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Reward dysfunction in AD/HD

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242 papers 100 to 500 followers Several notable papers detailing recent and historical evidence for amotivational symptoms in AD/HD
https://www.readbyqxmd.com/read/29661516/lisdexamfetamine-targets-amygdala-mechanisms-that-bias-cognitive-control-in-attention-deficit-hyperactivity-disorder
#1
Kurt P Schulz, Beth Krone, Lenard A Adler, Anne-Claude V Bédard, Stephanie Duhoux, Juan Pedraza, Sanweda Mahagabin, Jeffrey H Newcorn
BACKGROUND: Prefrontal-limbic circuits that form the neural architecture for emotion to influence behavior have been implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD) and represent a potentially important target of medication treatment that has not been substantively evaluated. This study tested the effect of the psychostimulant prodrug lisdexamfetamine dimesylate on amygdala activation and connectivity during the emotional bias of response execution and inhibition...
March 19, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29687930/deficient-neural-activity-subserving-decision-making-during-reward-waiting-time-in-intertemporal-choice-in-adult-adhd
#2
Ayako Todokoro, Saori C Tanaka, Yuki Kawakubo, Noriaki Yahata, Ayaka Ishii-Takahashi, Yukika Nishimura, Yukiko Kano, Fumio Ohtake, Kiyoto Kasai
AIM: Impulsivity, which significantly affects social adaptation, is an important target behavioral characteristic in interventions for attention deficit hyperactivity disorder (ADHD). Typically, people are willing to wait longer to acquire greater rewards. Impulsivity in ADHD may be associated with brain dysfunction in decision making involving waiting behavior under such situations. We tested the hypothesis that brain circuitry during a period of waiting, i.e., prior to the acquisition of reward, is altered in adults with ADHD...
April 24, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29706587/frontostriatal-dysfunction-during-decision-making-in-attention-deficit-hyperactivity-disorder-and-obsessive-compulsive-disorder
#3
Luke J Norman, Christina O Carlisi, Anastasia Christakou, Clodagh M Murphy, Kaylita Chantiluke, Vincent Giampietro, Andrew Simmons, Michael Brammer, David Mataix-Cols, Katya Rubia
BACKGROUND: The aim of the current paper is to provide the first comparison of computational mechanisms and neurofunctional substrates in adolescents with attention-deficit/hyperactivity disorder (ADHD) and adolescents with obsessive-compulsive disorder (OCD) during decision making under ambiguity. METHODS: Sixteen boys with ADHD, 20 boys with OCD, and 20 matched control subjects (12-18 years of age) completed a functional magnetic resonance imaging version of the Iowa Gambling Task...
March 24, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29706908/event-related-potential-erp-correlates-of-performance-monitoring-in-adults-with-attention-deficit-hyperactivity-disorder-adhd
#4
Lynn Marquardt, Heike Eichele, Astri J Lundervold, Jan Haavik, Tom Eichele
Introduction: Attention-deficit hyperactivity disorder (ADHD) is one of the most frequent neurodevelopmental disorders in children and tends to persist into adulthood. Evidence from neuropsychological, neuroimaging, and electrophysiological studies indicates that alterations of error processing are core symptoms in children and adolescents with ADHD. To test whether adults with ADHD show persisting deficits and compensatory processes, we investigated performance monitoring during stimulus-evaluation and response-selection, with a focus on errors, as well as within-group correlations with symptom scores...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29682852/novel-in-silico-multivariate-mapping-of-intrinsic-and-anticorrelated-connectivity-to-neurocognitive-functional-maps-supports-the-maturational-hypothesis-of-adhd
#5
Nina de Lacy, Ian Kodish, Srinivas Rachakonda, Vince D Calhoun
From childhood to adolescence, strengthened coupling in frontal, striatal and parieto-temporal regions associated with cognitive control, and increased anticorrelation between task-positive and task-negative circuits, subserve the reshaping of behavior. ADHD is a common condition peaking in adolescence and regressing in adulthood, with a wide variety of cognitive control deficits. Alternate hypotheses of ADHD emphasize lagging circuitry refinement versus categorical differences in network function. However, quantifying the individual circuit contributions to behavioral findings, and relative roles of maturational versus categorical effects, is challenging in vivo or in meta-analyses using task-based paradigms within the same pipeline, given the multiplicity of neurobehavioral functions implicated...
