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Topical abx higher local admin

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By David Bennett Pediatric Orthopaedic Surgeon in the United States
Alexander A Theologis, Gokhan Demirkiran, Matt Callahan, Murat Pekmezci, Christopher Ames, Vedat Deviren
STUDY DESIGN: Retrospective cohort analysis. OBJECTIVE: To evaluate the rate of surgical site infections (SSIs) and cost-effectiveness of the use of intraoperative vancomycin powder in thoracolumbar adult deformity procedures. SUMMARY OF BACKGROUND DATA: The rates of SSI remain unacceptably high in adult spinal deformity surgery despite routine intravenous antibiotics. Vancomycin powder applied directly to the wound intraoperatively has shown promise for decreasing SSI in spine surgery...
October 15, 2014: Spine
G Stringel, R Bawdon, M Savrich, L Guertin, J Horton
We evaluated under controlled conditions the efficacy of topical and systemic antibiotics, alone and in combination, in the prevention of wound infection and measured serum and tissue antibiotic levels in the wound and distant tissue after administration of antibiotics topically, systemically, and in combination. Adult Sprague-Dawley rats were contaminated on the dorsal paravertebral muscles with a preset standardized inoculum of Staphylococcus aureus, Escherichia coli, and Bacteroides fragilis. A second-generation cephalosporin was used; systemic administration was given intramuscularly and topically in powder form...
October 1989: Journal of Pediatric Surgery
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