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Vascular Calcification

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135 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://www.readbyqxmd.com/read/30103541/the-vitamin-k-metabolome-in-chronic-kidney-disease
#1
REVIEW
Mandy E Turner, Michael A Adams, Rachel M Holden
The purpose of this review is to summarize the research to date on the impact of chronic kidney disease (CKD) on the vitamin K metabolome. Vitamin K-dependent proteins contribute to cardiovascular disease (CVD) prevention via the prevention of ectopic mineralization. Sub-clinical vitamin K deficiency is common in CKD patients, and evidence suggests that it may contribute to the CVD burden in this population. Research from animal models suggests that CKD alters tissue measures of the two predominant forms of vitamin K: KI and MK-4...
August 12, 2018: Nutrients
https://www.readbyqxmd.com/read/30041207/pathogenesis-and-management-of-vascular-calcification-in-patients-with-end-stage-renal-disease
#2
Tetsuya Ogawa, Kosaku Nitta
Vascular calcification is common in patients with end-stage renal disease (ESRD). In addition to traditional cardiovascular risk factors, ESRD patients also have a number of nontraditional cardiovascular risk factors that may play an important role in the pathogenesis of vascular calcification. The transformation of vascular smooth muscle cells into osteoblast-like cells may be a key element in the pathogenesis of vascular calcification in the presence of calcium and phosphate deposition due to abnormal bone metabolism and impaired renal excretion...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/30041812/pit-2-a-type-iii-sodium-dependent-phosphate-transporter-protects-against-vascular-calcification-in-mice-with-chronic-kidney-disease-fed-a-high-phosphate-diet
#3
Shunsuke Yamada, Elizabeth M Leaf, Jia Jun Chia, Timothy C Cox, Mei Y Speer, Cecilia M Giachelli
PiT-2, a type III sodium-dependent phosphate transporter, is a causative gene for the brain arteriolar calcification in people with familial basal ganglion calcification. Here we examined the effect of PiT-2 haploinsufficiency on vascular calcification in uremic mice using wild-type and global PiT-2 heterozygous knockout mice. PiT-2 haploinsufficiency enhanced the development of vascular calcification in mice with chronic kidney disease fed a high-phosphate diet. No differences were observed in the serum mineral biomarkers and kidney function between the wild-type and PiT-2 heterozygous knockout groups...
July 21, 2018: Kidney International
https://www.readbyqxmd.com/read/30009696/the-role-of-matrix-gla-protein-mgp-in-vascular-calcification
#4
Geir Bjorklund, Erik Svanberg, Maryam Dadar, David J Card, Salvatore Chirumbolo, Dominic J Harrington, Jan Aaseth
Matrix Gla protein (MGP) is a vitamin K-dependent protein, which is synthesized in bone and many further mesenchymal cells, which is also highly expressed by vascular smooth 1muscle cells (VSMCs) and chondrocytes. Numerous studies have confirmed that MGP acts as a calcification-inhibitor although the mechanism of action is still not fully understood. The modulation of tissue calcification by MGP is potentially regulated in several ways including direct inhibition of calcium-phosphate precipitation, the formation of matrix vesicles (MVs), the formation of apoptotic bodies (ABs), and trans-differentiation of VSMCs...
July 15, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29960990/extracellular-fluid-excess-is-significantly-associated-with-coronary-artery-calcification-in-patients-with-chronic-kidney-disease
#5
Seohyun Park, Chan Joo Lee, Jong Hyun Jhee, Hae-Ryong Yun, Hyoungnae Kim, Su-Young Jung, Youn Kyung Kee, Chang-Yun Yoon, Jung Tak Park, Hyeon Chang Kim, Seung Hyeok Han, Shin-Wook Kang, Sungha Park, Tae-Hyun Yoo
BACKGROUND: Extracellular fluid (ECF) excess is an independent predictor of cardiovascular morbidity in patients undergoing dialysis. This study aimed to investigate the relationship between ECF status, which is affected by renal function, and coronary artery calcification (CAC), which is a marker of cardiovascular disease, in patients with chronic kidney disease (CKD). METHODS AND RESULTS: A total of 1741 patients at all stages of pre-dialysis CKD from the prospective observational cohort of CMERC-HI (Cardiovascular and Metabolic Disease Etiology Research Center-High Risk) were analyzed for the association between ECF status and CAC...
