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Oncology

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5 papers 500 to 1000 followers
By Brooke Manor Endocrinology
https://www.readbyqxmd.com/read/25060519/armed-oncolytic-virus-enhances-immune-functions-of-chimeric-antigen-receptor-modified-t-cells-in-solid-tumors
#1
Nobuhiro Nishio, Iulia Diaconu, Hao Liu, Vincenzo Cerullo, Ignazio Caruana, Valentina Hoyos, Lisa Bouchier-Hayes, Barbara Savoldo, Gianpietro Dotti
The clinical efficacy of chimeric antigen receptor (CAR)-redirected T cells remains marginal in solid tumors compared with leukemias. Failures have been attributed to insufficient T-cell migration and to the highly immunosuppressive milieu of solid tumors. To overcome these obstacles, we have combined CAR-T cells with an oncolytic virus armed with the chemokine RANTES and the cytokine IL15, reasoning that the modified oncolytic virus will both have a direct lytic effect on infected malignant cells and facilitate migration and survival of CAR-T cells...
September 15, 2014: Cancer Research
https://www.readbyqxmd.com/read/24954779/chemoimmunotherapy-still-waiting-for-the-magic-to-happen
#2
COMMENT
Anna K Nowak, Willem J Lesterhuis
No abstract text is available yet for this article.
July 2014: Lancet Oncology
https://www.readbyqxmd.com/read/23922062/mucosal-healing-and-risk-for-lymphoproliferative-malignancy-in-celiac-disease-a-population-based-cohort-study
#3
MULTICENTER STUDY
Benjamin Lebwohl, Fredrik Granath, Anders Ekbom, Karin E Smedby, Joseph A Murray, Alfred I Neugut, Peter H R Green, Jonas F Ludvigsson
BACKGROUND: Celiac disease (CD) is associated with an increased risk for lymphoproliferative malignancy (LPM). Whether this risk is affected by the results of follow-up intestinal biopsy, performed to document mucosal healing, is unknown. OBJECTIVE: To examine the association between mucosal healing in CD and subsequent LPM. DESIGN: Population-based cohort study. SETTING: 28 pathology departments in Sweden. PATIENTS: 7625 patients with CD who had follow-up biopsy after initial diagnosis...
August 6, 2013: Annals of Internal Medicine
https://www.readbyqxmd.com/read/24778417/chemotherapeutic-targeting-of-cancer-induced-immunosuppressive-cells
#4
REVIEW
Darya Alizadeh, Nicolas Larmonier
The expansion of immunosuppressive cells represents a cardinal strategy deployed by tumors to escape from detection and elimination by the immune system. Regulatory T lymphocytes (Treg) and myeloid-derived suppressor cells (MDSC), major components of these inhibitory cellular networks, have drawn intense scrutiny in recent years. In patients with cancer and in animal tumor models, these suppressor cells accumulate in the tumor microenvironment, secondary lymphoid tissues, and in the blood. Equipped with the ability to suppress innate and adaptive anticancer immunity, these cells also foster disease development by promoting tumor neoangiogenesis and by enhancing cancer metastasis...
May 15, 2014: Cancer Research
https://www.readbyqxmd.com/read/24762395/p53-is-positively-regulated-by-mir-542-3p
#5
Yemin Wang, Jen-Wei Huang, Maria Castella, David George Huntsman, Toshiyasu Taniguchi
The tumor suppressor p53 and miRNAs are linked through a complex network. Several miRNAs modulate p53 expression, while p53 regulates the transcription and/or biogenesis of several other miRNAs. Here, we report the development of a cell-based assay used with a library of human miRNA mimics in a high-throughput screen for miRNAs that modulate p53 expression. Overexpression of miRNA (miR)-542-3p in cancer cells elevated p53 expression, stimulated the expression of p53 targets, and inhibited cell proliferation...
June 15, 2014: Cancer Research
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