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Addiction treatment

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By Christopher Cook, BA,CADC, SAP Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's
https://www.readbyqxmd.com/read/28742932/a-pilot-randomized-clinical-trial-testing-integrated-12-step-facilitation-itsf-treatment-for-adolescent-substance-use-disorder
#1
John F Kelly, Yifrah Kaminer, Christopher W Kahler, Bettina Hoeppner, Julie Yeterian, Julie V Cristello, Christine Timko
BACKGROUND AND AIMS: The integration of 12-Step philosophy and practices is common in adolescent substance use disorder (SUD) treatment programs, particularly in North America. However, although numerous experimental studies have tested 12-Step facilitation (TSF) treatments among adults, no studies have tested TSF-specific treatments for adolescents. We tested the efficacy of a novel integrated TSF. DESIGN: Explanatory, parallel-group, randomized clinical trial comparing 10 sessions of either motivational enhancement therapy/cognitive-behavioral therapy (MET/CBT; n = 30) or a novel integrated TSF (iTSF; n = 29), with follow-up assessments at 3, 6 and 9 months following treatment entry...
December 2017: Addiction
https://www.readbyqxmd.com/read/29105925/precision-medicine-in-addiction-research-where-has-the-time-gone
#2
Jason A Oliver, F Joseph McClernon
No abstract text is available yet for this article.
December 2017: Addiction
https://www.readbyqxmd.com/read/29143400/pharmacokinetics-of-concentrated-naloxone-nasal-spray-for-opioid-overdose-reversal-phase-i-healthy-volunteer-study
#3
Rebecca McDonald, Ulrike Lorch, Jo Woodward, Björn Bosse, Helen Dooner, Gill Mundin, Kevin Smith, John Strang
BACKGROUND AND AIMS: Take-home naloxone can prevent death from heroin/opioid overdose, but pre-provision is difficult because naloxone is usually given by injection. Non-injectable alternatives, including naloxone nasal sprays, are currently being developed. To be effective, the intranasal (i.n.) spray dose must be adequate but not excessive, and early absorption must be comparable to intramuscular (i.m.) injection. We report on the pharmacokinetics (PK) of a specially produced concentrated novel nasal spray...
March 2018: Addiction
https://www.readbyqxmd.com/read/29152812/focus-on-cryptomarkets-and-online-reviews-too-narrow-to-debate-harms-of-drugs-bought-online
#4
Daan van der Gouwe, Sander Rigter, Tibor Markus Brunt
No abstract text is available yet for this article.
November 19, 2017: Addiction
https://www.readbyqxmd.com/read/29314336/first-do-no-harm-developing-interventions-that-combat-addiction-without-increasing-inequalities
#5
EDITORIAL
Clare Bambra
No abstract text is available yet for this article.
January 4, 2018: Addiction
https://www.readbyqxmd.com/read/29333634/euthanasia-and-the-nature-of-suffering-in-addiction
#6
Richard E Ashcroft
No abstract text is available yet for this article.
January 14, 2018: Addiction
https://www.readbyqxmd.com/read/29396985/extended-release-injectable-naltrexone-for-opioid-use-disorder-a-systematic-review
#7
REVIEW
Brantley P Jarvis, August F Holtyn, Shrinidhi Subramaniam, D Andrew Tompkins, Emmanuel A Oga, George E Bigelow, Kenneth Silverman
AIMS: To review systematically the published literature on extended-release naltrexone (XR-NTX, Vivitrol®), marketed as a once-per-month injection product to treat opioid use disorder. We addressed the following questions: (1) How successful is induction on XR-NTX?; (2) What are adherence rates to XR-NTX?; and (3) Does XR-NTX decrease opioid use? Factors associated with these outcomes as well as overdose rates were examined. METHODS: We searched PubMed and used Google Scholar for forward citation searches of peer-reviewed articles from January 2006 to June 2017...
February 3, 2018: Addiction
https://www.readbyqxmd.com/read/29436042/fulfilling-the-promise-of-choice-architecture-interventions-for-addictive-behaviors
#8
EDITORIAL
Jalie A Tucker
No abstract text is available yet for this article.
February 12, 2018: Addiction
https://www.readbyqxmd.com/read/9610980/nalmefene-a-long-acting-opioid-antagonist-clinical-applications-in-emergency-medicine
#9
REVIEW
D S Wang, G Sternbach, J Varon
The use of the opioid antagonist naloxone is well known to the experienced health care provider. The availability of the longer acting opioid antagonist nalmefene has several potential benefits in clinical practice. Nalmefene has a plasma half-life of almost 11 h, compared to 60-90 min for naloxone. Nalmefene has been shown to reverse opioid intoxication for as long as 8 h, reducing the need for continuous monitoring of intoxicated patients and repeated dosing of naloxone. Single dose administration has also been used effectively in the reversal of opiate-assisted conscious sedation...
