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Essential Surgical Knowledge

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2111 papers 1000+ followers Papers from the recent literature which are of interest to residents and practicing surgeons
https://www.readbyqxmd.com/read/29675566/the-surviving-sepsis-campaign-bundle-2018-update
#1
EDITORIAL
Mitchell M Levy, Laura E Evans, Andrew Rhodes
No abstract text is available yet for this article.
April 19, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29672405/necrotizing-soft-tissue-infection-diagnostic-accuracy-of-physical-examination-imaging-and-lrinec-score-a-systematic-review-and-meta-analysis
#2
Shannon M Fernando, Alexandre Tran, Wei Cheng, Bram Rochwerg, Kwadwo Kyeremanteng, Andrew J E Seely, Kenji Inaba, Jeffrey J Perry
OBJECTIVE: We sought to summarize accuracy of physical examination, imaging, and Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score in diagnosis of necrotizing soft tissue infection (NSTI) in adults with a soft tissue infection clinically concerning for NSTI. SUMMARY OF BACKGROUND DATA: NSTI is a life-threatening diagnosis. Delay to diagnosis and surgical management is associated with increased mortality. METHODS: We searched 6 databases from inception through November 2017...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29488089/pheochromocytoma-diagnosed-during-pregnancy-lessons-learned-from-a-series-of-ten-patients
#3
G Donatini, J L Kraimps, C Caillard, E Mirallie, F Pierre, Loïc De Calan, Hamy Antoine, O Larin, O Tovkay, S Cherenko
BACKGROUND: Pheochromocytoma (PHEO) in pregnancy is a life-threatening condition. Its management is challenging with regards to the timing and type of surgery. METHODS: A retrospective review of the management of ten patients diagnosed with pheochromocytoma during pregnancy was performed. Data were collected on the initial diagnostic workup, symptoms, treatment, and follow-up. RESULTS: PHEO was diagnosed in ten patients who were between the 10th and the 29th weeks of pregnancy...
February 27, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29650280/evaluation-of-the-quality-of-the-reporting-of-phase-ii-clinical-trials-in-oncology-a-systematic-review
#4
REVIEW
Romain Rivoirard, Julien Langrand-Escure, Mathieu Oriol, Fabien Tinquaut, Franck Chauvin, Chloé Rancoule, Nicolas Magné, Aurélie Bourmaud
OBJECTIVE: To describe the current state of knowledge concerning the quality of reporting in phase II clinical trials in oncology and to describe the various methods published allowing this quality evaluation. METHODS: databases including MEDLINE and COCHRANE were searched. Reviews and meta-analyses analyzing the quality of the reporting of phase II trials in oncology were included. Descriptive analysis of the results was performed. RESULTS: Thirteen publications were retained...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29644533/systematic-review-of-clinical-outcomes-following-various-treatment-options-for-patients-with-extraabdominal-desmoid-tumors
#5
Kortnye Smith, Jayesh Desai, Smaro Lazarakis, David Gyorki
BACKGROUND: Desmoid tumors (DT) are rare clonal proliferations that arise from mesenchymal cells. These tumors do not metastasize but are locally aggressive, and their growth may lead to significant morbidity. Their clinical course is both variable and unpredictable; tumors may rapidly progress but in other instances remain stable or regress without intervention. AIMS: To examine current treatment of DT and assist with decision-making at time of presentation. METHODS: A literature search was conducted of MEDLINE and Cochrane databases for published studies (1995-July 2015) using the search terms fibromatosis aggressive, desmoid with drug therapy, radiation therapy, prevention and control, radiotherapy, surgery, and therapy...
April 11, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29578908/defining-and-predicting-early-recurrence-in-957-patients-with-resected-pancreatic-ductal-adenocarcinoma
#6
Vincent P Groot, Georgios Gemenetzis, Alex B Blair, Roberto J Rivero-Soto, Jun Yu, Ammar A Javed, Richard A Burkhart, Inne H M Borel Rinkes, I Quintus Molenaar, John L Cameron, Matthew J Weiss, Christopher L Wolfgang, Jin He
OBJECTIVES: To establish an evidence-based cutoff to differentiate between early and late recurrence and to compare clinicopathologic risk factors between the two groups. SUMMARY BACKGROUND DATA: A clear definition of "early recurrence" after pancreatic ductal adenocarcinoma resection is currently lacking. METHODS: Patients undergoing pancreatectomy for pancreatic ductal adenocarcinoma between 2000 and 2013 were included. Exclusion criteria were neoadjuvant therapy and incomplete follow-up...