June 30, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29961069/differential-impact-of-chronic-kidney-disease-on-coronary-calcification-and-atherosclerosis-in-asymptomatic-individuals-with-or-without-diabetes-analysis-from-a-coronary-computed-tomographic-angiography-registry
#6
Ik Jun Choi, Sungmin Lim, Eun-Ho Choo, Jin-Jin Kim, Byung-Hee Hwang, Tae-Hoon Kim, Suk Min Seo, Yoon-Seok Koh, Dong Il Shin, Hun-Jun Park, Pum-Joon Kim, Doo-Soo Jeon, Seung-Hwan Lee, Jae-Hyoung Cho, Jung-Im Jung, Kiyuk Chang, Ki-Bae Seung
AIM: The aim of this study was to assess the combined effects of chronic kidney disease (CKD) and diabetes on the extent and developmental pattern of coronary artery disease (CAD). METHODS: A total of 3,017 self-referred asymptomatic individuals without known CAD who underwent 64-channel dual-source coronary computed tomography angiography between 2006 and 2010 were enrolled. The patients were divided into six groups based on their diabetes status (nondiabetic or diabetic) and estimated glomerular filtration rate (eGFR) (eGFR > 90 mL/min/1...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29933841/protein-carbamylation-a-key-driver-of-vascular-calcification-during-chronic-kidney-disease
#7
Clare L Hawkins
Vascular calcification is a frequent complication of advanced chronic kidney disease. Protein carbamylation is implicated in the acceleration of vascular disease in chronic kidney disease, but the mechanisms are not clear. Mori et al. report that protein carbamylation exacerbates vascular calcification by decreasing ectonucleotide pyrophosphate/phosphodiesterase 1 expression, owing to carbamylation of mitochondrial proteins and oxidative stress. This provides new insight into the pathways responsible for calcification in chronic kidney disease...
July 2018: Kidney International
https://www.readbyqxmd.com/read/29921207/role-of-bisphosphonates-in-vascular-calcification-and-bone-metabolism-a-clinical-summary
#8
Pradeep Dayanand, Harigopal Sandhyavenu, Sandeep Dayanand, Jasmin Martinez, Janani Rangaswami
Vascular calcification is known to be a strong risk factor for cardiovascular adverse events and mortality. Atherosclerosis, diabetes, aging, abnormal bone mineral homeostasis and high uremic milieu such as chronic kidney disease are major factors that contribute to the progression of vascular calcification. Several mechanisms such as the osteoblastic transition of vascular smooth muscle cells in response to oxidative stress have shed light on the active nature of vascular calcification, which was once thought to be a passive process...
June 18, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29908694/arterial-stiffness-in-ckd-a-review
#9
REVIEW
Raymond R Townsend
This narrative review summarizes a decade of experience examining the cross-sectional and longitudinal relationships of arterial stiffness, as assessed using carotid-femoral pulse wave velocity, with outcomes in patients with chronic kidney disease enrolled in the Chronic Renal Insufficiency Cohort. Our goal is to review the importance of the pulse wave contour and pulse wave velocity and present data on the reproducibility of pulse wave velocity measurements, determinants of pulse wave velocity, and the relationship that velocity measurements have with longitudinal kidney and cardiovascular outcomes...
June 13, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29903718/calcitriol-accelerates-vascular-calcification-irrespective-of-vitamin-k-status-in-a-rat-model-of-ckd-with-hyperphosphatemia-and-secondary-hyperparathyroidism
#10
Kristin M McCabe, Jason G Zelt, Martin Kaufmann, Kimberly Laverty, Emilie Ward, Henry Barron, Glenville Jones, Michael A Adams, Rachel M Holden
Patients with chronic kidney disease have a markedly increased risk for developing cardiovascular disease. Non-traditional risk factors, such as increased phosphate retention, and deficiencies in vitamins D and K metabolism, likely play key roles in the development of vascular calcification during CKD progression. Calcitriol (1,25-(OH)2-D3) is a key transcriptional regulator of Matrix Gla protein (MGP), a vitamin K dependent protein that inhibits vascular calcification. The objective of this study was to determine if calcitriol treatment could inhibit the development of vascular calcification and if this inhibition was dependent on vitamin K status in a rat model of CKD...
