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Breast Cancer

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4 papers 100 to 500 followers
By Brooke Manor Endocrinology
Hendrika M Oosterkamp, E Marielle Hijmans, Thijn R Brummelkamp, Sander Canisius, Lodewyk F A Wessels, Wilbert Zwart, René Bernards
Tamoxifen is one of the most widely used endocrine agents for the treatment of estrogen receptor α (ERα)-positive breast cancer. Although effective in most patients, resistance to tamoxifen is a clinically significant problem and the mechanisms responsible remain elusive. To address this problem, we performed a large scale loss-of-function genetic screen in ZR-75-1 luminal breast cancer cells to identify candidate resistance genes. In this manner, we found that loss of function in the deubiquitinase USP9X prevented proliferation arrest by tamoxifen, but not by the ER downregulator fulvestrant...
July 15, 2014: Cancer Research
Donald P McDonnell, Sunghee Park, Matthew T Goulet, Jeff Jasper, Suzanne E Wardell, Ching-Yi Chang, John D Norris, John R Guyton, Erik R Nelson
Obesity and altered lipid metabolism are risk factors for breast cancer in pre- and post-menopausal women. These pathologic relationships have been attributed in part to the impact of cholesterol on the biophysical properties of cell membranes and to the influence of these changes on signaling events initiated at the membrane. However, more recent studies have indicated that the oxysterol 27-hydroxycholesterol (27HC), and not cholesterol per se, may be the primary biochemical link between lipid metabolism and cancer...
September 15, 2014: Cancer Research
Chelsea Catsburg, Marc J Gunter, Chu Chen, Michele L Cote, Geoffrey C Kabat, Rami Nassir, Lesley Tinker, Jean Wactawski-Wende, David L Page, Thomas E Rohan
Women with benign proliferative breast disease (BPBD) are at increased risk for developing breast cancer. Evidence suggests that accumulation of adipose tissue can influence breast cancer development via hyperinsulinemia, increased estrogen, and/or inflammation. However, there are limited data investigating these pathways with respect to risk of BPBD. We evaluated serologic markers from these pathways in a case-control study of postmenopausal women nested within the Women's Health Initiative Clinical Trial...
June 15, 2014: Cancer Research
Allison W Kurian, Emily E Hare, Meredith A Mills, Kerry E Kingham, Lisa McPherson, Alice S Whittemore, Valerie McGuire, Uri Ladabaum, Yuya Kobayashi, Stephen E Lincoln, Michele Cargill, James M Ford
PURPOSE: Multiple-gene sequencing is entering practice, but its clinical value is unknown. We evaluated the performance of a customized germline-DNA sequencing panel for cancer-risk assessment in a representative clinical sample. METHODS: Patients referred for clinical BRCA1/2 testing from 2002 to 2012 were invited to donate a research blood sample. Samples were frozen at -80° C, and DNA was extracted from them after 1 to 10 years. The entire coding region, exon-intron boundaries, and all known pathogenic variants in other regions were sequenced for 42 genes that had cancer risk associations...
July 1, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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