March 23, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29610508/acg-clinical-guideline-management-of-crohn-s-disease-in-adults
#7
Gary R Lichtenstein, Edward V Loftus, Kim L Isaacs, Miguel D Regueiro, Lauren B Gerson, Bruce E Sands
Crohn's disease is an idiopathic inflammatory disorder of unknown etiology with genetic, immunologic, and environmental influences. The incidence of Crohn's disease has steadily increased over the past several decades. The diagnosis and treatment of patients with Crohn's disease has evolved since the last practice guideline was published. These guidelines represent the official practice recommendations of the American College of Gastroenterology and were developed under the auspices of the Practice Parameters Committee for the management of adult patients with Crohn's disease...
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29603126/thirty-day-mortality-in-patients-undergoing-laparotomy-for-small-bowel-obstruction
#8
O Peacock, M G Bassett, A Kuryba, K Walker, E Davies, I Anderson, R S Vohra
BACKGROUND: Small bowel obstruction (SBO) is a common indication for emergency laparotomy. There are currently variations in the timing of surgery for patients with SBO and limited evidence on whether delayed surgery affects outcomes. The aim of this study was to evaluate the impact of time to operation on 30-day mortality in patients requiring emergency laparotomy for SBO. METHODS: Data were collected from the National Emergency Laparotomy Audit (NELA) on all patients aged 18 years or older who underwent emergency laparotomy for all forms of SBO between December 2013 and November 2015...
March 30, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29574408/european-evidence-based-guidelines-on-pancreatic-cystic-neoplasms
#9
(no author information available yet)
Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology)...
March 24, 2018: Gut
https://www.readbyqxmd.com/read/29578910/multisource-evaluation-of-surgeon-behavior-is-associated-with-malpractice-claims
#10
Janaka Lagoo, William R Berry, Kate Miller, Brandon J Neal, Luke Sato, Keith D Lillemoe, Gerard M Doherty, James R Kasser, Elliot L Chaikof, Atul A Gawande, Alex B Haynes
OBJECTIVE: We merged direct, multisource, and systematic assessments of surgeon behavior with malpractice claims, to analyze the relationship between surgeon 360-degree reviews and malpractice history. BACKGROUND: Previous work suggests that malpractice claims are associated with a poor physician-patient relationship, which is likely related to behaviors captured by 360-degree review. We hypothesize that 360-degree review results are associated with malpractice claims...
March 23, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29566417/treatment-challenges-in-venous-thromboembolism-an-appraisal-of-rivaroxaban-studies
#11
Alok A Khorana, Jeffrey I Weitz
Venous thromboembolism (VTE) presents a continuing clinical burden to healthcare systems and there are patient groups for whom VTE management is challenging. Depending on the patient profile, the optimal duration of anticoagulation for VTE treatment can be unclear. EINSTEIN CHOICE was a Phase III, randomized, double-blind trial that compared the safety and efficacy of two once-daily (od) doses of the direct, oral factor Xa inhibitor rivaroxaban (20 and 10 mg) with acetylsalicylic acid (ASA; 100 mg daily) for prevention of recurrent VTE...
March 22, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29562073/association-of-frailty-with-failure-to-rescue-after-low-risk-and-high-risk-inpatient-surgery
#12
Rupen Shah, Kristopher Attwood, Shipra Arya, Daniel E Hall, Jason M Johanning, Emmanuel Gabriel, Anthony Visioni, Steven Nurkin, Moshim Kukar, Steven Hochwald, Nader N Massarweh
Importance: Failure to rescue (FTR), or death after a potentially preventable complication, is a nationally endorsed, publicly reported quality measure. However, little is known about the impact of frailty on FTR, in particular after low-risk surgical procedures. Objective: To assess the association of frailty with FTR in patients undergoing inpatient surgery. Design, Setting, and Participants: This study assessed a cohort of 984 550 patients undergoing inpatient general, vascular, thoracic, cardiac, and orthopedic surgery in the National Surgical Quality Improvement Program between January 1, 2005, and December 31, 2012...
March 21, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29557103/chemotherapy-and-radiotherapy-for-advanced-pancreatic-cancer
#13
REVIEW
Venessa Chin, Adnan Nagrial, Katrin Sjoquist, Chelsie A O'Connor, Lorraine Chantrill, Andrew V Biankin, Rob Jpm Scholten, Desmond Yip
BACKGROUND: Pancreatic cancer (PC) is a highly lethal disease with few effective treatment options. Over the past few decades, many anti-cancer therapies have been tested in the locally advanced and metastatic setting, with mixed results. This review attempts to synthesise all the randomised data available to help better inform patient and clinician decision-making when dealing with this difficult disease. OBJECTIVES: To assess the effect of chemotherapy, radiotherapy or both for first-line treatment of advanced pancreatic cancer...
