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Contrast Induced Nephropathy

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63 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/28528129/prophylactic-hydration-to-prevent-contrast-induced-nephropathy-much-ado-about-nothing
#1
Christina M Wyatt, Marianne Camargo, Steven G Coca
Clinical guidelines recommend prophylactic hydration to reduce the risk of contrast-induced nephropathy in high-risk patients, including those with chronic kidney disease. A recent single-center randomized trial showed no significant difference in the incidence of contrast-induced nephropathy in ambulatory patients with stage 3 chronic kidney disease who were randomized to no prophylactic hydration versus normal saline hydration. While these results may identify patients who are less likely to benefit from prophylactic hydration, nephrologists and interventionalists should carefully consider the generalizability of these results to individual patients...
May 18, 2017: Kidney International
https://www.readbyqxmd.com/read/28501073/prophylactic-hemodialysis-for-protection-against-gadolinium-induced-nephrogenic-systemic-fibrosis-a-doll-s-house
#2
EDITORIAL
Jerry Yee
No abstract text is available yet for this article.
May 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28501076/intravenous-contrast-friend-or-foe-a-review-on-contrast-induced-nephropathy
#3
REVIEW
Catherine Do
Intravenous iodinated contrast is used in many contrasted imaging studies ranging from computed tomography to angiography. The risks of contrast-induced nephropathy (CIN) and its incidence have not been clearly defined. Most iodinated contrast media used today are hypertonic compared with serum osmolality and pose biological risks. However, the risk of CIN in the general population may be overestimated. Confounding risk factors may contribute to acute kidney injury other than attributable risk of contrast exposure...
May 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28452187/n-acetylcysteine-versus-ascorbic-acid-or-n-acetylcysteine-plus-ascorbic-acid-in-preventing-contrast-induced-nephropathy-a-meta-analysis
#4
Ye Feng, Xing Huang, Lin Li, Zhi Chen
OBJECTIVES: The purpose was to evaluate the efficacy of N-acetylcysteine (NAC) versus ascorbic acid (VC) or NAC plus (+) VC on the prevention of contrast-induced nephropathy (CIN) in patients undergoing contrast administration. METHODS: We searched databases including Medline, Embase and Cochrane Library up to Feb 22 (th), 2017. Pooled risk ratios (RRs) or weighted mean difference (WMD) with their 95% confidence intervals (CIs) were calculated using fixed-effects model or random-effects model when appropriate...
April 27, 2017: Nephrology
https://www.readbyqxmd.com/read/28400120/impact-of-point-of-care-pre-procedure-creatinine-and-egfr-testing-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-pci-the-pilot-statcreat-study
#5
Grigoris V Karamasis, James Hampton-Till, Firas Al-Janabi, Shah Mohdnazri, Michael Parker, Adam Ioannou, Rohan Jagathesan, Alagmir Kabir, Jeremy W Sayer, Nicholas M Robinson, Rajesh K Aggarwal, Gerald J Clesham, Reto A Gamma, Paul A Kelly, Kare H Tang, John R Davies, Thomas Keeble
BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) is a recognised complication during primary PCI that affects short and long term prognosis. The aim of this study was to assess the impact of point-of-care (POC) pre-PPCI creatinine and eGFR testing in STEMI patients. METHODS: 160 STEMI patients (STATCREAT group) with pre-procedure POC testing of Cr and eGFR were compared with 294 consecutive retrospective STEMI patients (control group). Patients were further divided into subjects with or without pre-existing CKD...
April 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28382626/use-of-radiocontrast-agents-in-ckd-and-esrd
#6
Jehan Z Bahrainwala, Amanda K Leonberg-Yoo, Michael R Rudnick
Contrast exposure in a population with chronic kidney disease (CKD) requires additional consideration given the risk of contrast-induced nephropathy (CIN) after exposure to iodinated contrast as well as systemic injury with exposure to gadolinium-based contrast agents (GBCA). Strategies to avoid CIN, and manage patients after exposure, including extracorporeal removal of contrast media, may differ among an advanced CKD population as compared to a general population. There is strong evidence to support the use of isotonic volume expansion and the lowest dose of low-osmolar or iso-osmolar contrast media possible to decrease CIN...
April 5, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28362042/gadolinium-contrast-agents-are-they-really-safe
#7
Hana Malikova, Michal Holesta
Gadolinium-based contrast agents (GBCA) are used worldwide for enhanced MRI examinations, including heart and vessels. Gadolinium is a highly toxic heavy metal. If used in GBCA it must be tightly bound to ligands. The configuration of ligands influences the stability of the GBCA and two types of chelates have been used. Macrocyclic chelates offer better protection and binding of gadolinium ion than linear chelates with a flexible open chain - gadolinium could be more easily released from the latter ones. GBCAs are excreted from the body mostly by the kidneys, which is of importance in chronic kidney disease...
