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Reward dysfunction in AD/HD

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255 papers 500 to 1000 followers Several notable papers detailing recent and historical evidence for amotivational symptoms in AD/HD
https://www.readbyqxmd.com/read/29943173/the-relationship-between-responsiveness-to-social-and-monetary-rewards-and-adhd-symptoms
#1
Bernis Sutcubasi, Baris Metin, Cumhur Tas, Fatma Keskin Krzan, Berna A Sarı, Betul Ozcimen, Nevzat Tarhan
Alterations in reward processing are frequently reported in attention deficit hyperactivity disorder (ADHD). One important factor affecting reward processing is the quality of reward as social and monetary rewards are processed by different neural networks. However, the effect of reward type on reward processing in ADHD has not been extensively studied. Hence, in the current study, an exploratory research was conducted to investigate the effect of reward type (i.e., social or monetary) on different phases of reward processing...
June 25, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29924634/reward-based-learning-as-a-function-of-severity-of-substance-abuse-risk-in-drug-na%C3%A3-ve-youth-with-adhd
#2
Muhammad A Parvaz, Kristen Kim, Sean Froudist-Walsh, Jeffrey H Newcorn, Iliyan Ivanov
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is associated with elevated risk for later development of substance use disorders (SUD), specifically because youth with ADHD, similar to individuals with SUD, exhibit deficits in learning abilities and reward processing. Another known risk factor for SUD is familial history of substance dependence. Youth with familial SUD history show reward processing deficits, higher prevalence of externalizing disorders, and higher impulsivity scores...
June 20, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29888833/just-in-time-response-to-reward-as-a-function-of-adhd-symptom-severity
#3
Clara Pretus, Marisol Picado, Josep Antoni Ramos-Quiroga, Susana Carmona, Vanesa Richarte, Jordi Fauquet, Óscar Vilarroya
AIM: Attention-deficit hyperactivity disorder (ADHD) neuroimaging studies have identified substantial differences in reward-related circuits on a trial-by-trial basis. However, no research to date has evaluated the effect of motivational context on neural activity in settings with intermittent reward in ADHD. The present study was designed to identify neural processes underlying both immediate effects of reward and sustained effects of reward associated with motivational context in adult ADHD patients...
June 11, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29891732/cell-type-specific-role-of-%C3%AE-fosb-in-nucleus-accumbens-in-modulating-inter-male-aggression
#4
Hossein Aleyasin, Meghan E Flanigan, Sam A Golden, Aki Takahashi, Caroline Menard, Madeline L Pfau, Jacob Multer, Jacqueline Pina, Kathryn A McCabe, Naemal Bhatti, Georgia E Hodes, Mitra Heshmati, Rachael L Neve, Eric J Nestler, Elizabeth A Heller, Scott J Russo
A growing number of studies implicate the brain's reward circuitry in aggressive behavior. However, the cellular and molecular mechanisms within brain reward regions that modulate the intensity of aggression as well as motivation for it have been underexplored. Here, we investigate the cell-type-specific influence of ΔFosB, a transcription factor known to regulate a range of reward and motivated behaviors, acting in the nucleus accumbens (NAc)-a key reward region-in male aggression in mice. We show that ΔFosB is specifically increased in dopamine D1 receptor (Drd1) expressing medium spiny neurons (D1-MSNs) in NAc after repeated aggressive encounters...
June 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29905488/effects-of-interaction-between-drd4-methylation-and-prenatal-maternal-stress-on-methylphenidate-induced-changes-in-continuous-performance-test-performance-in-youth-with-attention-deficit-hyperactivity-disorder
#5
Johanna Inhyang Kim, Jae-Won Kim, Inkyung Shin, Bung-Nyun Kim
OBJECTIVES: Environmental factors may interact with genetic factors via the epigenetic process, and this interaction can contribute to inter-individual variability in the treatment response. The purpose of this study was to investigate the interaction effects between dopamine receptor D4 (DRD4) methylation and prenatal maternal stress on the methylphenidate (MPH) response of youth with attention-deficit/hyperactivity disorder (ADHD). METHODS: This study was an 8-week open-label trial of MPH that included 74 ADHD youth...
