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AKI

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268 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/28239173/acute-kidney-disease-and-renal-recovery-consensus-report-of-the-acute-disease-quality-initiative-adqi-16-workgroup
#1
REVIEW
Lakhmir S Chawla, Rinaldo Bellomo, Azra Bihorac, Stuart L Goldstein, Edward D Siew, Sean M Bagshaw, David Bittleman, Dinna Cruz, Zoltan Endre, Robert L Fitzgerald, Lui Forni, Sandra L Kane-Gill, Eric Hoste, Jay Koyner, Kathleen D Liu, Etienne Macedo, Ravindra Mehta, Patrick Murray, Mitra Nadim, Marlies Ostermann, Paul M Palevsky, Neesh Pannu, Mitchell Rosner, Ron Wald, Alexander Zarbock, Claudio Ronco, John A Kellum
Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice. The KDIGO guideline defines AKI as an abrupt decrease in kidney function occurring over 7 days or less, whereas CKD is defined by the persistence of kidney disease for a period of >90 days. AKI and CKD are increasingly recognized as related entities and in some instances probably represent a continuum of the disease process...
April 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28167845/acute-kidney-injury-diagnostic-approaches-and-controversies
#2
REVIEW
Konstantinos Makris, Loukia Spanou
Acute kidney injury (AKI) is a significant independent risk factor for morbidity and mortality. In the last ten years a large number of publications have highlighted the limitations of traditional approaches and the inadequacies of conventional biomarkers to diagnose and monitor renal insufficiency in the acute setting. A great effort was directed not only to the discovery and validation of new biomarkers aimed to detect AKI more accurately but also to standardise the definition of AKI. Despite the advances in both areas, biomarkers have not yet entered into routine clinical practice and the definition of this syndrome has many areas of uncertainty...
December 2016: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/28138736/the-intensive-care-medicine-agenda-on-acute-kidney-injury
#3
REVIEW
Peter Pickkers, Marlies Ostermann, Michael Joannidis, Alexander Zarbock, Eric Hoste, Rinaldo Bellomo, John Prowle, Michael Darmon, Joseph V Bonventre, Lui Forni, Sean M Bagshaw, Miet Schetz
Acute kidney injury (AKI) is a common complication in the critically ill. Current standard of care mainly relies on identification of patients at risk, haemodynamic optimization, avoidance of nephrotoxicity and the use of renal replacement therapy (RRT) in established AKI. The detection of early biomarkers of renal tissue damage is a recent development that allows amending the late and insensitive diagnosis with current AKI criteria. Increasing evidence suggests that the consequences of an episode of AKI extend long beyond the acute hospitalization...
January 30, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28120015/-acute-kidney-injury-often-overlooked-and-still-fatal
#4
EDITORIAL
A Zarbock
No abstract text is available yet for this article.
February 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28130688/akipredictor-an-online-prognostic-calculator-for-acute-kidney-injury-in-adult-critically-ill-patients-development-validation-and-comparison-to-serum-neutrophil-gelatinase-associated-lipocalin
#5
Marine Flechet, Fabian Güiza, Miet Schetz, Pieter Wouters, Ilse Vanhorebeek, Inge Derese, Jan Gunst, Isabel Spriet, Michaël Casaer, Greet Van den Berghe, Geert Meyfroidt
PURPOSE: Early diagnosis of acute kidney injury (AKI) remains a major challenge. We developed and validated AKI prediction models in adult ICU patients and made these models available via an online prognostic calculator. We compared predictive performance against serum neutrophil gelatinase-associated lipocalin (NGAL) levels at ICU admission. METHODS: Analysis of the large multicenter EPaNIC database. Model development (n = 2123) and validation (n = 2367) were based on clinical information available (1) before and (2) upon ICU admission, (3) after 1 day in ICU and (4) including additional monitoring data from the first 24 h...
January 27, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28119408/a-decision-making-algorithm-for-initiation-and-discontinuation-of-rrt-in-severe-aki
#6
Mallika L Mendu, George R Ciociolo, Sarah R McLaughlin, Dionne A Graham, Roya Ghazinouri, Siddharth Parmar, Alissa Grossier, Rebecca Rosen, Karl R Laskowski, Leonardo V Riella, Emily S Robinson, David M Charytan, Joseph V Bonventre, Jeffrey O Greenberg, Sushrut S Waikar
BACKGROUND AND OBJECTIVES: AKI is an increasingly common and devastating complication in hospitalized patients. Severe AKI requiring RRT is associated with in-hospital mortality rates exceeding 40%. Clinical decision making related to RRT initiation for patients with AKI in the medical intensive care unit is not standardized. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a 13-month (November of 2013 to December of 2014) prospective cohort study in an academic medical intensive care unit involving the implementation of an AKI Standardized Clinical Assessment and Management Plan, a decision-making algorithm to assist front-line clinicians caring for patients with AKI...
