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Statistics and Nephrology

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328 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Husam Abdel-Qadir, Jiming Fang, Douglas S Lee, Jack V Tu, Eitan Amir, Peter C Austin, Geoffrey M Anderson
BACKGROUND: Ignoring competing risks in time-to-event analyses can lead to biased risk estimates, particularly for elderly patients with multimorbidity. We aimed to demonstrate the impact of considering competing risks when estimating the cumulative incidence and risk of stroke among elderly atrial fibrillation patients. METHODS AND RESULTS: Using linked administrative databases, we identified patients with atrial fibrillation aged ≥66 years discharged from hospital in ON, Canada between January 1, 2007, and March 31, 2011...
July 2018: Circulation. Cardiovascular Quality and Outcomes
Xiaohui Lin, Xin Huang, Lina Zhou, Weijie Ren, Jun Zeng, Weihong Yao, Xingyuan Wang
Analyzing the disease data from the view of combinatorial features may better characterize the disease phenotype. In this study, a novel method is proposed to construct feature combinations and a classification model (CFC-CM) by mining key feature relationships. CFC-CM iteratively tests for differences in the feature relationship between different groups. To do this, it uses a modified -top-scoring pair () algorithm and then selects the most discriminative feature pairs in the current feature set to infer the combinatorial features and build the classification model...
December 4, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
Edward C Norton, Bryan E Dowd, Matthew L Maciejewski
No abstract text is available yet for this article.
July 3, 2018: JAMA: the Journal of the American Medical Association
Greg Koski, Larry Kennedy, Mary F Tobin, Matthew Whalen
Accreditation is used in many fields, including education, travel, construction, and health care. When implemented correctly, it improves quality, performance, and safety, while signaling to the public that an accredited entity is committed to an agreed-on set of values. Key to its effectiveness is..
June 27, 2018: New England Journal of Medicine
Amy J H Kind, William R Buckingham
Health disparities are a major problem in the United States: many conditions, including cardiovascular disease, diabetes, and Alzheimer’s disease, disproportionately affect racial and ethnic minorities and the socioeconomically disadvantaged. Few interventions have successfully reduced these..
June 28, 2018: New England Journal of Medicine
David C Aron, Paul R Conlin, Leonard Pogach
No abstract text is available yet for this article.
June 26, 2018: Annals of Internal Medicine
Robert L Goldenberg, Elizabeth M McClure, José M Belizán
The Jawaharlal Nehru Medical College (JNMC) Women's and Children's Health Research Unit (WCHRU) of the Karnataka Lingayat Education (KLE) Academy of Higher Education and Research Deemed-to-be-University and its collaborators convened the '2nd International Conference on Maternal and Newborn Health -Translating Research Evidence to Practice' to address the common theme of improving maternal and newborn health in low- and middle- income countries (LMIC). This supplement, including 16 manuscripts, reflects much of the research presented at the conference, including analyses of the state of knowledge, as well as completed, ongoing and planned research in these areas conducted by the WCHRU in India together with many collaborators across high-income and LMIC...
June 22, 2018: Reproductive Health
Anaïs Codorniu, Léa Lemasle, Matthieu Legrand, Alice Blet, Alexandre Mebazaa, Etienne Gayat
PURPOSE: Methods used to explore biomarkers for acute kidney injury (AKI) might have a major impact on the results and the use of these biomarkers. We evaluated the methods used to investigate biomarkers of AKI. MATERIALS AND METHODS: A systematic review and meta-analysis were performed using a computerized search of the MEDLINE and the EMBASE databases (PROSPERO CRD42017059618). Articles reporting biomarker's performance to diagnose AKI were included. The outcome included a description of the methods used to assess the performance of biomarkers to diagnose AKI...
June 26, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
P Gironés, D Burguete, R Machado, J M Dominguez, M Lillo
The family interview for organ donation continues to be one of the main concerns of transplant coordinators. We approach the family because we need to know the opinion of the person who has just died about the donation of his or her organs. The objective of this article is to describe how the application of the qualitative methodology has been followed to perceive what the relatives live in the moment in which they are informed of the death of their relative and they are offered the option of organ donation...
March 9, 2018: Transplantation Proceedings
Charlene A Wong, Adrian F Hernandez, Robert M Califf
No abstract text is available yet for this article.
June 21, 2018: JAMA: the Journal of the American Medical Association
Gijsbert Stoet, David C Geary
The underrepresentation of girls and women in science, technology, engineering, and mathematics (STEM) fields is a continual concern for social scientists and policymakers. Using an international database on adolescent achievement in science, mathematics, and reading ( N = 472,242), we showed that girls performed similarly to or better than boys in science in two of every three countries, and in nearly all countries, more girls appeared capable of college-level STEM study than had enrolled. Paradoxically, the sex differences in the magnitude of relative academic strengths and pursuit of STEM degrees rose with increases in national gender equality...