April 22, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29687078/firing-of-putative-dopamine-neurons-in-ventral-tegmental-area-is-modulated-by-probability-of-success-during-performance-of-a-stop-change-task
#6
Stephen S Tennyson, Adam T Brockett, Nicholas W Hricz, Daniel W Bryden, Matthew R Roesch
Response inhibition, the ability to refrain from unwanted actions, is an essential component of complex behavior and is often impaired across numerous neuropsychiatric disorders such as addiction, attention-deficit hyperactivity disorder (ADHD), schizophrenia, and obsessive-compulsive disorder. Accordingly, much research has been devoted to characterizing brain regions responsible for the regulation of response inhibition. The stop-signal task, a task in which animals are required to inhibit a prepotent response in the presence of a STOP cue, is one of the most well-studied tasks of response inhibition...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29739866/region-specific-regulation-of-presynaptic-dopamine-homeostasis-by-d2-autoreceptors-shapes-the-in-vivo-impact-of-the-neuropsychiatric-disease-associated-dat-variant-val559
#7
Raajaram Gowrishankar, Paul J Gresch, Gwynne L Davis, Rania M Katamish, Justin R Riele, Adele M Stewart, Roxanne A Vaughan, Maureen K Hahn, Randy D Blakely
Disruptions of dopamine (DA) signaling contribute to a broad spectrum of neuropsychiatric disorders, including attention-deficit hyperactivity disorder (ADHD), addiction, bipolar disorder and schizophrenia. Despite evidence that risk for these disorders derives from heritable variation in DA-linked genes, a better understanding is needed of the molecular and circuit context through which gene variation drives distinct disease traits. Previously, we identified the DA transporter (DAT) variant Val559 in subjects with ADHD and established that the mutation supports anomalous DAT-mediated DA efflux (ADE)...
May 8, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29725947/individual-differences-in-dopamine-d-2-receptor-availability-correlate-with-reward-valuation
#8
Linh C Dang, Gregory R Samanez-Larkin, Jaime J Castrellon, Scott F Perkins, Ronald L Cowan, David H Zald
Reward valuation, which underlies all value-based decision-making, has been associated with dopamine function in many studies of nonhuman animals, but there is relatively less direct evidence for an association in humans. Here, we measured dopamine D2 receptor (DRD2) availability in vivo in humans to examine relations between individual differences in dopamine receptor availability and neural activity associated with a measure of reward valuation, expected value (i.e., the product of reward magnitude and the probability of obtaining the reward)...
May 3, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29554302/ventral-striatal-d2-3-receptor-availability-is-associated-with-impulsive-choice-behavior-as-well-aslimbic-corticostriatal-connectivity
#9
Rebecca L Barlow, Martin Gorges, Alfie Wearn, Heiko G Niessen, Jan Kassubek, Jeffrey W Dalley, Anton Pekcec
Background: Low dopamine D2/3 receptor availability in the nucleus accumbens (NAcb) shell is associated with highly-impulsive behavior in rats, as measured by premature responses in a cued attentional task. However, it is unclear whether dopamine D2/3 receptor availability in the NAcb is equally linked to intolerance for delayed rewards, a related form of impulsivity. Methods: We investigated the relationship between D2/3 receptor availability in the NAcb and impulsivity in a delay-discounting task (DDT) where animals must choose between immediate small-magnitude rewards and delayed larger-magnitude rewards...
