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Adrenal insuff

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2 papers 25 to 100 followers
By Brooke Manor Endocrinology
Eva Boonen, Lies Langouche, Thomas Janssens, Philippe Meersseman, Hilke Vervenne, Emilie De Samblanx, Zoƫ Pironet, Lisa Van Dijck, Sarah Vander Perre, Inge Derese, Greet Van den Berghe
CONTEXT: Adrenal insufficiency is considered to be prevalent during critical illness, although the pathophysiology, diagnostic criteria, and optimal therapeutic strategy remain controversial. During critical illness, reduced cortisol breakdown contributes substantially to elevated plasma cortisol and low plasma ACTH concentrations. OBJECTIVE: Because ACTH has a trophic impact on the adrenal cortex, we hypothesized that with a longer duration of critical illness, subnormal ACTH adrenocortical stimulation predisposes to adrenal insufficiency...
November 2014: Journal of Clinical Endocrinology and Metabolism
Evangelia Charmandari, Nicolas C Nicolaides, George P Chrousos
Adrenal insufficiency is the clinical manifestation of deficient production or action of glucocorticoids, with or without deficiency also in mineralocorticoids and adrenal androgens. It is a life-threatening disorder that can result from primary adrenal failure or secondary adrenal disease due to impairment of the hypothalamic-pituitary axis. Prompt diagnosis and management are essential. The clinical manifestations of primary adrenal insufficiency result from deficiency of all adrenocortical hormones, but they can also include signs of other concurrent autoimmune conditions...
June 21, 2014: Lancet
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