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GMG/CARDIAC

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1420 papers 500 to 1000 followers CAD and Interventions
By Gregory Gustafson Interventional Cardiologist
https://www.readbyqxmd.com/read/30160521/serum-triglycerides-predict-first-cardiovascular-events-in-diabetic-patients-with-hypercholesterolemia-and-retinopathy
#1
Hayato Tada, Masa-Aki Kawashiri, Akihiro Nomura, Kenichi Yoshimura, Hiroshi Itoh, Issei Komuro, Masakazu Yamagishi
Aims Low-density lipoprotein cholesterol predicts cardiovascular events in patients with diabetes. However, it is uncertain whether serum triglycerides level is also associated with an occurrence of future cardiovascular events in diabetic patients. We aimed to test whether serum triglycerides is associated with first cardiovascular events in diabetic patients. Methods and results We recruited 5042 participants with diabetes mellitus from the standard versus intEnsive statin therapy for hypercholesteroleMic Patients with diAbetic retinopaTHY (EMPATHY), multicenter, prospective, randomized, open-label, blinded-endpoint study...
August 30, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/30269079/outcome-after-myocardial-infarction-without-obstructive-coronary-artery-disease
#2
Michael J A Williams, Peter R Barr, Mildred Lee, Katrina K Poppe, Andrew J Kerr
OBJECTIVE: The medium-term outcome and cause of death in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) is not well characterised. The aim of this study was to compare mortality and rates of recurrent events in post myocardial infarction (MI) patients with obstructive coronary artery disease (CAD) and in patients with MINOCA compared with an age and sex-matched cohort without cardiovascular disease (CVD). METHODS: We performed a national cohort study of consecutive patients undergoing coronary angiography for MI during 2 years between 2013 and 2015 from the All New Zealand Acute Coronary Syndrome-Quality Improvement (ANZACS QI) registry...
September 29, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30295766/inflammation-the-new-cardiovascular-risk-factor
#3
Thomas F Lüscher
No abstract text is available yet for this article.
October 7, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30312464/is-it-time-to-replace-conventional-angiography-with-coronary-computed-tomography
#4
Antonio Colombo, Francesco Giannini
No abstract text is available yet for this article.
November 1, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30328479/-minoca-myocardial-infarction-with-non-obstructive-coronary-arteries
#5
C Hamm, C W Hamm
In recent years it has been observed with increasing interest that there is a group of patients with electrocardiographic and laboratory features of myocardial infarction (MI) but no obstructive coronary artery disease (<50% diameter stenosis). For this entity the term myocardial infarction with non-obstructive coronary arteries (MINOCA) has been coined. The prevalence of MINOCA is estimated to be 6-9% among patients diagnosed with MI and it is more common in women than men as well as in patients presenting with NSTEMI than in those presenting with STEMI...
October 17, 2018: Herz
https://www.readbyqxmd.com/read/30289521/improving-outcomes-after-acute-coronary-events-what-works-and-what-doesn-t
#6
Thomas F Lüscher
No abstract text is available yet for this article.
August 1, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30242142/percutaneous-coronary-intervention-for-stable-coronary-artery-disease
#7
REVIEW
Rasha K Al-Lamee, Alexandra N Nowbar, Darrel P Francis
The adverse consequences of stable coronary artery disease (CAD) are death, myocardial infarction (MI) and angina. Trials in stable CAD show that percutaneous coronary intervention (PCI) does not reduce mortality. PCI does appear to reduce spontaneous MI rates but at the expense of causing some periprocedural MI. Therefore, the main purpose of PCI is to relieve angina. Indeed, patients and physicians often choose PCI rather than first attempting to control symptoms with anti-anginal medications as recommended by guidelines...
September 21, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30171861/the-septic-heart-current-understanding-of-molecular-mechanisms-and-clinical-implications
#8
REVIEW
Lukas Martin, Matthias Derwall, Sura Al Zoubi, Elisabeth Zechendorf, Daniel A Reuter, Chris Thiemermann, Tobias Schuerholz
Septic cardiomyopathy is a key feature of sepsis-associated cardiovascular failure. Despite the lack of consistent diagnostic criteria, patients typically exhibit ventricular dilatation, reduced ventricular contractility, and/or both right and left ventricular dysfunction with a reduced response to volume infusion. Although there is solid evidence that the presence of septic cardiomyopathy is a relevant contributor to organ dysfunction and an important factor in the already complicated therapeutic management of patients with sepsis, there are still several questions to be asked: Which factors/mechanisms cause a cardiac dysfunction associated with sepsis? How do we diagnose septic cardiomyopathy? How do we treat septic cardiomyopathy? How does septic cardiomyopathy influence the long-term outcome of the patient? Each of these questions is interrelated, and the answers require a profound understanding of the underlying pathophysiology that involves a complex mix of systemic factors and molecular, metabolic, and structural changes of the cardiomyocyte...
