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Renal Transplantation

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217 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29336856/evaluation-of-kidney-donors-core-curriculum-2018
#1
Deirdre Sawinski, Jayme E Locke
Nearly 100,000 patients are waiting for a kidney transplant, yet each year only 11,000 undergo transplantation with a deceased donor kidney. Annual death rates among waitlist registrants range from 5% to 15%; many die before receiving a transplant. Not surprisingly, registrants turn to family and friends to become living kidney donors on their behalf. Living kidney donor selection practices aim to quantify lifetime risk for kidney failure based on a candidate's predonation demographic and health characteristics...
January 11, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29330374/predicting-fibrosis-progression-in-renal-transplant-recipients-using-laser-based-infrared-spectroscopic-imaging
#2
Vishal K Varma, Andre Kajdacsy-Balla, Sanjeev Akkina, Suman Setty, Michael J Walsh
Renal transplants have not seen a significant improvement in their 10-year graft life. Chronic damage accumulation often leads to interstitial fibrosis and tubular atrophy (IF/TA) and thus graft function loss over time. For this reason, IF/TA has been the chief suspect for a potential prognostic marker for long term outcomes. In this study, we have used infrared spectroscopic (IR) imaging to interrogate the biochemistry of regions of fibrosis from renal transplant biopsies to identify a biochemical signature that can predict rapid progression of fibrosis...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29309901/ischemia-reperfusion-associated-tubular-cells-injury-in-renal-transplantation-can-metabolomics-inform-about-mechanisms-and-help-identify-new-therapeutic-targets
#3
REVIEW
Chantal Barin-Le Guellec, Bérenger Largeau, Delphine Bon, Pierre Marquet, Thierry Hauet
Tubular cells are central targets of ischemia-reperfusion (I/R) injury in kidney transplantation. Inflammation and metabolic disturbances occurring within these cells are deleterious by themselves but also favor secondary events, such as activation of immune response. It is critical to have an in depth understanding of the mechanisms governing tubular cells response to I/R if one wants to define pertinent biomarkers or to elaborate targeted therapeutic interventions. As oxidative damage was shown to be central in the patho-physiological mechanisms, the impact of I/R on proximal tubular cells metabolism has been widely studied, contrary to its effects on expression and activity of membrane transporters of the proximal tubular cells...
January 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29292693/efficacy-and-safety-of-everolimus-plus-low-dose-calcineurin-inhibitor-vs-mycophenolate-mofetil-plus-standard-dose-calcineurin-inhibitor-in-renal-transplant-recipients-a-systematic-review-and-meta-analysis%C3%A2
#4
Lihong He, Jin Deng, Bo Yang, Wei Jiang
BACKGROUND: To seek an optimized immunotherapy which can preserve renal function while maintaining low acute rejection rates, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of everolimus (EVR) plus low-dose calcineurin inhibitor (CNI) vs. mycophenolate mofetil (MMF) plus standard-dose CNI regimen after kidney transplantation (KT). MATERIALS AND METHODS: We searched for RCTs comparing the outcomes of EVR plus low-dose CNI and MMF plus standard-dose CNI regimen after KT and identified eligible RCTs according to strict inclusion and exclusion criteria...
January 2, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29255058/dynamic-prognostic-score-to-predict-kidney-allograft-survival-in-patients-with-antibody-mediated-rejection
#5
Denis Viglietti, Alexandre Loupy, Olivier Aubert, Oriol Bestard, Jean-Paul Duong Van Huyen, Jean-Luc Taupin, Denis Glotz, Christophe Legendre, Xavier Jouven, Michel Delahousse, Nassim Kamar, Carmen Lefaucheur
No tool is available for the early assessment of response to antibody-mediated rejection (ABMR) therapies in kidney allograft recipients. This study was designed to define a dynamic composite prognostic ABMR score to predict kidney allograft survival, integrating the disease characteristics at diagnosis and the response to treatment. Among 1978 kidney recipients who underwent transplant between 2008 and 2014, we included 278 patients diagnosed with active ABMR and receiving standard treatment, including plasma exchange, intravenous Ig, and rituximab...
December 18, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29246419/hla-epitope-matching-in-kidney-transplantation-an-overview-for-the-general-nephrologist
#6
REVIEW
Matthew Sypek, Joshua Kausman, Steve Holt, Peter Hughes
Rapid changes in tissue-typing technology, including the widespread availability of highly specific molecular typing methods and solid-phase assays for the detection of allele-specific anti-HLA antibodies, make it increasingly challenging to remain up to date with developments in organ matching. Terms such as epitopes and eplets abound in the transplantation literature, but often it can be difficult to see what they might mean for the patient awaiting transplantation. In this review, we provide the historical context for current practice in tissue typing and explore the potential role of HLA epitopes in kidney transplantation...
