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Renal Transplantation

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314 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/30223782/successful-reuse-of-a-transplanted-kidney-9-years-after-initial-transplantation-4-year-follow-up
#1
Wen-Hsin Tseng, Yu-Feng Tian, Alex Chien-Hwa Liao, Ming-Jenn Chen, Hsuan-Ying Ho, Jinn-Rung Kuo, Steven K Huang
BACKGROUND: Kidney transplantation is the preferred renal replacement therapy for patients with end-stage renal disease, but the waiting list for kidneys continues to grow because of a shortage of donor organs. The reuse of transplanted kidneys would seem to be a good approach to expand the pool of available organs. Here, we describe the reuse of a kidney 9 years after the initial transplantation. At 4-year follow-up, the second recipient is showing good renal function. CASE PRESENTATION: In 2005, a kidney was transplanted from a 40-year-old man, who suffered brain death due to an intracranial hemorrhage, into a 45-year-old man...
September 17, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30220651/the-use-of-hydrogels-for-cell-based-treatment-of-chronic-kidney-disease
#2
REVIEW
Meg L McFetridge, Mark P Del Borgo, Marie-Isabel Aguilar, Sharon D Ricardo
Chronic kidney disease (CKD) is a major and growing public health concern with increasing incidence and prevalence worldwide. The therapeutic potential of stem cell therapy, including mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) holds great promise for treatment of CKD. However, there are significant bottlenecks in the clinical translation due to the reduced number of transplanted cells and the duration of their presence at the site of tissue damage. Bioengineered hydrogels may provide a route of cell delivery to enhance treatment efficacy and optimise the targeting effectiveness while minimising any loss of cell function...
September 14, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/30218580/a-new-approach-to-kidney-waitlist-management-in-the-kidney-allocation-system-era-pilot-implementation-and-evaluation
#3
Xingxing S Cheng, Stephan Busque, Jenny Lee, Kevin Discipulo, Christine Hartley, Zeynep Tulu, John D Scandling, Jane C Tan
Kidney transplant waitlist management is becoming increasingly complex. We introduced a novel waitlist management strategy at our center, the Transplant Readiness Assessment Clinic (TRAC), whereby patients whose Kidney Allocation Scores surpass a threshold are actively managed. From January 1, 2016 through June 30, 2017, we evaluated 195 patients through TRAC. Compared to pre-TRAC systems at our institution, TRAC resulted in a higher proportion of activation at 18-months (38% versus 22-26%, p<0.0001), despite being enriched in patients with long dialysis duration...
September 15, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29796413/factors-associated-with-prolonged-warm-ischemia-time-among-deceased-donor-kidney-transplant-recipients
#4
Amanda J Vinson, Caren Rose, Bryce A Kiberd, Ayodele Odutayo, S Joseph Kim, Ian Alwayn, Karthik K Tennankore
Background: Prolonged warm ischemia time (WIT) is associated with graft failure and mortality, however less is known about factors associated with prolonged WIT. Methods: In a cohort of United States deceased donor kidney transplant recipients identified using the Scientific Registry of Transplant Recipients (Jan 2005-Dec 2013), we identified factors associated with prolonged WIT (defined as ≥ 30 minutes versus 10-30 minutes) using hierarchical multilevel models adjusting for center effect, and WIT as a continuous variable using multiple linear regression of log-transformed data...
