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Contrast Induced Nephropathy

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134 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Toshiki Kuno, Yohei Numasawa, Mitsuaki Sawano, Toshiomi Katsuki, Masaki Kodaira, Ikuko Ueda, Masahiro Suzuki, Shigetaka Noma, Koji Negishi, Shiro Ishikawa, Hiroaki Miyata, Keiichi Fukuda, Shun Kohsaka
BACKGROUND: Limiting the contrast volume to creatinine clearance (V/CrCl) ratio is crucial for preventing contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI). However, the incidence of CI-AKI and the distribution of V/CrCl ratios may vary according to patient body habitus. OBJECTIVE: We aimed to identify the clinical factors predicting CI-AKI in patients with different body mass indexes (BMIs). METHODS: We evaluated 8782 consecutive patients undergoing PCI and who were registered in a large Japanese database...
2018: PloS One
Deborah Levine, Robert J McDonald, Herbert Y Kressel
No abstract text is available yet for this article.
September 12, 2018: JAMA: the Journal of the American Medical Association
Lorenzo Azzalini, Luz María Vilca, Francesca Lombardo, Enrico Poletti, Alessandra Laricchia, Alessandro Beneduce, Davide Maccagni, Ozan M Demir, Massimo Slavich, Francesco Giannini, Mauro Carlino, Alberto Margonato, Alberto Cappelletti, Antonio Colombo
BACKGROUND: There is controversy as to whether iso-osmolar contrast media (IOCM) are associated with lower risk of contrast-induced acute kidney injury (CI-AKI), compared with low-osmolar contrast media (LOCM). We aimed to evaluate if a differential risk of CI-AKI exists after percutaneous coronary intervention (PCI) according to different contrast media (CM) types. METHODS: We performed a single-center retrospective study in a cohort of all-comers undergoing PCI between January 2012 and December 2016...
September 1, 2018: International Journal of Cardiology
Dadi Helgason, Thorir E Long, Solveig Helgadottir, Runolfur Palsson, Gisli H Sigurdsson, Tomas Gudbjartsson, Olafur S Indridason, Ingibjorg J Gudmundsdottir, Martin I Sigurdsson
BACKGROUND: We studied the incidence and risk factors of acute kidney injury (AKI) following coronary angiography (CA) and examined short- and long-term outcomes of patients who developed AKI, including progression of chronic kidney disease (CKD). METHODS: This was a retrospective study of all patients undergoing CA in Iceland from 2008 to 2015, with or without percutaneous coronary intervention. All procedures were performed with iso-osmolar contrast. AKI was defined according to the SCr component of the KDIGO criteria...
September 5, 2018: Journal of Nephrology
Kai-Yang Lin, Zhi-Yong Wu, Zhe-Bin You, Wei-Ping Zheng, Chun-Jin Lin, Hui Jiang, Jing-Ming Ruan, Yan-Song Guo, Peng-Li Zhu
The aim of the study is to evaluate the association of pre-procedural N-terminal pro-B type natriuretic peptide (NT-proBNP) with contrast-induced acute kidney injury (CI-AKI) and long-term outcomes in elderly patients undergoing elective percutaneous coronary intervention (PCI).A total of 540 patients aged ≥ 75 years who had undergone elective PCI between January 2012 and December 2015 were enrolled in this study. Admission NT-proBNP levels were measured before PCI. CI-AKI was defined as a relative increase in serum creatinine (SCr) of ≥50%, or an absolute increase of ≥ 0...
August 29, 2018: International Heart Journal
Ashraf O Oweis, Sameeha A Alshelleh, Ammar K Daoud, Mahmoud M Smadi, Karem H Alzoubi
Background: Acute kidney injury (AKI) caused by contrast exposure is a common problem, which may cause a significant increase in patients in-hospital stay and therefore the cost of treatment. This study was conducted to evaluate the role of inflammation, inflammatory markers in predicting contrast induced nephropathy (CIN). This is a prospective study that was carried out in a major tertiary referral hospital in Jordan. Methods: Clinical data, blood and urine samples were collected from all patients admitted to the cardiology unit...
2018: International Journal of Nephrology and Renovascular Disease
Hitinder S Gurm, Milan Seth, Simon R Dixon, P Michael Grossman, Devraj Sukul, Thomas Lalonde, Louis Cannon, Daniel West, Ryan D Madder, D Adam Lauver
BACKGROUND: The risk of contrast-induced acute kidney injury (CI-AKI) increases in a nonlinear fashion with increasing volume of contrast media. Prior studies recommend limiting contrast volume to less than three times the estimated creatinine clearance (CC). Recently, a number of operators have reported successful percutaneous coronary intervention (PCI) using even lower volumes of contrast. OBJECTIVES: To evaluate the prevalence and outcomes associated with ultra-low contrast volume among patients undergoing PCI...
