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GMG/CARDIAC

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1342 papers 500 to 1000 followers CAD and Interventions
By Gregory Gustafson Interventional Cardiologist
https://www.readbyqxmd.com/read/29376560/inotropic-agents-and-vasodilator-strategies-for-the-treatment-of-cardiogenic-shock-or-low-cardiac-output-syndrome
#1
REVIEW
Julia Schumann, Eva C Henrich, Hellen Strobl, Roland Prondzinsky, Sophie Weiche, Holger Thiele, Karl Werdan, Stefan Frantz, Susanne Unverzagt
BACKGROUND: Cardiogenic shock (CS) and low cardiac output syndrome (LCOS) as complications of acute myocardial infarction (AMI), heart failure (HF) or cardiac surgery are life-threatening conditions. While there is a broad body of evidence for the treatment of people with acute coronary syndrome under stable haemodynamic conditions, the treatment strategies for people who become haemodynamically unstable or develop CS remain less clear. We have therefore summarised here the evidence on the treatment of people with CS or LCOS with different inotropic agents and vasodilative drugs...
January 29, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29359673/non-traditional-cardiovascular-risk-markers-in-the-era-of-established-major-risk-factors-and-multiple-guidelines
#2
Thomas F Whayne
The non-traditional cardiovascular (CV) risk factors that appear to be of most clinical interest include: apolipoprotein A (ApoA), apolipoprotein B (ApoB), high-sensitivity C-Reactive protein (hsCRP), homocysteine, interleukin 1 (IL1), lipoprotein (a) [Lp(a)], the density of low-density lipoprotein (LDL) particles, the LDL particle number, tissue/tumor necrosis factor-α (TNF-α) and uric acid. These non-traditional risk factors may be of value in adding further confirmation and attention to suspected significant CV risk...
January 22, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29390051/mortality-associated-with-heart-failure-with-preserved-vs-reduced-ejection-fraction-in-a-prospective-international-multi-ethnic-cohort-study
#3
Carolyn S P Lam, Greg D Gamble, Lieng H Ling, David Sim, Kui Toh Gerard Leong, Poh Shuan Daniel Yeo, Hean Yee Ong, Fazlur Jaufeerally, Tze P Ng, Vicky A Cameron, Katrina Poppe, Mayanna Lund, Gerry Devlin, Richard Troughton, A Mark Richards, Robert N Doughty
Aims: Whether prevalence and mortality of patients with heart failure with preserved or mid-range (40-49%) ejection fraction (HFpEF and HFmREF) are similar to those of heart failure with reduced ejection fraction (HFrEF), as reported in some epidemiologic studies, remains highly controversial. We determined and compared characteristics and outcomes for patients with HFpEF, HFmREF, and HFrEF in a prospective, international, multi-ethnic population. Methods and results: Prospective multi-centre longitudinal study in New Zealand (NZ) and Singapore...
January 29, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29241485/normal-ldl-cholesterol-levels-are-associated-with-subclinical-atherosclerosis-in-the-absence-of-risk-factors
#4
Leticia Fernández-Friera, Valentín Fuster, Beatriz López-Melgar, Belén Oliva, José M García-Ruiz, José Mendiguren, Héctor Bueno, Stuart Pocock, Borja Ibáñez, Antonio Fernández-Ortiz, Javier Sanz
BACKGROUND: Absence of cardiovascular risk factors (CVRFs) is traditionally considered low risk for atherosclerosis; however, individuals without CVRFs, as currently defined, still have events. OBJECTIVES: This study sought to identify predictors of subclinical atherosclerosis in CVRF-free individuals. METHODS: Participants from the PESA (Progression of Early Subclinical Atherosclerosis) study (n = 4,184) without conventional CVRFs were evaluated (n = 1,779; 45...