May 2018: Transplantation Direct
https://www.readbyqxmd.com/read/30197644/graft-pre-conditioning-by-peri-operative-perfusion-of-kidney-allografts-with-rabbit-anti-human-t-lymphocyte-globulin-results-in-improved-kidney-graft-function-in-the-early-post-transplantation-period-a-prospective-randomized-placebo-controlled-trial
#5
Paul V Ritschl, Julia Günther, Lena Hofhansel, Anja A Kühl, Arne Sattler, Stefanie Ernst, Frank Friedersdorff, Susanne Ebner, Sascha Weiss, Claudia Bösmüller, Annemarie Weissenbacher, Rupert Oberhuber, Benno Cardini, Robert Öllinger, Stefan Schneeberger, Matthias Biebl, Christian Denecke, Christian Margreiter, Thomas Resch, Felix Aigner, Manuel Maglione, Johann Pratschke, Katja Kotsch
Introduction: Although prone to a higher degree of ischemia reperfusion injury (IRI), the use of extended criteria donor (ECD) organs has become reality in transplantation. We therefore postulated that peri-operative perfusion of renal transplants with anti-human T-lymphocyte globulin (ATLG) ameliorates IRI and results in improved graft function. Methods: We performed a randomized, single-blinded, placebo-controlled trial involving 50 kidneys (KTx). Prior to implantation organs were perfused and incubated with ATLG (AP) ( n = 24 kidney)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30177142/evaluation-of-the-relationship-between-concentrations-of-tacrolimus-metabolites-13-o-demethyl-tacrolimus-and-15-o-demethyl-tacrolimus-and-clinical-and-biochemical-parameters-in-kidney-transplant-recipients
#6
J Zegarska, E Hryniewiecka, D Zochowska, E Samborowska, R Jazwiec, K Maciej, S Nazarewski, M Dadlez, L Paczek
BACKGROUND: Tacrolimus (Tac), an essential component of immunosuppressive therapy after solid-organ transplantation, has a narrow therapeutic index and requires therapeutic drug monitoring. Monitoring of Tac predose blood concentrations seems to be not always sufficient to avoid adverse effects. The aim of the study was to evaluate the levels of main Tac metabolites, 13-O-demethyl tacrolimus (13-DMT), 31-O-demethyl tacrolimus (31-DMT), and 15-O-demethyl tacrolimus (15-DMT), in kidney transplant recipients and to link them to clinical and biochemical parameters...
September 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30045913/minding-the-missing-link-the-effect-of-donor-recipient-pairing-on-kidney-transplant-outcomes
#7
Amanda J Vinson, Karthik K Tennankore
No abstract text is available yet for this article.
July 25, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30157158/subclinical-changes-in-deceased-donor-kidney-proteomes-are-associated-with-12-month-allograft-function-posttransplantation-a-preliminary-study
#8
M Kaisar, Lfa van Dullemen, P D Charles, M Z Akhtar, M L Thézénas, H Huang, A Klooster, N A Watkins, B M Kessler, R J Ploeg
BACKGROUND: Cerebral injury during Donation after Brain Death (DBD) may induce systemic damage affecting long-term kidney function posttransplantation. Conventional evaluation of donor organ quality as a triage for transplantation is of limited utility. METHODS: We compared donor kidneys yielding opposing extremes of the continuum of posttransplantation outcomes by several common kidney biopsy evaluation techniques including Kidney Donor Profile Index (KDPI) and Remuzzi scoring, and analysed tissue from a minimal sample cohort using Label-Free Quantitation (LFQ) mass spectrometry...
September 11, 2018: Transplantation
https://www.readbyqxmd.com/read/30152018/hypoalbuminaemia-at-time-of-surgery-is-associated-with-an-increased-risk-for-overall-graft-loss-after-kidney-transplantation
#9
Benjamin Anderson, Khalid Khalil, Felicity Evison, Jay Nath, Adnan Sharif
AIM: The aim of this retrospective cohort study was to investigate whether pre-operative hypoalbuminaemia (<35 g/L) is associated with adverse outcomes post kidney transplantation. METHODS: Our retrospective, single-centre analysis included all patients who received their kidney transplant between 2007 and 2017, with documented admission albumin levels prior to surgery. Survival analyses were undertaken to explore the relationship of pre-transplant hypoalbuminaemia versus other baseline variables upon post-transplant outcomes...
August 27, 2018: Nephrology
https://www.readbyqxmd.com/read/30152890/interaction-between-socioeconomic-deprivation-and-likelihood-of-pre-emptive-transplantation-influence-of-competing-risks-and-referral-characteristics-a-retrospective-study
#10
Keith A Gillis, Jennifer S Lees, Maximilian R Ralston, Julie A Glen, Karen S Stevenson, Siobhan K McManus, Colin C Geddes, Marc Clancy, Jamie P Traynor, Patrick B Mark
Socioeconomic deprivation (SED) influences likelihood of pre-emptive kidney transplantation (PET), but the mechanisms behind this are unclear. We explored the relationships between SED and patient characteristics at referral, which might explain this discrepancy. A retrospective cohort study was performed. SED was measured by Scottish Index of Multiple Deprivation (SIMD). Logistic regression evaluated predictors of PET. A competing risks survival analysis evaluated the interaction between SED and progression to end-stage kidney disease (ESKD) and death...
