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GMG/CARDIAC

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1402 papers 500 to 1000 followers CAD and Interventions
By Gregory Gustafson Interventional Cardiologist
https://www.readbyqxmd.com/read/30070222/assessment-of-functional-capacity-before-major-non-cardiac-surgery-an-international-prospective-cohort-study
#1
Duminda N Wijeysundera, Rupert M Pearse, Mark A Shulman, Tom E F Abbott, Elizabeth Torres, Althea Ambosta, Bernard L Croal, John T Granton, Kevin E Thorpe, Michael P W Grocott, Catherine Farrington, Paul S Myles, Brian H Cuthbertson
BACKGROUND: Functional capacity is an important component of risk assessment for major surgery. Doctors' clinical subjective assessment of patients' functional capacity has uncertain accuracy. We did a study to compare preoperative subjective assessment with alternative markers of fitness (cardiopulmonary exercise testing [CPET], scores on the Duke Activity Status Index [DASI] questionnaire, and serum N-terminal pro-B-type natriuretic peptide [NT pro-BNP] concentrations) for predicting death or complications after major elective non-cardiac surgery...
June 30, 2018: Lancet
https://www.readbyqxmd.com/read/29957262/predictors-of-poor-clinical-outcomes-in-patients-with-acute-myocardial-infarction-and-non-obstructed-coronary-arteries-minoca
#2
Giuseppe Ciliberti, Stefano Coiro, Isabella Tritto, Martina Benedetti, Federico Guerra, Maurizio Del Pinto, Gherardo Finocchiaro, Claudio Cavallini, Alessandro Capucci, Juan Carlos Kaski, Giuseppe Ambrosio
OBJECTIVE: To assess the characteristics and prognosis of patients with myocardial infarction and non-obstructed coronary arteries (MINOCA). METHODS: MINOCA was defined as acute myocardial infarction (AMI) with angiographic coronary stenosis <50%.Cardiomyopathies and myocarditis were - a priori - excluded from the study. Stenoses <30% were considered normal coronary arteries (NCA); stenoses ≥30% but <50% were considered mild coronary artery disease (MCAD)...
September 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30054611/aspirin-plus-clopidogrel-vs-aspirin-alone-for-preventing-cardiovascular-events-among-patients-at-high-risk-for-cardiovascular-events
#3
Marco P Donadini, Marta Bellesini, Alessandro Squizzato
Clinical Question: Among patients at high risk for or with established cardiovascular disease (ie, history of peripheral artery disease, stroke, or coronary artery disease without a coronary stent), is the addition of clopidogrel to aspirin associated with lower risk of mortality and cardiovascular events compared with aspirin alone? Bottom Line: Clopidogrel plus aspirin is associated with a reduced risk for myocardial infarction and ischemic stroke and an increased risk for major bleeding compared with aspirin alone among patients at high risk for or with an established cardiovascular disease but without a coronary stent...
July 26, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/30060125/clinical-presentation-and-outcome-of-tricuspid-regurgitation-in-patients-with-systolic-dysfunction
#4
Yan Topilsky, Jose Medina Inojosa, Giovanni Benfari, Ori Vaturi, Simon Maltais, Hector Michelena, Sunil Mankad, Maurice Enriquez-Sarano
Aims: The impact of tricuspid regurgitation (TR) in patients with left ventricular systolic dysfunction on presentation and clinical outcome is uncertain due to confounding comorbidities and mediocre regurgitation ascertainment. Methods and results: In a cohort of patients with left ventricular systolic dysfunction (ejection fraction, EF < 50%) and functional TR (assessed quantitatively), we matched TR grade-groups for age, sex, EF, and TR velocity. Association of quantified TR (effective regurgitant orifice, ERO, severe if ≥0...
July 27, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30025580/coronary-calcium-score-and-cardiovascular-risk
#5
REVIEW
Philip Greenland, Michael J Blaha, Matthew J Budoff, Raimund Erbel, Karol E Watson
Coronary artery calcium (CAC) is a highly specific feature of coronary atherosclerosis. On the basis of single-center and multicenter clinical and population-based studies with short-term and long-term outcomes data (up to 15-year follow-up), CAC scoring has emerged as a widely available, consistent, and reproducible means of assessing risk for major cardiovascular outcomes, especially useful in asymptomatic people for planning primary prevention interventions such as statins and aspirin. CAC testing in asymptomatic populations is cost effective across a broad range of baseline risk...
July 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/30070223/antiphospholipid-syndrome-causing-reversible-internal-carotid-artery-thrombosis
#6
Fei Xiao, Xin Tian, Xue-Feng Wang
No abstract text is available yet for this article.
June 30, 2018: Lancet
https://www.readbyqxmd.com/read/30019765/omega-6-fats-for-the-primary-and-secondary-prevention-of-cardiovascular-disease
#7
REVIEW
Lee Hooper, Lena Al-Khudairy, Asmaa S Abdelhamid, Karen Rees, Julii S Brainard, Tracey J Brown, Sarah M Ajabnoor, Alex T O'Brien, Lauren E Winstanley, Daisy H Donaldson, Fujian Song, Katherine Ho Deane
BACKGROUND: Omega-6 fats are polyunsaturated fats vital for many physiological functions, but their effect on cardiovascular disease (CVD) risk is debated. OBJECTIVES: To assess effects of increasing omega-6 fats (linoleic acid (LA), gamma-linolenic acid (GLA), dihomo-gamma-linolenic acid (DGLA) and arachidonic acid (AA)) on CVD and all-cause mortality. SEARCH METHODS: We searched CENTRAL, MEDLINE and Embase to May 2017 and clinicaltrials...
