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RANDOMIZED CONTROLLED TRIAL
Glenn Hernández, Gustavo A Ospina-Tascón, Lucas Petri Damiani, Elisa Estenssoro, Arnaldo Dubin, Javier Hurtado, Gilberto Friedman, Ricardo Castro, Leyla Alegría, Jean-Louis Teboul, Maurizio Cecconi, Giorgio Ferri, Manuel Jibaja, Ronald Pairumani, Paula Fernández, Diego Barahona, Vladimir Granda-Luna, Alexandre Biasi Cavalcanti, Jan Bakker, Glenn Hernández, Gustavo Ospina-Tascón, Lucas Petri Damiani, Elisa Estenssoro, Arnaldo Dubin, Javier Hurtado, Gilberto Friedman, Ricardo Castro, Leyla Alegría, Jean-Louis Teboul, Maurizio Cecconi, Maurizio Cecconi, Giorgio Ferri, Manuel Jibaja, Ronald Pairumani, Paula Fernández, Diego Barahona, Alexandre Biasi Cavalcanti, Jan Bakker, Glenn Hernández, Leyla Alegría, Giorgio Ferri, Nicolás Rodriguez, Patricia Holger, Natalia Soto, Mario Pozo, Jan Bakker, Deborah Cook, Jean-Louis Vincent, Andrew Rhodes, Bryan P Kavanagh, Phil Dellinger, Wim Rietdijk, David Carpio, Nicolás Pavéz, Elizabeth Henriquez, Sebastian Bravo, Emilio Daniel Valenzuela, Magdalena Vera, Jorge Dreyse, Vanessa Oviedo, Maria Alicia Cid, Macarena Larroulet, Edward Petruska, Claudio Sarabia, David Gallardo, Juan Eduardo Sanchez, Hugo González, José Miguel Arancibia, Alex Muñoz, Germán Ramirez, Florencia Aravena, Andrés Aquevedo, Fabián Zambrano, Milan Bozinovic, Felipe Valle, Manuel Ramirez, Victor Rossel, Pilar Muñoz, Carolina Ceballos, Christian Esveile, Cristian Carmona, Eva Candia, Daniela Mendoza, Aída Sanchez, Daniela Ponce, Daniela Ponce, Jaime Lastra, Bárbara Nahuelpán, Fabrizio Fasce, Cecilia Luengo, Nicolas Medel, Cesar Cortés, Luz Campassi, Paolo Rubatto, Nahime Horna, Mariano Furche, Juan Carlos Pendino, Lisandro Bettini, Carlos Lovesio, María Cecilia González, Jésica Rodruguez, Héctor Canales, Francisco Caminos, Cayetano Galletti, Estefanía Minoldo, Maria Jose Aramburu, Daniela Olmos, Nicolás Nin, Jordán Tenzi, Carlos Quiroga, Pablo Lacuesta, Agustín Gaudín, Richard Pais, Ana Silvestre, Germán Olivera, Gloria Rieppi, Dolores Berrutti, Marcelo Ochoa, Paul Cobos, Fernando Vintimilla, Vanessa Ramirez, Milton Tobar, Fernanda García, Fabricio Picoita, Nelson Remache, Vladimir Granda, Fernando Paredes, Eduardo Barzallo, Paul Garcés, Fausto Guerrero, Santiago Salazar, German Torres, Cristian Tana, José Calahorrano, Freddy Solis, Pedro Torres, Luís Herrera, Antonio Ornes, Verónica Peréz, Glenda Delgado, Alexei López, Eliana Espinosa, José Moreira, Blanca Salcedo, Ivonne Villacres, Jhonny Suing, Marco Lopez, Luis Gomez, Guillermo Toctaquiza, Mario Cadena Zapata, Milton Alonso Orazabal, Ruben Pardo Espejo, Jorge Jimenez, Alexander Calderón, Gustavo Paredes, José Luis Barberán, Tatiana Moya, Horacio Atehortua, Rodolfo Sabogal, Guillermo Ortiz, Antonio Lara, Fabio Sanchez, Alvaro Hernán Portilla, Humberto Dávila, Jorge Antonio Mora, Luis Eduardo Calderón, Ingrid Alvarez, Elena Escobar, Alejandro Bejarano, Luis Alfonso Bustamante, José Luis Aldana
IMPORTANCE: Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic shock has not been established. OBJECTIVE: To determine if a peripheral perfusion-targeted resuscitation during early septic shock in adults is more effective than a lactate level-targeted resuscitation for reducing mortality...
February 19, 2019: JAMA
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JOURNAL ARTICLE
Signe Søvik, Marie Susanna Isachsen, Kine Marie Nordhuus, Christine Kooy Tveiten, Torsten Eken, Kjetil Sunde, Kjetil Gundro Brurberg, Sigrid Beitland
PURPOSE: To perform a systematic review and meta-analysis of acute kidney injury (AKI) in trauma patients admitted to the intensive care unit (ICU). METHODS: We conducted a systematic literature search of studies on AKI according to RIFLE, AKIN, or KDIGO criteria in trauma patients admitted to the ICU (PROSPERO CRD42017060420). We searched PubMed, Cochrane Database of Systematic Reviews, UpToDate, and NICE through 3 December 2018. Data were collected on incidence of AKI, risk factors, renal replacement therapy (RRT), renal recovery, length of stay (LOS), and mortality...
April 2019: Intensive Care Medicine
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COMPARATIVE STUDY
Halinder S Mangat, Xian Wu, Linda M Gerber, Justin T Schwarz, Malik Fakhar, Santosh B Murthy, Philip E Stieg, Jamshid Ghajar, Roger Härtl
BACKGROUND: Hypertonic saline (HTS) and mannitol are effective in reducing intracranial pressure (ICP) after severe traumatic brain injury (TBI). However, their simultaneous effect on the cerebral perfusion pressure (CPP) and ICP has not been studied rigorously. OBJECTIVE: To determine the difference in effects of HTS and mannitol on the combined burden of high ICP and low CPP in patients with severe TBI. METHODS: We performed a case-control study using prospectively collected data from the New York State TBI-trac® database (Brain Trauma Foundation, New York, New York)...
February 1, 2020: Neurosurgery
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REVIEW
David Slessor, Simon Hunter
STUDY OBJECTIVE: The role of emergency department (ED) thoracotomy after blunt trauma is controversial. The objective of this review is to determine whether patients treated with an ED thoracotomy after blunt trauma survive and whether survivors have a good neurologic outcome. METHODS: A structured search was performed with MEDLINE, EMBASE, CINAHL, and PubMed. Inclusion criteria were ED thoracotomy or out-of-hospital thoracotomy, cardiac arrest or periarrest, and blunt trauma...
March 2015: Annals of Emergency Medicine
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REVIEW
H M A Kaafarani, G C Velmahos
INTRODUCTION: Most preventable trauma deaths are due to uncontrolled hemorrhage. METHODS: In this article, we briefly describe the pathophysiology of the classical triad of death in trauma, namely, acidosis, hypothermia, and coagulopathy, and then suggest damage control resuscitation strategies to prevent and/or mitigate the effects of each in the bleeding patient. RESULTS: Damage control resuscitation strategies include body rewarming, restrictive fluid administration, permissive hypotension, balanced blood product administration, and the implementation of massive transfusion protocols...
June 2014: Scandinavian Journal of Surgery: SJS
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