May 1998: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29330156/application-of-receptor-theory-to-the-design-and-use-of-fixed-proportion-mu-opioid-agonist-and-antagonist-mixtures-in-rhesus-monkeys
#10
Jeremy C Cornelissen, Samuel Obeng, Kenner C Rice, Yan Zhang, S Stevens Negus, Matthew Banks
Receptor theory predicts that fixed-proportion mixtures of a competitive, reversible agonist (e.g. fentanyl) and antagonist (e.g. naltrexone) at a common receptor (e.g. mu opioid receptors; MOR) will result in antagonist proportion-dependent decreases in apparent efficacy of the mixtures and downward shifts in mixture dose-effect functions. The present study tested this hypothesis by evaluating behavioral effects of fixed-proportion fentanyl/naltrexone mixtures in a warm-water tail-withdrawal procedure in rhesus monkeys (n=4)...
January 12, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29378623/patient-perspectives-of-transitioning-from-prescription-opioids-to-heroin-and-the-role-of-route-of-administration
#11
Laura B Monico, Shannon Gwin Mitchell
BACKGROUND: As the availability of prescription opioids decreases and the availability of heroin increases, some prescription opioid users are transitioning to heroin. This study seeks to explore factors associated with respondents' transition from prescription opioid use to heroin. METHODS: In-depth, semi-structured qualitative interviews (n = 20) were conducted with buprenorphine patients in an opioid treatment program. Respondents were predominantly White (n = 13) and male (n = 13), with a range of treatment tenure (4 days to 2 years)...
January 29, 2018: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/29021832/pharmacogenomics-in-the-treatment-of-mood-disorders-strategies-and-opportunities-for-personalized-psychiatry
#12
REVIEW
Azmeraw T Amare, Klaus Oliver Schubert, Bernhard T Baune
Personalized medicine (personalized psychiatry in a specific setting) is a new model towards individualized care, in which knowledge from genomics and other omic pillars (microbiome, epigenomes, proteome, and metabolome) will be combined with clinical data to guide efforts to new drug development and targeted prescription of the existing treatment options. In this review, we summarize pharmacogenomic studies in mood disorders that may lay the foundation towards personalized psychiatry. In addition, we have discussed the possible strategies to integrate data from omic pillars as a future path to personalized psychiatry...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/29225566/cdk5-is-essential-for-amphetamine-to-increase-dendritic-spine-density-in-hippocampal-pyramidal-neurons
#13
Soledad Ferreras, Guillermo Fernández, Víctor Danelon, María V Pisano, Luján Masseroni, Christopher A Chapleau, Favio A Krapacher, Estela C Mlewski, Daniel H Mascó, Carlos Arias, Lucas Pozzo-Miller, María G Paglini
Psychostimulant drugs of abuse increase dendritic spine density in reward centers of the brain. However, little is known about their effects in the hippocampus, where activity-dependent changes in the density of dendritic spine are associated with learning and memory. Recent reports suggest that Cdk5 plays an important role in drug addiction, but its role in psychostimulant's effects on dendritic spines in hippocampus remain unknown. We used in vivo and in vitro approaches to demonstrate that amphetamine increases dendritic spine density in pyramidal neurons of the hippocampus...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29244621/on-mourning-and-recovery-integrating-stages-of-grief-and-change-toward-a-neuroscience-based-model-of-attachment-adaptation-in-addiction-treatment
#14
R Andrew Chambers, Sue C Wallingford
Interpersonal attachment and drug addiction share many attributes across their behavioral and neurobiological domains. Understanding the overlapping brain circuitry of attachment formation and addiction illuminates a deeper understanding of the pathogenesis of trauma-related mental illnesses and comorbid substance use disorders, and the extent to which ending an addiction is complicated by being a sort of mourning process. Attention to the process of addiction recovery-as a form of grieving-in which Kubler-Ross's stages of grief and Prochaska's stages of change are ultimately describing complementary viewpoints on a general process of neural network and attachment remodeling, could lead to more effective and integrative psychotherapy and medication strategies...
2017: Psychodynamic Psychiatry
https://www.readbyqxmd.com/read/6442439/beta-phenylethylamine-and-reinforcement
#15
COMPARATIVE STUDY
A J Greenshaw
beta-Phenylethylamine is an endogenous brain amine which has been characterised as an endogenous amphetamine. The rewarding properties of the structurally similar drug amphetamine in humans and other species indicate a possible role for endogenous beta-phenylethylamine in neural processes underlying reward or reinforcement. Evidence for reinforcing properties of beta-phenylethylamine in the drug self-administration and place preference paradigms is briefly reviewed. The possibility that endogenous beta-phenylethylamine may be involved in reinforcement processes is also considered in relation to studies of intracranial self-stimulation...