June 15, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29897417/prefrontal-d1-dopamine-receptor-neurons-and-delta-resonance-in-interval-timing
#6
Young-Cho Kim, Nandakumar S Narayanan
Considerable evidence has shown that prefrontal neurons expressing D1-type dopamine receptors (D1DRs) are critical for working memory, flexibility, and timing. This line of work predicts that frontal neurons expressing D1DRs mediate cognitive processing. During timing tasks, one form this cognitive processing might take is time-dependent ramping activity-monotonic changes in firing rate over time. Thus, we hypothesized the prefrontal D1DR+ neurons would strongly exhibit time-dependent ramping during interval timing...
June 12, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29799765/revisiting-the-marshmallow-test-a-conceptual-replication-investigating-links-between-early-delay-of-gratification-and-later-outcomes
#7
Tyler W Watts, Greg J Duncan, Haonan Quan
We replicated and extended Shoda, Mischel, and Peake's (1990) famous marshmallow study, which showed strong bivariate correlations between a child's ability to delay gratification just before entering school and both adolescent achievement and socioemotional behaviors. Concentrating on children whose mothers had not completed college, we found that an additional minute waited at age 4 predicted a gain of approximately one tenth of a standard deviation in achievement at age 15. But this bivariate correlation was only half the size of those reported in the original studies and was reduced by two thirds in the presence of controls for family background, early cognitive ability, and the home environment...
May 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29771559/body-mass-index-across-adolescence-and-substance-use-problems-in-early-adulthood
#8
Ashley N Gearhardt, Rebecca Waller, Jennifer M Jester, Luke W Hyde, Robert A Zucker
Excessive substance use and obesity are underpinned by a number of shared risk factors (e.g., reward dysfunction, impulsivity). Food and drugs of abuse engage similar reward-related neural circuitry and the food-drug competition hypothesis proposes that excess consumption of food may diminish desire for drugs of abuse by competing for neural receptors associated with reward and motivation. Adolescence is a high-risk period for both increased substance use and excessive weight gain. In the present study, the authors tested whether, consistent with the food-drug competition hypothesis, elevated body mass index (BMI) across adolescence predicted fewer substance use problems in young adulthood...
May 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29806533/adhd-and-the-choice-of-small-immediate-over-larger-delayed-rewards-a-comparative-meta-analysis-of-performance-on-simple-choice-delay-and-temporal-discounting-paradigms
#9
Ivo Marx, Thomas Hacker, Xue Yu, Samuele Cortese, Edmund Sonuga-Barke
OBJECTIVE: Impulsive choices can lead to suboptimal decision making, a tendency which is especially marked in individuals with ADHD. We compared two different paradigms assessing impulsive choice: the simple choice paradigm (SCP) and the temporal discounting paradigm (TDP). METHOD: Random effects meta-analyses on 37 group comparisons (22 SCP; 15 TDP) consisting of 3.763 participants (53% ADHD). RESULTS: Small-to-medium effect sizes emerged for both paradigms, confirming that participants with ADHD choose small immediate over large delayed rewards more frequently than controls...
May 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29784236/a-review-associations-between-attention-deficit-hyperactivity-disorder-physical-activity-medication-use-eating-behaviors-and-obesity-in-children-and-adolescents
#10
REVIEW
Danielle Quesada, Nasar U Ahmed, Kristopher P Fennie, Erica L Gollub, Boubakari Ibrahimou
In the past few years we have become increasingly aware of strong associations between obesity and ADHD. Both conditions are major public health issues, affecting children, adolescents and adults alike. OBJECTIVE: This review seeks to (1) examine prior research on the association between ADHD and obesity in children and adolescents; (2) discuss mechanisms and consequent behavioral attributes to gain understanding of the path association between ADHD and obesity, (3) review studies examining the role of physical activity, medication, eating behavior and gender on the relationship between ADHD and obesity in children and adolescents...
