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Statistics and Nephrology

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348 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/30238880/cochrane-review-methods-called-into-question
#1
Talha Burki
No abstract text is available yet for this article.
September 15, 2018: Lancet
https://www.readbyqxmd.com/read/30225865/establishing-surrogate-kidney-endpoints-for-lupus-nephritis-clinical-trials-development-and-validation-of-a-novel-approach-to-predict-future-kidney-outcomes
#2
Meggan Mackay, Maria Dall'Era, Joanna Fishbein, Kenneth Kalunian, Martin Lesser, Jorge Sanchez Guerrero, Deborah M Levy, Earl Silverman, Michelle Petri, Cristina Arriens, Edmund J Lewis, Stephen M Korbet, Fabrizio Conti, Vladimir Tesar, Zdenka Hruskova, Eduardo F Borba, Eloisa Bonfa, Tak Mao Chan, Manish Rathi, K L Gupta, Vivekanand Jha, Sarfaraz Hasni, Melissa R West, Elian Silverman, Neil Solomons, Frederic A Houssiau, Juanita Romera Diaz, Juan Mejia-Vilet, Brad H Rovin
OBJECTIVE: Endpoints currently used in lupus nephritis (LN) clinical trials lack uniformity and questionably reflect long-term kidney survival. The objective of this investigation was to identify short-term endpoints that predict long-term kidney outcomes for use in clinical trials. METHODS: A database of 944 LN patients was assembled from 3 clinical trials and 12 longitudinal cohorts. Variables from the first 12 months of treatment after diagnosis of active LN (prediction period) were assessed as potential predictors of long-term outcomes in a 36 month follow-up period...
September 17, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/30215791/merits-and-caveats-of-propensity-scores-to-adjust-for-confounding
#3
Edouard L Fu, Rolf H H Groenwold, Carmine Zoccali, Kitty J Jager, Merel van Diepen, Friedo W Dekker
Proper adjustment for confounding is essential when estimating the effects of treatments or risk factors on health outcomes in observational data. To this end, various statistical methods have been developed. In the past couple of years, the use of propensity scores (PSs) to control for confounding has increased. Proper understanding of this method is necessary to critically appraise research in which it is applied. In this article, we provide an overview of PS methods, explaining their concept, advantages and possible disadvantages...
September 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30209785/latent-class-analysis-stratifies-mortality-risk-in-patients-developing-acute-kidney-injury-after-high-risk-intraabdominal-general-surgery-a-historical-cohort-study
#4
Minjae Kim, Melanie M Wall, Ravi P Kiran, Guohua Li
PURPOSE: Risk stratification for postoperative acute kidney injury (AKI) evaluates a patient's risk for developing this complication using preoperative characteristics. Nevertheless, it is unclear if these characteristics are also associated with mortality in patients who actually develop this complication, so we aimed to determine these associations. METHODS: The 2011-15 American College of Surgeons National Surgical Quality Improvement Program was used to obtain a historical, observational cohort of high-risk intraabdominal general surgery patients with AKI, which was defined as an increase in serum creatinine > 177 µmol·L-1 (2 mg·dL-1 ) above the preoperative value and/or the need for dialysis...
September 12, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/30208404/annals-understanding-clinical-research-interpreting-results-with-large-p-values
#5
Joshua M Liao, Catharine B Stack, Steven Goodman
No abstract text is available yet for this article.
September 11, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30205392/endpoints-for-clinical-trials-of-acute-kidney-injury
#6
REVIEW
Paul M Palevsky
BACKGROUND: The selection of appropriate endpoints is critical to the success of any clinical trial. Endpoints need to be precisely defined and need to provide an appropriate balance between sensitivity for detection of the effects of the intervention of interest and specificity for the outcome of interest. SUMMARY: In acute kidney injury (AKI), the 2 most common endpoints utilized either rely on small, short-term changes in serum creatinine or are a composite of longer term major adverse kidney events, including death, need for dialysis, and a persistent decline in kidney function...
September 11, 2018: Nephron
https://www.readbyqxmd.com/read/30181639/radical-open-access-plan-could-spell-end-to-journal-subscriptions
#7
Holly Else
No abstract text is available yet for this article.
September 2018: Nature
https://www.readbyqxmd.com/read/30193302/a-randomized-clinical-trial-of-n-of-1-trials-tribulations-of-a-trial
#8
Reza D Mirza, Gordon H Guyatt
No abstract text is available yet for this article.
September 4, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/30178033/prisma-extension-for-scoping-reviews-prisma-scr-checklist-and-explanation
#9
Andrea C Tricco, Erin Lillie, Wasifa Zarin, Kelly K O'Brien, Heather Colquhoun, Danielle Levac, David Moher, Micah D J Peters, Tanya Horsley, Laura Weeks, Susanne Hempel, Elie A Akl, Christine Chang, Jessie McGowan, Lesley Stewart, Lisa Hartling, Adrian Aldcroft, Michael G Wilson, Chantelle Garritty, Simon Lewin, Christina M Godfrey, Marilyn T Macdonald, Etienne V Langlois, Karla Soares-Weiser, Jo Moriarty, Tammy Clifford, Özge Tunçalp, Sharon E Straus
Scoping reviews, a type of knowledge synthesis, follow a systematic approach to map evidence on a topic and identify main concepts, theories, sources, and knowledge gaps. Although more scoping reviews are being done, their methodological and reporting quality need improvement. This document presents the PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) checklist and explanation. The checklist was developed by a 24-member expert panel and 2 research leads following published guidance from the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) Network...