1984: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/23459152/transcranial-electrical-stimulation-accelerates-human-sleep-homeostasis
#16
Davide Reato, Fernando Gasca, Abhishek Datta, Marom Bikson, Lisa Marshall, Lucas C Parra
The sleeping brain exhibits characteristic slow-wave activity which decays over the course of the night. This decay is thought to result from homeostatic synaptic downscaling. Transcranial electrical stimulation can entrain slow-wave oscillations (SWO) in the human electro-encephalogram (EEG). A computational model of the underlying mechanism predicts that firing rates are predominantly increased during stimulation. Assuming that synaptic homeostasis is driven by average firing rates, we expected an acceleration of synaptic downscaling during stimulation, which is compensated by a reduced drive after stimulation...
2013: PLoS Computational Biology
https://www.readbyqxmd.com/read/29162499/metabolic-strategies-for-the-degradation-of-the-neuromodulator-agmatine-in-mammals
#17
REVIEW
José Benítez, David García, Nicol Romero, Arlette González, José Martinez, Maximiliano Figueroa, Mónica Salas, Vasthi López, Peter R Dodd, Gerhard Schenk, Nelson Carvajal, Elena Uribe
Agmatine (1-amino-4-guanidinobutane), a precursor for polyamine biosynthesis, has been identified as an important neuromodulator with anticonvulsant, antineurotoxic and antidepressant actions in the brain. In this context it has emerged as an important mediator of addiction/satiety pathways associated with alcohol misuse. Consequently, the regulation of the activity of key enzymes in agmatine metabolism is an attractive strategy to combat alcoholism and related addiction disorders. Agmatine results from the decarboxylation of L-arginine in a reaction catalyzed by arginine decarboxylase (ADC), and can be converted to either guanidine butyraldehyde by diamine oxidase (DAO) or putrescine and urea by the enzyme agmatinase (AGM) or the more recently identified AGM-like protein (ALP)...
November 18, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29077662/kratom-an-emerging-drug-of-abuse-a-case-report-of-overdose-and-management-of-withdrawal
#18
Jack Diep, David Tian Chin, Somdatta Gupta, Faraz Syed, Ming Xiong, Jianguo Cheng
Kratom is an herb indigenous to Southeast Asia with psychoactive opioid compounds, often used as a treatment for chronic pain or opiate withdrawal symptoms. It is legally and readily available via Internet sales and has been identified as an emerging drug of abuse in the United States. Kratom use has been associated with psychosis, seizures, and even death. At lower doses, kratom acts as a stimulant, while at higher doses, it produces analgesia and euphoria. Here, we describe the successful management of kratom overdose and withdrawal in a young man with negative toxicology screens...
October 26, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/24676047/systematic-review-of-n-acetylcysteine-in-the-treatment-of-addictions
#19
REVIEW
Elson Asevedo, Ana C Mendes, Michael Berk, Elisa Brietzke
OBJECTIVE: To conduct the first systematic literature review of clinical trials of N-acetylcysteine (NAC) for the treatment of substance abuse disorders and addictive behaviors. METHODS: A search of the MEDLINE, Embase and PsycINFO databases was conducted. The inclusion criteria for the review were clinical trials that used NAC in the treatment of a disorder related to substance use and/or addictive behaviors, limited to texts in English, Spanish, or French. The selected studies were evaluated with respect to type of trial, sample size, diagnostic input, intervention, length of follow-up, outcome variables, and results...
April 2014: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28940989/amino-acid-modulation-of-dopamine-in-the-nucleus-accumbens-mediates-sex-differences-in-nicotine-withdrawal
#20
Luis M Carcoba, Rodolfo J Flores, Luis A Natividad, Laura E O'Dell
The aversive effect of nicotine withdrawal is greater in female versus male rats, and we postulate that this sex difference is mediated in the nucleus accumbens (NAc). Nicotine withdrawal induces decreases in NAc dopamine and increases in acetylcholine (ACh) levels in male rats. To our knowledge, these neurochemical markers of nicotine withdrawal have not been compared in female versus male rats. Given the role of amino acids in modulating NAc dopaminergic and cholinergic transmission, concomitant measures of gamma-aminobutyric acid (GABA) and glutamate levels were also compared across sex...
September 22, 2017: Addiction Biology
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