December 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29386325/socioeconomic-deprivation-and-mode-specific-outcomes-in-patients-with-chronic-heart-failure
#5
Klaus K Witte, Peysh A Patel, Andrew M N Walker, Clyde B Schechter, Michael Drozd, Anshuman Sengupta, Rowenna Byrom, Lorraine C Kearney, Robert J Sapsford, Mark T Kearney, Richard M Cubbon
OBJECTIVE: To characterise the association between socioeconomic deprivation and adverse outcomes in patients with chronic heart failure (CHF). METHODS: We prospectively observed 1802 patients with CHF and left ventricular ejection fraction (LVEF) ≤45%, recruited in four UK hospitals between 2006 and 2014. We assessed the association between deprivation defined by the UK Index of Multiple Deprivation (IMD) and: mode-specific mortality (mean follow-up 4 years); mode-specific hospitalisation; and the cumulative duration of hospitalisation (after 1 year)...
January 31, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29121725/real-world-study-of-low-density-lipoprotein-cholesterol-levels-and-cardiovascular-outcomes-in-chinese-a-retrospective-cohort-study-in-post-percutaneous-coronary-intervention-acute-coronary-syndrome-patients
#6
Yun Wang, Bryan P Yan, Michael B Nichol, Brian Tomlinson, Vivian W Y Lee
BACKGROUND: This study aimed to assess the effect of low-density lipoprotein cholesterol (LDL-C) goal attainments (of <2.6mmol/L and <1.8mmol/L) on first major adverse cardiovascular events (MACEs) for acute coronary syndrome (ACS) patients who underwent percutaneous coronary intervention (PCI). METHODS: A retrospective cohort study was conducted using case reviews of post-PCI ACS patients at an acute public hospital in Hong Kong between January 2009 and August 2015...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28851544/pci-versus-cabg-in-patients-with-type-1-diabetes-and-multivessel-disease
#7
Thomas Nyström, Ulrik Sartipy, Stefan Franzén, Björn Eliasson, Soffia Gudbjörnsdottir, Mervete Miftaraj, Bo Lagerqvist, Ann-Marie Svensson, Martin J Holzmann
BACKGROUND: It is unknown if coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) may offer a survival benefit in patients with type 1 diabetes (T1D) in need of multivessel revascularization. OBJECTIVES: This study sought to determine if patients with T1D and multivessel disease may benefit from CABG compared with PCI. METHODS: In an observational cohort study, the authors included all patients with T1D who underwent a first multivessel revascularization in Sweden from 1995 to 2013...
September 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29305560/heart-failure-with-preserved-ejection-fraction-controversies-challenges-and-future-directions
#8
REVIEW
Rosita Zakeri, Martin R Cowie
Heart failure with preserved ejection fraction (HFpEF) comprises almost half of the population burden of HF. Because HFpEF likely includes a range of cardiac and non-cardiac abnormalities, typically in elderly patients, obtaining an accurate diagnosis may be challenging, not least due to the existence of multiple HFpEF mimics and a newly identified subset of patients with HFpEF and normal plasma natriuretic peptide concentrations. The lack of effective treatment for these patients represents a major unmet clinical need...
March 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29229649/isolated-tricuspid-regurgitation-outcomes-and-therapeutic-interventions
#9
REVIEW
Erin A Fender, Chad J Zack, Rick A Nishimura
Isolated tricuspid regurgitation (TR) can be caused by primary valvular abnormalities such as flail leaflet or secondary annular dilation as is seen in atrial fibrillation, pulmonary hypertension and left heart disease. There is an increasing recognition of a subgroup of patients with isolated TR in the absence of other associated cardiac abnormalities. Left untreated isolated TR significantly worsens survival. Stand-alone surgery for isolated TR is rarely performed due to an average operative mortality of 8%-10% and a paucity of data demonstrating improved survival...