March 15, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29735686/transcriptomic-context-of-drd1-is-associated-with-prefrontal-activity-and-behavior-during-working-memory
#10
Leonardo Fazio, Giulio Pergola, Marco Papalino, Pasquale Di Carlo, Anna Monda, Barbara Gelao, Nicola Amoroso, Sabina Tangaro, Antonio Rampino, Teresa Popolizio, Alessandro Bertolino, Giuseppe Blasi
Dopamine D1 receptor (D1 R) signaling shapes prefrontal cortex (PFC) activity during working memory (WM). Previous reports found higher WM performance associated with alleles linked to greater expression of the gene coding for D1 Rs ( DRD1 ). However, there is no evidence on the relationship between genetic modulation of DRD1 expression in PFC and patterns of prefrontal activity during WM. Furthermore, previous studies have not considered that D1 Rs are part of a coregulated molecular environment, which may contribute to D1 R-related prefrontal WM processing...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29609103/cognitive-control-training-for-emotion-related-impulsivity
#11
Andrew D Peckham, Sheri L Johnson
Many forms of psychopathology are tied to a heightened tendency to respond impulsively to strong emotions, and this tendency, in turn, is closely tied to problems with cognitive control. The goal of the present study was to test whether a two-week, six-session cognitive control training program is efficacious in reducing emotion-related impulsivity. Participants (N = 52) reporting elevated scores on an emotion-related impulsivity measure completed cognitive control training targeting working memory and response inhibition...
June 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29617066/the-mixed-opioid-receptor-antagonist-naltrexone-mitigates-stimulant-induced-euphoria-a-double-blind-placebo-controlled-trial-of-naltrexone
#12
Thomas J Spencer, Pradeep Bhide, Jinmin Zhu, Stephen V Faraone, Maura Fitzgerald, Amy M Yule, Mai Uchida, Andrea E Spencer, Anna M Hall, Ariana J Koster, Leah Feinberg, Sarah Kassabian, Barbara Storch, Joseph Biederman
OBJECTIVE: Supratherapeutic doses of methylphenidate activate μ-opioid receptors, which are linked to euphoria. This study assessed whether naltrexone, a mixed μ-opioid antagonist, may attenuate the euphoric effects of stimulants, thereby minimizing their abuse potential in subjects with attention-deficit/hyperactivity disorder (ADHD). METHODS: We conducted a 6-week, double-blind, placebo-controlled, randomized clinical trial of naltrexone in adults with DSM-IV ADHD receiving open treatment with a long-acting formulation of methylphenidate (January 2013 to June 2015)...
March 13, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29556859/children-s-reward-and-punishment-sensitivity-moderates-the-association-of-negative-and-positive-parenting-behaviors-in-child-adhd-symptoms
#13
James J Li
Atypical reward processing, including abnormal reward responsivity and sensitivity to punishment, has long been implicated in the etiology of ADHD. However, little is known about how these facets of behavior interact with positive (e.g., warmth, praise) and negative (e.g., hostility, harsh discipline) parenting behavior in the early expression of ADHD symptoms in young children. Understanding the interplay between children's reward processing and parenting may be crucial for identifying specific treatment targets in psychosocial interventions for ADHD, especially given that not all children benefit from contingency-based treatments (e...
March 20, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29553294/evaluation-of-the-interplay-between-homework-motivation-and-sluggish-cognitive-tempo-in-youth-with-adhd-associations-with-homework-performance
#14
Zoe R Smith, Rosanna P Breaux, Cathrin D Green, Joshua M Langberg
OBJECTIVE: This study evaluated which Sluggish Cognitive Tempo (SCT) factors (i.e., Slow, Sleepy, Daydreamer) are most strongly associated with homework motivation, and whether homework motivation mediates the path between SCT and academic impairment. METHOD: Participants were 285 middle school students (boys 209) in Grades 6 to 8 (ages 10-15 years) who were comprehensively diagnosed with ADHD. RESULTS: Parent- and self-report of SCT Slow behaviors predicted homework motivation above and beyond symptoms of ADHD, oppositional defiant disorder (ODD), anxiety, depression, and intelligence...
March 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29540712/accumbens-dopamine-d2-receptors-increase-motivation-by-decreasing-inhibitory-transmission-to-the-ventral-pallidum
#15
Eduardo F Gallo, Jozsef Meszaros, Jeremy D Sherman, Muhammad O Chohan, Eric Teboul, Claire S Choi, Holly Moore, Jonathan A Javitch, Christoph Kellendonk
Dopamine D2 receptors (D2Rs) in the nucleus accumbens (NAc) regulate motivated behavior, but the underlying neurobiological mechanisms remain unresolved. Here, we show that selective upregulation of D2Rs in the indirect pathway of the adult NAc enhances the willingness to work for food. Mechanistic studies in brain slices reveal that D2R upregulation attenuates inhibitory transmission at two main output projections of the indirect pathway, the classical long-range projections to the ventral pallidum (VP), as well as local collaterals to direct pathway medium spiny neurons...
