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Reward dysfunction in AD/HD

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203 papers 100 to 500 followers Several notable papers detailing recent and historical evidence for amotivational symptoms in AD/HD
https://www.readbyqxmd.com/read/28768457/greater-delay-discounting-among-girls-but-not-boys-with-adhd-correlates-with-cognitive-control
#1
Connor H G Patros, Kristie L Sweeney, E Mark Mahone, Stewart H Mostofsky, Keri S Rosch
Cognitive neuroscience models suggest both reward valuation and cognitive control contribute to reward-based decision-making. The current study examined the relationship between cognitive control and delay discounting (i.e., choosing smaller, immediate over larger, delayed rewards) in a large sample of boys and girls diagnosed with attention-deficit/hyperactivity disorder (ADHD; N = 95) and typically developing control children (TD; N = 59). Specifically, we examined performance on multiple measures of cognitive control (i...
August 2, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28782975/heterogeneity-in-development-of-aspects-of-working-memory-predicts-longitudinal-attention-deficit-hyperactivity-disorder-symptom-change
#2
Sarah L Karalunas, Hanna C Gustafsson, Nathan F Dieckmann, Jessica Tipsord, Suzanne H Mitchell, Joel T Nigg
The role of cognitive mechanisms in the clinical course of neurodevelopmental disorders is poorly understood. Attention Deficit Hyperactivity Disorder (ADHD) is emblematic in that numerous alterations in cognitive development are apparent, yet how they relate to changes in symptom expression with age is unclear. To resolve the role of cognitive mechanisms in ADHD, a developmental perspective that takes into account expected within-group heterogeneity is needed. METHOD: The current study uses an accelerated longitudinal design and latent trajectory growth mixture models in a sample of children ages 7-13 years carefully characterized as with (n = 437) and without (n = 297) ADHD to (a) identify heterogeneous developmental trajectories for response inhibition, visual spatial working memory maintenance, and delayed reward discounting and (b) to assess the relationships between these cognitive trajectories and ADHD symptom change...
August 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28689673/the-anatomy-of-apathy-a-neurocognitive-framework-for-amotivated-behaviour
#3
C Le Heron, M A J Apps, M Husain
Apathy is a debilitating syndrome associated with many neurological disorders, including several common neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, and focal lesion syndromes such as stroke. Here, we review neuroimaging studies to identify anatomical correlates of apathy, across brain disorders. Our analysis reveals that apathy is strongly associated with disruption particularly of dorsal anterior cingulate cortex (dACC), ventral striatum (VS) and connected brain regions...
July 8, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28741623/effects-of-suvorexant-a-dual-orexin-hypocretin-receptor-antagonist-on-impulsive-behavior-associated-with-cocaine
#4
Taylor A Gentile, Steven J Simmons, Mia N Watson, Krista L Connelly, Eugen Brailoiu, Yanan Zhang, John W Muschamp
Hypothalamic hypocretin (orexin) peptides mediate arousal, attention, and reward processing. Fibers containing orexins project to brain structures that govern motivated behavior, including the ventral tegmental area (VTA). A number of psychiatric conditions, including attention deficit hyperactivity disorder (ADHD) and substance use disorders, are characterized by deficits in impulse control, however the relationship between orexin and impulsive behavior is incompletely characterized. The effects of systemic or centrally administered orexin receptor (OXR) antagonists on measures of impulsive-like behavior in rats were evaluated using the five-choice serial reaction time task (5-CSRTT) and delay discounting procedures...
July 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28707986/developing-adhd-in-preschool-testing-the-dual-pathway-model-of-temperament
#5
Julia Kerner Auch Koerner, Nicole Gust, Franz Petermann
The dual pathway model of Attention Deficit Hyperactivity Disorder (ADHD) suggests that effortful control and positive approach, or surgency, are independent pathways leading to ADHD. This model has been proven on the basis of temperament in school children, however not in preschool children. In this study we tested whether the dual pathway model of ADHD can be replicated in preschool children using temperamental measures. One hundred and nineteen children (59 girls, M-age = 4.97 years, SD = 0.96) participated in a study...