June 14, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29904040/a-pilot-trial-to-examine-the-changes-in-carotid-arterial-inflammation-in-renal-transplant-recipients-as-assessed-by-18f-fluorodeoxyglucose-18f-fdg-positron-emission-tomography-computed-tomography-pet-ct
#11
Hye Eun Yoon, Yaeni Kim, Sang Dong Kim, Jin Kyoung Oh, Yong-An Chung, Seok Joon Shin, Chul Woo Yang, Suk Min Seo
BACKGROUND Inflammatory activity of the artery can be assessed by measuring 18F-fluorodeoxyglucose (18F-FDG) uptake with positron emission tomography computed tomography (PET/CT). Improvement in vascular function after renal transplantation has been reported, but no studies have used 18F-FDG PET/CT to examine the changes in vascular inflammation. This study investigated the changes in the inflammatory activity in the carotid artery after renal transplantation in patients with chronic kidney disease (CKD). MATERIAL AND METHODS 18F-FDG PET/CT was performed before and at 4 months after transplantation...
June 15, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29850246/phosphate-and-cardiovascular-disease-beyond-chronic-kidney-disease-and-vascular-calcification
#12
REVIEW
Sinee Disthabanchong
Phosphate is essential for life but its accumulation can be detrimental. In end-stage renal disease, widespread vascular calcification occurs as a result of chronic phosphate load. The accumulation of phosphate is likely to occur long before the rise in serum phosphate above the normal range since several observational studies in both general population and early-stage CKD patients have identified the relationship between high-normal serum phosphate and adverse cardiovascular outcomes. Consumption of food high in phosphate increases both fasting and postprandial serum phosphate and habitual intake of high phosphate diet is associated with aging, cardiac hypertrophy, endothelial dysfunction, and subclinical atherosclerosis...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29793668/magnesium-as-a-calcification-inhibitor
#13
REVIEW
Lucie Hénaut, Ziad A Massy
Vascular calcification (VC) is associated with elevated cardiovascular mortality rates in patients with CKD. Recent clinical studies of patients with advanced CKD have observed an association between low serum magnesium (Mg) levels on one hand and elevated VC and cardiovascular mortality on the other. These findings have stimulated interest in understanding Mg's impact on CKD in general and the associated VC in particular. In vitro and preclinical in vivo data indicate that Mg has the potential to protect vascular smooth muscle cells against calcification via several different molecular mechanisms...
May 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29786640/vitamin-d-in-vascular-calcification-a-double-edged-sword
#14
REVIEW
Jeffrey Wang, Jimmy J Zhou, Graham R Robertson, Vincent W Lee
Vascular calcification (VC) as a manifestation of perturbed mineral balance, is associated with aging, diabetes and kidney dysfunction, as well as poorer patient outcomes. Due to the current limited understanding of the pathophysiology of vascular calcification, the development of effective preventative and therapeutic strategies remains a significant clinical challenge. Recent evidence suggests that traditional risk factors for cardiovascular disease, such as left ventricular hypertrophy and dyslipidaemia, fail to account for clinical observations of vascular calcification...
May 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29779091/two-years-of-maintenance-hemodialysis-has-a-pronounced-effect-on-arterial-stiffness-progression
#15
Agne Laucyte-Cibulskiene, Laurynas Rimsevicius, Liutauras Gumbys, Dileta Valanciene, Marius Miglinas
BACKGROUND: The change of aortic stiffness, but not the particular baseline value, plays a crucial role in estimating the patient risk with end-stage renal disease. Therefore, we aimed to analyze the evolution of central and peripheral arterial stiffness in hemodialysis population without previous cardiovascular events during a 2-year follow-up. METHODS: 60 hemodialysis patients (mean age 57.61 ± 13.01 years) were prospectively interviewed, and they underwent blood tests, chest X-ray for aortic calcification evaluation and pulse wave velocity (PWV) measurements at the baseline, after 6 months and after 2 years of observation period...
