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Statistics and Nephrology

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283 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/29324582/quality-measures-in-acute-kidney-injury
#1
Amjad Mehboob, Robert Zimmerman, Stuart Abramson, Mark G Parker
PURPOSE OF REVIEW: Quality measure assessment and reporting is evolving in end-stage renal disease care and is inchoate in ambulatory nephrology clinic care. Acute kidney injury (AKI) quality measures have not received sufficient attention, yet deserve consideration in view of the substantial proportion of effort nephrology providers devote to AKI care. RECENT FINDINGS: Accumulating literature permits consideration of timing of nephrology consultation, follow-up after AKI hospitalization, early detection, medication dosing, hospital readmissions and length of stay, cost, and mortality as putative AKI quality measures...
January 10, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29289476/perspectives-on-research-participation-and-facilitation-among-dialysis-patients-clinic-personnel-and-medical-providers-a-focus-group-study
#2
Jennifer E Flythe, Julia H Narendra, Adeline Dorough, Jonathan Oberlander, Antoinette Ordish, Caroline Wilkie, Laura M Dember
BACKGROUND: Most prospective studies involving individuals receiving maintenance dialysis have been small, and many have had poor clinical translatability. Research relevance can be enhanced through stakeholder engagement. However, little is known about dialysis clinic stakeholders' perceptions of research participation and facilitation. The objective of this study was to characterize the perspectives of dialysis clinic stakeholders (patients, clinic personnel, and medical providers) on: (1) research participation by patients and (2) research facilitation by clinic personnel and medical providers...
December 19, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29260229/guidelines-for-the-content-of-statistical-analysis-plans-in-clinical-trials
#3
Carrol Gamble, Ashma Krishan, Deborah Stocken, Steff Lewis, Edmund Juszczak, Caroline Doré, Paula R Williamson, Douglas G Altman, Alan Montgomery, Pilar Lim, Jesse Berlin, Stephen Senn, Simon Day, Yolanda Barbachano, Elizabeth Loder
Importance: While guidance on statistical principles for clinical trials exists, there is an absence of guidance covering the required content of statistical analysis plans (SAPs) to support transparency and reproducibility. Objective: To develop recommendations for a minimum set of items that should be addressed in SAPs for clinical trials, developed with input from statisticians, previous guideline authors, journal editors, regulators, and funders. Design: Funders and regulators (n = 39) of randomized trials were contacted and the literature was searched to identify existing guidance; a survey of current practice was conducted across the network of UK Clinical Research Collaboration-registered trial units (n = 46, 1 unit had 2 responders) and a Delphi survey (n = 73 invited participants) was conducted to establish consensus on SAPs...
December 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29253223/big-data-in-nephrology-a-time-to-rethink
#4
Rajiv Agarwal, Arjun D Sinha
No abstract text is available yet for this article.
December 14, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29256405/public-availability-of-trial-protocols
#5
Morgan Lucey, Jocalyn Clark, Paul Glasziou
No abstract text is available yet for this article.
December 16, 2017: Lancet
https://www.readbyqxmd.com/read/29225906/patient-engagement-in-kidney-research-opportunities-and-challenges-ahead
#6
REVIEW
Amber O Molnar, Moumita Barua, Ana Konvalinka, Kara Schick-Makaroff
Purpose of Review: Patient engagement in research is increasingly recognized as an important component of the research process and may facilitate translation of research findings. To heighten awareness on this important topic, this review presents opportunities and challenges of patient engagement in research, drawing on specific examples from 4 areas of Canadian kidney research conducted by New Investigators in the Kidney Research Scientist Core Education and National Training (KRESCENT) Program...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29205452/an-r2-curve-for-evaluating-the-accuracy-of-dynamic-predictions
#7
Marie-Cécile Fournier, Etienne Dantan, Paul Blanche
In the context of chronic diseases, patient's health evolution is often evaluated through the study of longitudinal markers and major clinical events such as relapses or death. Dynamic predictions of such types of events may be useful to improve patients management all along their follow-up. Dynamic predictions consist of predictions that are based on information repeatedly collected over time, such as measurements of a biomarker, and that can be updated as soon as new information becomes available. Several techniques to derive dynamic predictions have already been suggested, and computation of dynamic predictions is becoming increasingly popular...
December 4, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29070032/collaborative-partnership-and-the-social-value-of-clinical-research-a-qualitative-secondary-analysis
#8
Sanna-Maria Nurmi, Arja Halkoaho, Mari Kangasniemi, Anna-Maija Pietilä
BACKGROUND: Protecting human subjects from being exploited is one of the main ethical challenges for clinical research. However, there is also a responsibility to protect and respect the communities who are hosting the research. Recently, attention has focused on the most efficient way of carrying out clinical research, so that it benefits society by providing valuable research while simultaneously protecting and respecting the human subjects and the communities where the research is conducted...
October 25, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/29157119/biomarker-combinations-for-diagnosis-and-prognosis-in-multicenter-studies-principles-and-methods
#9
Allison Meisner, Chirag R Parikh, Kathleen F Kerr
Many investigators are interested in combining biomarkers to predict a binary outcome or detect underlying disease. This endeavor is complicated by the fact that many biomarker studies involve data from multiple centers. Depending upon the relationship between center, the biomarkers, and the target of prediction, care must be taken when constructing and evaluating combinations of biomarkers. We introduce a taxonomy to describe the role of center and consider how a biomarker combination should be constructed and evaluated...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29153136/randomized-controlled-trials-significant-results-fragile-though
#10
Tri-Long Nguyen, Paul Landais
In their systematic review, Shochet et al. question the robustness of the statistical significance of the results of randomized controlled trials (RCTs) in nephrology reported in high-impact journals (2005-2014). They hypothesized that a high proportion of RCTs in nephrology would be fragile. They calculated a Fragility Index that is a tool for testing robustness of RCTs, based on 107 RCT reports. The observation of an alarming median Fragility Index equal to 3 suggests that in half of the trials, the sole additional occurrence of 3 events would compromise the significance of nominally significant results...