July 14, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/28686562/-impulsivity-as-an-immediate-factor-between-addictive-disorders-and-attention-deficit-hyperactivity-disorder
#6
H Lazaratou, A Palaiologou, D Anagnostopoulos
Impulsivity is a behavior in everyday life of mentally healthy individuals. But in some cases the degree of impulsivity begins to create negative effects on one's life and acquires pathological connotation. Two clinical entities in which can be observed a high degree of impulsivity is Attention Deficit Hyperactivity Disorder (ADHD) and Addictive disorders. In these disorders, both impulsive act and impulsive choice are observed. According to some researchers, genetic factors are involved in the control of impulsivity...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28671298/explaining-the-relationship-between-temperament-and-symptoms-of-psychiatric-disorders-from-preschool-to-middle-childhood-hybrid-fixed-and-random-effects-models-of-norwegian-and-spanish-children
#7
Lars Wichstrøm, Eva Penelo, Kristine Rensvik Viddal, Nuria de la Osa, Lourdes Ezpeleta
BACKGROUND: Four explanations for the concurrent and prospective associations between temperament and psychopathology in children have been suggested: predisposition, complication/scar, common cause/continuity, and pathoplasty/exacerbation. Because the confounding effects of common causes have not been ruled out in prior work, the support for the various explanations is uncertain. METHODS: Screen-stratified community samples of 4-year olds in Trondheim, Norway (n = 1,042), and 3-year olds in Barcelona, Spain (n = 622), were assessed biennially for symptoms of attention-deficit/hyperactivity (ADHD), oppositional defiant (ODD), conduct (CD), anxiety, and depressive disorders through interviewer-based psychiatric interviews across four waves of data collection...
July 3, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28630479/attention-cognitive-control-and-motivation-in-adhd-linking-event-related-brain-potentials-and-dna-methylation-patterns-in-boys-at-early-school-age
#8
Hartmut Heinrich, Juliane Grunitz, Valeska Stonawski, Stefan Frey, Simone Wahl, Björn Albrecht, Tamme W Goecke, Matthias W Beckmann, Johannes Kornhuber, Peter A Fasching, Gunther H Moll, Anna Eichler
In order to better understand the underpinnings of attention-deficit/hyperactivity disorder (ADHD), we targeted the relationship of attentional, cognitive control and motivational processes with DNA methylation patterns of 60 candidate genes in boys at early school age. Participants (6 to 8 years; N = 82) were selected from a German longitudinal cohort (FRANCES). ADHD-related behaviour was assessed via maternal ratings. Performance and event-related potential measures (inter alia Cue-P3 and Nogo-P3), which were recorded in a motivational go/nogo task, indicated diminished attentional orienting, reduced inhibitory response control and a larger motivational effect on performance in ADHD already at this relatively young age...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28640989/stimulant-treatment-trajectories-are-associated-with-neural-reward-processing-in-attention-deficit-hyperactivity-disorder
#9
Lizanne J S Schweren, Annabeth Groenman, Daniel von Rhein, Wouter Weeda, Stephen F Faraone, Marjolein Luman, Hanneke van Ewijk, Dirk J Heslenfeld, Barbara Franke, Jan K Buitelaar, Jaap Oosterlaan, Pieter J Hoekstra, Catharina A Hartman
OBJECTIVE: The past decades have seen a surge in stimulant prescriptions for the treatment of attention-deficit/hyperactivity disorder (ADHD). Stimulants acutely alleviate symptoms and cognitive deficits associated with ADHD by modulating striatal dopamine neurotransmission and induce therapeutic changes in brain activation patterns. Long-term functional changes after treatment are unknown, as long-term studies are scarce and have focused on brain structure. In this observational study (2009-2012), we investigated associations between lifetime stimulant treatment history and neural activity during reward processing...
June 20, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28551713/atomoxetine-effects-on-attentional-bias-to-drug-related-cues-in-cocaine-dependent-individuals
#10
Luca Passamonti, M Luijten, H Ziauddeen, I T S Coyle-Gilchrist, T Rittman, S A E Brain, R Regenthal, I H A Franken, B J Sahakian, E T Bullmore, T W Robbins, K D Ersche
RATIONALE: Biased attention towards drug-related cues and reduced inhibitory control over the regulation of drug-intake characterize drug addiction. The noradrenaline system has been critically implicated in both attentional and response inhibitory processes and is directly affected by drugs such as cocaine. OBJECTIVES: We examined the potentially beneficial effects of the noradrenaline reuptake inhibitor atomoxetine in improving cognitive control during two tasks that used cocaine- and non-cocaine-related stimuli...