December 11, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29338684/a-simple-prediction-model-to-estimate-obstructive-coronary-artery-disease
#10
Shiqun Chen, Yong Liu, Sheikh Mohammed Shariful Islam, Hua Yao, Yingling Zhou, Ji-Yan Chen, Qiang Li
BACKGROUND: A simple noninvasive model to predict obstructive coronary artery disease (OCAD) may promote risk stratification and reduce the burden of coronary artery disease (CAD). This study aimed to develop pre-procedural, noninvasive prediction models that better estimate the probability of OCAD among patients with suspected CAD undergoing elective coronary angiography (CAG). METHODS: We included 1262 patients, who had reliable Framingham risk variable data, in a cohort without known CAD from a prospective registry of patients referred for elective CAG...
January 16, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29162611/hdl-subspecies-defined-by-presence-of-apolipoprotein-c-iii-and-incident-coronary-heart-disease-in-four-cohorts
#11
Majken K Jensen, Sarah A Aroner, Kenneth J Mukamal, Jeremy D Furtado, Wendy S Post, Michael Y Tsai, Anne Tjønneland, Joseph F Polak, Eric B Rimm, Kim Overvad, Robyn L McClelland, Frank M Sacks
Background -The causal role of high density lipoprotein (HDL) cholesterol in cardioprotection has been questioned by genetic and randomized studies. Novel measures that relate to HDL function may contribute new information to prediction of cardiovascular risk. Apolipoprotein C-III (apoC-III) is a key regulator of lipoprotein metabolism. We investigated whether subspecies of HDL defined by apoC-III are associated with coronary heart disease (CHD). Methods -We used immuno-affinity chromatography to measure the apoA-I concentrations of HDL that contains and lacks apoC-III in two prospective studies of adults free of CHD...
November 21, 2017: Circulation
https://www.readbyqxmd.com/read/29326185/enhancing-prescribing-of-guideline-recommended-medications-for-ischaemic-heart-diseases-a-systematic-review-and-meta-analysis-of-interventions-targeted-at-healthcare-professionals
#12
Thang Nguyen, Hoa Q Nguyen, Niken N Widyakusuma, Thao H Nguyen, Tam T Pham, Katja Taxis
OBJECTIVES: Ischaemic heart diseases (IHDs) are a leading cause of death worldwide. Although prescribing according to guidelines improves health outcomes, it remains suboptimal. We determined whether interventions targeted at healthcare professionals are effective to enhance prescribing and health outcomes in patients with IHDs. METHODS: We systematically searched PubMed and EMBASE for studies published between 1 January 2000 and 31 August 2017. We included original studies of interventions targeted at healthcare professionals to enhance prescribing guideline-recommended medications for IHDs...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29297177/low-cpne3-expression-is-associated-with-risk-of-acute-myocardial-infarction-a-feasible-genetic-marker-of-acute-myocardial-infarction-in-patients-with-stable-coronary-artery-disease
#13
Buchuan Tan, Long Liu, Yushuang Yang, Qian Liu, Liping Yang, Fanbo Meng
BACKGROUND: Gene COPINE III may be related to a phosphoprotein with intrinsic kinase activity and belongs to an unconventional kinase family. The CPNE3 gene may be used as a biomarker for assessment of occurrence and prognosis of various tumors. METHODS: Peripheral blood was collected from 87 stable CAD patients and 91 AMI patients. Real-time quantitative PCR test and the western blot method were adopted to measure expression quantity of CPNE3 gene at the mRNA level and the protein level...
January 3, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29352374/quantification-of-myocardial-blood-flow-and-myocardial-flow-reserve-with-spect-imaging-technique
#14
Thet Khaing, Ching Chiew Wong Raymond, Wan Xian Chan, Chen Hao, Siong Sung Wong
No abstract text is available yet for this article.