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29778625/the-mediating-role-of-phosphodiesterase-type-4-in-the-dopaminergic-modulation-of-motor-impulsivity
#11
P R A Heckman, A Blokland, N P Van Goethem, B T J Van Hagen, J Prickaerts
The current study investigated the mediating role of phosphodiesterase type 4 (PDE4) regulated cAMP in the dopaminergic modulation of premature responding (action restraint) in rats. Response inhibition, which includes action restraint, finds its neurobiological origin in cortico-striatal-thalamic circuitry and can be modulated by dopamine. Intracellularly, the effect of dopamine is largely mediated through the cAMP/PKA signaling cascade. Areas in the prefrontal cortex are very sensitive to their neurochemical environment, including catecholamine levels...
September 17, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29792726/i-like-them%C3%A2-will-they-like-me-evidence-for-the-role-of-the-ventrolateral-prefrontal-cortex-during-mismatched-social-appraisals-in-anxious-youth
#12
Ashley R Smith, Eric E Nelson, Brent I Rappaport, Daniel S Pine, Ellen Leibenluft, Johanna M Jarcho
OBJECTIVE: Socially anxious adolescents report distress during social decision-making, wherein their favorable view of peers directly conflicts with their expectation to be viewed negatively by peers; a phenomenon we refer to as "mismatch bias." The present study utilizes a novel paradigm with dynamic social stimuli to explore the correlates of mismatch biases in anxious and healthy youth. METHOD: The behavioral and neural correlates of mismatch biases were assessed in healthy (N = 17) and anxious (N = 14) youth during functional MRI...
May 24, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29780881/nucleus-accumbens-microcircuit-underlying-d2-msn-driven-increase-in-motivation
#13
Carina Soares-Cunha, Bárbara Coimbra, Ana Verónica Domingues, Nivaldo Vasconcelos, Nuno Sousa, Ana João Rodrigues
The nucleus accumbens (NAc) plays a central role in reinforcement and motivation. Around 95% of the NAc neurons are medium spiny neurons (MSNs), divided into those expressing dopamine receptor D1 (D1R) or dopamine receptor D2 (D2R). Optogenetic activation of D2-MSNs increased motivation, whereas inhibition of these neurons produced the opposite effect. Yet, it is still unclear how activation of D2-MSNs affects other local neurons/interneurons or input terminals and how this contributes for motivation enhancement...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29661516/lisdexamfetamine-targets-amygdala-mechanisms-that-bias-cognitive-control-in-attention-deficit-hyperactivity-disorder
#14
Kurt P Schulz, Beth Krone, Lenard A Adler, Anne-Claude V Bédard, Stephanie Duhoux, Juan Pedraza, Sanweda Mahagabin, Jeffrey H Newcorn
BACKGROUND: Prefrontal-limbic circuits that form the neural architecture for emotion to influence behavior have been implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD) and represent a potentially important target of medication treatment that has not been substantively evaluated. This study tested the effect of the psychostimulant prodrug lisdexamfetamine dimesylate on amygdala activation and connectivity during the emotional bias of response execution and inhibition...
March 19, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29687930/deficient-neural-activity-subserving-decision-making-during-reward-waiting-time-in-intertemporal-choice-in-adult-attention-deficit-hyperactivity-disorder
#15
Ayako Todokoro, Saori C Tanaka, Yuki Kawakubo, Noriaki Yahata, Ayaka Ishii-Takahashi, Yukika Nishimura, Yukiko Kano, Fumio Ohtake, Kiyoto Kasai
AIM: Impulsivity, which significantly affects social adaptation, is an important target behavioral characteristic in interventions for attention-deficit hyperactivity disorder (ADHD). Typically, people are willing to wait longer to acquire greater rewards. Impulsivity in ADHD may be associated with brain dysfunction in decision-making involving waiting behavior under such situations. We tested the hypothesis that brain circuitry during a period of waiting (i.e., prior to the acquisition of reward) is altered in adults with ADHD...