August 29, 2018: Chest
https://www.readbyqxmd.com/read/30197243/vasospastic-angina-a-literature-review-of-current-evidence
#9
REVIEW
Fabien Picard, Neila Sayah, Vincent Spagnoli, Julien Adjedj, Olivier Varenne
Vasospastic angina (VSA) is a variant form of angina pectoris, in which angina occurs at rest, with transient electrocardiogram modifications and preserved exercise capacity. VSA can be involved in many clinical scenarios, such as stable angina, sudden cardiac death, acute coronary syndrome, arrhythmia or syncope. Coronary vasospasm is a heterogeneous phenomenon that can occur in patients with or without coronary atherosclerosis, can be focal or diffuse, and can affect epicardial or microvasculature coronary arteries...
September 6, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/30190010/the-blood-pressure-landscape-schism-among-guidelines-confusion-among-physicians-and-anxiety-among-patients
#10
EDITORIAL
Franz H Messerli, Sripal Bangalore
No abstract text is available yet for this article.
September 11, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/30165617/fourth-universal-definition-of-myocardial-infarction-2018
#11
Kristian Thygesen, Joseph S Alpert, Allan S Jaffe, Bernard R Chaitman, Jeroen J Bax, David A Morrow, Harvey D White
No abstract text is available yet for this article.
August 25, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30166073/ticagrelor-plus-aspirin-for-1-month-followed-by-ticagrelor-monotherapy-for-23-months-vs-aspirin-plus-clopidogrel-or-ticagrelor-for-12-months-followed-by-aspirin-monotherapy-for-12-months-after-implantation-of-a-drug-eluting-stent-a-multicentre-open-label-randomised
#12
MULTICENTER STUDY
Pascal Vranckx, Marco Valgimigli, Peter Jüni, Christian Hamm, Philippe Gabriel Steg, Dik Heg, Gerrit Anne van Es, Eugene P McFadden, Yoshinobu Onuma, Cokky van Meijeren, Ply Chichareon, Edouard Benit, Helge Möllmann, Luc Janssens, Maurizio Ferrario, Aris Moschovitis, Aleksander Zurakowski, Marcello Dominici, Robert Jan Van Geuns, Kurt Huber, Ton Slagboom, Patrick W Serruys, Stephan Windecker
BACKGROUND: We hypothesised that ticagrelor, in combination with aspirin for 1 month, followed by ticagrelor alone, improves outcomes after percutaneous coronary intervention compared with standard antiplatelet regimens. METHODS: GLOBAL LEADERS was a randomised, open-label superiority trial at 130 sites in 18 countries. Patients undergoing percutaneous coronary intervention with a biolimus A9-eluting stent for stable coronary artery disease or acute coronary syndromes were randomly assigned (1:1) to 75-100 mg aspirin daily plus 90 mg ticagrelor twice daily for 1 month, followed by 23 months of ticagrelor monotherapy, or standard dual antiplatelet therapy with 75-100 mg aspirin daily plus either 75 mg clopidogrel daily (for patients with stable coronary artery disease) or 90 mg ticagrelor twice daily (for patients with acute coronary syndromes) for 12 months, followed by aspirin monotherapy for 12 months...
September 15, 2018: Lancet
https://www.readbyqxmd.com/read/29983721/a-study-on-the-relationship-between-waist-phenotype-hypertriglyceridemia-coronary-artery-lesions-and-serum-free-fatty-acids-in-adult-and-elderly-patients-with-coronary-diseases
#13
Rui-Feng Yang, Hanlei Zhang, Zhongchun Wang, Xiao-Yong Liu, Zhi Lin
Background: Abdominal obesity is an independent risk factor for coronary heart disease (CHD) and high serum triglyceride (TG) and free fatty acid levels may precipitate or aggravate CHD. Methods: We enrolled patients with coronary heart disease in our hospital from October 2008 to July 2009. Patients with high TG and increased WC, i.e. waist phenotype WP were included in group A. In group B, were included patients with high TG but not WP. Group C consisted of patients with WP but not high TG...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30152252/partial-oral-versus-intravenous-antibiotic-treatment-of-endocarditis
#14
Kasper Iversen, Nikolaj Ihlemann, Sabine U Gill, Trine Madsen, Hanne Elming, Kaare T Jensen, Niels E Bruun, Dan E Høfsten, Kurt Fursted, Jens J Christensen, Martin Schultz, Christine F Klein, Emil L Fosbøll, Flemming Rosenvinge, Henrik C Schønheyder, Lars Køber, Christian Torp-Pedersen, Jannik Helweg-Larsen, Niels Tønder, Claus Moser, Henning Bundgaard
Background Patients with infective endocarditis on the left side of the heart are typically treated with intravenous antibiotic agents for up to 6 weeks. Whether a shift from intravenous to oral antibiotics once the patient is in stable condition would result in efficacy and safety similar to those with continued intravenous treatment is unknown. Methods In a randomized, noninferiority, multicenter trial, we assigned 400 adults in stable condition who had endocarditis on the left side of the heart caused by streptococcus, Enterococcus faecalis, Staphylococcus aureus, or coagulase-negative staphylococci and who were being treated with intravenous antibiotics to continue intravenous treatment (199 patients) or to switch to oral antibiotic treatment (201 patients)...