July 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29930142/atherosclerosis-and-inflammation-overview-and-updates
#8
REVIEW
Glaucylara Reis Geovanini, Peter Libby
The concept that inflammation participates pivotally in the pathogenesis of atherosclerosis and its complications has gained considerable attention, but has not yet entered clinical practice. Experimental work has elucidated molecular and cellular pathways of inflammation that promote atherosclerosis. The recognition of atherogenesis as an active process rather than a cholesterol storage disease or a repository of calcium has highlighted some key inflammatory mechanisms. For example, mononuclear phagocytes contribute to all stages of this disease, illustrating the link between inflammation and atherosclerosis...
June 29, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29933080/pharmacological-strategies-to-inhibit-intra-plaque-angiogenesis-in-atherosclerosis
#9
REVIEW
Paola Perrotta, Besa Emini Veseli, Bieke Van der Veken, Lynn Roth, Wim Martinet, Guido R Y De Meyer
Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world. There is a considerable difference in safety profile between a stable and a vulnerable, rupture-prone lesion. The need for plaque-stabilizing therapies is high, and for a long time the lack of a suitable animal model mimicking advanced human atherosclerotic plaques made it very difficult to make progress in this area...
June 19, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29935936/unmet-need-for-adjunctive-dyslipidemia-therapy-in-hypertriglyceridemia-management
#10
REVIEW
Om P Ganda, Deepak L Bhatt, R Preston Mason, Michael Miller, William E Boden
Despite the important role of high-intensity statins in reducing atherosclerotic cardiovascular disease events in secondary and primary prevention, substantial residual risk persists, particularly among high-risk patients with type 2 diabetes mellitus, metabolic syndrome, and obesity. Considerable attention is currently directed to the role that elevated triglycerides (TGs) and non-high-density lipoprotein cholesterol levels play as important mediators of residual atherosclerotic cardiovascular disease risk, which is further strongly supported by genetic linkage studies...
July 17, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/30004115/ldl-cholesterol-is-not-the-only-clinically-relevant-biomarker-for-coronary-artery-disease-or-acute-coronary-syndrome
#11
Patrick A Field, Ramachandran S Vasan
Coronary artery disease (CAD) is a progressive disorder and its risk is best determined using multiple biomarkers and risk factors. Many novel biomarkers have been shown to improve cardiovascular disease risk beyond that of the traditional risk factors, including polygenic risk scores, small very low-density lipoprotein (VLDL), ApoB, triglycerides (TG), non-HDL-c, lipoprotein (a) (Lp(a)), coronary calcium scores, C-reactive protein (CRP), B-type natriuretic peptide (BNP), troponins, and many other novel biomarkers that have been measured using high throughput assays...
July 13, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29969621/triglyceride-to-high-density-lipoprotein-cholesterol-ratio-may-serve-as-a-useful-predictor-of-major-adverse-coronary-event-in-female-revascularized-st-elevation-myocardial-infarction
#12
Guo-Xing Wan, Wen-Bin Xia, Li-Hua Ji, Hai-Lun Qin, Yong-Gang Zhang
BACKGROUND: Elevated triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio has been identified as a surrogate marker of insulin resistance and an independent predictor for cardiovascular events in the general population. However, the prognostic value of TG/HDL-C ratio in revascularized ST-elevation myocardial infarction(STEMI) patients remains unclear. We examined the association between TG/HDL-C ratio and clinical outcome of revascularized STEMI patients in the Chinese population...
June 30, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29986961/sex-differences-in-cardiovascular-pathophysiology-why-women-are-overrepresented-in-heart-failure-with-preserved-ejection-fraction
#13
REVIEW
Anna L Beale, Philippe Meyer, Thomas H Marwick, Carolyn S P Lam, David M Kaye
Consistent epidemiological data demonstrate that patients with heart failure with preserved ejection fraction (HFpEF) are more likely to be women than men. Exploring mechanisms behind this sex difference in heart failure epidemiology may enrich the understanding of underlying HFpEF pathophysiology and phenotypes, with the ultimate goal of identifying therapeutic approaches for the broader HFpEF population. In this review we evaluate the influence of sex on the key domains of cardiac structure and function, the systemic and pulmonary circulation, as well as extracardiac factors and comorbidities that may explain the predisposition of women to HFpEF...