August 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28536846/time-on-task-effects-in-children-with-and-without-adhd-depletion-of-executive-resources-or-depletion-of-motivation
#11
Tycho J Dekkers, Joost A Agelink van Rentergem, Alette Koole, Wery P M van den Wildenberg, Arne Popma, Anika Bexkens, Reino Stoffelsen, Anouk Diekmann, Hilde M Huizenga
Children with attention-deficit/hyperactivity disorder (ADHD) are characterized by deficits in their executive functioning and motivation. In addition, these children are characterized by a decline in performance as time-on-task increases (i.e., time-on-task effects). However, it is unknown whether these time-on-task effects should be attributed to deficits in executive functioning or to deficits in motivation. Some studies in typically developing (TD) adults indicated that time-on-task effects should be interpreted as depletion of executive resources, but other studies suggested that they represent depletion of motivation...
May 23, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28608744/methylphenidate-related-improvements-in-math-performance-cannot-be-explained-by-better-cognitive-functioning-or-higher-academic-motivation-evidence-from-a-randomized-controlled-trial
#12
Anne Fleur Kortekaas-Rijlaarsdam, Marjolein Luman, Edmund Sonuga-Barke, Pierre Bet, Jaap Oosterlaan
OBJECTIVE: This study investigated whether improvements in working memory, reaction time, lapses of attention, interference control, academic motivation, and perceived competence mediated effects of methylphenidate on math performance. METHOD: Sixty-three children (ADHD diagnosis; methylphenidate treatment; age 8-13; IQ > 70) were randomly allocated to a 7-day methylphenidate or placebo treatment in this double-blind placebo-controlled crossover study and compared with 67 controls...
June 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28511579/does-an-attention-bias-to-appetitive-and-aversive-words-modulate-interference-control-in-youth-with-adhd
#13
Ili Ma, Gabry W Mies, Nanda N J Lambregts-Rommelse, Jan K Buitelaar, Antonius H N Cillessen, Anouk Scheres
Interference control refers to the ability to selectively attend to certain information while ignoring distracting information. This ability can vary as a function of distractor relevance. Distractors that are particularly relevant to an individual may attract more attention than less relevant distractors. This is referred to as attention bias. Weak interference control and altered reward sensitivity are both important features of attention deficit hyperactivity disorder (ADHD). However, interference control is typically studied in isolation...
May 16, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28557437/differentiating-physicochemical-properties-between-addictive-and-nonaddictive-adhd-drugs-revealed-by-molecular-dynamics-simulation-studies
#14
Panpan Wang, Xiaoyu Zhang, Tingting Fu, Shuang Li, Bo Li, Weiwei Xue, Xiaojun Yao, Yuzong Chen, Feng Zhu
Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed mental disorder of children and adolescents. Although psychostimulants are currently the first-line drugs for ADHD, their highly addictive profile raises great abuse concerns. It is known that psychostimulants' addictiveness is largely attributed to their interaction with dopamine transporter (DAT) and their binding modes in DAT can thus facilitate the understanding of the mechanism underlining drugs' addictiveness. However, no DAT residue able to discriminate ADHD drugs' addictiveness is identified, and the way how different drug structures affect their abuse liability is still elusive...
June 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/25998281/is-adult-adhd-a-childhood-onset-neurodevelopmental-disorder-evidence-from-a-four-decade-longitudinal-cohort-study
#15
Terrie E Moffitt, Renate Houts, Philip Asherson, Daniel W Belsky, David L Corcoran, Maggie Hammerle, HonaLee Harrington, Sean Hogan, Madeline H Meier, Guilherme V Polanczyk, Richie Poulton, Sandhya Ramrakha, Karen Sugden, Benjamin Williams, Luis Augusto Rohde, Avshalom Caspi
OBJECTIVE: Despite a prevailing assumption that adult ADHD is a childhood-onset neurodevelopmental disorder, no prospective longitudinal study has described the childhoods of the adult ADHD population. The authors report follow-back analyses of ADHD cases diagnosed in adulthood, alongside follow-forward analyses of ADHD cases diagnosed in childhood, in one cohort. METHOD: Participants belonged to a representative birth cohort of 1,037 individuals born in Dunedin, New Zealand, in 1972 and 1973 and followed to age 38, with 95% retention...
