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Statistics and Nephrology

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295 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Surendra Shenoy, Michael Allon, Gerald Beathard, Deborah Brouwer-Maier, Laura M Dember, Mark Glickman, Celeste Lee, Terry Litchfield, Charmaine Lok, Thomas Huber, Prabir Roy-Chaudhury, Jack Work, Melissa West, Haimanot Wasse
No abstract text is available yet for this article.
March 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Bénédicte Sautenet, Allison Tong, Gabrielle Williams, Brenda R Hemmelgarn, Braden Manns, David C Wheeler, Peter Tugwell, Wim van Biesen, Wolfgang C Winkelmayer, Sally Crowe, Tess Harris, Nicole Evangelidis, Carmel M Hawley, Carol Pollock, David W Johnson, Kevan R Polkinghorne, Kirsten Howard, Martin P Gallagher, Peter G Kerr, Stephen P McDonald, Angela Ju, Jonathan C Craig
BACKGROUND: Clinical trials are most informative for evidence-based decision making when they consistently measure and report outcomes of relevance to stakeholders. We aimed to assess the scope and consistency of outcomes reported in trials for hemodialysis. STUDY DESIGN: Systematic review. SETTING & POPULATION: Adults requiring maintenance hemodialysis enrolled in clinical trials. SELECTION CRITERIA: All Cochrane systematic reviews of interventions published by August 29, 2016, and the trials published and registered in ClinicalTrials...
February 21, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Maarten J G Leening, Michael J Pencina
No abstract text is available yet for this article.
February 13, 2018: JAMA: the Journal of the American Medical Association
Ann M O'Hare
There is growing interest in patient-centered care, defined by the Institute of Medicine as "care that is respectful of and responsive to individual patient preferences, needs, and values." Although generally accepted as uncontroversial, the notion of "centering" care on our patients is in fact quite revolutionary. Because medical teaching, research, and practice have traditionally been organized around diseases and organ systems rather than patients, making care more patient centered would require no less than a paradigm shift in how we practice medicine...
February 9, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Bo Shen, Jiarui Xu, Yimei Wang, Wuhua Jiang, Zhen Zhang, Jiawei Yu, Jianzhou Zou, Jie Teng, Xiaoqiang Ding
Acute kidney injury (AKI) is common in clinical practice and associated with increased risk for death and major morbidity. Although some meaningful clinical guidelines were published, the quality of AKI healthcare remains suboptimal. Some AKI quality improvement methods, such as guidelines-based training programs, the referral from nephrology, and electronic data system have been found to be potentially beneficial, but further validation is required. Quality measures (QMs) for structure, process, and outcome of AKI care need to be further developed, evaluated, and implemented to ensure utmost quality of AKI care...
2018: Contributions to Nephrology
Stylianos Serghiou, John P A Ioannidis
No abstract text is available yet for this article.
January 23, 2018: JAMA: the Journal of the American Medical Association
Matthew D F McInnes, David Moher, Brett D Thombs, Trevor A McGrath, Patrick M Bossuyt, Tammy Clifford, Jérémie F Cohen, Jonathan J Deeks, Constantine Gatsonis, Lotty Hooft, Harriet A Hunt, Christopher J Hyde, Daniël A Korevaar, Mariska M G Leeflang, Petra Macaskill, Johannes B Reitsma, Rachel Rodin, Anne W S Rutjes, Jean-Paul Salameh, Adrienne Stevens, Yemisi Takwoingi, Marcello Tonelli, Laura Weeks, Penny Whiting, Brian H Willis
Importance: Systematic reviews of diagnostic test accuracy synthesize data from primary diagnostic studies that have evaluated the accuracy of 1 or more index tests against a reference standard, provide estimates of test performance, allow comparisons of the accuracy of different tests, and facilitate the identification of sources of variability in test accuracy. Objective: To develop the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagnostic test accuracy guideline as a stand-alone extension of the PRISMA statement...
January 23, 2018: JAMA: the Journal of the American Medical Association
Emily Decker, Jessica Kendrick
Despite rates of CKD continuing to increase, the current evidence base used to guide CKD management is smaller than that for many other chronic diseases. Clinical investigators face multiple barriers to conducting research in patients with CKD. CKD patients have multiple comorbidities that make them a risky intervention target; thus, they are often excluded from trials. The lack of approved surrogate endpoints for kidney disease progression makes testing therapies to slow progression very challenging and expensive...
July 2014: Advances in Chronic Kidney Disease
Nandita S Mani, Emily Ginier
With the growing need to integrate best evidence to inform clinical care, systematic reviews have continued to flourish. Although this type of review is integral to the synthesis of evidence-based information, systematic reviews are often conducted omitting well-established processes that ensure the validity and replicability of the study; elements of which are integral based on standards developed by the Cochrane Collaboration and the National Academy of Medicine. This review article will share best practices associated with conducting systematic reviews on the topic of CKD using an 8-step process and an evidence-based approach to retrieving and abstracting data...
November 2016: Advances in Chronic Kidney Disease
Joyce P Samuel, Cynthia S Bell
Alternatives to the traditional parallel-group trial design may be required to answer clinical questions in special populations, rare conditions, or with limited resources. N-of-1 trials are a unique trial design which can inform personalized evidence-based decisions for the patient when data from traditional clinical trials are lacking or not generalizable. A concise overview of factorial design, cluster randomization, adaptive designs, crossover studies, and n-of-1 trials will be provided along with pertinent examples in nephrology...