March 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29541789/new-blood-for-old-high-quality-evidence-that-fresh-red-blood-cells-confer-no-benefit-for-critically-ill-patients
#14
EDITORIAL
Timothy S Walsh, Nicole P Juffermans
No abstract text is available yet for this article.
March 14, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29532343/the-new-american-joint-commission-on-cancer-staging-system-for-soft-tissue-sarcomas-splitting-versus-lumping
#15
EDITORIAL
Sam S Yoon
No abstract text is available yet for this article.
March 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29520647/colonic-interposition-after-adult-oesophagectomy-systematic-review-and-meta-analysis-of-conduit-choice-and-outcome
#16
Jade Brown, Wyn G Lewis, Antonio Foliaki, Geoffrey W B Clark, Guy R J C Blackshaw, David S Y Chan
BACKGROUND: Colonic interposition is a second-line option after oesophagectomy when a gastric neo-oesophagus is not viable. There is no consensus on the optimum anatomical colonic conduit (right or left), or route of placement (posterior mediastinal, retrosternal or subcutaneous). The aim of this review was to determine the optimum site and route of neo-oesophageal conduit after adult oesophagectomy. METHODS: PubMed, MEDLINE, and the Cochrane Library (January 1985 to January 2017) were systematically searched for studies which reported outcomes following colonic interposition in adults...
March 8, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29514787/frequency-and-level-of-evidence-used-in-recommendations-by-the-national-comprehensive-cancer-network-guidelines-beyond-approvals-of-the-us-food-and-drug-administration-retrospective-observational-study
#17
COMPARATIVE STUDY
Jeffrey Wagner, John Marquart, Julia Ruby, Austin Lammers, Sham Mailankody, Victoria Kaestner, Vinay Prasad
OBJECTIVE: To determine the differences between recommendations by the National Comprehensive Cancer Network (NCNN) guidelines and Food and Drug Administration approvals of anticancer drugs, and the evidence cited by the NCCN to justify recommendations where differences exist. DESIGN: Retrospective observational study. SETTING: National Comprehensive Cancer Network and FDA. PARTICIPANTS: 47 new molecular entities approved by the FDA between 2011 and 2015...
March 7, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29462280/clinical-practice-guidelines-for-clostridium-difficile-infection-in-adults-and-children-2017-update-by-the-infectious-diseases-society-of-america-idsa-and-society-for-healthcare-epidemiology-of-america-shea
#18
L Clifford McDonald, Dale N Gerding, Stuart Johnson, Johan S Bakken, Karen C Carroll, Susan E Coffin, Erik R Dubberke, Kevin W Garey, Carolyn V Gould, Ciaran Kelly, Vivian Loo, Julia Shaklee Sammons, Thomas J Sandora, Mark H Wilcox
A panel of experts was convened by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) to update the 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults. The update, which has incorporated recommendations for children (following the adult recommendations for epidemiology, diagnosis, and treatment), includes significant changes in the management of this infection and reflects the evolving controversy over best methods for diagnosis...
February 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29500685/neoadjuvant-radiation-is-associated-with-fistula-formation-following-pancreaticoduodenectomy
#19
Sara L Zettervall, Tammy Ju, Jeremy L Holzmacher, Lisbi Rivas, Paul P Lin, Khashayar Vaziri
BACKGROUND: Post-operative pancreatic fistulas remain a significant source of morbidity following pancreatic surgery. Few studies have evaluated the effect of neoadjuvant chemotherapy and radiation on this adverse outcome. This study aims to evaluate the effects of neoadjuvant therapy on 30-day morbidity and mortality following pancreaticoduodenectomy. STUDY DESIGN: A retrospective analysis was performed utilizing the targeted pancreas module of the National Surgical Quality Improvement Project (NSQIP) from 2014 to 2015 for patients undergoing pancreaticoduodenectomy with pancreaticojejunal reconstruction...
March 2, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29485131/acg-clinical-guideline-diagnosis-and-management-of-pancreatic-cysts
#20
Grace H Elta, Brintha K Enestvedt, Bryan G Sauer, Anne Marie Lennon
Pancreatic cysts are very common with the majority incidentally identified. There are several types of pancreatic cysts; some types can contain cancer or have malignant potential, whereas others are benign. However, even the types of cysts with malignant potential rarely progress to cancer. At the present time, the only viable treatment for pancreatic cysts is surgical excision, which is associated with a high morbidity and occasional mortality. The small risk of malignant transformation, the high risks of surgical treatment, and the lack of high-quality prospective studies have led to contradictory recommendations for their immediate management and for their surveillance...
February 27, 2018: American Journal of Gastroenterology
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