February 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28095822/hyperuricemia-increases-the-risk-of-acute-kidney-injury-a-systematic-review-and-meta-analysis
#7
Xialian Xu, Jiachang Hu, Nana Song, Rongyi Chen, Ting Zhang, Xiaoqiang Ding
BACKGROUND: Mounting evidence indicated that the elevated serum uric acid level was associated with an increased risk of acute kidney injury (AKI). Our goal was to systematically evaluate the correlation of serum uric acid (SUA) level and incidence of AKI by longitudinal cohort studies. METHODS: We searched electronic databases and the reference lists of relevant articles. 18 cohort studies with 75,200 patients were analyzed in this random-effect meta-analysis. Hyperuricemia was defined as SUA levels greater than 360-420 μmol/L (6-7 mg/dl), which was various according to different studies...
January 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28049623/acute-kidney-injury-culprits-cures-and-consequences
#8
EDITORIAL
Richard Solomon, Harold L Dauerman
No abstract text is available yet for this article.
January 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27990707/acute-kidney-injury-and-mortality-prognosis-in-acute-coronary-syndrome-patients-a-meta-analysis
#9
John W Pickering, Isabella Rh Blunt, Martin P Than
AIM: To provide a robust estimates of mortality risk in acute coronary syndrome (ACS) associated acute kidney injury (AKI) to inform clinical practice and policy. METHODS: A meta-analysis of cohort studies evaluating outcomes of ACS and which reported AKI and AKI associated mortality. Studies were excluded if they incorporated patients not admitted through the emergency department (i.e. for elective procedures), were limited to cardiogenic shock or cardiac arrest, or relied on registry data for outcomes without further adjudication...
December 19, 2016: Nephrology
https://www.readbyqxmd.com/read/27561544/latent-aki-is%C3%A2-still-aki-the-quantification-of-the-burden-of-renal-dysfunction
#10
Zaccaria Ricci, Stefano Romagnoli, Luca Di Chiara
The association between pediatric cardiac surgery, acute kidney injury (AKI), and clinical outcomes has been studied several times in the recent literature. In this issue of Critical Care an interesting and original study analyzed the path from causal AKI entities to clinical AKI consequences through the application of structural equation modeling. The authors described the complex connections linking duration of cardiopulmonary bypass, cross clamp-time, and descriptors of low cardiac output syndrome to AKI modeled as a complex variable composed of post-operative serum creatinine increase of 50 % over baseline, urine output <0...
August 26, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27622526/international-criteria-for-acute-kidney-injury-advantages-and-remaining-challenges
#11
Nicholas M Selby, Richard J Fluck, Nitin V Kolhe, Maarten W Taal
Nicholas Selby and colleagues describe how the definition of acute kidney injury brings opportunities and challenges in identifying patients at higher risk of adverse outcomes.
September 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27599630/end-points-for-clinical-trials-in-acute-kidney-injury
#12
David E Leaf, Sushrut S Waikar
Acute kidney injury (AKI) is an increasingly common and feared complication in hospitalized patients. The selection of appropriate primary and secondary end points is critical to the design and eventual success of clinical trials aimed at preventing and treating AKI. In this article, we provide an overview of AKI definitions and suggestions on the rational selection of end points for clinical trials in various settings, including the prevention of contrast-induced AKI, prevention of cardiac surgery-associated AKI, treatment of established AKI, and treatment of dialysis-requiring AKI...
January 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27555107/intermediate-and-long-term-outcomes-of-survivors-of-acute-kidney-injury-episodes-a-large-population-based-cohort-study
#13
Simon Sawhney, Angharad Marks, Nick Fluck, Adeera Levin, Gordon Prescott, Corri Black
BACKGROUND: The long-term prognosis after acute kidney injury (AKI) is variable. It is unclear how the prognosis of AKI and its relationship to prognostic factors (baseline kidney function, AKI severity, prior AKI episodes, and recovery of kidney function) change as follow-up progresses. STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: The Grampian Laboratory Outcomes Morbidity and Mortality Study II (GLOMMS-II) is a large regional population cohort with complete serial biochemistry and outcome data capture through data linkage...
January 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27495094/early-postoperative-albumin-level-following-total-knee-arthroplasty-is-associated-with-acute-kidney-injury-a-retrospective-analysis-of-1309-consecutive-patients-based-on-kidney-disease-improving-global-outcomes-criteria
#14
Ha-Jung Kim, Won-Uk Koh, Sae-Gyeol Kim, Hyeok-Seong Park, Jun-Gol Song, Young-Jin Ro, Hong-Seuk Yang
Hypoalbuminemia has been reported to be an independent risk factor for acute kidney injury (AKI). However, little is known about the relationship between the albumin level and the incidence of AKI in patients undergoing total knee arthroplasty (TKA). The aim of our study was to assess incidence and risk factors for AKI and to evaluate the relationship between albumin level and AKI following TKA.The study included a retrospective review of medical records of 1309 consecutive patients who underwent TKA between January 2008 and December 2014...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27455063/serum-creatinine-trajectories-for-community-versus-hospital-acquired-acute-kidney-injury
#15
David G Warnock, T Clark Powell, Edward D Siew, John P Donnelly, Henry E Wang, Ravindra L Mehta
BACKGROUND: Patterns of acute kidney injury (AKI) can be distinguished by the rate of changes in the serum creation concentrations during hospitalizations. We hypothesized that the timing and values of minimum and maximum serum creatinine (sCr) could be used to distinguish between transient hospital-associated AKI (THA-AKI) and hospital-acquired AKI (HA-AKI). MATERIALS AND METHODS: We evaluated adults admitted to 2 regionally distinct academic medical centers. Peak sCr during the hospitalization was used to define AKI, using absolute changes and timing from the minimum sCr...