December 12, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29217537/characteristics-and-performance-of-unilateral-kidney-transplants-from-deceased-donors
#7
Syed Ali Husain, Mariana C Chiles, Samnang Lee, Stephen O Pastan, Rachel E Patzer, Bekir Tanriover, Lloyd E Ratner, Sumit Mohan
BACKGROUND AND OBJECTIVES: The fraction of kidneys procured for transplant that are discarded is rising in the United States. Identifying donors from whom only one kidney was discarded allows us to control for donor traits and better assess reasons for organ discard. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a retrospective cohort study using United Network for Organ Sharing Standard Transplant Analysis and Research file data to identify deceased donors from whom two kidneys were procured and at least one was transplanted...
December 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28925596/a-kidney-offer-acceptance-decision-tool-to-inform-the-decision-to-accept-an-offer-or-wait-for-a-better-kidney
#8
Andrew Wey, Nicholas Salkowski, Walter K Kremers, Cory R Schaffhausen, Bertram L Kasiske, Ajay K Israni, Jon J Snyder
We developed a kidney offer acceptance decision tool to predict the probability of graft survival and patient survival for first-time kidney-alone candidates after an offer is accepted or declined, and we characterized the effect of restricting the donor pool with a maximum acceptable kidney donor profile index (KDPI). For accepted offers, Cox proportional hazards models estimated these probabilities using transplanted kidneys. For declined offers, these probabilities were estimated by considering the experience of similar candidates who declined offers and the probability that declining would lead to these outcomes...
September 19, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29166338/use-of-organs-from-hepatitis-c-virus-positive-donors-for-uninfected-recipients-a-potential-cost-effective-approach-to-save-lives
#9
Patrick B Trotter, Dominic M Summers, Ines Ushiro-Lumb, Matthew Robb, J Andrew Bradley, James Powell, Christopher J E Watson, James Neuberger
BACKGROUND: Organs from hepatitis C virus (HCV) seropositive (HCVpos) individuals are seldom used for transplantation because of the risk of disease transmission. Because transmitted HCV is now amenable to effective treatment we estimated the potential impact of using HCVpos deceased donor organs for transplantation. METHODS: The Potential Donor Audit (PDA) of patients (<80years) dying in UK critical care units and the UK Transplant Registry (UKTR) was searched to identify HCVpos potential and proceeding deceased donors...
November 22, 2017: Transplantation
https://www.readbyqxmd.com/read/28886219/comparison-of-outcomes-of-kidney-transplantation-from-donation-after-brain-death-donation-after-circulatory-death-and-donation-after-brain-death-followed-by-circulatory-death-donors
#10
Guodong Chen, Chang Wang, Dicken Shiu-Chung Ko, Jiang Qiu, Xiaopeng Yuan, Ming Han, Changxi Wang, Xiaoshun He, Lizhong Chen
BACKGROUND: There are three categories of deceased donors of kidney transplantation in China, donation after brain death (DBD), donation after circulatory death (DCD), and donation after brain death followed by circulatory death (DBCD) donors. The aim of this study was to compare the outcomes of kidney transplantation from these three categories of deceased donors. METHODS: We retrospectively reviewed 469 recipients who received deceased kidney transplantation in our hospital from February 2007 to June 2015...
November 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29169514/serum-uric-acid-levels-and-kidney-transplant-outcomes-cause-consequence-or-confounded
#11
EDITORIAL
S Joseph Kim
No abstract text is available yet for this article.
December 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29145879/allogeneic-mesenchymal-stem-cell-as-induction-therapy-to-prevent-both-delayed-graft-function-and-acute-rejection-in-deceased-donor-renal-transplantation-study-protocol-for-a-randomized-controlled-trial
#12
Qipeng Sun, Liangqing Hong, Zhengyu Huang, Ning Na, Xuefeng Hua, Yanwen Peng, Ming Zhao, Ronghua Cao, Qiquan Sun
BACKGROUND: Using kidneys from deceased donors is an available strategy to meet the growing need of grafts. However, higher incidences of delayed graft function (DGF) and acute rejection exert adverse effects on graft outcomes. Since ischemia-reperfusion injury (IRI) and ongoing process of immune response to grafts are the major causes of DGF and acute rejection, the optimal induction intervention should possess capacities of both repairing renal structure injury and suppressing immune response simultaneously...
November 16, 2017: Trials
https://www.readbyqxmd.com/read/29135859/developing-a-risk-score-to-predict-long-term-adverse-outcomes-after-kidney-transplantation
#13
Shi-Yu Wang, Fu-Shan Xue, Gui-Zhen Yang
No abstract text is available yet for this article.
