryam Shahmanesh, Mitzy Gafos
BACKGROUND: 'Chemsex' is the use of drugs before or during planned sexual events to facilitate, enhance, prolong and sustain the experience. Drugs associated with chemsex are methamphetamine, GHB/GBL, mephedrone, cocaine and ketamine. This review syntheses published research on the antecedents, behaviours and consequences associated with chemsex behaviours among men who have sex with men (MSM). METHODS: Papers from high income countries which were published between January 2000 and September 2018 reporting the use of chemsex drugs before or during sex were identified through Medline, Web of Science, CINAHL and Central...
December 1, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29722031/indirect-acting-strategy-of-opioid-action-instead-of-direct-receptor-activation-dual-acting-enkephalinase-inhibitors-denkis
#5
REVIEW
R B Raffa, J V Pergolizzi, R Taylor, M H Ossipov
WHAT IS KNOWN AND OBJECTIVE: Although pain is one of the most common afflictions, it is often inadequately managed because the available analgesic options are relatively limited due to insufficient efficacy, unacceptable adverse effects or the potential for misuse or abuse. However, recent publications suggest that an alternative approach-indirect enhancement of endogenous pain-relieving pathways-might be desirable. We review this approach, in particular the dual enkephalinase inhibitors (DENKIs)...
August 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27451854/auricular-acupuncture-for-substance-use-a-randomized-controlled-trial-of-effects-on-anxiety-sleep-drug-use-and-use-of-addiction-treatment-services
#6
RANDOMIZED CONTROLLED TRIAL
Rickard Ahlberg, Kurt Skårberg, Ole Brus, Lars Kjellin
BACKGROUND: A common alternative treatment for substance abuse is auricular acupuncture. The aim of the study was to evaluate the short and long-term effect of auricular acupuncture on anxiety, sleep, drug use and addiction treatment utilization in adults with substance abuse. METHOD: Of the patients included, 280 adults with substance abuse and psychiatric comorbidity, 80 were randomly assigned to auricular acupuncture according to the NADA protocol, 80 to auricular acupuncture according to a local protocol (LP), and 120 to relaxation (controls)...
July 25, 2016: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/29414848/nada-protocol-for-behavioral-health-putting-tools-in-the-hands-of-behavioral-health-providers-the-case-for-auricular-detoxification-specialists
#7
Elizabeth B Stuyt, Claudia A Voyles, Sara Bursac
Background: The National Acupuncture Detoxification Association (NADA) protocol, a simple standardized auricular treatment has the potential to provide vast public health relief on issues currently challenging our world. This includes but is not limited to addiction, such as the opioid epidemic, but also encompasses mental health, trauma, PTSD, chronic stress, and the symptoms associated with these conditions. Simple accessible tools that improve outcomes can make profound differences. We assert that the NADA protocol can have greatest impact when broadly applied by behavioral health professionals, Auricular Detoxification Specialists (ADSes)...
February 7, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/30462318/the-association-between-acupuncture-training-and-opioid-prescribing-practices
#8
Paul Crawford, Jeremy T Jackson, Christy J W Ledford
No abstract text is available yet for this article.
November 20, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/30403753/a-computational-strategy-for-finding-novel-targets-and-therapeutic-compounds-for-opioid-dependence
#9
Xiaojun Wu, Siwei Xie, Lirong Wang, Peihao Fan, Songwei Ge, Xiang-Qun Xie, Wei Wu
Opioids are widely used for treating different types of pains, but overuse and abuse of prescription opioids have led to opioid epidemic in the United States. Besides analgesic effects, chronic use of opioid can also cause tolerance, dependence, and even addiction. Effective treatment of opioid addiction remains a big challenge today. Studies on addictive effects of opioids focus on striatum, a main component in the brain responsible for drug dependence and addiction. Some transcription regulators have been associated with opioid addiction, but relationship between analgesic effects of opioids and dependence behaviors mediated by them at the molecular level has not been thoroughly investigated...
2018: PloS One
https://www.readbyqxmd.com/read/25050276/traditional-chinese-and-indian-medicine-in-the-treatment-of-opioid-dependence-a-review
#10
REVIEW
Fatemeh Doosti, Saeedeh Dashti, Seyed Meghdad Tabatabai, Hossein Hosseinzadeh
OBJECTIVE: In this study, the current literatures on the use of herbs and herbal preparations of Traditional Chinese and Indian Medicine for the treatment of opioid addiction were reviewed. Matherials and Methods: Search was done in databases such as Pub Med, Science Direct, Scopus, Springer Link, and Google Scholar. RESULTS: Among 18 retrieved studies, 3 studies were about asafetida extract, an approved preparation for ameliorating drug abstinence in China. Chinese preparations including Composite Dong Yuan Gao, Qingjunyin and TJ-97 (a water extract of dai-bofu-to) as well as Indian ones, Mentate and Shilajit, were reported to have positive effects against opioid withdrawal, dependence, and tolerance...
2013: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/24786196/effects-of-jitai-tablet-a-traditional-chinese-medicine-on-plasma-adrenocorticotropic-hormone-and-cortisol-levels-in-heroin-addicts-during-abstinence
#11
RANDOMIZED CONTROLLED TRIAL
Hua-ying Fan, Li Sun, Xiao-xiao Li, Shao-bo Zhou, Jun-cheng Liang, Ben-yong Yan, Yu Li, Yan-ping Deng
OBJECTIVES: To investigate the changes in adrenocorticotropic hormone (ACTH) and cortisol in heroin addicts given Jitai tablet treatment during abstinence. DESIGN: Double-blind, randomized, placebo-controlled clinical trial. SETTINGS/LOCATION: Drug Rehabilitation Bureau of Shanghai Police, China. PARTICIPANTS: 99 volunteers, including 69 heroin addicts and 30 healthy volunteers. INTERVENTIONS: 69 heroin addicts randomly divided into two groups: the Jitai tablet group, which comprised 34 heroin addicts given Jitai tablet treatment during abstinence, and the placebo group, which comprised 35 heroin addicts given placebo...