August 28, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30143068/the-age-calibrated-measured-glomerular-filtration-rate-improves-living-kidney-donation-selection-process
#11
François Gaillard, Marie Courbebaisse, Nassim Kamar, Lionel Rostaing, Arnaud Del Bello, Sophie Girerd, Michèle Kessler, Martin Flamant, Emmanuelle Vidal-Petiot, Marie-Noelle Peraldi, Lionel Couzi, Pierre Merville, Paolo Malvezzi, Benedicte Janbon, Bruno Moulin, Sophie Caillard, Philippe Gatault, Matthias Büchler, Nicolas Maillard, Laurence Dubourg, Olga Roquet, Cyril Garrouste, Christophe Legendre, Pierre Delanaye, Christophe Mariat
Recommendations on the glomerular filtration rate (GFR) threshold compatible with living kidney donation are not agreed upon. The recent KDIGO guidelines suggested a reset of the conventional cutoff value of 80 to 90 mL/min/1.73 m2 . While GFR physiologically declines with age, it is unclear whether and how age should be taken into account for selecting acceptable pre-donation GFR. In this multicenter retrospective study encompassing 2007 kidney donors in France, we evaluated the impact of age using two threshold measured GFR (mGFR)s (80 and 90 mL/min/1...
September 2018: Kidney International
https://www.readbyqxmd.com/read/30130325/outcomes-in-third-and-fourth-kidney-transplants-based-on-the-type-of-donor
#12
Dilan Dabare, Theodoros Kassimatis, James Hodson, Muhammad Arslan Khurram, Georgios Papadakis, Gianluca Rompianesi, Olivia Shaw, Nikolaos Karydis, Chris Callaghan, Jonathon Olsburgh, Nizam Mamode, Nicos Kessaris, Ioannis Loukopoulos
BACKGROUND: An increasing number of patients are requiring multiple retransplants. We assessed outcomes of third and fourth kidney transplants, to aid decision-making on the most suitable donor type. METHODS: Data were collected retrospectively for 2561 transplants, including 69 third and 8 fourth, performed from 2000-2017. Demographics and outcomes for the combined third/fourth group were compared to first and second transplants. Within the third/fourth kidney transplant group, comparisons were made between deceased-donors (n=39), live-donor-HLA-compatible (n=23) and -incompatible (n=13) transplants, as well as between standard (n=25) and extended-criteria (n=14) deceased-donor transplants...
August 20, 2018: Transplantation
https://www.readbyqxmd.com/read/30124906/monoclonal-immunoglobulin-g-deposits-on-tubular-basement-membrane-in-renal-allograft-is-this-significant-for-chronic-allograft-injury
#13
Anri Sawada, Kunio Kawanishi, Shigeru Horita, Kazuya Omoto, Masayoshi Okumi, Tomokazu Shimizu, Sekiko Taneda, Shohei Fuchinoue, Hideki Ishida, Kazuho Honda, Motoshi Hattori, Kazunari Tanabe, Junki Koike, Yoji Nagashima, Kosaku Nitta
Background: Tubular basement membrane immune deposits (TBMID) has rarely been observed in renal allografts. It is usually found in BK virus nephropathy and immune complex glomerulonephritis; however, its significance is not well understood. We conducted a retrospective clinicopathological study on monoclonal immunoglobulin G (IgG) TBMID. Methods: We studied 7177 renal allograft biopsy specimens obtained from Tokyo Women's Medical University from 2007 to 2015 and performed light microscopic, electron microscopic and immunofluorescence studies...