August 28, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30153967/fourth-universal-definition-of-myocardial-infarction-2018
#15
Kristian Thygesen, Joseph S Alpert, Allan S Jaffe, Bernard R Chaitman, Jeroen J Bax, David A Morrow, Harvey D White
No abstract text is available yet for this article.
October 30, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/30146935/rivaroxaban-in-patients-with-heart-failure-sinus-rhythm-and-coronary-disease
#16
RANDOMIZED CONTROLLED TRIAL
Faiez Zannad, Stefan D Anker, William M Byra, John G F Cleland, Min Fu, Mihai Gheorghiade, Carolyn S P Lam, Mandeep R Mehra, James D Neaton, Christopher C Nessel, Theodore E Spiro, Dirk J van Veldhuisen, Barry Greenberg
BACKGROUND: Heart failure is associated with activation of thrombin-related pathways, which predicts a poor prognosis. We hypothesized that treatment with rivaroxaban, a factor Xa inhibitor, could reduce thrombin generation and improve outcomes for patients with worsening chronic heart failure and underlying coronary artery disease. METHODS: In this double-blind, randomized trial, 5022 patients who had chronic heart failure, a left ventricular ejection fraction of 40% or less, coronary artery disease, and elevated plasma concentrations of natriuretic peptides and who did not have atrial fibrillation were randomly assigned to receive rivaroxaban at a dose of 2...
October 4, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30145934/coronary-ct-angiography-and-5-year-risk-of-myocardial-infarction
#17
RANDOMIZED CONTROLLED TRIAL
David E Newby, Philip D Adamson, Colin Berry, Nicholas A Boon, Marc R Dweck, Marcus Flather, John Forbes, Amanda Hunter, Stephanie Lewis, Scott MacLean, Nicholas L Mills, John Norrie, Giles Roditi, Anoop S V Shah, Adam D Timmis, Edwin J R van Beek, Michelle C Williams
BACKGROUND: Although coronary computed tomographic angiography (CTA) improves diagnostic certainty in the assessment of patients with stable chest pain, its effect on 5-year clinical outcomes is unknown. METHODS: In an open-label, multicenter, parallel-group trial, we randomly assigned 4146 patients with stable chest pain who had been referred to a cardiology clinic for evaluation to standard care plus CTA (2073 patients) or to standard care alone (2073 patients)...
September 6, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30019767/polyunsaturated-fatty-acids-for-the-primary-and-secondary-prevention-of-cardiovascular-disease
#18
REVIEW
Asmaa S Abdelhamid, Nicole Martin, Charlene Bridges, Julii S Brainard, Xia Wang, Tracey J Brown, Sarah Hanson, Oluseyi F Jimoh, Sarah M Ajabnoor, Katherine Ho Deane, Fujian Song, Lee Hooper
BACKGROUND: Evidence on the health effects of total polyunsaturated fatty acids (PUFA) is equivocal. Fish oils are rich in omega-3 PUFA and plant oils in omega-6 PUFA. Evidence suggests that increasing PUFA-rich foods, supplements or supplemented foods can reduce serum cholesterol, but may increase body weight, so overall cardiovascular effects are unclear. OBJECTIVES: To assess effects of increasing total PUFA intake on cardiovascular disease and all-cause mortality, lipids and adiposity in adults...
July 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30092659/cardiac-rehabilitation-and-its-effects-on-cognition-in-patients-with-coronary-artery-disease-and-heart-failure
#19
REVIEW
Kannayiram Alagiakrishnan, Darren Mah, Gabor Gyenes
Cardiac rehabilitation program is an evidence-based intervention and established model of exercise delivery following myocardial infarction and heart failure. Although it forms an important part of recovery and helps to prevent future events and complications, there has been little focus on its potential cognitive benefits. Areas covered: Coronary artery disease and heart failure are common heart problems associated with significant morbidity and mortality, and cognitive decline is commonly seen in affected individuals...
September 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/30070222/assessment-of-functional-capacity-before-major-non-cardiac-surgery-an-international-prospective-cohort-study
#20
MULTICENTER STUDY
Duminda N Wijeysundera, Rupert M Pearse, Mark A Shulman, Tom E F Abbott, Elizabeth Torres, Althea Ambosta, Bernard L Croal, John T Granton, Kevin E Thorpe, Michael P W Grocott, Catherine Farrington, Paul S Myles, Brian H Cuthbertson
BACKGROUND: Functional capacity is an important component of risk assessment for major surgery. Doctors' clinical subjective assessment of patients' functional capacity has uncertain accuracy. We did a study to compare preoperative subjective assessment with alternative markers of fitness (cardiopulmonary exercise testing [CPET], scores on the Duke Activity Status Index [DASI] questionnaire, and serum N-terminal pro-B-type natriuretic peptide [NT pro-BNP] concentrations) for predicting death or complications after major elective non-cardiac surgery...
June 30, 2018: Lancet
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