March 28, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28356658/n-acetyl-cysteine-versus-allopurinol-in-the-prevention-of-contrast-nephropathy-in-patients-with-chronic-kidney-disease-a-randomized-controlled-trial
#8
R Sadineni, K R Karthik, G Swarnalatha, U Das, G Taduri
Contrast media administration can lead to acute deterioration in renal function particularly in patients with pre-existing chronic kidney disease. This prospective, randomized controlled open-label parallel group study was undertaken at Nizam's Institute of Medical Sciences, Hyderabad, from June to December 2015. A total of 95 patients were included, of which 35 received n-acetylcysteine (NAC) + normal saline (NS), 30 patients received allopurinol (ALL) + NS, and 30 patients received placebo. In our study, the overall incidence of CIN was 24%...
March 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28344330/acute-kidney-injury-intravenous-hydration-for-the-prevention-of-ciaki
#9
Carlo Briguori, Giuseppe Signoriello
No abstract text is available yet for this article.
May 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28342840/the-ratio-of-contrast-volume-to-glomerular-filtration-rate-predicts-acute-kidney-injury-and-mortality-after-transcatheter-aortic-valve-implantation
#10
Francesco Giannini, Azeem Latib, Richard J Jabbour, Massimo Slavich, Susanna Benincasa, Alaide Chieffo, Matteo Montorfano, Stefano Stella, Nicola Buzzatti, Ottavio Alfieri, Antonio Colombo
OBJECTIVE: The aim of this study was to assess the impact of the ratio of volume of contrast medium to the glomerular filtration rate (V/GFR) on acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI) and its impact on long-term mortality. METHODS: We retrospectively calculated V/GFR in 397 patients undergoing TAVI. AKI was defined as VARC-modified Risk, Injury, Failure, Loss and End-stage (RIFLE) kidney disease score≥2. RESULTS: The incidence of AKI was 17...
February 20, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28320994/a-nomogram-to-predict-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention
#11
Xun Hu, Xiao-Dong Zhuang, Yi Li, Fei-Fei Li, Yue Guo, Zhi-Min Du, Xin-Xue Liao
Contrast-induced nephropathy (CIN) is the third leading cause of hospital-acquired acute kidney injury (AKI). Emerging evidence has revealed that soluble klotho (sklotho) could be a novel biomarker for early AKI diagnosis. The aims of this study were to assess the predictive role of sklotho for CIN and to develop a prediction nomogram in patients undergoing percutaneous coronary intervention (PCI). This study is registered on Clinicaltrials.gov (NCT 02650336).Patients aged 18 years or older undergoing planned PCI were prospectively recruited between May 2014 and July 2015...
April 6, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28236468/volume-expansion-and-contrast-induced-acute-kidney-injury
#12
Peter A McCullough, Jun Zhang, Claudio Ronco
No abstract text is available yet for this article.
April 1, 2017: Lancet
https://www.readbyqxmd.com/read/28151965/prevention-of-contrast-induced-acute-kidney-injury-in-patients-undergoing-cardiovascular-procedures-a-systematic-review-and-network-meta-analysis
#13
Eliano P Navarese, Paul A Gurbel, Felicita Andreotti, Michalina Marta Kołodziejczak, Suetonia C Palmer, Sofia Dias, Antonino Buffon, Jacek Kubica, Mariusz Kowalewski, Tomasz Jadczyk, Michał Laskiewicz, Marek Jędrzejek, Maximillian Brockmeyer, Flavio Airoldi, Marinella Ruospo, Stefano De Servi, Wojciech Wojakowski, Christopher O' Connor, Giovanni F M Strippoli
BACKGROUND: Interventional diagnostic and therapeutic procedures requiring intravascular iodinated contrast steadily increase patient exposure to the risks of contrast-induced acute kidney injury (CIAKI), which is associated with death, nonfatal cardiovascular events, and prolonged hospitalization. The aim of this study was to investigate the efficacy of pharmacological and non-pharmacological treatments for CIAKI prevention in patients undergoing cardiovascular invasive procedures with iodinated contrast...
2017: PloS One
https://www.readbyqxmd.com/read/28138128/understanding-and-preventing-contrast-induced-acute-kidney-injury
#14
REVIEW
Michael Fähling, Erdmann Seeliger, Andreas Patzak, Pontus B Persson
Contrast-induced acute kidney injury (CIAKI) occurs in up to 30% of patients who receive iodinated contrast media and is generally considered to be the third most common cause of hospital-acquired AKI. Accurate assessment of the incidence of CIAKI is obscured, however, by the use of various definitions for diagnosis, the different populations studied and the prophylactic measures put in place. A deeper understanding of the mechanisms that underlie CIAKI is required to enable reliable risk assessment for individual patients, as their medical histories will determine the specific pathways by which contrast media administration might lead to kidney damage...