August 16, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30121777/optimizing-renal-transplant-doppler-ultrasound
#14
REVIEW
Samuel J Galgano, Mark E Lockhart, Ghaneh Fananapazir, Rupan Sanyal
Doppler ultrasound is routinely used for the post-operative evaluation of renal transplant patients. Knowledge of the surgical anatomy and application of a robust technique are important for appropriate evaluation of a transplanted kidney. In this review article, we discuss the surgical anatomy of renal transplantation, techniques to optimize image acquisition, as well as commonly associated pitfalls with Doppler ultrasound evaluation of renal grafts.
October 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/30098052/the-risk-of-graft-loss-5-years-after-kidney-transplantation-is-increased-if-cold-ischemia-time-exceeds-14-hours
#15
Josefin Hansson, Lars Mjörnstedt, Per Lindnér
BACKGROUND: The state of the evidence is unclear regarding the impact of cold ischemia time (CIT) on the outcome of kidney transplantation. The aim of this study was to investigate the effect of CIT on the short- and long-term function of kidneys transplanted at the Sahlgrenska University Hospital in 2007-2009 from donors after brain death (DBDs). METHODS: This study was designed as a retrospective analysis of data from local and national transplantation registers...
August 10, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30098053/racial-disparity-in-kidney-transplant-survival-relates-to-late-rejection-and-is-independent-of-steroid-withdrawal
#16
Angela Liu, Kenneth J Woodside, Joshua J Augustine, Nagaraju Sarabu
Black kidney transplant recipients have more acute rejection (AR) and inferior graft survival. We sought to determine whether early steroid withdrawal (ESW) had an impact on AR and death-censored graft loss (DCGL) in blacks. From 2006 to 2012, AR and graft survival were analyzed in 483 kidney recipients (208 black and 275 non-black). Rates of ESW were similar between blacks (65%) and non-blacks (67%). AR was defined as early (≤3 months) or late (>3 months). The impact of black race, early AR, and late AR on death-censored graft failure was analyzed using univariate and multivariate Cox models...
August 11, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30093695/m-regs-kick-start-transplant-tolerance
#17
Grant Otto
No abstract text is available yet for this article.
August 9, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30086198/living-donor-postnephrectomy-kidney-function-and-recipient-graft-loss-a-dose-response-relationship
#18
Courtenay M Holscher, Tanveen Ishaque, Jacqueline M Garonzik Wang, Christine E Haugen, Sandra R DiBrito, Kyle R Jackson, Abimereki D Muzaale, Allan B Massie, Fawaz Al Ammary, Shane E Ottman, Macey L Henderson, Dorry L Segev
Development of end-stage renal disease (ESRD) in living kidney donors is associated with increased graft loss in the recipients of their kidneys. Our goal was to investigate if this relationship was reflected at an earlier stage postdonation, possibly early enough for recipient risk prediction based on donor response to nephrectomy. Using national registry data, we studied 29 464 recipients and their donors from 2008-2016 to determine the association between donor 6-month postnephrectomy estimated GFR (eGFR) and recipient death-censored graft failure (DCGF)...
August 7, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/30082055/precision-medicine-and-personalized-approach-to-renal-transplantation
#19
REVIEW
Donald C Dafoe, Ekamol Tantisattamo, Uttam Reddy
Successful renal transplantation is a highly effective endeavor that improves and prolongs the lives of patients with chronic kidney disease. Transplant surgery and immunosuppression carries risk and the demand for donor kidneys outstrips supply by far. These realities mandate thoughtful allocation and utilization of this limited resource to select candidates. As the criteria for candidates and donor grafts continue to expand, the field must adapt and seek new approaches. The complex process-from evaluation of candidates, transplant surgery, immunosuppression, and follow-up care after transplantation-is, of necessity, tightly structured and regulated...
July 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/27405070/pharmacologic-considerations-for-solid-organ-transplant-recipients-who-become-pregnant
#20
REVIEW
Jillian P Casale, Christina T Doligalski
Females of childbearing age represent a large population of solid organ transplant recipients. With fertility commonly restored after transplantation, the possibility of pregnancy becomes a reality for many patients. Since the first published report of a successful pregnancy after solid organ transplantation in 1963, the number of pregnancies reported for female organ recipients has continued to increase. Despite this, information on the management of immunosuppression during pregnancy is limited, and a summary of these data is lacking in the literature...
September 2016: Pharmacotherapy
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