2016: Nephron
https://www.readbyqxmd.com/read/27466238/hundred-top-cited-articles-focusing-on-acute-kidney-injury-a-bibliometric-analysis
#16
Yuan-Hui Liu, Sheng-Qi Wang, Jin-Hua Xue, Yong Liu, Ji-Yan Chen, Guo-Feng Li, Peng-Cheng He, Ning Tan
BACKGROUND: Acute kidney injury (AKI) is a major global health issue, associated with poor short-term and long-term outcomes. Research on AKI is increasing with numerous articles published. However, the quantity and quality of research production in the field of AKI is unclear. METHODS AND ANALYSIS: To analyse the characteristics of the most cited articles on AKI and to provide information about achievements and developments in AKI, we searched the Science Citation Index Expanded for citations of AKI articles...
July 27, 2016: BMJ Open
https://www.readbyqxmd.com/read/27472700/outcome-in-noncritically-ill-patients-with-acute-kidney-injury-requiring-dialysis-effects-of-differing-medical-staffs-and-organizations
#17
Riccardo Maria Fagugli, Francesco Patera, Sara Battistoni, Giovanni Tripepi
Acute kidney injury requiring dialysis (AKI-D) treatment has significantly increased in incidence over the years, with more than 400 new cases per million population/y, 2/3 of which concern noncritically ill patients. In these patients, there are little data on mortality or on information of care organization and its impact on outcome. Specialty training and integrated teams, as well as a high volume of activity, seem to be linked to better hospital outcome. The study investigates mortality of patients admitted to and in-care of nephrology (NEPHROpts), a closed-staff organization, and to other medical wards (MEDpts), representing a model of open-staff organization...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27461745/the-pressing-need-for-real-time-risk-assessment-of-hospital-acquired-acute-kidney-injury
#18
REVIEW
David G Warnock
Acute Kidney Injury (AKI) is associated with short- and long-term outcomes that reflect the severity of the injury. Recent studies have suggested that 'early' initiation of renal replacement therapy may alter the course of AKI and improve short-term outcomes like inpatient mortality. The current Kidney Disease Improving Global Outcomes (KDIGO) consensus definition of AKI has been criticized for misclassification bias, lack of sensitivity and the static manner in which AKI stages are defined. This editorial reviews various approaches to improving the specificity and sensitivity of the KDIGO AKI criteria, and also concludes that a staging system based on creatinine trajectories would be better suited for developing a prognostic index for real-time, dynamic risk assessment that the current KDIGO staging criteria...
July 26, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27443673/daily-urinary-creatinine-predicts-the-weaning-of-renal-replacement-therapy-in-icu-acute-kidney-injury-patients
#19
Nicolas Viallet, Vincent Brunot, Nils Kuster, Delphine Daubin, Noémie Besnard, Laura Platon, Aurèle Buzançais, Romaric Larcher, Olivier Jonquet, Kada Klouche
BACKGROUND: In acute kidney injury (AKI), useless continuation of renal replacement therapy (RRT) may delay renal recovery and impair patient's outcome. In this study, we aimed to identify predictive parameters that may help to a successful RRT weaning for AKI patients. METHODS: We studied 54 surviving AKI patients in which a weaning of RRT was attempted. On the day of weaning (D0) and the following 2 days (D1 and D2), SAPS II and SOFA scores, 24-h diuresis, 24-h urinary creatinine and urea (UCr and UUr), creatinine and urea generation rates (CrGR and UrGR) and clearances (CrCl and UrCl) were collected...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27387426/urinary-retinol-binding-protein-as-a-risk-factor-of-poor-prognosis-in-acute-on-chronic-renal-injury
#20
Yanhong Yuan, Chunlin Wang, Xinghua Shao, Qin Wang, Xiajing Che, Minfang Zhang, Yuanyuan Xie, Lei Tian, Zhaohui Ni, Shan Mou
BACKGROUND: Acute-on-chronic renal injury was commonly seen in clinical practice. Reversibility of acute-on-chronic renal injury had not yet been carefully explored. This study tested whether urinary biomarkers could be used as a noninvasive prognostic marker in patients with acute-on-chronic renal injury. METHODS: 108 adult patients with pre-existing chronic kidney disease presenting with acute-on-chronic renal injury were included. Urinary retinol-binding protein (uRBP), N-Acetyl-b-D-Glucosaminidase (uNAG) and albumin (uALB) was quantified...
December 2016: Journal of Nephrology
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