collection
MENU ▼
Read by QxMD icon Read
search

Neurotransmitters and related Papers: medical and naturopahic

shared collection
11 papers 1000+ followers
By Christopher Cook, BA,CADC, SAP Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's
https://www.readbyqxmd.com/read/6442439/beta-phenylethylamine-and-reinforcement
#1
COMPARATIVE STUDY
A J Greenshaw
beta-Phenylethylamine is an endogenous brain amine which has been characterised as an endogenous amphetamine. The rewarding properties of the structurally similar drug amphetamine in humans and other species indicate a possible role for endogenous beta-phenylethylamine in neural processes underlying reward or reinforcement. Evidence for reinforcing properties of beta-phenylethylamine in the drug self-administration and place preference paradigms is briefly reviewed. The possibility that endogenous beta-phenylethylamine may be involved in reinforcement processes is also considered in relation to studies of intracranial self-stimulation...
1984: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/15447669/dopamine-transporter-dependent-and-independent-actions-of-trace-amine-beta-phenylethylamine
#2
Tatyana D Sotnikova, Evgeny A Budygin, Sara R Jones, Linda A Dykstra, Marc G Caron, Raul R Gainetdinov
Beta-phenylethylamine (beta-PEA) is an endogenous amine that is found in trace amounts in the brain. It is believed that the locomotor-stimulating action of beta-PEA, much like amphetamine, depends on its ability to increase extracellular dopamine (DA) concentrations owing to reversal of the direction of dopamine transporter (DAT)-mediated DA transport. beta-PEA can also bind directly to the recently identified G protein-coupled receptors, but the physiological significance of this interaction is unclear. To assess the mechanism by which beta-PEA mediates its effects, we compared the neurochemical and behavioral effects of this amine in wild type (WT), heterozygous and 'null' DAT mutant mice...
October 2004: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29096071/molecular-neuroscience-in-the-21st-century-a-personal-perspective
#3
REVIEW
Thomas C Südhof
Neuroscience is inherently interdisciplinary in its quest to explain the brain. Like all biological structures, the brain operates at multiple levels, from nano-scale molecules to meter-scale systems. Here, I argue that understanding the nano-scale organization of the brain is not only helpful for insight into its function, but is a requisite for such insight. I propose that one impediment to a better understanding of the brain is that most of its molecular processes are incompletely understood, and suggest a number of key questions that require our attention so that progress can be achieved in neuroscience beyond a description of the activity of neural circuits...
November 1, 2017: Neuron
https://www.readbyqxmd.com/read/10785653/is-agmatine-a-novel-neurotransmitter-in-brain
#4
REVIEW
D J Reis, S Regunathan
Recent evidence suggests that agmatine, which is an intermediate in polyamine biosynthesis, might be an important neurotransmitter in mammals. Agmatine is synthesized in the brain, stored in synaptic vesicles in regionally selective neurons, accumulated by uptake, released by depolarization, and inactivated by agmatinase. Agmatine binds to alpha2-adrenoceptors and imidazoline binding sites, and blocks NMDA receptor channels and other ligand-gated cationic channels. Furthermore, agmatine inhibits nitric oxide synthase, and induces the release of some peptide hormones...
May 2000: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/21893093/the-pharmacological-importance-of-agmatine-in-the-brain
#5
REVIEW
Tayfun I Uzbay
Agmatine is a polyamine that is produced via decarboxylation of l-arginine by the enzyme arginine decarboxylase. It binds to various receptors and has been accepted as a novel neurotransmitter in brain. In experimental studies, agmatine exhibited anticonvulsant, antinociceptive, anxiolytic and antidepressant-like actions. Furthermore, it has some beneficial effects on cerebral ischemia models in animals. Agmatine interacts with the mechanisms of withdrawal syndromes for several addictive agents. It also modulates some processes involved in learning and memory...
January 2012: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/15764732/primate-trace-amine-receptor-1-modulation-by-the-dopamine-transporter
#6
Gregory M Miller, Christopher D Verrico, Amy Jassen, Martha Konar, Hong Yang, Helen Panas, Mary Bahn, Ryan Johnson, Bertha K Madras
Recently identified trace amine receptors are potential direct targets for drugs of abuse, including amphetamine and 3,4-methylenedioxymethamphetamine (MDMA). We cloned full-length rhesus monkey trace amine receptor 1 (rhTA(1)) that was 96% homologous to human TA(1). The trace amines tyramine and beta-phenylethylamine (PEA) and the monoamine transporter substrates (+/-)-amphetamine and (+/-)-MDMA stimulated cAMP accumulation in rhTA(1)-expressing cell lines, as measured by a cAMP response element-luciferase assay...
