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Propofol vs benzodiazepines

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By Ali Alenazy Cardiologist
Nick W Lonardo, Mary C Mone, Raminder Nirula, Edward J Kimball, Kyle Ludwig, Xi Zhou, Brian C Sauer, Kevin Nechodom, Chiachen Teng, Richard G Barton
RATIONALE: Mechanically ventilated intensive care unit (ICU) patients are frequently managed using a continuous-infusion sedative. Although recent guidelines suggest avoiding benzodiazepines for sedation, this class of drugs is still widely used. There are limited data comparing sedative agents in terms of clinical outcomes in an ICU setting. OBJECTIVES: Comparison of propofol to midazolam and lorazepam in adult ICU patients. METHODS: Data were obtained from a multicenter ICU database (2003-2009)...
June 1, 2014: American Journal of Respiratory and Critical Care Medicine
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