November 10, 2017: Transplantation
https://www.readbyqxmd.com/read/29030886/genetics-of-acute-rejection-after-kidney-transplantation
#14
REVIEW
Casey R Dorr, William S Oetting, Pamala A Jacobson, Ajay K Israni
Treatment of acute rejection (AR) following kidney transplantation has improved in recent years, but there are still limitations to successful outcomes. This review article covers literature in regard to recipient and donor genetics of AR kidney and secondarily of liver allografts. Many candidate gene and some genome-wide association studies (GWASs) have been conducted for AR in kidney transplantation. Genetic associations with AR in kidney and liver are mostly weak, and in most cases, the associations have not been reproducible...
October 14, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28967964/effects-of-recurrent-urinary-tract-infections-on-graft-and-patient-outcomes-after-kidney-transplantation
#15
Nicholas S Britt, Jennifer C Hagopian, Daniel C Brennan, April A Pottebaum, Carlos A Q Santos, Ara Gharabagi, Timothy A Horwedel
Background: Urinary tract infections (UTIs) are common following kidney transplantation (KT); however, the influence of recurrent post-KT UTI (R-UTI) is not well-characterized. Methods: We compared graft outcomes, patient outcomes and multidrug-resistance rates between patients with no UTI, nonrecurrent UTI (NR-UTI) (urine sample containing >105 bacterial colony-forming units/mL) and R-UTI (≥2 UTIs in any 6-month period or ≥3 UTIs in any 12-month period) post-KT in a retrospective cohort study (1999-2014) at Barnes-Jewish Hospital (St Louis, MO)...
October 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28960938/acute-allograft-dysfunction-with-abnormal-ultrasound-findings-in-a-renal-transplant-recipient
#16
EDITORIAL
Carrie A Carson, Aisling E Courtney, Jennifer A McCaughan
No abstract text is available yet for this article.
October 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28960455/nontraditional-sites-for-vascular-anastomoses-to-enable-kidney-transplantation-in-patients-with-major-systemic-venous-thromboses
#17
Bonnie E Lonze, Nabil N Dagher, Nada Alachkar, Annette M Jackson, Robert A Montgomery
Successful renal transplantation requires low-pressure venous drainage to permit adequate outflow from the allograft. We report here a series of three patients in whom the inferior vena cava as well as bilateral iliac veins were thrombosed, making it necessary to explore less traditional vessels for venous drainage of the renal allograft. We utilized the splanchnic vasculature in two cases and the native left renal vein in another. The resulting atypical intra-abdominal locations of these allografts also presented difficulties for arterial anastomoses and for urinary drainage...
December 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28938312/long-cold-ischemia-times-in-same-hospital-deceased-donor-transplants
#18
Eric Kh Chow, Sandra DiBrito, Xun Luo, Corey Wickliffe, Allan B Massie, Jayme E Locke, Sommer E Gentry, Jacqueline Garonzik-Wang, Dorry L Segev
BACKGROUND: Recent changes in deceased donor organ allocation for livers (Share-35) and kidneys (KAS) have resulted in broader sharing of organs and increased cold ischemia time (CIT). Broader organ sharing however is not the only cause of increased CIT. METHODS: This was a retrospective registry study of CIT in same-hospital liver transplants (SHLT, n=4,347) and kidney transplants (SHKT, n=9,707) between 2004 and 2014. RESULTS: In SHLT, median (IQR) CIT was 5...
September 20, 2017: Transplantation
https://www.readbyqxmd.com/read/28905454/management-considerations-in-the-failing-renal-allograft
#19
REVIEW
Tom Lea-Henry, Bobby Chacko
Patients with a failed or failing renal transplant are increasing in number. Graft failure resulting in dialysis re-initiation is not uncommon, yet there are limited data to guide management of these patients. Physician practices vary regarding timing of dialysis initiation and the timing and extent of immunosuppression withdrawal. The risks of immunosuppression withdrawal need to be carefully balanced against the benefits of continuing low-dose therapy. The latter helps minimise the risk of sensitisation and has been proposed to possibly slow the loss of residual renal function; however, the use of common immunosuppressive agents may contribute to cardiovascular disease, malignancy, and infection, the major causes of death following the loss of a renal transplant...
September 14, 2017: Nephrology
https://www.readbyqxmd.com/read/28882367/defining-the-phenotype-of-antibody-mediated-rejection-in-kidney-transplantation-advances-in-diagnosis-of-antibody-injury
#20
REVIEW
Neetika Garg, Milagros D Samaniego, Dana Clark, Arjang Djamali
The diagnostic criteria for antibody-mediated rejection (ABMR) are constantly evolving in light of the evidence. Inclusion of C4d-negative ABMR has been one of the major advances in the Banff Classification in recent years. Currently Banff 2015 classification requires evidence of donor specific antibodies (DSA), interaction between DSA and the endothelium, and acute tissue injury (in the form of microvasculature injury (MVI); acute thrombotic microangiopathy; or acute tubular injury in the absence of other apparent cause)...
October 2017: Transplantation Reviews
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