January 19, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28303624/effect-of-eplerenone-in-patients-with-heart-failure-and-reduced-ejection-fraction-potential-effect-modification-by-abdominal-obesity-insight-from-the-emphasis-hf-trial
#15
Arnaud Olivier, Bertram Pitt, Nicolas Girerd, Zohra Lamiral, Jean-Loup Machu, John J V McMurray, Karl Swedberg, Dirk J van Veldhuisen, Timothy J Collier, Stuart J Pocock, Patrick Rossignol, Faiez Zannad, Anne Pizard
AIMS: An excessive production of aldosterone influences outcome in patients with heart failure (HF) and in obese patients. Findings from laboratory studies suggest that chronic aldosterone blockade maybe more beneficial in abdominally obese HF-prone rats. In the current study, we investigated if the clinical response to a mineralocorticoid receptor antagonist in mildly symptomatic HF patients varied by abdominal obesity. METHODS AND RESULTS: A total of 2587 NYHA class II, reduced ejection fraction HF (HFrEF) patients enrolled in the EMPHASIS-HF trial were randomly assigned to eplerenone and placebo...
September 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29287973/myocardial-infarction-with-non-obstructive-coronary-arteries-the-importance-of-achieving-secondary-prevention-targets
#16
K M Eggers, N Hadziosmanovic, T Baron, K Hambraeus, T Jernberg, A Nordenskjöld, P Tornvall, B Lindahl
BACKGROUND: Around 5-10% of all myocardial infarction patients have non-obstructive coronary arteries. Studies investigating the importance of follow-up and achievement of conventional secondary prevention targets in these patients are lacking. METHODS: In this analysis from the SWEDEHEART registry, we investigated 5830 myocardial infarction patients with non-obstructive coronary arteries (group 1) and 54,637 myocardial infarction patients with significant coronary artery disease (≥50% stenosis; group 2)...
December 26, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29158679/treatment-of-pulmonary-hypertension-with-left-heart-disease-a-concise-review
#17
REVIEW
Anish Desai, Shilpa A Desouza
Pulmonary hypertension (PH) is defined by a mean pulmonary artery pressure ≥ 25 mmHg, as determined by right heart catheterization. Pulmonary arterial hypertension (PAH) can no longer be considered an orphan disease given the increase in awareness and availability of new drugs. PH carries with it a dismal prognosis and leads to significant morbidity and mortality. Symptoms can range from dyspnea, fatigue and chest pain to right ventricular failure and death. PH is divided into five groups by the World Health Organization (WHO), based on etiology...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29325062/st-segment-elevation-myocardial-infarction-the-new-esc-guidelines
#18
Thomas F Lüscher
No abstract text is available yet for this article.
January 7, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29277442/plasma-levels-of-n-3-fatty-acids-and-risk-of-coronary-heart-disease-among-japanese-the-japan-public-health-center-based-jphc-study
#19
Kei Hamazaki, Hiroyasu Iso, Ehab S Eshak, Satoyo Ikehara, Ai Ikeda, Motoki Iwasaki, Tomohito Hamazaki, Shoichiro Tsugane
BACKGROUND AND AIMS: Higher intake of fish or n-3 polyunsaturated fatty acids (PUFAs) has been associated with reduced risk of coronary heart disease (CHD). However, it is unclear whether increased blood levels of n-3 PUFAs are associated with reduced risk of CHD in the Japanese population. METHODS: The relationship between circulating levels of n-3 PUFAs (eicosapentaenoic acid + docosapentaenoic acid + docosahexaenoic acid) and risk of CHD was examined in a nested case-control study among participants in the Japan Public Health Center (JPHC)-based Study Cohort...
December 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29329384/plaque-erosion-a-new-in-vivo-diagnosis-and-a-potential-major-shift-in-the-management-of-patients-with-acute-coronary-syndromes
#20
Ramon A Partida, Peter Libby, Filippo Crea, Ik-Kyung Jang
Pathology and in vivo imaging studies have identified superficial plaque erosion as a frequent and important mechanism underlying acute coronary syndromes (ACS). In contrast with plaque rupture, the pathophysiological mechanisms leading to plaque erosion remain poorly understood. The advent of intravascular imaging techniques, particularly optical coherence tomography, has aided understanding of this mode of ACS in vivo by complementing previous insights from pathology studies. Appreciation of the distinct biological and clinical mechanisms of plaque erosion points to the possibility of tailored management strategies for patients presenting with ACS...
January 9, 2018: European Heart Journal
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