September 4, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30178036/scoping-reviews-and-systematic-reviews-is-it-an-either-or-question
#10
Stephanie Chang
No abstract text is available yet for this article.
September 4, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30156992/-transparency-as-mask-the-epa-s-proposed-rule-on-scientific-data
#11
Joel Schwartz
The Environmental Protection Agency (EPA) recently proposed excluding from consideration in setting environmental standards any studies whose raw, individual-level data are not publicly available. This proposal was preceded by the wholesale exclusion from the EPA’s scientific advisory boards of..
August 29, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30143529/young-kidney-professionals-perspectives-and-attitudes-about-consuming-scientific-information-a-focus-group-study
#12
Allison Tong, Deidra C Crews, Jane O Schell, Ian H de Boer, Michel Chonchol, Rajnish Mehrotra
The digital era has seen rapid changes in how information is consumed. Traditional dissemination of scholarly work through biomedical journals may not be optimally tailored to the preferences of younger clinicians and researchers. We aimed to describe the perspectives of young clinicians and researchers in kidney disease on consuming scientific information. Three focus groups were conducted during the 2017 American Society of Nephrology Kidney Week with a total of 29 nephrologists and researchers (ages 40 years old and younger) purposively sampled through our networks and the American Society of Nephrology registration database...
August 24, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30140919/the-importance-of-reporting-biases-in-patient-care-can-we-trust-the-evidence-from-either-individual-studies-or-systematic-reviews
#13
Kay Dickersin, Riaz Qureshi
No abstract text is available yet for this article.
August 21, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30140933/association-between-publication-characteristics-and-treatment-effect-estimates-a-meta-epidemiologic-study
#14
Agnes Dechartres, Ignacio Atal, Carolina Riveros, Joerg Meerpohl, Philippe Ravaud
Background: Evidence about the effect on meta-analysis results of including unpublished trials or those published in languages other than English is unclear or discordant. Purpose: To compare treatment effects between published and unpublished randomized controlled trials (RCTs) and between trials published in English and other languages using a meta-epidemiologic approach. Data Sources: Cochrane reviews published between March 2011 and January 2017 and trial references cited in the reviews...
August 21, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30124633/systematic-reviews-and-meta-analyses-in-transplantation-challenges-and-pitfalls
#15
Germaine Wong, Ankit Sharma, Armando Teixeira-Pinto, Martin Howell
Decision making in transplantation is complex, dynamic, and often made under the context of uncertainties. In the case of diagnostic uncertainties, symptoms can be indistinct, with overlap between many different conditions. Even if the correct diagnoses are known, treatment strategies for the same condition may vary and are largely dependent on clinicians' preference and personal experiences. Systematic reviews and meta-analyses challenge the conventional role of the experts and their perceptions and rely, instead, on the best available evidence to guide clinical decision making...
September 2018: Transplantation
https://www.readbyqxmd.com/read/29925973/bias-detectives-the-researchers-striving-to-make-algorithms-fair
#16
Rachel Courtland
No abstract text is available yet for this article.
June 2018: Nature
https://www.readbyqxmd.com/read/30085838/propensity-score-matching-as-a-substitute-for-randomized-controlled-trials-on-acute-kidney-injury-after-contrast-media-administration-a-systematic-review
#17
Ilona A Dekkers, Aart J van der Molen
OBJECTIVE: Controversy exists regarding the causal relationship between contrast media administration and the development of acute kidney injury because prospective randomized controlled trials (RCTs) confirming this relationship are lacking. In this systematic review we address studies using propensity score matching with regard to contrast-induced acute kidney injury and possible implications for future practice guideline development. CONCLUSION: Propensity score matching can overcome the main limitations of conventional observational studies and could serve as an alternative in the absence of RCTs...
October 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/30039173/deriving-real-world-insights-from-real-world-data-biostatistics-to-the-rescue
#18
Michael J Pencina, Frank W Rockhold, Ralph B D'Agostino
No abstract text is available yet for this article.
July 24, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30018051/rebuilding-the-pipeline-of-investigators-in-nephrology-research-in-the-united-states
#19
Jenna M Norton, Christian J Ketchum, Tracy L Rankin, Robert A Star
No abstract text is available yet for this article.
August 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30014127/early-experiences-with-journal-data-sharing-policies-a-survey-of-published-clinical-trial-investigators
#20
Sara Tannenbaum, Joseph S Ross, Harlan M Krumholz, Nihar R Desai, Jessica D Ritchie, Richard Lehman, Ginger M Gamble, Jacqueline Bachand, Sara Schroter, Trish Groves, Cary P Gross
No abstract text is available yet for this article.
July 17, 2018: Annals of Internal Medicine
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