July 10, 2018: Circulation
https://www.readbyqxmd.com/read/29958048/sex-differences-in-traditional-and-nontraditional-risk-factors-for-obstructive-coronary-artery-disease-in-stable-symptomatic-patients
#14
Hack-Lyoung Kim, Myung-A Kim, Sohee Oh, Mina Kim, Hyun Ju Yoon, Seong Mi Park, Mi Seung Shin, Kyung-Soon Hong, Gil Ja Shin, Wan-Joo Shim
BACKGROUND: There have been limited data on sex-specific risk factors for coronary artery disease (CAD) in patients with stable chest pain. This study was performed to investigate whether risk factors for CAD differ by sex in stable symptomatic patients. METHODS: Data were obtained from a nation-wide registry, enrolling 1025 patients (age, 62.0 ± 11.0 years, 587 women) with chest pain who underwent elective invasive coronary angiography under the suspicion of CAD...
June 29, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29939237/questioning-the-obvious-does-dyspnoea-really-matter-in-heart-failure
#15
Milton Packer
No abstract text is available yet for this article.
June 22, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29957236/the-role-of-nutraceuticals-in-statin-intolerant-patients
#16
REVIEW
Maciej Banach, Angelo Maria Patti, Rosaria Vincenza Giglio, Arrigo F G Cicero, Atanas G Atanasov, Gani Bajraktari, Eric Bruckert, Olivier Descamps, Dragan M Djuric, Marat Ezhov, Zlatko Fras, Stephan von Haehling, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, G B John Mancini, Dimitri P Mikhailidis, Olena Mitchenko, Patrick M Moriarty, Paul Muntner, Dragana Nikolic, Demosthenes B Panagiotakos, Gyorgy Paragh, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Željko Reiner, Giuseppe M C Rosano, Robert S Rosenson, Jacek Rysz, Amirhossein Sahebkar, Maria-Corina Serban, Dragos Vinereanu, Michal Vrablík, Gerald F Watts, Nathan D Wong, Manfredi Rizzo
Statins are the most common drugs administered for patients with cardiovascular disease. However, due to statin-associated muscle symptoms, adherence to statin therapy is challenging in clinical practice. Certain nutraceuticals, such as red yeast rice, bergamot, berberine, artichoke, soluble fiber, and plant sterols and stanols alone or in combination with each other, as well as with ezetimibe, might be considered as an alternative or add-on therapy to statins, although there is still insufficient evidence available with respect to long-term safety and effectiveness on cardiovascular disease prevention and treatment...
July 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29921571/marital-status-and-risk-of-cardiovascular-diseases-a-systematic-review-and-meta-analysis
#17
Chun Wai Wong, Chun Shing Kwok, Aditya Narain, Martha Gulati, Anastasia S Mihalidou, Pensee Wu, Mirvat Alasnag, Phyo Kyaw Myint, Mamas A Mamas
BACKGROUND: The influence of marital status on the incidence of cardiovascular disease (CVD) and prognosis after CVD is inconclusive. We systematically reviewed the literature to determine how marital status influences CVD and prognosis after CVD. METHODS: A search of MEDLINE and Embase in January 2018 without language restriction was performed to identify studies that evaluated the association between marital status and risk of CVD. Search terms related to both marital status and CVD were used and included studies had to be prospective in design...
June 19, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29948898/are-there-any-guarantees-with-the-warranty-period-for-normal-stress-spect-myocardial-perfusion-imaging
#18
EDITORIAL
Gary R Small, Terrence D Ruddy
No abstract text is available yet for this article.
June 14, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29896637/screening-for-cardiovascular-disease-risk-with-electrocardiography
#19
R Sacha Bhatia, Paul Dorian
No abstract text is available yet for this article.
June 12, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29753395/quantitative-extent-of-atherosclerotic-plaque-in-the-major-epicardial-coronary-arteries-in-patients-with-fatal-coronary-heart-disease-in-coronary-endarterectomy-specimens-in-aorta-coronary-saphenous-venous-conduits-and-means-to-prevent-the-plaques-a-review
#20
William C Roberts
This review tries to answer the following 15 questions: Is atherosclerosis a systemic or a regional disease? Is atherosclerosis in any particular region focal or diffuse? What is the quantity of atherosclerotic plaques in endarterectomy specimens of the right coronary artery in patients undergoing coronary artery bypass grafting (CABG) compared to that in the right coronary artery in patients with fatal coronary artery disease? How do the units used for measuring arterial narrowing by angiography compare to the units used for measuring arterial narrowing at necropsy? What do atherosclerotic plaques consist of in coronary arteries in patients with fatal coronary disease? What is the quantity of atherosclerotic plaque in bypassed -vs- non-bypassed native coronary arteries in patients dying early (<60 days) or late (>60 days) after coronary artery bypass grafting? What is the frequency of acute coronary lesions and multi-luminal channels at necropsy in patients with unstable angina pectoris, sudden coronary death, and acute myocardial infarction? What is the mechanism of luminal widening by angioplasty in the coronary arteries? What observations suggest that atherosclerotic plaques are the result at least in part of organization of thrombi? Is atherosclerosis a multifactoral or a unifactoral disease? What characteristics distinguish carnivores and herbivores? What are reasonable guidelines for whom to treat with lipid-altering agents? What is the rule of 5 and the rule of 7 in statin therapy? What is the effect of lipid lowering drug therapy on coronary luminal narrowing? What are some requisites for a healthy life?...
June 1, 2018: American Journal of Cardiology
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