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Statistics and Nephrology

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308 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Marco Fiorentino, John A Kellum
BACKGROUND: Several cellular and molecular targets and mechanisms have been investigated in preclinical studies of acute kidney injury (AKI), but translation in successful clinical studies has failed to date. This article reviews many issues that have limited this and the potential future perspectives in AKI prevention and treatment. SUMMARY: Preclinical models of AKI should closely mimic the complexity of human AKI, considering the importance of several comorbidities in determining the clinical course and outcomes in the human disease...
May 23, 2018: Nephron
Bénédicte Sautenet, Allison Tong, Jeremy R Chapman, Anthony N Warrens, David Rosenbloom, Germaine Wong, John Gill, Klemens Budde, Lionel Rostaing, Lorna Marson, Michelle A Josephson, Peter P Reese, Timothy L Pruett, Nicole Evangelidis, Jonathan C Craig
BACKGROUND: The potential for clinical trials to impact patient care may be limited if the outcomes reported vary by trial and lack direct relevance to patients. Despite the many trials conducted in kidney transplantation, premature death due to cardiovascular disease, infection and malignancy remains high. We aimed to assess the range and consistency of outcomes reported in trials in kidney transplantation. METHODS: We searched for randomized trials conducted in kidney transplantation...
May 16, 2018: Transplantation
Raymond L Heilman, Titte R Srinivas, Bruce Kaplan
No abstract text is available yet for this article.
May 14, 2018: Transplantation
Nolwenn Le Meur, Cécile Vigneau, Mathilde Lefort, Saïd Lebbah, Jean-Philippe Jais, Eric Daugas, Sahar Bayat
Background Patients with chronic diseases, like patients with end-stage renal disease (ESRD), have long history of care driven by multiple determinants (medical, social, economic, etc.). Although in most epidemiological studies, analyses of health care determinants are computed on single health care events using classical multivariate statistical regression methods. Only few studies have integrated the concept of treatment trajectories as a whole and studied their determinants. Methods All 18- to 80-year-old incident ESRD patients who started dialysis in Ile-de-France or Bretagne between 2006 and 2009 and could be followed for a period of 48 months after initiation of a renal replacement therapy were included ( n = 5568)...
January 1, 2018: Statistical Methods in Medical Research
Jamie Lundine, Ivy Lynn Bourgeault, Jocalyn Clark, Shirin Heidari, Dina Balabanova
No abstract text is available yet for this article.
May 5, 2018: Lancet
Sheng Zhou, Courtenay M Holscher, Allan B Massie, Dorry L Segev, Lauren Hersch Nicholas
No abstract text is available yet for this article.
April 23, 2018: Transplantation
P Saha-Chaudhuri, P J Heagerty
Cancer patients, chronic kidney disease patients, and subjects infected with HIV are routinely monitored over time using biomarkers that represent key health status indicators. Furthermore, biomarkers are frequently used to guide initiation of new treatments or to inform changes in intervention strategies. Since key medical decisions can be made on the basis of a longitudinal biomarker, it is important to evaluate the potential accuracy associated with longitudinal monitoring. To characterize the overall accuracy of a time-dependent marker, we introduce a summary ROC curve that displays the overall sensitivity associated with a time-dependent threshold that controls time-varying specificity...
April 19, 2018: Statistics in Medicine
L M Vernooij, W A van Klei, M Machina, W Pasma, W S Beattie, L M Peelen
BACKGROUND: Associations between intraoperative hypotension (IOH) and postoperative complications have been reported. We examined whether using different methods to model IOH affected the association with postoperative myocardial injury (POMI) and acute kidney injury (AKI). METHODS: This two-centre cohort study included 10 432 patients aged ≥50 yr undergoing non-cardiac surgery. Twelve different methods to statistically model IOH [representing presence, depth, duration, and area under the threshold (AUT)] were applied to examine the association with POMI and AKI using logistic regression analysis...
May 2018: British Journal of Anaesthesia
Melissa Greenwald
In 2016, the Scientific Registry of Transplant Recipients (SRTR) posted a 5-tier rating system intended to provide patient-friendly, granular information regarding one-year patient and graft transplant outcomes. To that end, Agency for Healthcare Research and Quality best practices in communicating healthcare quality information recommendations were applied (1). The proposed rating system, and the optimal presentation of ratings, has been subsequently the focus of a wide-ranging conversation within the organ donation and transplantation communities...
April 2, 2018: American Journal of Transplantation
Tea Marasović, Ana Utrobiĉić, Ana Maruŝić
No abstract text is available yet for this article.