April 24, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29706587/frontostriatal-dysfunction-during-decision-making-in-attention-deficit-hyperactivity-disorder-and-obsessive-compulsive-disorder
#16
Luke J Norman, Christina O Carlisi, Anastasia Christakou, Clodagh M Murphy, Kaylita Chantiluke, Vincent Giampietro, Andrew Simmons, Michael Brammer, David Mataix-Cols, Katya Rubia
BACKGROUND: The aim of the current paper is to provide the first comparison of computational mechanisms and neurofunctional substrates in adolescents with attention-deficit/hyperactivity disorder (ADHD) and adolescents with obsessive-compulsive disorder (OCD) during decision making under ambiguity. METHODS: Sixteen boys with ADHD, 20 boys with OCD, and 20 matched control subjects (12-18 years of age) completed a functional magnetic resonance imaging version of the Iowa Gambling Task...
March 24, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29706908/event-related-potential-erp-correlates-of-performance-monitoring-in-adults-with-attention-deficit-hyperactivity-disorder-adhd
#17
Lynn Marquardt, Heike Eichele, Astri J Lundervold, Jan Haavik, Tom Eichele
Introduction: Attention-deficit hyperactivity disorder (ADHD) is one of the most frequent neurodevelopmental disorders in children and tends to persist into adulthood. Evidence from neuropsychological, neuroimaging, and electrophysiological studies indicates that alterations of error processing are core symptoms in children and adolescents with ADHD. To test whether adults with ADHD show persisting deficits and compensatory processes, we investigated performance monitoring during stimulus-evaluation and response-selection, with a focus on errors, as well as within-group correlations with symptom scores...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29682852/novel-in-silico-multivariate-mapping-of-intrinsic-and-anticorrelated-connectivity-to-neurocognitive-functional-maps-supports-the-maturational-hypothesis-of-adhd
#18
Nina de Lacy, Ian Kodish, Srinivas Rachakonda, Vince D Calhoun
From childhood to adolescence, strengthened coupling in frontal, striatal and parieto-temporal regions associated with cognitive control, and increased anticorrelation between task-positive and task-negative circuits, subserve the reshaping of behavior. ADHD is a common condition peaking in adolescence and regressing in adulthood, with a wide variety of cognitive control deficits. Alternate hypotheses of ADHD emphasize lagging circuitry refinement versus categorical differences in network function. However, quantifying the individual circuit contributions to behavioral findings, and relative roles of maturational versus categorical effects, is challenging in vivo or in meta-analyses using task-based paradigms within the same pipeline, given the multiplicity of neurobehavioral functions implicated...
April 22, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29687078/firing-of-putative-dopamine-neurons-in-ventral-tegmental-area-is-modulated-by-probability-of-success-during-performance-of-a-stop-change-task
#19
Stephen S Tennyson, Adam T Brockett, Nicholas W Hricz, Daniel W Bryden, Matthew R Roesch
Response inhibition, the ability to refrain from unwanted actions, is an essential component of complex behavior and is often impaired across numerous neuropsychiatric disorders such as addiction, attention-deficit hyperactivity disorder (ADHD), schizophrenia, and obsessive-compulsive disorder. Accordingly, much research has been devoted to characterizing brain regions responsible for the regulation of response inhibition. The stop-signal task, a task in which animals are required to inhibit a prepotent response in the presence of a STOP cue, is one of the most well-studied tasks of response inhibition...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29739866/region-specific-regulation-of-presynaptic-dopamine-homeostasis-by-d-2-autoreceptors-shapes-the-in-vivo-impact-of-the-neuropsychiatric-disease-associated-dat-variant-val559
#20
Raajaram Gowrishankar, Paul J Gresch, Gwynne L Davis, Rania M Katamish, Justin R Riele, Adele M Stewart, Roxanne A Vaughan, Maureen K Hahn, Randy D Blakely
Disruptions of dopamine (DA) signaling contribute to a broad spectrum of neuropsychiatric disorders, including attention-deficit hyperactivity disorder (ADHD), addiction, bipolar disorder, and schizophrenia. Despite evidence that risk for these disorders derives from heritable variation in DA-linked genes, a better understanding is needed of the molecular and circuit context through which gene variation drives distinct disease traits. Previously, we identified the DA transporter (DAT) variant Val559 in subjects with ADHD and established that the mutation supports anomalous DAT-mediated DA efflux (ADE)...
June 6, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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