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78 papers 25 to 100 followers
By Erica Yama Nephrologist
https://www.readbyqxmd.com/read/27555797/current-best-practice-in-the-management-of-hypertensive-disorders-in-pregnancy
#1
REVIEW
Rosemary Townsend, Patrick O'Brien, Asma Khalil
Preeclampsia is a potentially serious complication of pregnancy with increasing significance worldwide. Preeclampsia is the cause of 9%-26% of global maternal mortality and a significant proportion of preterm delivery, and maternal and neonatal morbidity. Incidence is increasing in keeping with the increase in obesity, maternal age, and women with medical comorbidities entering pregnancy. Recent developments in the understanding of the pathophysiology of preeclampsia have opened new avenues for prevention, screening, and management of this condition...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/27616593/interpretation-of-the-evidence-for-the-efficacy-and-safety-of-statin-therapy
#2
Rory Collins, Christina Reith, Jonathan Emberson, Jane Armitage, Colin Baigent, Lisa Blackwell, Roger Blumenthal, John Danesh, George Davey Smith, David DeMets, Stephen Evans, Malcolm Law, Stephen MacMahon, Seth Martin, Bruce Neal, Neil Poulter, David Preiss, Paul Ridker, Ian Roberts, Anthony Rodgers, Peter Sandercock, Kenneth Schulz, Peter Sever, John Simes, Liam Smeeth, Nicholas Wald, Salim Yusuf, Richard Peto
This Review is intended to help clinicians, patients, and the public make informed decisions about statin therapy for the prevention of heart attacks and strokes. It explains how the evidence that is available from randomised controlled trials yields reliable information about both the efficacy and safety of statin therapy. In addition, it discusses how claims that statins commonly cause adverse effects reflect a failure to recognise the limitations of other sources of evidence about the effects of treatment...
September 8, 2016: Lancet
https://www.readbyqxmd.com/read/22713617/the-role-of-plasmapheresis-in-critical-illness
#3
REVIEW
Trung C Nguyen, Joseph E Kiss, Jordana R Goldman, Joseph A Carcillo
In this article, the authors review the current recommendations from the American Society for Apheresis regarding the use of plasmapheresis in many of the diseases that intensivists commonly encounter in critically ill patients. Recent experience indicates that therapeutic plasma exchange may be useful in a wide spectrum of illnesses characterized by microvascular thrombosis, the presence of autoantibodies, immune activation with dysregulation of immune response, and some infections.
July 2012: Critical Care Clinics
https://www.readbyqxmd.com/read/26976277/crystalloid-fluid-therapy
#4
REVIEW
Sumeet Reddy, Laurence Weinberg, Paul Young
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at http://www.biomedcentral.com/collections/annualupdate2016. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.
March 15, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26851273/antibiotics-from-prehistory-to-the-present-day
#5
REVIEW
Kate Gould
Antimicrobials have been in use for many thousands of years in a variety of formats. In this article, I trace how we have moved from ingenious use of agents available in the environment to chemically engineered agents.
March 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26903338/the-third-international-consensus-definitions-for-sepsis-and-septic-shock-sepsis-3
#6
Mervyn Singer, Clifford S Deutschman, Christopher Warren Seymour, Manu Shankar-Hari, Djillali Annane, Michael Bauer, Rinaldo Bellomo, Gordon R Bernard, Jean-Daniel Chiche, Craig M Coopersmith, Richard S Hotchkiss, Mitchell M Levy, John C Marshall, Greg S Martin, Steven M Opal, Gordon D Rubenfeld, Tom van der Poll, Jean-Louis Vincent, Derek C Angus
IMPORTANCE: Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination. OBJECTIVE: To evaluate and, as needed, update definitions for sepsis and septic shock. PROCESS: A task force (n = 19) with expertise in sepsis pathobiology, clinical trials, and epidemiology was convened by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine...
February 23, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26927525/new-sepsis-criteria-a-change-we-should-not%C3%A2-make
#7
EDITORIAL
Steven Q Simpson
No abstract text is available yet for this article.
May 2016: Chest
https://www.readbyqxmd.com/read/26952548/teratogenic-effects-of-the-zika-virus-and-the-role-of-the-placenta
#8
Jennifer J Adibi, Ernesto T A Marques, Abigail Cartus, Richard H Beigi
The mechanism by which the Zika virus can cause fetal microcephaly is not known. Reports indicate that Zika is able to evade the normal immunoprotective responses of the placenta. Microcephaly has genetic causes, some associated with maternal exposures including radiation, tobacco smoke, alcohol, and viruses. Two hypotheses regarding the role of the placenta are possible: one is that the placenta directly conveys the Zika virus to the early embryo or fetus. Alternatively, the placenta itself might be mounting a response to the exposure; this response might be contributing to or causing the brain defect...