May 19, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29761287/activation-of-the-mtorc1-pathway-by-inflammation-contributes-to-vascular-calcification-in-patients-with-end-stage-renal-disease
#16
Jing Liu, Wei Zhu, Chun Ming Jiang, Yuan Feng, Yang Yang Xia, Qing Yan Zhang, Miao Zhang
BACKGROUND: Chronic inflammation plays an important role in the progression of vascular calcification (VC). This study was designed to explore the effects and underlying mechanisms of inflammation on VC in the radial arteries of patients with end-stage renal disease (ESRD) with arteriovenostomy. METHODS: Forty-eight ESRD patients were divided into control (n = 25) and inflammation groups (n = 23) according to plasma C-reactive protein (CRP) level. Surgically removed tissues from the radial arteries of patients receiving arteriovenostomy were used in this study...
May 14, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29753400/updates-on-the-mechanisms-and-the-care-of-cardiovascular-calcification-in-chronic-kidney-disease
#17
REVIEW
Lucie Hénaut, Jean-Marc Chillon, Saïd Kamel, Ziad A Massy
In chronic kidney disease (CKD), the progressive decrease in renal function leads to disturbances of mineral metabolism that generally cause secondary hyperparathyroidism. The increase in serum parathyroid hormone is associated with reduced serum calcium and calcitriol levels and/or increased serum fibroblast growth factor-23 and phosphate levels. The resulting CKD-associated disorder of mineral and bone metabolism is associated with various other metabolic dysregulations such as acidosis, malnutrition, inflammation, and accumulation of uremic toxins...
May 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29733462/current-and-potential-therapeutic-strategies-for-the-management-of-vascular-calcification-in-patients-with-chronic-kidney-disease-including-those-on-dialysis
#18
REVIEW
Irene Ruderman, Stephen G Holt, Tim D Hewitson, Edward R Smith, Nigel D Toussaint
Patients with CKD have accelerated vascular stiffening contributing significantly to excess cardiovascular morbidity and mortality. Much of the arterial stiffening is thought to involve vascular calcification (VC), but the pathogenesis of this phenomenon is complex, resulting from a disruption of the balance between promoters and inhibitors of calcification in a uremic milieu, along with derangements in calcium and phosphate metabolic pathways. Management of traditional cardiovascular risk factors to reduce VC may be influential but has not been shown to significantly improve mortality...
May 7, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29716796/protein-carbamylation-exacerbates-vascular-calcification
#19
Daisuke Mori, Isao Matsui, Akihiro Shimomura, Nobuhiro Hashimoto, Ayumi Matsumoto, Karin Shimada, Satoshi Yamaguchi, Tatsufumi Oka, Keiichi Kubota, Sayoko Yonemoto, Yusuke Sakaguchi, Atsushi Takahashi, Yasunori Shintani, Seiji Takashima, Yoshitsugu Takabatake, Takayuki Hamano, Yoshitaka Isaka
Protein carbamylation is a posttranslational modification that can occur non-enzymatically in the presence of high concentrations of urea. Although carbamylation is recognized as a prognostic biomarker, the contribution of protein carbamylation to organ dysfunction remains uncertain. Because vascular calcification is common under carbamylation-prone situations, we investigated the effects of carbamylation on this pathologic condition. Protein carbamylation exacerbated the calcification of human vascular smooth muscle cells (hVSMCs) by suppressing the expression of ectonucleotide pyrophosphate/phosphodiesterase 1 (ENPP1), a key enzyme in the generation of pyrophosphate, which is a potent inhibitor of ectopic calcification...
July 2018: Kidney International
https://www.readbyqxmd.com/read/29709832/effect-of-magnesium-supplementation-on-endothelial-function-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Manije Darooghegi Mofrad, Kurosh Djafarian, Hadis Mozaffari, Sakineh Shab-Bidar
BACKGROUND AND AIMS: Findings of past studies are inconsistent regarding the effects of magnesium (Mg) supplementation on endothelial function (EF). We performed this meta-analysis to examine the effects of magnesium supplementation on flow-mediated dilation (FMD) and carotid intima media thickness (CIMT) as markers of EF. METHODS: Literature searches of English publications in MEDLINE and EMBASE databases were conducted up to November 2017. Results are reported as weighted mean difference (MD) with 95% confidence intervals (CI) using random effects model (DerSimonian-Laird method)...
June 2018: Atherosclerosis
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