August 25, 2018: Catheterization and Cardiovascular Interventions
Charles E Chambers
No abstract text is available yet for this article.
August 27, 2018: JACC. Cardiovascular Interventions
Roxana Mehran, Michela Faggioni, Jaya Chandrasekhar, Dominick J Angiolillo, Barry Bertolet, Robert Lee Jobe, Bassam Al-Joundi, Somjot Brar, George Dangas, Wayne Batchelor, Anand Prasad, Hitinder S Gurm, James Tumlin, Gregg W Stone
OBJECTIVES: The aim of the AVERT (AVERT Clinical Trial for Contrast Media Volume Reduction and Incidence of CIN) trial was to test the efficacy of the AVERT system to reduce the contrast media volume (CMV) used during coronary angiographic procedures without impairing image quality and to prevent contrast-induced acute kidney injury (CI-AKI) in patients at risk for CI-AKI. BACKGROUND: CI-AKI is a common complication of percutaneous coronary procedures, associated with increased morbidity and mortality...
August 27, 2018: JACC. Cardiovascular Interventions
Shilei Yang, Yongguo Dai, Zhihao Liu, Changyuan Wang, Qiang Meng, Xiaokui Huo, Huijun Sun, Xiaodong Ma, Jinyong Peng, Kexin Liu
The application of iodinated contrast medium has become a risk factor for metformin-associated lactic acidosis (MALA), which leads to the accumulation of metformin in vivo is one of the principal reasons for MALA. However, the molecular mechanism of the adverse event is not yet clear. In this study, iohexol injection was used as a model drug. The contrast agent acute kidney injury rat model, in vivo rat pharmacokinetic study, kidney slices and HK-2 cells were performed to elucidate the pharmacokinetic molecular mechanism of accumulation of metformin caused by contrast-induced nephropathy (CIN)...
October 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jayakumar Sreenivasan, Min Zhuo, Muhammad Shahzeb Khan, Heyi Li, Setri Fugar, Parth Desai, Neha Yadav
Contrast-induced acute kidney injury (CI-AKI) following coronary angiography is associated with increased mortality. The association between severity of anemia and CI-AKI following coronary angiography is not well-established. In this retrospective study, we aimed at assessing the association of anemia of various severity with the risk of CI-AKI in patients who underwent coronary angiography. We included all patients who underwent coronary angiography with or without percutaneous coronary intervention from January 2012 to December 2016 at a single tertiary care hospital...
June 22, 2018: American Journal of Cardiology
Geng Qian, Chang-Fu Liu, Jun Guo, Wei Dong, Jin Wang, Yun-Dai Chen
OBJECTIVES: This study aimed to explore the adequate hydration with nitrates for patients with chronic kidney disease (CKD) and congestive heart failure (CHF) to reduce the risk of contrast-induced nephropathy (CIN) and at the same time avoid the acute heart failure. METHODS: 394 consecutive patients with CKD and CHF undergoing coronary procedures were randomized to either adequate hydration with nitrates (n=196) or to routine hydration (control group; n=198). The adequate hydration group received continuous intravenous infusion of isosorbide dinitrate combined with intravenous infusion of isotonic saline at a rate of 1...
July 27, 2018: Clinical Cardiology
Ning Geng, Deling Zou, Yanli Chen, Li Ren, Lisheng Xu, Wenyue Pang, Yingxian Sun
BACKGROUND: PGE1 has been studied for prevention of CI-AKI in several RCTs and significant heterogeneous results exist. METHODS: We searched PubMed, EMBase, and Cochrane Central Register of Controlled Trials up to December 26, 2017 for RCTs comparing PGE1 with placebo or other active medications for the prevention of CI-AKI in patients. Odds ratio and 95% confidence interval (CI) were used for pooling dichotomous data, while mean difference and 95% confidence interval for pooling continuous data...
July 2018: Medicine (Baltimore)
Jennifer S McDonald, Erik M Steckler, Robert J McDonald, Richard W Katzberg, Eric E Williamson, Joseph G Cernigliaro, Abdurrahman M Hamadah, Kamel Gharaibeh, David F Kallmes, Nelson Leung
OBJECTIVE: To determine whether persistent bilateral global nephrograms are associated with acute kidney injury (AKI), dialysis, and mortality. PATIENTS AND METHODS: All patients who underwent (1) contrast-enhanced computed tomography (CT) or cardiac catheterization with iohexol between January 1, 2000, and December 31, 2014, and (2) noncontrast abdominal CT in the subsequent 24±6 hours were identified. Patients without preprocedure and postprocedure creatinine measurements or who received additional contrast material were excluded...
