R Lawrence Moss, Reed A Dimmitt, Douglas C Barnhart, Karl G Sylvester, Rebeccah L Brown, David M Powell, Saleem Islam, Jacob C Langer, Thomas T Sato, Mary L Brandt, Hanmin Lee, Martin L Blakely, Eric L Lazar, Ronald B Hirschl, Brian D Kenney, David J Hackam, Daniel Zelterman, Bonnie L Silverman
BACKGROUND: Perforated necrotizing enterocolitis is a major cause of morbidity and mortality in premature infants, and the optimal treatment is uncertain. We designed this multicenter randomized trial to compare outcomes of primary peritoneal drainage with laparotomy and bowel resection in preterm infants with perforated necrotizing enterocolitis. METHODS: We randomly assigned 117 preterm infants (delivered before 34 weeks of gestation) with birth weights less than 1500 g and perforated necrotizing enterocolitis at 15 pediatric centers to undergo primary peritoneal drainage or laparotomy with bowel resection...
May 25, 2006: New England Journal of Medicine