March 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28131489/risk-of-acute-kidney-injury-after-intravenous-contrast-media-administration
#15
Jeremiah S Hinson, Michael R Ehmann, Derek M Fine, Elliot K Fishman, Matthew F Toerper, Richard E Rothman, Eili Y Klein
STUDY OBJECTIVE: The study objective was to determine whether intravenous contrast administration for computed tomography (CT) is independently associated with increased risk for acute kidney injury and adverse clinical outcomes. METHODS: This single-center retrospective cohort analysis was performed in a large, urban, academic emergency department with an average census of 62,179 visits per year; 17,934 ED visits for patients who underwent contrast-enhanced, unenhanced, or no CT during a 5-year period (2009 to 2014) were included...
January 19, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28114465/review-some-drugs-added-to-hydration-prevent-contrast-induced-acute-kidney-injury
#16
Catherine M Clase
No abstract text is available yet for this article.
January 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27821094/outcomes-risk-factors-and-health-burden-of-contrast-induced-acute-kidney-injury-an-observational-study-of-one-million-hospitalizations-with-image-guided-cardiovascular-procedures
#17
Pierre Aubry, Georges Brillet, Laura Catella, Aurélie Schmidt, Stève Bénard
BACKGROUND: Despite the use of low-osmolar contrast media that have significantly reduced the occurrence of severe adverse reactions, contrast-induced (CI) acute kidney injury (AKI) remains the third cause of AKI in hospitals. We sought to estimate the frequency of CI-AKI among hospitalized patients undergoing image-guided cardiovascular procedures, to quantify the effect of risk factors on the development of this complication and to assess relative organizational and economic burden in healthcare...
November 8, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27723839/remote-ischemic-preconditioning-for-the-prevention-of-contrast-induced-acute-kidney-injury-in-diabetics-receiving-elective-percutaneous-coronary-intervention
#18
RANDOMIZED CONTROLLED TRIAL
Gillian Balbir Singh, Soe Hee Ann, Jongha Park, Hyun Chul Chung, Jong Soo Lee, Eun-Sook Kim, Jung Il Choi, Jiho Lee, Shin-Jae Kim, Eun-Seok Shin
OBJECTIVE: Remote ischemic preconditioning (RIPC) induces transient episodes of ischemia by the occlusion of blood flow in non-target tissue, before a subsequent ischemia-reperfusion injury. When RIPC is applied before percutaneous coronary intervention (PCI), the kidneys may be protected against ischemia-reperfusion injury and subsequently contrast-induced acute kidney injury (CI-AKI). The aim of this study was to evaluate the efficacy of RIPC for the prevention of CI-AKI in patients with diabetes with pre-existing chronic kidney disease (CKD) undergoing elective PCI...
2016: PloS One
https://www.readbyqxmd.com/read/27707552/comparative-effectiveness-of-12-treatment-strategies-for-preventing-contrast-induced-acute-kidney-injury-a-systematic-review-and-bayesian-network-meta-analysis
#19
Xiaole Su, Xinfang Xie, Lijun Liu, Jicheng Lv, Fujian Song, Vlado Perkovic, Hong Zhang
BACKGROUND: To simultaneously evaluate the relative efficacy of multiple pharmacologic strategies for preventing contrast-induced acute kidney injury (AKI). STUDY DESIGN: Systematic review containing a Bayesian network meta-analysis of randomized controlled trials. SETTING & POPULATION: Participants undergoing diagnostic and/or interventional procedures with contrast media. SELECTION CRITERIA FOR STUDIES: Randomized controlled trials comparing the active drug treatments with each other or with hydration alone...
January 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27688297/estimating-the-risk-of-radiocontrast-associated-nephropathy
#20
Emilee Wilhelm-Leen, Maria E Montez-Rath, Glenn Chertow
Estimates of the incidence of radiocontrast-associated nephropathy vary widely and suffer from misclassification of the cause of AKI and confounding. Using the Nationwide Inpatient Sample, we created multiple estimates of the risk of radiocontrast-associated nephropathy among adult patients hospitalized in the United States in 2009. First, we stratified patients according to the presence or absence of 12 relatively common diagnoses associated with AKI and evaluated the rate of AKI between strata. Next, we created a logistic regression model, controlling for comorbidity and acuity of illness, to estimate the risk of AKI associated with radiocontrast administration within each stratum...
February 2017: Journal of the American Society of Nephrology: JASN
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