April 9, 2016: Lancet
https://www.readbyqxmd.com/read/26928912/diagnosis-and-management-of-diabetes-synopsis-of-the-2016-american-diabetes-association-standards-of-medical-care-in-diabetes
#9
James J Chamberlain, Andrew S Rhinehart, Charles F Shaefer, Annie Neuman
DESCRIPTION: The American Diabetes Association (ADA) published the 2016 Standards of Medical Care in Diabetes (Standards) to provide clinicians, patients, researchers, payers, and other interested parties with the components of diabetes care, general treatment goals, and tools to evaluate the quality of care. METHODS: The ADA Professional Practice Committee performed a systematic search on MEDLINE to revise or clarify recommendations based on new evidence. The committee assigns the recommendations a rating of A, B, or C, depending on the quality of evidence...
April 19, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/26761185/zika-virus-in-the-americas-yet-another-arbovirus-threat
#10
Anthony S Fauci, David M Morens
The explosive pandemic of Zika virus infection occurring throughout South America, Central America, and the Caribbean (see map) and potentially threatening the United States is the most recent of four unexpected arrivals of important arthropod-borne viral diseases in the Western Hemisphere over the..
February 18, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26616536/managing-urolithiasis
#11
REVIEW
Ralph C Wang
No abstract text is available yet for this article.
April 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/26684610/happiness-and-unhappiness-have-no-direct-effect-on-mortality
#12
COMMENT
Philipe de Souto Barreto, Yves Rolland
No abstract text is available yet for this article.
February 27, 2016: Lancet
https://www.readbyqxmd.com/read/26547467/does-this-patient-with-chest-pain-have-acute-coronary-syndrome-the-rational-clinical-examination-systematic-review
#13
REVIEW
Alexander C Fanaroff, Jennifer A Rymer, Sarah A Goldstein, David L Simel, L Kristin Newby
IMPORTANCE: About 10% of patients with acute chest pain are ultimately diagnosed with acute coronary syndrome (ACS). Early, accurate estimation of the probability of ACS in these patients using the clinical examination could prevent many hospital admissions among low-risk patients and ensure that high-risk patients are promptly treated. OBJECTIVE: To review systematically the accuracy of the initial history, physical examination, electrocardiogram, and risk scores incorporating these elements with the first cardiac-specific troponin...
November 10, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26340972/management-of-endocrine-disease-metabolic-effects-of-bariatric-surgery
#14
REVIEW
Ricard Corcelles, Christopher R Daigle, Philip R Schauer
Obesity is associated with an increased risk of type 2 diabetes, hypertension, dyslipidemia, cardiovascular disease, osteoarthritis, numerous cancers and increased mortality. It is estimated that at least 2.8 million adults die each year due to obesity-related cardiovascular disease. Increasing in parallel with the global obesity problem is metabolic syndrome, which has also reached epidemic levels. Numerous studies have demonstrated that bariatric surgery is associated with significant and durable weight loss with associated improvement of obesity-related comorbidities...
January 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/26251395/towards-long-term-responses-in-fukushima
#15
Michael R Reich, Aya Goto
No abstract text is available yet for this article.
August 1, 2015: Lancet
https://www.readbyqxmd.com/read/26132942/an-integrated-view-of-potassium-homeostasis
#16
REVIEW
Michelle L Gumz, Lawrence Rabinowitz, Charles S Wingo
New England Journal of Medicine, Volume 373, Issue 1, Page 60-72, July 2015.
July 2, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26244308/electrolyte-and-acid-base-disturbances-in-patients-with-diabetes-mellitus
#17
REVIEW
Biff F Palmer, Deborah J Clegg
No abstract text is available yet for this article.
August 6, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25777666/oral-anticoagulants-for-stroke-prevention-in-atrial-fibrillation-current-status-special-situations-and-unmet-needs
#18
REVIEW
Freek W A Verheugt, Christopher B Granger
In patients with non-valvular atrial fibrillation, oral anticoagulation with vitamin K antagonists reduces the risk of stroke by more than 60%. But vitamin K antagonists have limitations, including causing serious bleeding such as intracranial haemorrhage and the need for anticoagulation monitoring. In part related to these limitations, they are used in only about half of patients who should be treated according to guideline recommendations. In the past decade, oral agents have been developed that directly block the activity of thrombin (factor IIa), as well as drugs that directly inhibit activated factor X (Xa), which is the first protein in the final common pathway to the activation of thrombin...
July 18, 2015: Lancet
https://www.readbyqxmd.com/read/25494270/lactic-acidosis
#19
REVIEW
Jeffrey A Kraut, Nicolaos E Madias
New England Journal of Medicine, Volume 371, Issue 24, Page 2309-2319, December 2014.
December 11, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/21037016/a-concise-review-of-pulmonary-sarcoidosis
#20
REVIEW
Robert P Baughman, Daniel A Culver, Marc A Judson
This is an update on sarcoidosis, focusing on etiology, diagnosis, and treatment. In the area of etiopathogenesis, we now have a better understanding of the immune response that leads to the disease as well as genetic factors that modify both the risk for the disease and its clinical outcome. Several groups have also identified possible agents as a cause for sarcoidosis. Although none of these potential causes has been definitely confirmed, there is increasing evidence to support that one or more infectious agents may cause sarcoidosis, although this organism may no longer be viable in the patient...
March 1, 2011: American Journal of Respiratory and Critical Care Medicine
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