October 2015: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28481903/attention-deficit-hyperactivity-disorder-delay-discounting-and-risky-financial-behaviors-a-preliminary-analysis-of-self-report-data
#16
Theodore P Beauchaine, Itzhak Ben-David, Aner Sela
Delay discounting-often referred to as hyperbolic discounting in the financial literature-is defined by a consistent preference for smaller, immediate rewards over larger, delayed rewards, and by failure of future consequences to curtail current consummatory behaviors. Previous research demonstrates (1) excessive delay discounting among individuals with attention-deficit/hyperactivity disorder (ADHD), (2) common neural substrates of delay discounting and hyperactive-impulsive symptoms of ADHD, and (3) associations between delay discounting and both debt burden and high interest rate borrowing...
2017: PloS One
https://www.readbyqxmd.com/read/28421658/transcriptional-signatures-of-connectomic-subregions-of-the-human-striatum
#17
Linden Parkes, Ben Fulcher, Murat Yücel, Alex Fornito
Functionally distinct regions of the brain are thought to possess a characteristic connectional fingerprint - a profile of incoming and outgoing connections that defines the function of that area. This observation has motivated efforts to subdivide brain areas using their connectivity patterns. However, it remains unclear whether these connectomically-defined subregions can be distinguished at the molecular level. Here, we combine high-resolution diffusion-weighted magnetic resonance imaging with transcriptomic data to show that connectomically-defined subregions of the striatum carry distinct transcriptional signatures...
April 19, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28445519/the-effect-of-atomoxetine-on-random-and-directed-exploration-in-humans
#18
Christopher M Warren, Robert C Wilson, Nic J van der Wee, Eric J Giltay, Martijn S van Noorden, Jonathan D Cohen, Sander Nieuwenhuis
The adaptive regulation of the trade-off between pursuing a known reward (exploitation) and sampling lesser-known options in search of something better (exploration) is critical for optimal performance. Theory and recent empirical work suggest that humans use at least two strategies for solving this dilemma: a directed strategy in which choices are explicitly biased toward information seeking, and a random strategy in which decision noise leads to exploration by chance. Here we examined the hypothesis that random exploration is governed by the neuromodulatory locus coeruleus-norepinephrine system...
2017: PloS One
https://www.readbyqxmd.com/read/28423978/reward-processing-deficits-during-a-spatial-attention-task-in-patients-with-adhd-an-fmri-study
#19
Baris Metin, Zeynep C Tas, Merve Çebi, Ayşe Büyükaslan, Aysegül Soysal, Deniz Hatıloglu, Nevzat Tarhan
OBJECTIVE: In this study, we aimed to explore how cues signaling rewards and feedbacks about rewards are processed in ADHD. METHOD: Inside the scanner, 16 healthy children and 19 children with ADHD completed a spatial attention paradigm where cues informed about the availability of reward and feedbacks were provided about the earned reward. RESULTS: In ventral anterior thalamus (VA), the controls exhibited greater activation in response to reward-predicting cues, as compared with no-reward cues, whereby in the ADHD group, the reverse pattern was observed (nonreward > reward)...
April 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28433093/impact-of-a-common-genetic-variation-associated-with-putamen-volume-on-neural-mechanisms-of-attention-deficit-hyperactivity-disorder
#20
Bing Xu, Tianye Jia, Christine Macare, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J Conrod, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Michael N Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Sylvane Desrivières
OBJECTIVE: In a recent genomewide association study of subcortical brain volumes, a common genetic variation at rs945270 was identified as having the strongest effect on putamen volume, a brain measurement linked to familial risk for attention-deficit/hyperactivity disorder (ADHD). To determine whether rs945270 might be a genetic determinant of ADHD, its effects on ADHD-related symptoms and neural mechanisms of ADHD, such as response inhibition and reward sensitivity, were explored. METHOD: A large population sample of 1,834 14-year-old adolescents was used to test the effects of rs945270 on ADHD symptoms assessed through the Strengths and Difficulties Questionnaire and region-of-interest analyses of putamen activation by functional magnetic resonance imaging using the stop signal and monetary incentive delay tasks, assessing response inhibition and reward sensitivity, respectively...
May 2017: Journal of the American Academy of Child and Adolescent Psychiatry
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