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Allergy & Immunology

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7 papers 100 to 500 followers
By Brooke Manor Endocrinology
https://www.readbyqxmd.com/read/24776388/the-involvement-of-glucocorticoids-in-psychological-stress-induced-exacerbations-of-experimental-allergic-asthma
#1
Kaori Okuyama, Kazuhisa Dobashi, Tomomitsu Miyasaka, Naoki Yamazaki, Toshiaki Kikuchi, Ichiro Sora, Motoaki Takayanagi, Hirohito Kita, Isao Ohno
BACKGROUND: Psychological stress is associated with the aggravation of asthma symptoms. Glucocorticoids (GC), which are stress hormones released upon exposure to stress, have the potential to shift immune responses towards a predominant Th2 response by priming antigen-presenting cells to produce lower levels of IL-12 as well as reducing the development of regulatory T cells. However, the involvement of GC in psychological stress-induced exacerbations of allergic asthma has not yet been clarified...
2014: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/24796647/ccl11-as-a-potential-diagnostic-marker-for-asthma
#2
REVIEW
Dandan Wu, Ji Zhou, Hui Bi, Lingling Li, Wei Gao, Mao Huang, Ian M Adcock, Peter J Barnes, Xin Yao
OBJECTIVE: Asthma is an inflammatory airway disease characterized by airway eosinophilia, in which CCL11 (eotaxin) plays a crucial role. The aim of study is to determine the elevation of CCL11 levels in bronchoalveolar lavage fluid (BALF), blood, exhaled breath condensate (EBC) and sputum in asthma patients and to identify which medium yields the most significant change in CCL11 level. METHODS: The databases of PubMed, Embase and Cochrane Centre Register of Controlled Trials were systematically searched from inception to September 2013...
October 2014: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/24256378/vitamin-d-binding-protein-and-vitamin-d-status-of-black-americans-and-white-americans
#3
COMPARATIVE STUDY
Camille E Powe, Michele K Evans, Julia Wenger, Alan B Zonderman, Anders H Berg, Michael Nalls, Hector Tamez, Dongsheng Zhang, Ishir Bhan, S Ananth Karumanchi, Neil R Powe, Ravi Thadhani
BACKGROUND: Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency. METHODS: In the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort of blacks and whites (2085 participants), we measured levels of total 25-hydroxyvitamin D, vitamin D-binding protein, and parathyroid hormone as well as bone mineral density (BMD). We genotyped study participants for two common polymorphisms in the vitamin D-binding protein gene (rs7041 and rs4588)...
November 21, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/24131275/%C3%AE-2-adrenergic-receptor-gene-methylation-is-associated-with-decreased-asthma-severity-in-inner-city-schoolchildren-asthma-and-rhinitis
#4
J M Gaffin, B A Raby, C R Petty, E B Hoffman, A A Baccarelli, D R Gold, W Phipatanakul
BACKGROUND: Genetic variation in the β-2 adrenergic receptor gene (ADRB2) has been implicated in asthma severity and control with conflicting results. Epigenetic variation in the ADRB2 may play an important role in asthma phenotype. OBJECTIVE: We aimed to evaluate whether DNA methylation of ADRB2 is associated with asthma phenotypes in inner-city school-aged children. METHODS: Multiple CpG sites in the promoter region of ADRB2 gene were analysed in 177 children enrolled in the School Inner-City Asthma Study...
2014: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/24697316/environmental-exposures-and-asthma-morbidity-in-children-living-in-urban-neighborhoods
#5
REVIEW
E C Matsui
A substantial disparity in asthma prevalence and morbidity among urban children compared with their nonurban counterparts has been recognized for more than two decades. Because of the nature of urban neighborhoods, pest allergens, such as cockroach and mouse, are present in high concentrations in US urban housing and have both repeatedly been linked to asthma morbidity in sensitized children. In addition, there is a growing body of evidence demonstrating that concentrations of many pollutants are higher indoors than outdoors in both US and European urban communities and that exposures to indoor pollutants such as particulate matter (PM) and nitrogen dioxide (NO2 ) are independently associated with symptoms in children with asthma...
May 2014: Allergy
https://www.readbyqxmd.com/read/23612223/the-osteocyte-an-endocrine-cell-and-more
#6
REVIEW
Sarah L Dallas, Matthew Prideaux, Lynda F Bonewald
Few investigators think of bone as an endocrine gland, even after the discovery that osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and potentially other organs. In fact, until the last few years, osteocytes were perceived by many as passive, metabolically inactive cells. However, exciting recent discoveries have shown that osteocytes encased within mineralized bone matrix are actually multifunctional cells with many key regulatory roles in bone and mineral homeostasis. In addition to serving as endocrine cells and regulators of phosphate homeostasis, these cells control bone remodeling through regulation of both osteoclasts and osteoblasts, are mechanosensory cells that coordinate adaptive responses of the skeleton to mechanical loading, and also serve as a manager of the bone's reservoir of calcium...
October 2013: Endocrine Reviews
https://www.readbyqxmd.com/read/21757592/plasmablastic-lymphoma-and-related-disorders
#7
REVIEW
Eric D Hsi, Robert B Lorsbach, Falko Fend, Ahmet Dogan
B-cell lymphomas with plasmablastic features are a heterogeneous group of lymphomas. While they may share overlapping morphologic or immunophenotypic features, distinct clinicopathologic or molecular genetic features exist for some that have allowed their recognition as distinct entities. Session 2 of the 2009 Society for Hematopathology/European Association for Haematopathology Workshop dealt with the theme of plasmablastic lymphomas (PBLs) and related disorders. Topics included human herpesvirus 8-associated Castleman disease and PBLs, PBLs occurring in the setting of HIV infection, anaplastic large cell lymphoma kinase+ diffuse large B-cell lymphoma, and other lymphomas with plasmablastic or plasmacytic features...
August 2011: American Journal of Clinical Pathology
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