Chris P H Lexis, Iwan C C van der Horst, Erik Lipsic, Wouter G Wieringa, Rudolf A de Boer, Ad F M van den Heuvel, Hindrik W van der Werf, Remco A J Schurer, Gabija Pundziute, Eng S Tan, Wybe Nieuwland, Hendrik M Willemsen, Bernard Dorhout, Barbara H W Molmans, Anouk N A van der Horst-Schrivers, Bruce H R Wolffenbuttel, Gert J ter Horst, Albert C van Rossum, Jan G P Tijssen, Hans L Hillege, Bart J G L de Smet, Pim van der Harst, Dirk J van Veldhuisen
IMPORTANCE: Metformin treatment is associated with improved outcome after myocardial infarction in patients with diabetes. In animal experimental studies metformin preserves left ventricular function. OBJECTIVE: To evaluate the effect of metformin treatment on preservation of left ventricular function in patients without diabetes presenting with ST-segment elevation myocardial infarction (STEMI). DESIGN, SETTING, AND PARTICIPANTS: Double-blind, placebo-controlled study conducted among 380 patients who underwent primary percutaneous coronary intervention (PCI) for STEMI at the University Medical Center Groningen, The Netherlands, between January 1, 2011, and May 26, 2013...
April 16, 2014: JAMA