December 2017: Kidney International
https://www.readbyqxmd.com/read/28957311/ten-simple-rules-for-structuring-papers
#11
EDITORIAL
Brett Mensh, Konrad Kording
No abstract text is available yet for this article.
September 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/24626938/writing-scientific-articles-like-a-native-english-speaker-top-ten-tips-for-portuguese-speakers
#12
EDITORIAL
Mariel A Marlow
No abstract text is available yet for this article.
March 2014: Clinics
https://www.readbyqxmd.com/read/29126280/composing-a-new-song-for-trials-the-standardized-outcomes-in-nephrology-song-initiative
#13
Allison Tong, Jonathan C Craig, Evi V Nagler, Wim Van Biesen
No abstract text is available yet for this article.
November 3, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28104076/comparison-of-propensity-score-methods-and-covariate-adjustment-evaluation-in-4-cardiovascular-studies
#14
REVIEW
Markus C Elze, John Gregson, Usman Baber, Elizabeth Williamson, Samantha Sartori, Roxana Mehran, Melissa Nichols, Gregg W Stone, Stuart J Pocock
Propensity scores (PS) are an increasingly popular method to adjust for confounding in observational studies. Propensity score methods have theoretical advantages over conventional covariate adjustment, but their relative performance in real-word scenarios is poorly characterized. We used datasets from 4 large-scale cardiovascular observational studies (PROMETHEUS, ADAPT-DES [the Assessment of Dual AntiPlatelet Therapy with Drug-Eluting Stents], THIN [The Health Improvement Network], and CHARM [Candesartan in Heart Failure-Assessment of Reduction in Mortality and Morbidity]) to compare the performance of conventional covariate adjustment with 4 common PS methods: matching, stratification, inverse probability weighting, and use of PS as a covariate...
January 24, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29059685/rethinking-rates-of-undiagnosed-diabetes-the-value-of-a-confirmatory-test
#15
COMMENT
Anne L Peters
No abstract text is available yet for this article.
December 5, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29059688/when-clinical-practice-guidelines-collide-finding-a-way-forward
#16
Sheldon Greenfield, Sherrie H Kaplan
No abstract text is available yet for this article.
November 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29030992/inadequate-safety-reporting-in-pre-eclampsia-trials-a-systematic-evaluation
#17
James M N Duffy, Martin Hirsch, Louise Pealing, Marian Showell, Khalid S Khan, Sue Ziebland, Richard J McManus
BACKGROUND: Randomised trials and their syntheses in meta-analyses offer a unique opportunity to assess the frequency and severity of adverse reactions. OBJECTIVE: To assess safety reporting in pre-eclampsia trials. SEARCH STRATEGY: Systematic search using bibliographic databases, including Cochrane Central Register of Controlled Trials, Embase, and MEDLINE, from inception to August 2017. SELECTION CRITERIA: Randomised trials evaluating anticonvulsant or antihypertensive medication for pre-eclampsia...
October 14, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29024071/an-unjustified-benefit-immortal-time-bias-in-the-analysis-of-time-dependent-events
#18
REVIEW
Andreas Gleiss, Rainer Oberbauer, Georg Heinze
Immortal time bias is a problem arising from methodologically wrong analyses of time-dependent events in survival analyses. We illustrate the problem by analysis of a kidney transplantation study. Following patients from transplantation to death, groups defined by the occurrence or nonoccurrence of graft failure during follow-up seemingly had equal overall mortality. Such naive analysis assumes that patients were assigned to the two groups at time of transplantation, which actually are a consequence of occurrence of a time-dependent event later during follow-up...
October 11, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28992275/cautionary-note-propensity-score-matching-does-not-account-for-bias-due-to-censoring
#19
Bas B L Penning de Vries, Rolf H H Groenwold
This article gives a review of the limitations of propensity score matching as a tool for confounding control in the presence of censoring. Using an illustrative simulation study, we emphasize the importance of explicit adjustment for selective loss to follow-up and explain how this may be achieved.
July 8, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28864689/stepped-wedge-cluster-randomised-controlled-trial-to-assess-the-cardiovascular-health-effects-of-a-managed-aquifer-recharge-initiative-to-reduce-drinking-water-salinity-in-southwest-coastal-bangladesh-study-design-and-rationale
#20
Abu Mohd Naser, Leanne Unicomb, Solaiman Doza, Kazi Matin Ahmed, Mahbubur Rahman, Mohammad Nasir Uddin, Shamshad B Quraishi, Shahjada Selim, Mohammad Shamsudduha, William Burgess, Howard H Chang, Matthew O Gribble, Thomas F Clasen, Stephen P Luby
INTRODUCTION: Saltwater intrusion and salinisation have contributed to drinking water scarcity in many coastal regions globally, leading to dependence on alternative sources for water supply. In southwest coastal Bangladesh, communities have few options but to drink brackish groundwater which has been associated with high blood pressure among the adult population, and pre-eclampsia and gestational hypertension among pregnant women. Managed aquifer recharge (MAR), the purposeful recharge of surface water or rainwater to aquifers to bring hydrological equilibrium, is a potential solution for salinity problem in southwest coastal Bangladesh by creating a freshwater lens within the brackish aquifer...
September 1, 2017: BMJ Open
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