November 2016: Advances in Chronic Kidney Disease
Thomas W Ferguson, Navdeep Tangri
Observational studies are common in the nephrology literature, particularly given the lack of large randomized trials. While these studies have identified important associations, potential biases, if unrecognized, can result in misinterpreted conclusions. In this review, we present an example of four potentially important biases (lead time bias, survivor bias, immortal time bias, and index event bias) that can result in inaccurate estimates of association between risk factors or treatments and outcomes. Recognition of these potential biases can help improve study design and interpretation...
November 2016: Advances in Chronic Kidney Disease
S A Theze, D M O'Sullivan, E D O'Sullivan
No abstract text is available yet for this article.
February 2018: Nephrology
Amjad Mehboob, Robert Zimmerman, Stuart Abramson, Mark G Parker
PURPOSE OF REVIEW: Quality measure assessment and reporting is evolving in end-stage renal disease care and is inchoate in ambulatory nephrology clinic care. Acute kidney injury (AKI) quality measures have not received sufficient attention, yet deserve consideration in view of the substantial proportion of effort nephrology providers devote to AKI care. RECENT FINDINGS: Accumulating literature permits consideration of timing of nephrology consultation, follow-up after AKI hospitalization, early detection, medication dosing, hospital readmissions and length of stay, cost, and mortality as potential AKI quality measures...
March 2018: Current Opinion in Nephrology and Hypertension
Jennifer E Flythe, Julia H Narendra, Adeline Dorough, Jonathan Oberlander, Antoinette Ordish, Caroline Wilkie, Laura M Dember
BACKGROUND: Most prospective studies involving individuals receiving maintenance dialysis have been small, and many have had poor clinical translatability. Research relevance can be enhanced through stakeholder engagement. However, little is known about dialysis clinic stakeholders' perceptions of research participation and facilitation. The objective of this study was to characterize the perspectives of dialysis clinic stakeholders (patients, clinic personnel, and medical providers) on: (1) research participation by patients and (2) research facilitation by clinic personnel and medical providers...
December 19, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Carrol Gamble, Ashma Krishan, Deborah Stocken, Steff Lewis, Edmund Juszczak, Caroline Doré, Paula R Williamson, Douglas G Altman, Alan Montgomery, Pilar Lim, Jesse Berlin, Stephen Senn, Simon Day, Yolanda Barbachano, Elizabeth Loder
Importance: While guidance on statistical principles for clinical trials exists, there is an absence of guidance covering the required content of statistical analysis plans (SAPs) to support transparency and reproducibility. Objective: To develop recommendations for a minimum set of items that should be addressed in SAPs for clinical trials, developed with input from statisticians, previous guideline authors, journal editors, regulators, and funders. Design: Funders and regulators (n = 39) of randomized trials were contacted and the literature was searched to identify existing guidance; a survey of current practice was conducted across the network of UK Clinical Research Collaboration-registered trial units (n = 46, 1 unit had 2 responders) and a Delphi survey (n = 73 invited participants) was conducted to establish consensus on SAPs...
December 19, 2017: JAMA: the Journal of the American Medical Association
Rajiv Agarwal, Arjun D Sinha
No abstract text is available yet for this article.
December 14, 2017: Nephrology, Dialysis, Transplantation
Morgan Lucey, Jocalyn Clark, Paul Glasziou
No abstract text is available yet for this article.
December 16, 2017: Lancet
Amber O Molnar, Moumita Barua, Ana Konvalinka, Kara Schick-Makaroff
Purpose of Review: Patient engagement in research is increasingly recognized as an important component of the research process and may facilitate translation of research findings. To heighten awareness on this important topic, this review presents opportunities and challenges of patient engagement in research, drawing on specific examples from 4 areas of Canadian kidney research conducted by New Investigators in the Kidney Research Scientist Core Education and National Training (KRESCENT) Program...
2017: Canadian Journal of Kidney Health and Disease
Marie-Cécile Fournier, Etienne Dantan, Paul Blanche
In the context of chronic diseases, patient's health evolution is often evaluated through the study of longitudinal markers and major clinical events such as relapses or death. Dynamic predictions of such types of events may be useful to improve patients management all along their follow-up. Dynamic predictions consist of predictions that are based on information repeatedly collected over time, such as measurements of a biomarker, and that can be updated as soon as new information becomes available. Several techniques to derive dynamic predictions have already been suggested, and computation of dynamic predictions is becoming increasingly popular...
March 30, 2018: Statistics in Medicine
Sanna-Maria Nurmi, Arja Halkoaho, Mari Kangasniemi, Anna-Maija Pietilä
BACKGROUND: Protecting human subjects from being exploited is one of the main ethical challenges for clinical research. However, there is also a responsibility to protect and respect the communities who are hosting the research. Recently, attention has focused on the most efficient way of carrying out clinical research, so that it benefits society by providing valuable research while simultaneously protecting and respecting the human subjects and the communities where the research is conducted...
October 25, 2017: BMC Medical Ethics
2017-11-25 08:21:16
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