July 2018: Mayo Clinic Proceedings
Nicola Schieda, Jason I Blaichman, Andreu F Costa, Rafael Glikstein, Casey Hurrell, Matthew James, Pejman Jabehdar Maralani, Wael Shabana, An Tang, Anne Tsampalieros, Christian B van der Pol, Swapnil Hiremath
Purpose of review: Use of gadolinium-based contrast agents (GBCA) in renal impairment is controversial, with physician and patient apprehension in acute kidney injury (AKI), chronic kidney disease (CKD), and dialysis because of concerns regarding nephrogenic systemic fibrosis (NSF). The position that GBCA are absolutely contraindicated in AKI, category G4 and G5 CKD (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m2 ), and dialysis-dependent patients is outdated and may limit access to clinically necessary contrast-enhanced magnetic resonance imaging (MRI) examinations...
2018: Canadian Journal of Kidney Health and Disease
Catherine Mao, Bobby Chacko
Contrast-associated nephropathy (CAN) is an extensively studied but equally controversial sequela of intravascular contrast use. Despite this, there is still significant debate about its definition and thus incidence, the impact of route of contrast administration, and ultimately, what constitutes appropriate clinical practice in light of risks. While guidelines cannot replace clinical judgment, without consensus either enthusiastic withholding of contrast from necessary procedures or its administration despite increased risk may be deleterious to patient outcomes...
September 2018: Clinical Nephrology
Mauro Maioli, Anna Toso, Mario Leoncini, Nicola Musilli, Gabriele Grippo, Claudio Ronco, Peter A McCullough, Francesco Bellandi
BACKGROUND: Intravascular volume expansion plays a major role in the prevention of contrast-induced acute kidney injury (CI-AKI). Recommended standard amounts of fluid infusion before procedures do not produce homogeneous responses in subjects with different initial hydration status. OBJECTIVES: The goal of this study was to compare the effect of standard and double intravenous (IV) infusion volumes in patients with low body fluid level, assessed by using bioimpedance vector analysis (BIVA), on the incidence of CI-AKI after elective coronary angiographic procedures...
June 26, 2018: Journal of the American College of Cardiology
Myoung Hwa Kim, Shin Ok Koh, Eun Jung Kim, Jin Sun Cho, Sung-Won Na
BACKGROUND: Contrast medium used for radiologic tests can decrease renal function. However there have been few studies on contrast-associated acute kidney injury in intensive care unit (ICU) patients. The objective of this study was to evaluate the incidence, characteristics, and outcome of contrast-associated acute kidney injury (CA-AKI) patients using the Risk, Injury, Failure, Loss, and End-stage kidney disease (RIFLE) criteria in critically ill patients in the ICU. METHODS: We conducted a retrospective study of adult patients who underwent contrast-enhanced radiologic tests from January 2011 to December 2012 in a 30-bed medical ICU and a 24-bed surgical ICU...
2015: BMC Anesthesiology
Martin Windpessl, Andreas Kronbichler
The administration of iodinated contrast medium (CM) has immediate negative impact on multiple levels of the nephron, including vasoconstriction, an increase in apoptotic pathways and oxidative stress. Therefore, contrast-induced acute kidney injury (CI-AKI) remains an important cause of sudden impairment of renal function. Far from being just a transient phenomenon, CI-AKI has consistently been shown to be associated with adverse outcomes. The phenomenon of chronic kidney disease (CKD) following AKI might explain why this entity portends a poor prognosis in the long run...
June 3, 2018: Nephrology, Dialysis, Transplantation
Michael J Ewing, John F Eidt
The incidence of acute kidney injury (AKI) attributed to iodinated contrast has been over-estimated and this has led clinicians to withhold potentially life-saving diagnostic and therapeutic interventions. There is mounting evidence that iodinated contrast plays only a minor role in the development of AKI in comparison with more significant risk factors such as pre-existing renal dysfunction, hemodynamic instability and exposure to nephrotoxic drugs. We will present data which challenge the dogma of avoiding iodinated contrast in patients with reduced renal function...
June 3, 2018: Nephrology, Dialysis, Transplantation
2018-06-07 09:00:13
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