April 2018: Psychological Science
Matthew T James, Neesh Pannu
Quality indicators are measurements of healthcare outcome, process, or structure that can be used as tools to measure the quality of care and identify opportunities for improvement. Acute kidney injury (AKI) has many characteristics that make it a potential target for quality indicator development. It is common, associated with a high risk of adverse outcomes, and there are reports of gaps in the quality of care in several clinical settings despite publication of evidence-based guidelines. Substantial work has already been undertaken to develop quality measures related to AKI following percutaneous coronary interventions and major surgical procedures...
2015: Nephron
Michael Kossmeier, Georg Heinze
MAIN PROBLEM: Citations are widely used for measuring scientific impact. The goal of the present study is to predict citation counts of manuscripts submitted to Transplant International (TI) in the two calendar years following publication. METHODS: We considered a comprehensive set of 21 manuscript, author, and peer review related predictor variables available early in the peer review process. We also evaluated how successfully the peer-review process at TI identified and accepted the most promising manuscripts for publication...
June 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
L Nelson Sanchez-Pinto, Laura Ruth Venable, John Fahrenbach, Matthew M Churpek
OBJECTIVE: Modern machine learning-based modeling methods are increasingly applied to clinical problems. One such application is in variable selection methods for predictive modeling. However, there is limited research comparing the performance of classic and modern for variable selection in clinical datasets. MATERIALS AND METHODS: We analyzed the performance of eight different variable selection methods: four regression-based methods (stepwise backward selection using p-value and AIC, Least Absolute Shrinkage and Selection Operator, and Elastic Net) and four tree-based methods (Variable Selection Using Random Forest, Regularized Random Forests, Boruta, and Gradient Boosted Feature Selection)...
August 2018: International Journal of Medical Informatics
Kristine Broglio
No abstract text is available yet for this article.
June 5, 2018: JAMA: the Journal of the American Medical Association
Michelle M Mello, Van Lieou, Steven N Goodman
Background Sharing of participant-level clinical trial data has potential benefits, but concerns about potential harms to research participants have led some pharmaceutical sponsors and investigators to urge caution. Little is known about clinical trial participants' perceptions of the risks of data sharing. Methods We conducted a structured survey of 771 current and recent participants from a diverse sample of clinical trials at three academic medical centers in the United States. Surveys were distributed by mail (350 completed surveys) and in clinic waiting rooms (421 completed surveys) (overall response rate, 79%)...
June 7, 2018: New England Journal of Medicine
Alex Dmitrienko, Ralph B D'Agostino
New England Journal of Medicine, Volume 378, Issue 22, Page 2115-2122, May 2018.
May 31, 2018: New England Journal of Medicine
Daniel S Nagin, Bobby L Jones, Valéria Lima Passos, Richard E Tremblay
Identifying and monitoring multiple disease biomarkers and other clinically important factors affecting the course of a disease, behavior or health status is of great clinical relevance. Yet conventional statistical practice generally falls far short of taking full advantage of the information available in multivariate longitudinal data for tracking the course of the outcome of interest. We demonstrate a method called multi-trajectory modeling that is designed to overcome this limitation. The method is a generalization of group-based trajectory modeling...
July 2018: Statistical Methods in Medical Research
Milos Brankovic, Isabella Kardys, Ewout J Hoorn, Sara Baart, Eric Boersma, Dimitris Rizopoulos
In nephrology, repeated measures are frequently available (glomerular filtration rate or proteinuria) and linked to adverse outcomes. However, several features of these longitudinal data should be considered before making such inferences. These considerations are discussed, and we describe how joint modeling of repeatedly measured and time-to-event data may help to assess disease dynamics and to derive personalized prognosis. Joint modeling combines linear mixed-effects models and Cox regression model to relate patient-specific trajectory to their prognosis...
July 2018: Kidney International
Cynthia J Janmaat, Merel van Diepen, Roula Tsonaka, Kitty J Jager, Carmine Zoccali, Friedo W Dekker
Clinical epidemiological studies often focus on investigating the underlying causes of disease. For instance, a nephrologist may be interested in the association between blood pressure and the development of chronic kidney disease (CKD). However, instead of focusing on the mere occurrence of CKD, the decline of kidney function over time might be the outcome of interest. For examining this kidney function trajectory, patients are typically followed over time with their kidney function estimated at several time points...
May 22, 2018: Nephrology, Dialysis, Transplantation
2018-05-30 17:42:20
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