June 2005: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/22397264/the-use-of-a-food-supplementation-with-d-phenylalanine-l-glutamine-and-l-5-hydroxytriptophan-in-the-alleviation-of-alcohol-withdrawal-symptoms
#7
RANDOMIZED CONTROLLED TRIAL
Tomislav Jukić, Bojan Rojc, Darja Boben-Bardutzky, Mateja Hafner, Alojz Ihan
We described the use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytriptophan in the alleviation of alcohol withdrawal symptoms in patients starting a detoxification therapy. Since abstinence from ethanol causes a hypodopaminergic and a hypoopioidergic environment in the reword system circuits, manifesting with withdrawal symptoms, food supplements that contains D-phenylalanine a peptidase inhibitor (of opioide inactivation) and L-amino-acids (for dopamine synthesis) were used to replenish a lack in neurotransmitters and alleviate the symptoms of alcohol withdrawal...
December 2011: Collegium Antropologicum
https://www.readbyqxmd.com/read/25199705/bidirectional-modulation-of-incubation-of-cocaine-craving-by-silent-synapse-based-remodeling-of-prefrontal-cortex-to-accumbens-projections
#8
Yao-Ying Ma, Brian R Lee, Xiusong Wang, Changyong Guo, Lei Liu, Ranji Cui, Yan Lan, Judith J Balcita-Pedicino, Marina E Wolf, Susan R Sesack, Yavin Shaham, Oliver M Schlüter, Yanhua H Huang, Yan Dong
Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens (NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of the two major mPFC-to-NAc projections differentially regulated the progressive increase in cue-induced cocaine seeking after withdrawal (incubation of cocaine craving). Specifically, cocaine self-administration in rats generated AMPA receptor-silent glutamatergic synapses within both infralimbic (IL) and prelimbic mPFC (PrL) to NAc projections, measured after 1 day of withdrawal...
September 17, 2014: Neuron
https://www.readbyqxmd.com/read/25471559/met-receptor-tyrosine-kinase-controls-dendritic-complexity-spine-morphogenesis-and-glutamatergic-synapse-maturation-in-the-hippocampus
#9
Shenfeng Qiu, Zhongming Lu, Pat Levitt
The MET receptor tyrosine kinase (RTK), implicated in risk for autism spectrum disorder (ASD) and in functional and structural circuit integrity in humans, is a temporally and spatially regulated receptor enriched in dorsal pallial-derived structures during mouse forebrain development. Here we report that loss or gain of function of MET in vitro or in vivo leads to changes, opposite in nature, in dendritic complexity, spine morphogenesis, and the timing of glutamatergic synapse maturation onto hippocampus CA1 neurons...
December 3, 2014: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/22969831/complementary-medicine-exercise-meditation-diet-and-lifestyle-modification-for-anxiety-disorders-a-review-of-current-evidence
#10
J Sarris, S Moylan, D A Camfield, M P Pase, D Mischoulon, M Berk, F N Jacka, I Schweitzer
Use of complementary medicines and therapies (CAM) and modification of lifestyle factors such as physical activity, exercise, and diet are being increasingly considered as potential therapeutic options for anxiety disorders. The objective of this metareview was to examine evidence across a broad range of CAM and lifestyle interventions in the treatment of anxiety disorders. In early 2012 we conducted a literature search of PubMed, Scopus, CINAHL, Web of Science, PsycInfo, and the Cochrane Library, for key studies, systematic reviews, and metaanalyses in the area...
2012: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/24612097/activation-of-n-methyl-d-aspartate-receptor-glycine-site-temporally-ameliorates-neuropsychiatric-symptoms-of-parkinson-s-disease-with-dementia
#11
RANDOMIZED CONTROLLED TRIAL
Chon-Haw Tsai, Hui-Chun Huang, Bey-Ling Liu, Chia-Ing Li, Ming-Kuei Lu, Xianxiu Chen, Mu-Chieh Tsai, Yu-Wan Yang, Hsien-Yuan Lane
AIM: We have previously found that sarcosine, a glycine transporter I inhibitor, can improve the psychiatric symptoms of schizophrenia. In this study, we aimed to investigate whether the agent can also ameliorate neuropsychiatric symptoms of Parkinson's disease (PD) patients with dementia. METHODS: An 8-week, double-blind, placebo-controlled trial was conducted in patients who had PD with dementia (PD-D). Neuropsychiatric manifestations were measured before and at week 2 (V1), week 4 (V2) and week 8 (V3) after treatment...
September 2014: Psychiatry and Clinical Neurosciences
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"