March 31, 2018: Lancet
(no author information available yet)
No abstract text is available yet for this article.
March 26, 2018: JAMA Internal Medicine
Roy O Mathew, Sripal Bangalore, Mandeep S Sidhu, Jerome L Fleg, Franklin W Maddux
No abstract text is available yet for this article.
April 2018: Kidney International
John P A Ioannidis
No abstract text is available yet for this article.
March 22, 2018: JAMA: the Journal of the American Medical Association
Surendra Shenoy, Michael Allon, Gerald Beathard, Deborah Brouwer-Maier, Laura M Dember, Mark Glickman, Celeste Lee, Terry Litchfield, Charmaine Lok, Thomas Huber, Prabir Roy-Chaudhury, Jack Work, Melissa West, Haimanot Wasse
No abstract text is available yet for this article.
March 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Bénédicte Sautenet, Allison Tong, Gabrielle Williams, Brenda R Hemmelgarn, Braden Manns, David C Wheeler, Peter Tugwell, Wim van Biesen, Wolfgang C Winkelmayer, Sally Crowe, Tess Harris, Nicole Evangelidis, Carmel M Hawley, Carol Pollock, David W Johnson, Kevan R Polkinghorne, Kirsten Howard, Martin P Gallagher, Peter G Kerr, Stephen P McDonald, Angela Ju, Jonathan C Craig
BACKGROUND: Clinical trials are most informative for evidence-based decision making when they consistently measure and report outcomes of relevance to stakeholders. We aimed to assess the scope and consistency of outcomes reported in trials for hemodialysis. STUDY DESIGN: Systematic review. SETTING & POPULATION: Adults requiring maintenance hemodialysis enrolled in clinical trials. SELECTION CRITERIA: All Cochrane systematic reviews of interventions published by August 29, 2016, and the trials published and registered in ClinicalTrials...
February 21, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Maarten J G Leening, Michael J Pencina
No abstract text is available yet for this article.
February 13, 2018: JAMA: the Journal of the American Medical Association
Ann M O'Hare
There is growing interest in patient-centered care, defined by the Institute of Medicine as "care that is respectful of and responsive to individual patient preferences, needs, and values." Although generally accepted as uncontroversial, the notion of "centering" care on our patients is in fact quite revolutionary. Because medical teaching, research, and practice have traditionally been organized around diseases and organ systems rather than patients, making care more patient centered would require no less than a paradigm shift in how we practice medicine...
May 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Bo Shen, Jiarui Xu, Yimei Wang, Wuhua Jiang, Zhen Zhang, Jiawei Yu, Jianzhou Zou, Jie Teng, Xiaoqiang Ding
Acute kidney injury (AKI) is common in clinical practice and associated with increased risk for death and major morbidity. Although some meaningful clinical guidelines were published, the quality of AKI healthcare remains suboptimal. Some AKI quality improvement methods, such as guidelines-based training programs, the referral from nephrology, and electronic data system have been found to be potentially beneficial, but further validation is required. Quality measures (QMs) for structure, process, and outcome of AKI care need to be further developed, evaluated, and implemented to ensure utmost quality of AKI care...
2018: Contributions to Nephrology
Stylianos Serghiou, John P A Ioannidis
No abstract text is available yet for this article.
January 23, 2018: JAMA: the Journal of the American Medical Association
Matthew D F McInnes, David Moher, Brett D Thombs, Trevor A McGrath, Patrick M Bossuyt, Tammy Clifford, Jérémie F Cohen, Jonathan J Deeks, Constantine Gatsonis, Lotty Hooft, Harriet A Hunt, Christopher J Hyde, Daniël A Korevaar, Mariska M G Leeflang, Petra Macaskill, Johannes B Reitsma, Rachel Rodin, Anne W S Rutjes, Jean-Paul Salameh, Adrienne Stevens, Yemisi Takwoingi, Marcello Tonelli, Laura Weeks, Penny Whiting, Brian H Willis
Importance: Systematic reviews of diagnostic test accuracy synthesize data from primary diagnostic studies that have evaluated the accuracy of 1 or more index tests against a reference standard, provide estimates of test performance, allow comparisons of the accuracy of different tests, and facilitate the identification of sources of variability in test accuracy. Objective: To develop the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagnostic test accuracy guideline as a stand-alone extension of the PRISMA statement...
January 23, 2018: JAMA: the Journal of the American Medical Association
2018-01-28 22:40:05
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