July 2014: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/30295400/preliminary-evidence-of-different-and-clinically-meaningful-opioid-withdrawal-phenotypes
#12
Kelly E Dunn, Elise M Weerts, Andrew S Huhn, Jennifer R Schroeder, David Andrew Tompkins, George E Bigelow, Eric C Strain
Opioid use disorder (OUD) is a public health crisis. Differences in opioid withdrawal severity that predict treatment outcome could facilitate the process of matching patients to treatments. This is a secondary analysis of a randomized controlled trial (RCT) that enrolled treatment seeking heroin-users (N = 89, males = 78) into a residential study. Participants maintained on morphine (30 mg, subcutaneous, four-times daily) underwent a naloxone (0.4 mg, IM = intramuscular) challenge session to precipitate withdrawal...
October 8, 2018: Addiction Biology
https://www.readbyqxmd.com/read/16430680/research-of-stimulants-and-anabolic-steroids-in-dietary-supplements
#13
N Baume, N Mahler, M Kamber, P Mangin, M Saugy
The purpose of this study was to analyze the composition of 103 dietary supplements bought on the internet. The supplements were dispatched in four different categories according to their announced contents [creatine, prohormones, "mental enhancers" and branched chain amino acids (BCAA)]. All the supplements were screened for the presence of stimulants and main anabolic steroids parent compounds. At the same time, the research was focused on the precursors and metabolites of testosterone and nandrolone...
February 2006: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/30221197/emerging-evidence-for-cannabis-role-in-opioid-use-disorder
#14
REVIEW
Beth Wiese, Adrianne R Wilson-Poe
Introduction: The opioid epidemic has become an immense problem in North America, and despite decades of research on the most effective means to treat opioid use disorder (OUD), overdose deaths are at an all-time high, and relapse remains pervasive. Discussion: Although there are a number of FDA-approved opioid replacement therapies and maintenance medications to help ease the severity of opioid withdrawal symptoms and aid in relapse prevention, these medications are not risk free nor are they successful for all patients...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/30238023/anti-stress-neuropharmacological-mechanisms-and-targets-for-addiction-treatment-a-translational-framework
#15
REVIEW
Mark K Greenwald
Stress-related substance use is a major challenge for treating substance use disorders. This selective review focuses on emerging pharmacotherapies with potential for reducing stress-potentiated seeking and consumption of nicotine, alcohol, marijuana, cocaine, and opioids (i.e., key phenotypes for the most commonly abused substances). I evaluate neuropharmacological mechanisms in experimental models of drug-maintenance and relapse, which translate more readily to individuals presenting for treatment (who have initiated and progressed)...
November 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/30240683/asking-how-our-patients-understand-addiction
#16
EDITORIAL
Helen E Jack, Devin Oller, John Kelly, Jessica F Magidson, Sarah E Wakeman
No abstract text is available yet for this article.
September 18, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/30240785/geranylgeranylacetone-blocks-the-reinstatement-of-morphine-conditioned-place-preference
#17
Ningning Guo, Xianwen Zhang, Mengbing Huang, Xiang Li, Ye Li, Xiaoshuang Zhou, Jie Bai
Morphine is widely used for clinical pain management and induces the dependence. Addiction to morphine is a major public health issue. Geranylgeranylacetone (GGA) is widely used in clinic for treating ulcer. GGA induces expression of thioredoxin-1 (Trx-1) extensively. Trx-1 is a redox regulating protein and plays protecting roles in nervous system. GGA prevents mice against morphine-induced hyperlocomotion, rewarding effect, and withdrawal syndrome. However, whether GGA blocks morphine-conditioned place preference (CPP) reinstatement is still unknown...
December 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29730987/stigma-associated-with-medication-treatment-for-young-adults-with-opioid-use-disorder-a-case-series
#18
Scott E Hadland, Tae Woo Park, Sarah M Bagley
BACKGROUND: Opioid-related overdose deaths have risen sharply among young adults. Despite this increase, access to evidence-based medication for opioid agonist treatment (OAT) for youth remains low. Among older adults, barriers to OAT include the paucity of buprenorphine-waivered prescribers and low rates of prescribing among waivered physicians. We have increasingly found in our clinical practice significant stigma related to using OAT to treat addiction for young adults. In this series, we describe three cases of young adults who faced significant stigma related to their treatment...
May 7, 2018: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/30078375/emergency-department-screening-and-interventions-for-substance-use-disorders
#19
REVIEW
Kathryn Hawk, Gail D'Onofrio
The emergency department (ED) has long been recognized as providing critical access to the health care system for many, yet only in the past few decades has the ED visit been recognized as an opportunity to identify and link patients to care for substance use disorders (SUDs). This review explores the evidence for ED-based screening, psychosocial and pharmacological interventions, and linkage to treatment for the spectrum of SUDs including high risk alcohol use and alcohol, opioid, tobacco and other SUDs. Despite knowledge gaps, methodological challenges and some inconsistency across interventions studied, opportunities for EDs to improve the care of patients across the spectrum of SUDs are robust...
August 6, 2018: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/30207010/double-standards-and-gold-standards-in-the-evaluation-of-how-a-person-feels-and-functions-in-substance-use-disorder-pharmacotherapy-trials
#20
Katie Witkiewitz
No abstract text is available yet for this article.
September 11, 2018: Addiction
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