March 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29496512/pharmacological-analysis-of-zebrafish-lphn3-1-morphant-larvae-suggests-that-saturated-dopaminergic-signaling-could-underlie-the-adhd-like-locomotor-hyperactivity
#16
Merlin Lange, Cynthia Froc, Hannah Grunwald, William H J Norton, Laure Bally-Cuif
Polymorphisms in the gene coding for the adhesion G-protein coupled receptor LPHN3 are a risk factor for attention-deficit/hyperactivity disorder (ADHD). Transient down-regulation of latrophilin3.1 (lphn3.1), the zebrafish LPHN3 homologue, causes hyperactivity. Zebrafish injected with a lphn3.1-specific morpholino are hyperactive and display an impairment in dopaminergic neuron development. In the present study we used lphn3.1 morphants to further characterize the changes to dopaminergic signaling that trigger hyperactivity...
June 8, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29468918/relations-between-sleep-and-temperament-in-preschool-children-with-adhd
#17
Maria Grazia Melegari, Stefania Sette, Elena Vittori, Luca Mallia, Alessandra Devoto, Fabio Lucidi, Raffaele Ferri, Oliviero Bruni
OBJECTIVE: The objective of this study was to assess the links between temperament and sleep in a group of preschoolers with ADHD. METHOD: Twenty-five ADHD ( M = 5.37 years, SD = 1.09) and 22 typically developing (TD; M = 5.10, SD = 1.18) preschoolers participated in the study. Sleep was assessed with the Sleep Disturbance Scale and wrist actigraphy. The Preschool Temperament and Character Inventory (PsTCI) was used to evaluate the child temperament. RESULTS: ADHD children showed a temperamental profile characterized by higher novelty seeking, lower persistence, self-directness, and cooperativeness and marginally lower harm avoidance (HA) compared with controls...
February 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29476896/systemic-administration-of-guanfacine-improves-food-motivated-impulsive-choice-behavior-primarily-via-direct-stimulation-of-postsynaptic-%C3%AE-2a-adrenergic-receptors-in-rats
#18
Kouhei Nishitomi, Koji Yano, Mika Kobayashi, Kohei Jino, Takuya Kano, Naotaka Horiguchi, Shunji Shinohara, Minoru Hasegawa
Impulsive choice behavior, which can be assessed using the delay discounting task, is a characteristic of various psychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD). Guanfacine is a selective α2A -adrenergic receptor agonist that is clinically effective in treating ADHD. However, there is no clear evidence that systemic guanfacine administration reduces impulsive choice behavior in the delay discounting task in rats. In the present study, we examined the effect of systemic guanfacine administration on food-motivated impulsive choice behavior in rats and the neuronal mechanism underlying this effect...
June 1, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29483340/inter-individual-differences-in-the-impulsive-compulsive-dimension-deciphering-related-dopaminergic-and-serotonergic-metabolisms-at-rest
#19
Françoise Dellu-Hagedorn, Marion Rivalan, Aurélie Fitoussi, Philippe De Deurwaerdère
Several impulse control disorders such as ADHD, mania, personality disorders or substance abuse share common behavioural traits, like impulsiveness, risk-taking or inflexible behaviour. These disorders are treated with drugs targeting dopamine (DA) and/or serotonin (5-HT). However, the patient's monoamine imbalance that these neurotransmitters compensate is unclear. This study aims to investigate the patterns of DA and 5-HT metabolisms at rest within selected brain regions related to inter-individual variability in six main components of impulsivity/compulsivity (anticipatory hyperactivity, premature responses, delay discounting, risk-taking, perseveration, flexibility)...
April 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29423135/altered-reward-system-reactivity-for-personalized-circumscribed-interests-in-autism
#20
Gregor Kohls, Ligia Antezana, Maya G Mosner, Robert T Schultz, Benjamin E Yerys
Background: Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain's reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study's central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i...
2018: Molecular Autism
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